Mitochondrial RNA binding complex 1 subunit

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WYR4_LEIDO

TriTrypDb:

LdBPK_250180.1 , LdCL_250006900 , LDHU3_25.0240

Length:

1049

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WYR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYR4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	515	519	PF00656	0.589
CLV_C14_Caspase3-7	719	723	PF00656	0.555
CLV_C14_Caspase3-7	855	859	PF00656	0.513
CLV_C14_Caspase3-7	908	912	PF00656	0.371
CLV_NRD_NRD_1	145	147	PF00675	0.627
CLV_NRD_NRD_1	219	221	PF00675	0.398
CLV_NRD_NRD_1	343	345	PF00675	0.412
CLV_NRD_NRD_1	534	536	PF00675	0.465
CLV_NRD_NRD_1	976	978	PF00675	0.485
CLV_PCSK_KEX2_1	145	147	PF00082	0.525
CLV_PCSK_KEX2_1	219	221	PF00082	0.398
CLV_PCSK_KEX2_1	978	980	PF00082	0.533
CLV_PCSK_PC1ET2_1	978	980	PF00082	0.533
CLV_PCSK_SKI1_1	146	150	PF00082	0.513
CLV_PCSK_SKI1_1	219	223	PF00082	0.450
CLV_PCSK_SKI1_1	283	287	PF00082	0.568
CLV_PCSK_SKI1_1	298	302	PF00082	0.434
CLV_PCSK_SKI1_1	340	344	PF00082	0.351
CLV_PCSK_SKI1_1	345	349	PF00082	0.351
CLV_PCSK_SKI1_1	357	361	PF00082	0.358
CLV_PCSK_SKI1_1	435	439	PF00082	0.494
CLV_PCSK_SKI1_1	462	466	PF00082	0.428
CLV_PCSK_SKI1_1	48	52	PF00082	0.534
CLV_PCSK_SKI1_1	590	594	PF00082	0.516
CLV_PCSK_SKI1_1	892	896	PF00082	0.415
DEG_APCC_DBOX_1	127	135	PF00400	0.541
DEG_SCF_FBW7_1	122	127	PF00400	0.594
DEG_SPOP_SBC_1	238	242	PF00917	0.452
DOC_CYCLIN_RxL_1	888	896	PF00134	0.373
DOC_CYCLIN_yCln2_LP_2	324	330	PF00134	0.382
DOC_MAPK_gen_1	402	410	PF00069	0.414
DOC_MAPK_gen_1	51	60	PF00069	0.525
DOC_MAPK_MEF2A_6	154	162	PF00069	0.444
DOC_MAPK_MEF2A_6	54	62	PF00069	0.544
DOC_PP1_RVXF_1	355	361	PF00149	0.414
DOC_PP2B_LxvP_1	324	327	PF13499	0.462
DOC_PP2B_LxvP_1	330	333	PF13499	0.423
DOC_PP2B_LxvP_1	378	381	PF13499	0.450
DOC_PP2B_LxvP_1	958	961	PF13499	0.382
DOC_PP4_FxxP_1	262	265	PF00568	0.320
DOC_PP4_FxxP_1	604	607	PF00568	0.429
DOC_PP4_FxxP_1	913	916	PF00568	0.540
DOC_SPAK_OSR1_1	392	396	PF12202	0.305
DOC_USP7_MATH_1	1024	1028	PF00917	0.572
DOC_USP7_MATH_1	117	121	PF00917	0.720
DOC_USP7_MATH_1	232	236	PF00917	0.504
DOC_USP7_MATH_1	291	295	PF00917	0.440
DOC_USP7_MATH_1	443	447	PF00917	0.595
DOC_USP7_MATH_1	514	518	PF00917	0.616
DOC_USP7_MATH_1	607	611	PF00917	0.570
DOC_USP7_MATH_1	635	639	PF00917	0.607
DOC_USP7_MATH_1	675	679	PF00917	0.437
DOC_USP7_MATH_1	833	837	PF00917	0.419
DOC_USP7_MATH_1	971	975	PF00917	0.471
DOC_WW_Pin1_4	1012	1017	PF00397	0.611
DOC_WW_Pin1_4	1039	1044	PF00397	0.517
DOC_WW_Pin1_4	113	118	PF00397	0.744
DOC_WW_Pin1_4	120	125	PF00397	0.685
DOC_WW_Pin1_4	265	270	PF00397	0.541
DOC_WW_Pin1_4	492	497	PF00397	0.554
DOC_WW_Pin1_4	664	669	PF00397	0.628
DOC_WW_Pin1_4	721	726	PF00397	0.445
DOC_WW_Pin1_4	757	762	PF00397	0.433
DOC_WW_Pin1_4	790	795	PF00397	0.590
DOC_WW_Pin1_4	912	917	PF00397	0.538
LIG_14-3-3_CanoR_1	112	117	PF00244	0.652
LIG_14-3-3_CanoR_1	138	147	PF00244	0.559
LIG_14-3-3_CanoR_1	161	170	PF00244	0.548
LIG_14-3-3_CanoR_1	22	26	PF00244	0.685
LIG_14-3-3_CanoR_1	32	38	PF00244	0.539
LIG_14-3-3_CanoR_1	322	327	PF00244	0.625
LIG_14-3-3_CanoR_1	402	410	PF00244	0.379
LIG_14-3-3_CanoR_1	467	473	PF00244	0.461
LIG_14-3-3_CanoR_1	535	544	PF00244	0.511
LIG_14-3-3_CanoR_1	59	69	PF00244	0.501
LIG_14-3-3_CanoR_1	772	778	PF00244	0.467
LIG_14-3-3_CanoR_1	788	794	PF00244	0.399
LIG_14-3-3_CanoR_1	854	863	PF00244	0.443
LIG_14-3-3_CanoR_1	957	961	PF00244	0.443
LIG_Actin_WH2_2	33	50	PF00022	0.444
LIG_Actin_WH2_2	98	114	PF00022	0.585
LIG_AP2alpha_1	420	424	PF02296	0.435
LIG_AP2alpha_2	599	601	PF02296	0.381
LIG_BIR_III_2	448	452	PF00653	0.545
LIG_BIR_III_4	570	574	PF00653	0.520
LIG_BRCT_BRCA1_1	255	259	PF00533	0.467
LIG_BRCT_BRCA1_1	597	601	PF00533	0.403
LIG_BRCT_BRCA1_1	909	913	PF00533	0.373
LIG_CaM_IQ_9	37	53	PF13499	0.518
LIG_Clathr_ClatBox_1	862	866	PF01394	0.469
LIG_deltaCOP1_diTrp_1	858	865	PF00928	0.414
LIG_EH_1	775	779	PF12763	0.479
LIG_FHA_1	113	119	PF00498	0.680
LIG_FHA_1	121	127	PF00498	0.586
LIG_FHA_1	142	148	PF00498	0.612
LIG_FHA_1	175	181	PF00498	0.431
LIG_FHA_1	239	245	PF00498	0.593
LIG_FHA_1	287	293	PF00498	0.329
LIG_FHA_1	405	411	PF00498	0.439
LIG_FHA_1	469	475	PF00498	0.441
LIG_FHA_1	591	597	PF00498	0.423
LIG_FHA_1	635	641	PF00498	0.548
LIG_FHA_1	711	717	PF00498	0.566
LIG_FHA_1	740	746	PF00498	0.485
LIG_FHA_1	791	797	PF00498	0.442
LIG_FHA_2	130	136	PF00498	0.615
LIG_FHA_2	305	311	PF00498	0.408
LIG_FHA_2	380	386	PF00498	0.463
LIG_FHA_2	442	448	PF00498	0.495
LIG_FHA_2	717	723	PF00498	0.497
LIG_FHA_2	726	732	PF00498	0.365
LIG_FHA_2	853	859	PF00498	0.582
LIG_FHA_2	876	882	PF00498	0.555
LIG_FHA_2	95	101	PF00498	0.502
LIG_LIR_Apic_2	260	265	PF02991	0.307
LIG_LIR_Apic_2	910	916	PF02991	0.458
LIG_LIR_Gen_1	1003	1012	PF02991	0.503
LIG_LIR_Gen_1	248	257	PF02991	0.337
LIG_LIR_Gen_1	598	607	PF02991	0.471
LIG_LIR_Gen_1	857	865	PF02991	0.421
LIG_LIR_Nem_3	1003	1007	PF02991	0.483
LIG_LIR_Nem_3	152	158	PF02991	0.443
LIG_LIR_Nem_3	248	253	PF02991	0.339
LIG_LIR_Nem_3	256	262	PF02991	0.321
LIG_LIR_Nem_3	418	423	PF02991	0.488
LIG_LIR_Nem_3	42	47	PF02991	0.450
LIG_LIR_Nem_3	598	604	PF02991	0.462
LIG_LIR_Nem_3	857	863	PF02991	0.516
LIG_LYPXL_yS_3	155	158	PF13949	0.518
LIG_NRBOX	296	302	PF00104	0.440
LIG_NRBOX	342	348	PF00104	0.342
LIG_PCNA_PIPBox_1	198	207	PF02747	0.429
LIG_PCNA_yPIPBox_3	198	206	PF02747	0.432
LIG_Pex14_2	420	424	PF04695	0.359
LIG_SH2_CRK	1004	1008	PF00017	0.349
LIG_SH2_STAP1	1032	1036	PF00017	0.449
LIG_SH2_STAP1	250	254	PF00017	0.460
LIG_SH2_STAT3	737	740	PF00017	0.354
LIG_SH2_STAT5	250	253	PF00017	0.386
LIG_SH2_STAT5	503	506	PF00017	0.441
LIG_SH2_STAT5	654	657	PF00017	0.484
LIG_SH2_STAT5	968	971	PF00017	0.513
LIG_SH2_STAT5	993	996	PF00017	0.477
LIG_SH3_3	119	125	PF00018	0.641
LIG_SH3_3	612	618	PF00018	0.557
LIG_SH3_3	763	769	PF00018	0.459
LIG_SH3_3	919	925	PF00018	0.329
LIG_SUMO_SIM_anti_2	129	135	PF11976	0.538
LIG_SUMO_SIM_anti_2	179	184	PF11976	0.425
LIG_SUMO_SIM_anti_2	240	248	PF11976	0.433
LIG_SUMO_SIM_par_1	132	137	PF11976	0.618
LIG_SUMO_SIM_par_1	245	251	PF11976	0.513
LIG_SUMO_SIM_par_1	286	295	PF11976	0.473
LIG_SUMO_SIM_par_1	405	412	PF11976	0.374
LIG_SUMO_SIM_par_1	475	481	PF11976	0.331
LIG_TRAF2_1	97	100	PF00917	0.497
LIG_TRAF2_2	618	623	PF00917	0.475
LIG_TYR_ITIM	348	353	PF00017	0.424
LIG_WRC_WIRS_1	862	867	PF05994	0.328
MOD_CDC14_SPxK_1	667	670	PF00782	0.615
MOD_CDK_SPK_2	790	795	PF00069	0.412
MOD_CDK_SPxK_1	664	670	PF00069	0.566
MOD_CDK_SPxK_1	757	763	PF00069	0.340
MOD_CK1_1	1003	1009	PF00069	0.498
MOD_CK1_1	120	126	PF00069	0.603
MOD_CK1_1	141	147	PF00069	0.551
MOD_CK1_1	237	243	PF00069	0.655
MOD_CK1_1	24	30	PF00069	0.629
MOD_CK1_1	245	251	PF00069	0.410
MOD_CK1_1	284	290	PF00069	0.546
MOD_CK1_1	403	409	PF00069	0.534
MOD_CK1_1	441	447	PF00069	0.589
MOD_CK1_1	771	777	PF00069	0.466
MOD_CK1_1	852	858	PF00069	0.441
MOD_CK1_1	871	877	PF00069	0.520
MOD_CK1_1	906	912	PF00069	0.501
MOD_CK2_1	1024	1030	PF00069	0.510
MOD_CK2_1	1038	1044	PF00069	0.622
MOD_CK2_1	304	310	PF00069	0.500
MOD_CK2_1	403	409	PF00069	0.394
MOD_CK2_1	441	447	PF00069	0.429
MOD_CK2_1	621	627	PF00069	0.539
MOD_CK2_1	725	731	PF00069	0.475
MOD_CK2_1	875	881	PF00069	0.474
MOD_CK2_1	94	100	PF00069	0.600
MOD_Cter_Amidation	533	536	PF01082	0.441
MOD_GlcNHglycan	1026	1029	PF01048	0.492
MOD_GlcNHglycan	165	168	PF01048	0.614
MOD_GlcNHglycan	226	229	PF01048	0.580
MOD_GlcNHglycan	324	327	PF01048	0.622
MOD_GlcNHglycan	623	626	PF01048	0.499
MOD_GlcNHglycan	778	781	PF01048	0.629
MOD_GlcNHglycan	973	976	PF01048	0.503
MOD_GSK3_1	113	120	PF00069	0.671
MOD_GSK3_1	134	141	PF00069	0.687
MOD_GSK3_1	170	177	PF00069	0.517
MOD_GSK3_1	233	240	PF00069	0.641
MOD_GSK3_1	24	31	PF00069	0.609
MOD_GSK3_1	248	255	PF00069	0.497
MOD_GSK3_1	281	288	PF00069	0.532
MOD_GSK3_1	400	407	PF00069	0.515
MOD_GSK3_1	630	637	PF00069	0.565
MOD_GSK3_1	701	708	PF00069	0.579
MOD_GSK3_1	716	723	PF00069	0.466
MOD_GSK3_1	757	764	PF00069	0.470
MOD_GSK3_1	768	775	PF00069	0.524
MOD_GSK3_1	848	855	PF00069	0.504
MOD_GSK3_1	871	878	PF00069	0.435
MOD_GSK3_1	90	97	PF00069	0.637
MOD_GSK3_1	903	910	PF00069	0.470
MOD_GSK3_1	956	963	PF00069	0.420
MOD_LATS_1	770	776	PF00433	0.519
MOD_NEK2_1	1	6	PF00069	0.634
MOD_NEK2_1	111	116	PF00069	0.564
MOD_NEK2_1	170	175	PF00069	0.566
MOD_NEK2_1	21	26	PF00069	0.647
MOD_NEK2_1	285	290	PF00069	0.505
MOD_NEK2_1	438	443	PF00069	0.460
MOD_NEK2_1	478	483	PF00069	0.584
MOD_NEK2_1	639	644	PF00069	0.452
MOD_NEK2_1	739	744	PF00069	0.372
MOD_NEK2_1	875	880	PF00069	0.476
MOD_NEK2_2	415	420	PF00069	0.414
MOD_PIKK_1	170	176	PF00454	0.549
MOD_PIKK_1	26	32	PF00454	0.497
MOD_PIKK_1	497	503	PF00454	0.333
MOD_PIKK_1	608	614	PF00454	0.504
MOD_PKA_1	978	984	PF00069	0.452
MOD_PKA_2	111	117	PF00069	0.649
MOD_PKA_2	14	20	PF00069	0.673
MOD_PKA_2	162	168	PF00069	0.554
MOD_PKA_2	184	190	PF00069	0.563
MOD_PKA_2	199	205	PF00069	0.564
MOD_PKA_2	21	27	PF00069	0.666
MOD_PKA_2	630	636	PF00069	0.496
MOD_PKA_2	656	662	PF00069	0.558
MOD_PKA_2	771	777	PF00069	0.643
MOD_PKA_2	903	909	PF00069	0.433
MOD_PKA_2	956	962	PF00069	0.352
MOD_PKA_2	978	984	PF00069	0.452
MOD_PKB_1	161	169	PF00069	0.440
MOD_PKB_1	942	950	PF00069	0.369
MOD_Plk_1	134	140	PF00069	0.633
MOD_Plk_1	272	278	PF00069	0.485
MOD_Plk_1	852	858	PF00069	0.511
MOD_Plk_1	871	877	PF00069	0.389
MOD_Plk_1	880	886	PF00069	0.419
MOD_Plk_2-3	129	135	PF00069	0.575
MOD_Plk_2-3	379	385	PF00069	0.406
MOD_Plk_4	129	135	PF00069	0.566
MOD_Plk_4	234	240	PF00069	0.608
MOD_Plk_4	242	248	PF00069	0.439
MOD_Plk_4	39	45	PF00069	0.531
MOD_Plk_4	415	421	PF00069	0.456
MOD_Plk_4	468	474	PF00069	0.518
MOD_Plk_4	635	641	PF00069	0.560
MOD_Plk_4	762	768	PF00069	0.401
MOD_ProDKin_1	1012	1018	PF00069	0.613
MOD_ProDKin_1	1039	1045	PF00069	0.520
MOD_ProDKin_1	113	119	PF00069	0.745
MOD_ProDKin_1	120	126	PF00069	0.685
MOD_ProDKin_1	265	271	PF00069	0.535
MOD_ProDKin_1	492	498	PF00069	0.550
MOD_ProDKin_1	664	670	PF00069	0.624
MOD_ProDKin_1	721	727	PF00069	0.443
MOD_ProDKin_1	757	763	PF00069	0.446
MOD_ProDKin_1	790	796	PF00069	0.585
MOD_ProDKin_1	912	918	PF00069	0.544
MOD_SUMO_for_1	205	208	PF00179	0.519
MOD_SUMO_rev_2	539	544	PF00179	0.391
TRG_DiLeu_BaLyEn_6	319	324	PF01217	0.344
TRG_ENDOCYTIC_2	1004	1007	PF00928	0.426
TRG_ENDOCYTIC_2	155	158	PF00928	0.518
TRG_ENDOCYTIC_2	250	253	PF00928	0.340
TRG_ENDOCYTIC_2	350	353	PF00928	0.458
TRG_ER_diArg_1	145	147	PF00400	0.629
TRG_ER_diArg_1	158	161	PF00400	0.349
TRG_ER_diArg_1	218	220	PF00400	0.463
TRG_ER_diArg_1	941	944	PF00400	0.355
TRG_ER_diArg_1	976	979	PF00400	0.499
TRG_NLS_MonoExtC_3	534	540	PF00514	0.503
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	435	439	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	670	674	PF00026	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM25	Leptomonas seymouri	45%	98%
A0A3S5IR32	Trypanosoma rangeli	28%	100%
A4HDW5	Leishmania braziliensis	74%	100%
A4I160	Leishmania infantum	99%	100%
D0A5E5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AX94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QA78	Leishmania major	90%	100%
V5B7P7	Trypanosoma cruzi	27%	100%