Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WYS7_LEIDO

TriTrypDb:

LdBPK_250390.1 , LdCL_250009000 , LDHU3_25.0460

Length:

850

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WYS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYS7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	246	248	PF00675	0.423
CLV_NRD_NRD_1	260	262	PF00675	0.440
CLV_NRD_NRD_1	405	407	PF00675	0.516
CLV_NRD_NRD_1	431	433	PF00675	0.553
CLV_NRD_NRD_1	446	448	PF00675	0.446
CLV_NRD_NRD_1	621	623	PF00675	0.530
CLV_NRD_NRD_1	659	661	PF00675	0.581
CLV_NRD_NRD_1	739	741	PF00675	0.473
CLV_PCSK_KEX2_1	248	250	PF00082	0.387
CLV_PCSK_KEX2_1	405	407	PF00082	0.518
CLV_PCSK_KEX2_1	431	433	PF00082	0.436
CLV_PCSK_KEX2_1	505	507	PF00082	0.429
CLV_PCSK_KEX2_1	659	661	PF00082	0.658
CLV_PCSK_KEX2_1	739	741	PF00082	0.473
CLV_PCSK_KEX2_1	792	794	PF00082	0.471
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.387
CLV_PCSK_PC1ET2_1	505	507	PF00082	0.482
CLV_PCSK_PC1ET2_1	792	794	PF00082	0.437
CLV_PCSK_SKI1_1	261	265	PF00082	0.489
CLV_PCSK_SKI1_1	331	335	PF00082	0.456
CLV_PCSK_SKI1_1	347	351	PF00082	0.486
CLV_PCSK_SKI1_1	378	382	PF00082	0.455
CLV_PCSK_SKI1_1	397	401	PF00082	0.461
CLV_PCSK_SKI1_1	405	409	PF00082	0.427
CLV_PCSK_SKI1_1	465	469	PF00082	0.436
CLV_PCSK_SKI1_1	484	488	PF00082	0.435
CLV_PCSK_SKI1_1	501	505	PF00082	0.355
CLV_PCSK_SKI1_1	574	578	PF00082	0.548
CLV_PCSK_SKI1_1	614	618	PF00082	0.449
CLV_PCSK_SKI1_1	637	641	PF00082	0.448
CLV_PCSK_SKI1_1	732	736	PF00082	0.555
DEG_APCC_KENBOX_2	417	421	PF00400	0.499
DEG_SPOP_SBC_1	109	113	PF00917	0.555
DEG_SPOP_SBC_1	178	182	PF00917	0.569
DEG_SPOP_SBC_1	268	272	PF00917	0.471
DEG_SPOP_SBC_1	556	560	PF00917	0.628
DEG_SPOP_SBC_1	675	679	PF00917	0.615
DEG_SPOP_SBC_1	98	102	PF00917	0.568
DOC_CKS1_1	549	554	PF01111	0.565
DOC_CKS1_1	806	811	PF01111	0.534
DOC_CYCLIN_RxL_1	259	269	PF00134	0.472
DOC_CYCLIN_yClb3_PxF_3	114	120	PF00134	0.614
DOC_MAPK_gen_1	481	489	PF00069	0.378
DOC_MAPK_gen_1	634	642	PF00069	0.448
DOC_MAPK_MEF2A_6	459	468	PF00069	0.450
DOC_PP1_RVXF_1	511	518	PF00149	0.419
DOC_PP2B_LxvP_1	273	276	PF13499	0.594
DOC_USP7_MATH_1	109	113	PF00917	0.601
DOC_USP7_MATH_1	128	132	PF00917	0.565
DOC_USP7_MATH_1	192	196	PF00917	0.781
DOC_USP7_MATH_1	266	270	PF00917	0.498
DOC_USP7_MATH_1	3	7	PF00917	0.601
DOC_USP7_MATH_1	539	543	PF00917	0.615
DOC_USP7_MATH_1	555	559	PF00917	0.639
DOC_USP7_MATH_1	578	582	PF00917	0.632
DOC_USP7_MATH_1	719	723	PF00917	0.595
DOC_USP7_MATH_1	810	814	PF00917	0.538
DOC_USP7_MATH_1	98	102	PF00917	0.540
DOC_USP7_UBL2_3	501	505	PF12436	0.486
DOC_WW_Pin1_4	105	110	PF00397	0.630
DOC_WW_Pin1_4	148	153	PF00397	0.800
DOC_WW_Pin1_4	195	200	PF00397	0.613
DOC_WW_Pin1_4	278	283	PF00397	0.643
DOC_WW_Pin1_4	548	553	PF00397	0.581
DOC_WW_Pin1_4	576	581	PF00397	0.698
DOC_WW_Pin1_4	582	587	PF00397	0.630
DOC_WW_Pin1_4	727	732	PF00397	0.553
DOC_WW_Pin1_4	77	82	PF00397	0.520
DOC_WW_Pin1_4	805	810	PF00397	0.523
DOC_WW_Pin1_4	99	104	PF00397	0.574
LIG_14-3-3_CanoR_1	369	376	PF00244	0.506
LIG_14-3-3_CanoR_1	637	643	PF00244	0.514
LIG_14-3-3_CanoR_1	65	74	PF00244	0.549
LIG_14-3-3_CanoR_1	732	741	PF00244	0.499
LIG_14-3-3_CanoR_1	762	767	PF00244	0.456
LIG_14-3-3_CanoR_1	793	799	PF00244	0.462
LIG_14-3-3_CanoR_1	820	825	PF00244	0.504
LIG_Actin_WH2_2	409	426	PF00022	0.437
LIG_Actin_WH2_2	450	467	PF00022	0.437
LIG_Actin_WH2_2	623	639	PF00022	0.429
LIG_Actin_WH2_2	769	785	PF00022	0.437
LIG_BIR_II_1	1	5	PF00653	0.644
LIG_BRCT_BRCA1_1	584	588	PF00533	0.567
LIG_CaM_NSCaTE_8	517	524	PF13499	0.424
LIG_DLG_GKlike_1	820	827	PF00625	0.497
LIG_EVH1_2	116	120	PF00568	0.619
LIG_FHA_1	167	173	PF00498	0.578
LIG_FHA_1	180	186	PF00498	0.580
LIG_FHA_1	268	274	PF00498	0.542
LIG_FHA_1	30	36	PF00498	0.663
LIG_FHA_1	390	396	PF00498	0.431
LIG_FHA_1	549	555	PF00498	0.621
LIG_FHA_1	570	576	PF00498	0.593
LIG_FHA_1	58	64	PF00498	0.478
LIG_FHA_1	592	598	PF00498	0.538
LIG_FHA_1	649	655	PF00498	0.510
LIG_FHA_1	68	74	PF00498	0.517
LIG_FHA_1	721	727	PF00498	0.688
LIG_FHA_1	772	778	PF00498	0.433
LIG_FHA_1	786	792	PF00498	0.384
LIG_FHA_1	844	850	PF00498	0.528
LIG_FHA_2	22	28	PF00498	0.767
LIG_FHA_2	230	236	PF00498	0.457
LIG_FHA_2	369	375	PF00498	0.583
LIG_FHA_2	39	45	PF00498	0.403
LIG_FHA_2	733	739	PF00498	0.493
LIG_FHA_2	763	769	PF00498	0.455
LIG_FHA_2	773	779	PF00498	0.493
LIG_Integrin_RGD_1	527	529	PF01839	0.571
LIG_LIR_Gen_1	747	754	PF02991	0.461
LIG_LIR_Gen_1	84	94	PF02991	0.587
LIG_LIR_LC3C_4	723	728	PF02991	0.588
LIG_LIR_Nem_3	581	587	PF02991	0.688
LIG_LIR_Nem_3	747	752	PF02991	0.472
LIG_LIR_Nem_3	84	89	PF02991	0.587
LIG_NRBOX	344	350	PF00104	0.472
LIG_NRBOX	823	829	PF00104	0.461
LIG_NRP_CendR_1	847	850	PF00754	0.556
LIG_Pex14_2	685	689	PF04695	0.598
LIG_PTAP_UEV_1	17	22	PF05743	0.564
LIG_Rb_LxCxE_1	41	60	PF01857	0.452
LIG_SH2_CRK	584	588	PF00017	0.567
LIG_SH2_CRK	86	90	PF00017	0.595
LIG_SH2_NCK_1	315	319	PF00017	0.440
LIG_SH2_NCK_1	584	588	PF00017	0.567
LIG_SH2_NCK_1	8	12	PF00017	0.540
LIG_SH2_STAP1	31	35	PF00017	0.600
LIG_SH2_STAT3	430	433	PF00017	0.500
LIG_SH2_STAT5	31	34	PF00017	0.672
LIG_SH3_3	111	117	PF00018	0.717
LIG_SH3_3	15	21	PF00018	0.751
LIG_SH3_3	279	285	PF00018	0.587
LIG_SH3_3	33	39	PF00018	0.530
LIG_SH3_3	546	552	PF00018	0.591
LIG_SH3_3	572	578	PF00018	0.613
LIG_SH3_3	580	586	PF00018	0.567
LIG_SH3_3	670	676	PF00018	0.588
LIG_SH3_3	725	731	PF00018	0.576
LIG_SH3_3	803	809	PF00018	0.493
LIG_SUMO_SIM_anti_2	722	730	PF11976	0.527
LIG_SUMO_SIM_par_1	253	259	PF11976	0.360
LIG_SUMO_SIM_par_1	485	490	PF11976	0.496
LIG_SUMO_SIM_par_1	551	563	PF11976	0.503
LIG_SUMO_SIM_par_1	722	730	PF11976	0.581
LIG_TRAF2_1	765	768	PF00917	0.455
LIG_TRAF2_2	731	736	PF00917	0.506
LIG_TYR_ITIM	582	587	PF00017	0.562
LIG_UBA3_1	629	634	PF00899	0.509
MOD_CDK_SPK_2	727	732	PF00069	0.532
MOD_CK1_1	108	114	PF00069	0.613
MOD_CK1_1	180	186	PF00069	0.566
MOD_CK1_1	195	201	PF00069	0.654
MOD_CK1_1	231	237	PF00069	0.522
MOD_CK1_1	269	275	PF00069	0.494
MOD_CK1_1	30	36	PF00069	0.786
MOD_CK1_1	533	539	PF00069	0.588
MOD_CK1_1	558	564	PF00069	0.594
MOD_CK1_1	6	12	PF00069	0.622
MOD_CK1_1	648	654	PF00069	0.445
MOD_CK2_1	21	27	PF00069	0.753
MOD_CK2_1	229	235	PF00069	0.521
MOD_CK2_1	348	354	PF00069	0.550
MOD_CK2_1	368	374	PF00069	0.529
MOD_CK2_1	38	44	PF00069	0.450
MOD_CK2_1	434	440	PF00069	0.425
MOD_CK2_1	443	449	PF00069	0.443
MOD_CK2_1	560	566	PF00069	0.650
MOD_CK2_1	697	703	PF00069	0.647
MOD_CK2_1	732	738	PF00069	0.524
MOD_CK2_1	744	750	PF00069	0.650
MOD_CK2_1	762	768	PF00069	0.384
MOD_CK2_1	772	778	PF00069	0.433
MOD_DYRK1A_RPxSP_1	77	81	PF00069	0.504
MOD_GlcNHglycan	1	4	PF01048	0.681
MOD_GlcNHglycan	131	134	PF01048	0.700
MOD_GlcNHglycan	311	314	PF01048	0.440
MOD_GlcNHglycan	425	428	PF01048	0.425
MOD_GlcNHglycan	522	525	PF01048	0.467
MOD_GlcNHglycan	663	666	PF01048	0.619
MOD_GlcNHglycan	685	688	PF01048	0.737
MOD_GlcNHglycan	691	695	PF01048	0.591
MOD_GlcNHglycan	9	12	PF01048	0.650
MOD_GlcNHglycan	90	93	PF01048	0.594
MOD_GSK3_1	105	112	PF00069	0.648
MOD_GSK3_1	193	200	PF00069	0.651
MOD_GSK3_1	202	209	PF00069	0.542
MOD_GSK3_1	227	234	PF00069	0.520
MOD_GSK3_1	267	274	PF00069	0.574
MOD_GSK3_1	27	34	PF00069	0.578
MOD_GSK3_1	277	284	PF00069	0.634
MOD_GSK3_1	3	10	PF00069	0.637
MOD_GSK3_1	389	396	PF00069	0.432
MOD_GSK3_1	555	562	PF00069	0.734
MOD_GSK3_1	578	585	PF00069	0.569
MOD_GSK3_1	677	684	PF00069	0.619
MOD_GSK3_1	68	75	PF00069	0.693
MOD_GSK3_1	685	692	PF00069	0.573
MOD_N-GLC_1	434	439	PF02516	0.421
MOD_N-GLC_1	539	544	PF02516	0.636
MOD_N-GLC_1	793	798	PF02516	0.459
MOD_NEK2_1	228	233	PF00069	0.507
MOD_NEK2_1	236	241	PF00069	0.550
MOD_NEK2_1	348	353	PF00069	0.498
MOD_NEK2_1	423	428	PF00069	0.428
MOD_NEK2_1	487	492	PF00069	0.497
MOD_NEK2_1	685	690	PF00069	0.618
MOD_NEK2_1	73	78	PF00069	0.741
MOD_NEK2_1	828	833	PF00069	0.441
MOD_NEK2_2	569	574	PF00069	0.539
MOD_PIKK_1	229	235	PF00454	0.440
MOD_PIKK_1	236	242	PF00454	0.471
MOD_PIKK_1	522	528	PF00454	0.575
MOD_PIKK_1	640	646	PF00454	0.446
MOD_PIKK_1	65	71	PF00454	0.489
MOD_PIKK_1	677	683	PF00454	0.617
MOD_PKA_2	298	304	PF00069	0.483
MOD_PKA_2	368	374	PF00069	0.529
MOD_PKA_2	393	399	PF00069	0.478
MOD_PKA_2	681	687	PF00069	0.692
MOD_PKA_2	689	695	PF00069	0.569
MOD_PKA_2	761	767	PF00069	0.455
MOD_PKB_1	307	315	PF00069	0.513
MOD_Plk_1	648	654	PF00069	0.651
MOD_Plk_1	793	799	PF00069	0.465
MOD_Plk_2-3	713	719	PF00069	0.553
MOD_Plk_4	31	37	PF00069	0.708
MOD_Plk_4	323	329	PF00069	0.382
MOD_Plk_4	772	778	PF00069	0.497
MOD_ProDKin_1	110	116	PF00069	0.637
MOD_ProDKin_1	148	154	PF00069	0.799
MOD_ProDKin_1	195	201	PF00069	0.614
MOD_ProDKin_1	278	284	PF00069	0.633
MOD_ProDKin_1	548	554	PF00069	0.584
MOD_ProDKin_1	576	582	PF00069	0.697
MOD_ProDKin_1	727	733	PF00069	0.548
MOD_ProDKin_1	77	83	PF00069	0.517
MOD_ProDKin_1	805	811	PF00069	0.526
MOD_ProDKin_1	99	105	PF00069	0.580
MOD_SUMO_for_1	407	410	PF00179	0.450
MOD_SUMO_for_1	480	483	PF00179	0.369
MOD_SUMO_for_1	834	837	PF00179	0.507
MOD_SUMO_rev_2	419	426	PF00179	0.490
MOD_SUMO_rev_2	601	610	PF00179	0.504
TRG_DiLeu_BaEn_1	625	630	PF01217	0.516
TRG_DiLeu_BaEn_1	649	654	PF01217	0.533
TRG_DiLeu_BaEn_1	755	760	PF01217	0.447
TRG_DiLeu_BaEn_4	210	216	PF01217	0.498
TRG_DiLeu_BaEn_4	449	455	PF01217	0.425
TRG_DiLeu_BaEn_4	768	774	PF01217	0.450
TRG_DiLeu_BaLyEn_6	344	349	PF01217	0.469
TRG_DiLeu_LyEn_5	649	654	PF01217	0.533
TRG_ENDOCYTIC_2	584	587	PF00928	0.562
TRG_ENDOCYTIC_2	86	89	PF00928	0.593
TRG_ER_diArg_1	215	218	PF00400	0.522
TRG_ER_diArg_1	247	250	PF00400	0.389
TRG_ER_diArg_1	430	432	PF00400	0.439
TRG_ER_diArg_1	463	466	PF00400	0.457
TRG_ER_diArg_1	659	661	PF00400	0.513
TRG_ER_diArg_1	739	741	PF00400	0.473
TRG_Pf-PMV_PEXEL_1	455	460	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	506	511	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	602	606	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	652	656	PF00026	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Y9	Leptomonas seymouri	46%	95%
A4H4A4	Leishmania braziliensis	66%	100%
A4I181	Leishmania infantum	99%	100%
E9AXB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QA57	Leishmania major	90%	100%