Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WYR3_LEIDO

TriTrypDb:

LdBPK_250340.1 , LdCL_250008500 , LDHU3_25.0410

Length:

685

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S7WYR3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYR3

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	2
GO:0006518	peptide metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0019538	protein metabolic process	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	2
GO:0043043	peptide biosynthetic process	5	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043603	amide metabolic process	3	2
GO:0043604	amide biosynthetic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	2
GO:0005198	structural molecule activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	355	359	PF00656	0.726
CLV_C14_Caspase3-7	502	506	PF00656	0.494
CLV_NRD_NRD_1	342	344	PF00675	0.845
CLV_NRD_NRD_1	364	366	PF00675	0.673
CLV_NRD_NRD_1	423	425	PF00675	0.629
CLV_NRD_NRD_1	457	459	PF00675	0.684
CLV_NRD_NRD_1	562	564	PF00675	0.718
CLV_NRD_NRD_1	573	575	PF00675	0.397
CLV_PCSK_FUR_1	560	564	PF00082	0.813
CLV_PCSK_FUR_1	571	575	PF00082	0.417
CLV_PCSK_KEX2_1	248	250	PF00082	0.855
CLV_PCSK_KEX2_1	342	344	PF00082	0.772
CLV_PCSK_KEX2_1	423	425	PF00082	0.629
CLV_PCSK_KEX2_1	457	459	PF00082	0.684
CLV_PCSK_KEX2_1	562	564	PF00082	0.718
CLV_PCSK_KEX2_1	573	575	PF00082	0.397
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.855
CLV_PCSK_PC7_1	338	344	PF00082	0.724
CLV_PCSK_PC7_1	419	425	PF00082	0.707
CLV_PCSK_SKI1_1	119	123	PF00082	0.649
CLV_PCSK_SKI1_1	129	133	PF00082	0.542
CLV_PCSK_SKI1_1	372	376	PF00082	0.578
CLV_PCSK_SKI1_1	585	589	PF00082	0.591
DEG_Nend_Nbox_1	1	3	PF02207	0.756
DEG_SCF_FBW7_2	300	306	PF00400	0.755
DEG_SPOP_SBC_1	152	156	PF00917	0.695
DEG_SPOP_SBC_1	609	613	PF00917	0.686
DOC_CKS1_1	265	270	PF01111	0.717
DOC_CKS1_1	300	305	PF01111	0.752
DOC_CKS1_1	427	432	PF01111	0.687
DOC_CYCLIN_yCln2_LP_2	265	271	PF00134	0.783
DOC_CYCLIN_yCln2_LP_2	525	531	PF00134	0.461
DOC_MAPK_DCC_7	661	671	PF00069	0.487
DOC_MAPK_gen_1	127	134	PF00069	0.684
DOC_MAPK_gen_1	571	580	PF00069	0.572
DOC_MAPK_MEF2A_6	571	580	PF00069	0.572
DOC_PP1_RVXF_1	476	483	PF00149	0.545
DOC_PP2B_LxvP_1	400	403	PF13499	0.682
DOC_PP2B_LxvP_1	525	528	PF13499	0.489
DOC_USP7_MATH_1	103	107	PF00917	0.735
DOC_USP7_MATH_1	110	114	PF00917	0.582
DOC_USP7_MATH_1	152	156	PF00917	0.641
DOC_USP7_MATH_1	22	26	PF00917	0.758
DOC_USP7_MATH_1	244	248	PF00917	0.704
DOC_USP7_MATH_1	255	259	PF00917	0.788
DOC_USP7_MATH_1	276	280	PF00917	0.822
DOC_USP7_MATH_1	285	289	PF00917	0.745
DOC_USP7_MATH_1	293	297	PF00917	0.650
DOC_USP7_MATH_1	307	311	PF00917	0.779
DOC_USP7_MATH_1	325	329	PF00917	0.624
DOC_USP7_MATH_1	411	415	PF00917	0.651
DOC_USP7_MATH_1	439	443	PF00917	0.641
DOC_USP7_MATH_1	77	81	PF00917	0.668
DOC_USP7_MATH_1	86	90	PF00917	0.760
DOC_WW_Pin1_4	148	153	PF00397	0.670
DOC_WW_Pin1_4	166	171	PF00397	0.496
DOC_WW_Pin1_4	18	23	PF00397	0.780
DOC_WW_Pin1_4	186	191	PF00397	0.663
DOC_WW_Pin1_4	213	218	PF00397	0.670
DOC_WW_Pin1_4	259	264	PF00397	0.805
DOC_WW_Pin1_4	279	284	PF00397	0.600
DOC_WW_Pin1_4	287	292	PF00397	0.700
DOC_WW_Pin1_4	29	34	PF00397	0.627
DOC_WW_Pin1_4	294	299	PF00397	0.689
DOC_WW_Pin1_4	326	331	PF00397	0.776
DOC_WW_Pin1_4	348	353	PF00397	0.718
DOC_WW_Pin1_4	360	365	PF00397	0.722
DOC_WW_Pin1_4	426	431	PF00397	0.648
DOC_WW_Pin1_4	433	438	PF00397	0.636
DOC_WW_Pin1_4	441	446	PF00397	0.691
DOC_WW_Pin1_4	47	52	PF00397	0.609
DOC_WW_Pin1_4	547	552	PF00397	0.515
LIG_14-3-3_CanoR_1	159	165	PF00244	0.747
LIG_14-3-3_CanoR_1	204	209	PF00244	0.840
LIG_14-3-3_CanoR_1	324	330	PF00244	0.739
LIG_14-3-3_CanoR_1	342	350	PF00244	0.643
LIG_14-3-3_CanoR_1	365	374	PF00244	0.789
LIG_14-3-3_CanoR_1	424	430	PF00244	0.724
LIG_14-3-3_CanoR_1	539	545	PF00244	0.550
LIG_BIR_III_4	238	242	PF00653	0.652
LIG_BRCT_BRCA1_1	540	544	PF00533	0.387
LIG_EVH1_2	260	264	PF00568	0.618
LIG_FHA_1	404	410	PF00498	0.702
LIG_FHA_1	427	433	PF00498	0.641
LIG_FHA_1	448	454	PF00498	0.673
LIG_FHA_1	48	54	PF00498	0.663
LIG_FHA_1	502	508	PF00498	0.462
LIG_FHA_1	600	606	PF00498	0.466
LIG_IBAR_NPY_1	90	92	PF08397	0.794
LIG_KLC1_Yacidic_2	643	647	PF13176	0.556
LIG_LIR_Apic_2	462	468	PF02991	0.615
LIG_LIR_Apic_2	618	624	PF02991	0.557
LIG_LIR_Apic_2	96	100	PF02991	0.786
LIG_LIR_Nem_3	584	590	PF02991	0.488
LIG_NRBOX	677	683	PF00104	0.371
LIG_PDZ_Class_2	680	685	PF00595	0.483
LIG_Pex14_2	544	548	PF04695	0.464
LIG_PTAP_UEV_1	256	261	PF05743	0.623
LIG_SH2_CRK	54	58	PF00017	0.791
LIG_SH2_CRK	621	625	PF00017	0.618
LIG_SH2_SRC	465	468	PF00017	0.692
LIG_SH2_SRC	625	628	PF00017	0.608
LIG_SH2_SRC	645	648	PF00017	0.576
LIG_SH2_STAP1	45	49	PF00017	0.751
LIG_SH2_STAT5	229	232	PF00017	0.818
LIG_SH2_STAT5	45	48	PF00017	0.752
LIG_SH2_STAT5	497	500	PF00017	0.395
LIG_SH2_STAT5	599	602	PF00017	0.468
LIG_SH2_STAT5	645	648	PF00017	0.576
LIG_SH2_STAT5	67	70	PF00017	0.755
LIG_SH2_STAT5	72	75	PF00017	0.732
LIG_SH2_STAT5	92	95	PF00017	0.734
LIG_SH3_1	347	353	PF00018	0.778
LIG_SH3_1	361	367	PF00018	0.556
LIG_SH3_1	465	471	PF00018	0.571
LIG_SH3_1	621	627	PF00018	0.616
LIG_SH3_2	100	105	PF14604	0.673
LIG_SH3_2	300	305	PF14604	0.752
LIG_SH3_3	159	165	PF00018	0.687
LIG_SH3_3	208	214	PF00018	0.733
LIG_SH3_3	251	257	PF00018	0.751
LIG_SH3_3	297	303	PF00018	0.699
LIG_SH3_3	347	353	PF00018	0.778
LIG_SH3_3	361	367	PF00018	0.556
LIG_SH3_3	435	441	PF00018	0.784
LIG_SH3_3	465	471	PF00018	0.603
LIG_SH3_3	621	627	PF00018	0.616
LIG_SH3_3	662	668	PF00018	0.436
LIG_SH3_3	80	86	PF00018	0.667
LIG_SH3_3	97	103	PF00018	0.784
LIG_SUMO_SIM_anti_2	504	511	PF11976	0.619
LIG_SUMO_SIM_par_1	667	673	PF11976	0.443
LIG_SxIP_EBH_1	19	33	PF03271	0.804
MOD_CDC14_SPxK_1	292	295	PF00782	0.751
MOD_CDC14_SPxK_1	331	334	PF00782	0.831
MOD_CDC14_SPxK_1	34	37	PF00782	0.684
MOD_CDC14_SPxK_1	363	366	PF00782	0.780
MOD_CDK_SPK_2	360	365	PF00069	0.766
MOD_CDK_SPxK_1	289	295	PF00069	0.754
MOD_CDK_SPxK_1	299	305	PF00069	0.712
MOD_CDK_SPxK_1	31	37	PF00069	0.687
MOD_CDK_SPxK_1	328	334	PF00069	0.826
MOD_CDK_SPxK_1	360	366	PF00069	0.786
MOD_CDK_SPxxK_3	441	448	PF00069	0.684
MOD_CK1_1	151	157	PF00069	0.770
MOD_CK1_1	184	190	PF00069	0.765
MOD_CK1_1	215	221	PF00069	0.739
MOD_CK1_1	279	285	PF00069	0.649
MOD_CK1_1	310	316	PF00069	0.731
MOD_CK1_1	328	334	PF00069	0.715
MOD_CK1_1	360	366	PF00069	0.795
MOD_CK1_1	461	467	PF00069	0.639
MOD_CK1_1	55	61	PF00069	0.720
MOD_CK1_1	550	556	PF00069	0.586
MOD_CK1_1	610	616	PF00069	0.651
MOD_CK1_1	75	81	PF00069	0.467
MOD_CK1_1	9	15	PF00069	0.668
MOD_CK2_1	120	126	PF00069	0.535
MOD_CK2_1	309	315	PF00069	0.753
MOD_CK2_1	41	47	PF00069	0.724
MOD_GlcNHglycan	105	108	PF01048	0.801
MOD_GlcNHglycan	112	115	PF01048	0.646
MOD_GlcNHglycan	155	158	PF01048	0.776
MOD_GlcNHglycan	220	223	PF01048	0.734
MOD_GlcNHglycan	24	27	PF01048	0.769
MOD_GlcNHglycan	256	260	PF01048	0.716
MOD_GlcNHglycan	278	281	PF01048	0.781
MOD_GlcNHglycan	29	32	PF01048	0.725
MOD_GlcNHglycan	318	321	PF01048	0.811
MOD_GlcNHglycan	368	371	PF01048	0.770
MOD_GlcNHglycan	38	42	PF01048	0.608
MOD_GlcNHglycan	403	406	PF01048	0.709
MOD_GlcNHglycan	486	489	PF01048	0.480
MOD_GlcNHglycan	54	57	PF01048	0.707
MOD_GlcNHglycan	557	560	PF01048	0.721
MOD_GlcNHglycan	59	62	PF01048	0.734
MOD_GlcNHglycan	613	616	PF01048	0.658
MOD_GlcNHglycan	64	67	PF01048	0.661
MOD_GlcNHglycan	672	675	PF01048	0.576
MOD_GlcNHglycan	74	77	PF01048	0.460
MOD_GlcNHglycan	8	11	PF01048	0.664
MOD_GSK3_1	148	155	PF00069	0.640
MOD_GSK3_1	18	25	PF00069	0.760
MOD_GSK3_1	181	188	PF00069	0.699
MOD_GSK3_1	255	262	PF00069	0.809
MOD_GSK3_1	27	34	PF00069	0.622
MOD_GSK3_1	285	292	PF00069	0.738
MOD_GSK3_1	307	314	PF00069	0.738
MOD_GSK3_1	316	323	PF00069	0.703
MOD_GSK3_1	348	355	PF00069	0.748
MOD_GSK3_1	37	44	PF00069	0.618
MOD_GSK3_1	55	62	PF00069	0.588
MOD_GSK3_1	581	588	PF00069	0.465
MOD_GSK3_1	607	614	PF00069	0.565
MOD_GSK3_1	71	78	PF00069	0.610
MOD_GSK3_1	86	93	PF00069	0.713
MOD_NEK2_1	153	158	PF00069	0.663
MOD_NEK2_1	160	165	PF00069	0.725
MOD_NEK2_1	409	414	PF00069	0.682
MOD_NEK2_1	432	437	PF00069	0.721
MOD_NEK2_1	535	540	PF00069	0.465
MOD_NEK2_1	57	62	PF00069	0.760
MOD_NEK2_1	598	603	PF00069	0.408
MOD_PIKK_1	342	348	PF00454	0.633
MOD_PKA_1	342	348	PF00069	0.633
MOD_PKA_2	158	164	PF00069	0.745
MOD_PKA_2	341	347	PF00069	0.747
MOD_PKA_2	425	431	PF00069	0.780
MOD_PKA_2	447	453	PF00069	0.736
MOD_PKA_2	538	544	PF00069	0.397
MOD_PKA_2	555	561	PF00069	0.704
MOD_Plk_1	176	182	PF00069	0.763
MOD_Plk_1	37	43	PF00069	0.732
MOD_ProDKin_1	148	154	PF00069	0.675
MOD_ProDKin_1	166	172	PF00069	0.495
MOD_ProDKin_1	18	24	PF00069	0.779
MOD_ProDKin_1	186	192	PF00069	0.663
MOD_ProDKin_1	213	219	PF00069	0.670
MOD_ProDKin_1	259	265	PF00069	0.808
MOD_ProDKin_1	279	285	PF00069	0.593
MOD_ProDKin_1	287	293	PF00069	0.701
MOD_ProDKin_1	29	35	PF00069	0.622
MOD_ProDKin_1	294	300	PF00069	0.686
MOD_ProDKin_1	326	332	PF00069	0.770
MOD_ProDKin_1	348	354	PF00069	0.716
MOD_ProDKin_1	360	366	PF00069	0.721
MOD_ProDKin_1	426	432	PF00069	0.652
MOD_ProDKin_1	433	439	PF00069	0.637
MOD_ProDKin_1	441	447	PF00069	0.693
MOD_ProDKin_1	47	53	PF00069	0.610
MOD_ProDKin_1	547	553	PF00069	0.529
TRG_DiLeu_BaEn_2	592	598	PF01217	0.485
TRG_ENDOCYTIC_2	54	57	PF00928	0.791
TRG_ER_diArg_1	143	146	PF00400	0.595
TRG_ER_diArg_1	423	425	PF00400	0.594
TRG_ER_diArg_1	456	458	PF00400	0.711
TRG_ER_diArg_1	560	563	PF00400	0.718
TRG_ER_diArg_1	571	574	PF00400	0.424
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.684
TRG_Pf-PMV_PEXEL_1	136	140	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	478	483	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7X1	Leptomonas seymouri	41%	95%
A4HDY0	Leishmania braziliensis	71%	100%
A4I176	Leishmania infantum	100%	100%
E9AXB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QA62	Leishmania major	89%	100%