Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WYU6_LEIDO

TriTrypDb:

LdBPK_250560.1 , LdCL_250010700 , LDHU3_25.0670

Length:

676

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WYU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYU6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.259
CLV_C14_Caspase3-7	177	181	PF00656	0.563
CLV_C14_Caspase3-7	358	362	PF00656	0.507
CLV_C14_Caspase3-7	43	47	PF00656	0.514
CLV_NRD_NRD_1	16	18	PF00675	0.638
CLV_NRD_NRD_1	275	277	PF00675	0.348
CLV_NRD_NRD_1	369	371	PF00675	0.482
CLV_NRD_NRD_1	523	525	PF00675	0.396
CLV_NRD_NRD_1	526	528	PF00675	0.362
CLV_NRD_NRD_1	548	550	PF00675	0.390
CLV_NRD_NRD_1	73	75	PF00675	0.255
CLV_PCSK_FUR_1	521	525	PF00082	0.550
CLV_PCSK_FUR_1	71	75	PF00082	0.287
CLV_PCSK_KEX2_1	16	18	PF00082	0.638
CLV_PCSK_KEX2_1	165	167	PF00082	0.527
CLV_PCSK_KEX2_1	275	277	PF00082	0.353
CLV_PCSK_KEX2_1	369	371	PF00082	0.482
CLV_PCSK_KEX2_1	523	525	PF00082	0.411
CLV_PCSK_KEX2_1	526	528	PF00082	0.377
CLV_PCSK_KEX2_1	548	550	PF00082	0.436
CLV_PCSK_KEX2_1	73	75	PF00082	0.255
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.527
CLV_PCSK_SKI1_1	220	224	PF00082	0.367
CLV_PCSK_SKI1_1	276	280	PF00082	0.455
CLV_PCSK_SKI1_1	542	546	PF00082	0.421
CLV_PCSK_SKI1_1	549	553	PF00082	0.364
CLV_Separin_Metazoa	436	440	PF03568	0.491
DEG_APCC_DBOX_1	219	227	PF00400	0.438
DEG_APCC_DBOX_1	548	556	PF00400	0.371
DEG_SPOP_SBC_1	173	177	PF00917	0.584
DEG_SPOP_SBC_1	179	183	PF00917	0.554
DEG_SPOP_SBC_1	193	197	PF00917	0.512
DEG_SPOP_SBC_1	247	251	PF00917	0.537
DEG_SPOP_SBC_1	28	32	PF00917	0.501
DOC_CYCLIN_RxL_1	378	391	PF00134	0.510
DOC_CYCLIN_RxL_1	482	492	PF00134	0.463
DOC_CYCLIN_RxL_1	546	557	PF00134	0.496
DOC_CYCLIN_RxL_1	562	572	PF00134	0.241
DOC_MAPK_gen_1	217	225	PF00069	0.481
DOC_MAPK_gen_1	275	283	PF00069	0.351
DOC_MAPK_gen_1	369	377	PF00069	0.393
DOC_MAPK_gen_1	548	555	PF00069	0.434
DOC_MAPK_gen_1	661	670	PF00069	0.463
DOC_MAPK_gen_1	71	81	PF00069	0.268
DOC_MAPK_MEF2A_6	275	282	PF00069	0.301
DOC_MAPK_MEF2A_6	548	555	PF00069	0.397
DOC_MAPK_NFAT4_5	275	283	PF00069	0.333
DOC_MAPK_NFAT4_5	548	556	PF00069	0.432
DOC_PP1_RVXF_1	483	490	PF00149	0.442
DOC_USP7_MATH_1	12	16	PF00917	0.740
DOC_USP7_MATH_1	134	138	PF00917	0.622
DOC_USP7_MATH_1	144	148	PF00917	0.600
DOC_USP7_MATH_1	154	158	PF00917	0.590
DOC_USP7_MATH_1	179	183	PF00917	0.722
DOC_USP7_MATH_1	187	191	PF00917	0.742
DOC_USP7_MATH_1	193	197	PF00917	0.492
DOC_USP7_MATH_1	199	203	PF00917	0.463
DOC_USP7_MATH_1	28	32	PF00917	0.634
DOC_USP7_MATH_1	438	442	PF00917	0.720
DOC_USP7_MATH_1	543	547	PF00917	0.493
DOC_USP7_MATH_1	99	103	PF00917	0.408
DOC_USP7_UBL2_3	161	165	PF12436	0.581
DOC_WW_Pin1_4	194	199	PF00397	0.618
DOC_WW_Pin1_4	241	246	PF00397	0.584
DOC_WW_Pin1_4	262	267	PF00397	0.432
LIG_14-3-3_CanoR_1	123	128	PF00244	0.270
LIG_14-3-3_CanoR_1	166	172	PF00244	0.595
LIG_14-3-3_CanoR_1	22	29	PF00244	0.698
LIG_14-3-3_CanoR_1	275	281	PF00244	0.463
LIG_14-3-3_CanoR_1	369	377	PF00244	0.588
LIG_14-3-3_CanoR_1	439	448	PF00244	0.598
LIG_14-3-3_CanoR_1	488	494	PF00244	0.284
LIG_14-3-3_CanoR_1	542	552	PF00244	0.508
LIG_14-3-3_CanoR_1	554	563	PF00244	0.381
LIG_Actin_WH2_2	117	133	PF00022	0.411
LIG_Actin_WH2_2	202	219	PF00022	0.387
LIG_Actin_WH2_2	472	490	PF00022	0.267
LIG_BIR_III_2	115	119	PF00653	0.393
LIG_CaM_IQ_9	584	600	PF13499	0.334
LIG_deltaCOP1_diTrp_1	424	429	PF00928	0.454
LIG_FHA_1	157	163	PF00498	0.587
LIG_FHA_1	211	217	PF00498	0.383
LIG_FHA_1	233	239	PF00498	0.396
LIG_FHA_1	277	283	PF00498	0.438
LIG_FHA_1	311	317	PF00498	0.510
LIG_FHA_1	320	326	PF00498	0.462
LIG_FHA_1	339	345	PF00498	0.430
LIG_FHA_1	361	367	PF00498	0.571
LIG_FHA_1	488	494	PF00498	0.352
LIG_FHA_1	532	538	PF00498	0.455
LIG_FHA_1	575	581	PF00498	0.359
LIG_FHA_1	629	635	PF00498	0.445
LIG_FHA_2	175	181	PF00498	0.616
LIG_FHA_2	356	362	PF00498	0.503
LIG_FHA_2	41	47	PF00498	0.628
LIG_FHA_2	577	583	PF00498	0.379
LIG_GBD_Chelix_1	335	343	PF00786	0.346
LIG_LIR_Gen_1	603	612	PF02991	0.466
LIG_LIR_Gen_1	640	651	PF02991	0.334
LIG_LIR_LC3C_4	313	318	PF02991	0.258
LIG_LIR_Nem_3	125	130	PF02991	0.289
LIG_LIR_Nem_3	413	417	PF02991	0.508
LIG_LIR_Nem_3	603	607	PF02991	0.507
LIG_LIR_Nem_3	640	646	PF02991	0.320
LIG_MAD2	345	353	PF02301	0.472
LIG_MYND_1	446	450	PF01753	0.468
LIG_PCNA_yPIPBox_3	334	347	PF02747	0.438
LIG_PDZ_Class_3	671	676	PF00595	0.572
LIG_Pex14_1	128	132	PF04695	0.411
LIG_Pex14_2	221	225	PF04695	0.458
LIG_RPA_C_Fungi	11	23	PF08784	0.522
LIG_SH2_PTP2	414	417	PF00017	0.495
LIG_SH2_SRC	414	417	PF00017	0.495
LIG_SH2_SRC	506	509	PF00017	0.521
LIG_SH2_STAT5	414	417	PF00017	0.527
LIG_SH2_STAT5	456	459	PF00017	0.417
LIG_SH2_STAT5	506	509	PF00017	0.543
LIG_SH3_3	168	174	PF00018	0.554
LIG_SH3_3	195	201	PF00018	0.626
LIG_SH3_3	314	320	PF00018	0.471
LIG_SUMO_SIM_anti_2	279	284	PF11976	0.341
LIG_SUMO_SIM_anti_2	322	329	PF11976	0.358
LIG_SUMO_SIM_anti_2	372	379	PF11976	0.473
LIG_SUMO_SIM_par_1	117	122	PF11976	0.331
LIG_SUMO_SIM_par_1	372	379	PF11976	0.444
LIG_SUMO_SIM_par_1	536	541	PF11976	0.381
LIG_TRAF2_1	108	111	PF00917	0.411
LIG_TRAF2_1	353	356	PF00917	0.630
LIG_TYR_ITIM	412	417	PF00017	0.493
LIG_UBA3_1	120	129	PF00899	0.411
LIG_UBA3_1	343	352	PF00899	0.496
LIG_UBA3_1	479	485	PF00899	0.302
LIG_UBA3_1	642	650	PF00899	0.347
LIG_UBA3_1	93	98	PF00899	0.287
LIG_WW_3	436	440	PF00397	0.491
MOD_CK1_1	30	36	PF00069	0.579
MOD_CK1_1	557	563	PF00069	0.543
MOD_CK1_1	605	611	PF00069	0.443
MOD_CK1_1	614	620	PF00069	0.488
MOD_CK2_1	449	455	PF00069	0.465
MOD_Cter_Amidation	71	74	PF01082	0.273
MOD_GlcNHglycan	101	104	PF01048	0.216
MOD_GlcNHglycan	141	144	PF01048	0.632
MOD_GlcNHglycan	156	159	PF01048	0.507
MOD_GlcNHglycan	162	165	PF01048	0.768
MOD_GlcNHglycan	185	188	PF01048	0.701
MOD_GlcNHglycan	254	257	PF01048	0.675
MOD_GlcNHglycan	336	339	PF01048	0.426
MOD_GlcNHglycan	441	444	PF01048	0.661
MOD_GlcNHglycan	559	562	PF01048	0.342
MOD_GlcNHglycan	613	616	PF01048	0.598
MOD_GlcNHglycan	622	625	PF01048	0.510
MOD_GlcNHglycan	83	86	PF01048	0.479
MOD_GSK3_1	119	126	PF00069	0.252
MOD_GSK3_1	134	141	PF00069	0.621
MOD_GSK3_1	152	159	PF00069	0.710
MOD_GSK3_1	17	24	PF00069	0.658
MOD_GSK3_1	174	181	PF00069	0.815
MOD_GSK3_1	183	190	PF00069	0.735
MOD_GSK3_1	237	244	PF00069	0.510
MOD_GSK3_1	246	253	PF00069	0.741
MOD_GSK3_1	27	34	PF00069	0.630
MOD_GSK3_1	334	341	PF00069	0.484
MOD_GSK3_1	357	364	PF00069	0.596
MOD_GSK3_1	365	372	PF00069	0.621
MOD_GSK3_1	527	534	PF00069	0.375
MOD_GSK3_1	538	545	PF00069	0.355
MOD_GSK3_1	557	564	PF00069	0.220
MOD_GSK3_1	614	621	PF00069	0.614
MOD_GSK3_1	77	84	PF00069	0.420
MOD_GSK3_1	99	106	PF00069	0.265
MOD_LATS_1	332	338	PF00433	0.389
MOD_N-GLC_1	183	188	PF02516	0.597
MOD_NEK2_1	1	6	PF00069	0.739
MOD_NEK2_1	119	124	PF00069	0.382
MOD_NEK2_1	192	197	PF00069	0.588
MOD_NEK2_1	216	221	PF00069	0.521
MOD_NEK2_1	238	243	PF00069	0.464
MOD_NEK2_1	248	253	PF00069	0.501
MOD_NEK2_1	29	34	PF00069	0.714
MOD_NEK2_1	365	370	PF00069	0.466
MOD_NEK2_1	538	543	PF00069	0.409
MOD_NEK2_1	569	574	PF00069	0.378
MOD_NEK2_1	602	607	PF00069	0.578
MOD_NEK2_1	638	643	PF00069	0.387
MOD_NEK2_2	144	149	PF00069	0.617
MOD_NEK2_2	456	461	PF00069	0.369
MOD_PIKK_1	1	7	PF00454	0.590
MOD_PIKK_1	156	162	PF00454	0.481
MOD_PIKK_1	17	23	PF00454	0.649
MOD_PIKK_1	487	493	PF00454	0.386
MOD_PIKK_1	50	56	PF00454	0.406
MOD_PIKK_1	543	549	PF00454	0.395
MOD_PIKK_1	554	560	PF00454	0.531
MOD_PKA_1	369	375	PF00069	0.392
MOD_PKA_2	122	128	PF00069	0.270
MOD_PKA_2	21	27	PF00069	0.709
MOD_PKA_2	216	222	PF00069	0.477
MOD_PKA_2	310	316	PF00069	0.416
MOD_PKA_2	369	375	PF00069	0.578
MOD_PKA_2	438	444	PF00069	0.489
MOD_PKA_2	487	493	PF00069	0.535
MOD_PKA_2	569	575	PF00069	0.407
MOD_PKA_2	628	634	PF00069	0.521
MOD_Plk_1	360	366	PF00069	0.459
MOD_Plk_1	423	429	PF00069	0.548
MOD_Plk_1	602	608	PF00069	0.386
MOD_Plk_2-3	576	582	PF00069	0.468
MOD_Plk_4	123	129	PF00069	0.320
MOD_Plk_4	361	367	PF00069	0.456
MOD_Plk_4	456	462	PF00069	0.391
MOD_Plk_4	561	567	PF00069	0.391
MOD_Plk_4	576	582	PF00069	0.336
MOD_Plk_4	638	644	PF00069	0.363
MOD_Plk_4	77	83	PF00069	0.301
MOD_ProDKin_1	194	200	PF00069	0.612
MOD_ProDKin_1	241	247	PF00069	0.595
MOD_ProDKin_1	262	268	PF00069	0.426
TRG_DiLeu_BaEn_1	312	317	PF01217	0.492
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.411
TRG_DiLeu_BaLyEn_6	443	448	PF01217	0.531
TRG_ENDOCYTIC_2	292	295	PF00928	0.382
TRG_ENDOCYTIC_2	395	398	PF00928	0.571
TRG_ENDOCYTIC_2	414	417	PF00928	0.495
TRG_ER_diArg_1	369	371	PF00400	0.482
TRG_ER_diArg_1	521	524	PF00400	0.433
TRG_ER_diArg_1	70	73	PF00400	0.406
TRG_NES_CRM1_1	455	469	PF08389	0.389
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	307	312	PF00026	0.340
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	384	389	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P679	Leptomonas seymouri	49%	94%
A0A0S4IKU7	Bodo saltans	28%	100%
A0A1X0P4F4	Trypanosomatidae	30%	100%
A0A3R7MYK8	Trypanosoma rangeli	29%	100%
A4HEG3	Leishmania braziliensis	75%	99%
A4I196	Leishmania infantum	99%	100%
D0A5I7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AXD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QA40	Leishmania major	90%	100%
V5BXH6	Trypanosoma cruzi	29%	100%