DUF805 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical predicted multi-pass transmembrane protein

Species:

Leishmania donovani

UniProt:

A0A3S7WYQ2_LEIDO

TriTrypDb:

LdBPK_242320.1 , LdCL_240028800 , LDHU3_24.2870

Length:

175

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A0A3S7WYQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYQ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	5	7	PF00675	0.428
CLV_NRD_NRD_1	8	10	PF00675	0.420
CLV_PCSK_FUR_1	6	10	PF00082	0.417
CLV_PCSK_KEX2_1	7	9	PF00082	0.418
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.418
CLV_PCSK_SKI1_1	101	105	PF00082	0.552
CLV_PCSK_SKI1_1	55	59	PF00082	0.425
DEG_Nend_UBRbox_3	1	3	PF02207	0.656
DOC_CKS1_1	59	64	PF01111	0.509
DOC_MAPK_gen_1	6	15	PF00069	0.554
DOC_MAPK_MEF2A_6	126	135	PF00069	0.362
DOC_MAPK_MEF2A_6	8	17	PF00069	0.521
DOC_USP7_MATH_1	161	165	PF00917	0.642
DOC_WW_Pin1_4	58	63	PF00397	0.438
LIG_14-3-3_CanoR_1	106	115	PF00244	0.294
LIG_14-3-3_CanoR_1	6	12	PF00244	0.592
LIG_Actin_WH2_2	41	57	PF00022	0.429
LIG_EH1_1	44	52	PF00400	0.414
LIG_eIF4E_1	25	31	PF01652	0.354
LIG_EVH1_2	71	75	PF00568	0.613
LIG_FHA_1	130	136	PF00498	0.396
LIG_FHA_1	8	14	PF00498	0.596
LIG_FHA_1	80	86	PF00498	0.394
LIG_FHA_2	140	146	PF00498	0.647
LIG_GBD_Chelix_1	15	23	PF00786	0.366
LIG_GBD_Chelix_1	46	54	PF00786	0.414
LIG_LIR_Gen_1	74	83	PF02991	0.591
LIG_LIR_Nem_3	61	67	PF02991	0.617
LIG_LIR_Nem_3	74	78	PF02991	0.587
LIG_Pex14_1	14	18	PF04695	0.433
LIG_SH2_STAT5	114	117	PF00017	0.349
LIG_SH2_STAT5	129	132	PF00017	0.302
LIG_SH2_STAT5	18	21	PF00017	0.327
LIG_SH2_STAT5	25	28	PF00017	0.330
LIG_SH3_3	128	134	PF00018	0.405
LIG_TRAF2_1	142	145	PF00917	0.611
LIG_WRC_WIRS_1	80	85	PF05994	0.430
MOD_CDK_SPxxK_3	58	65	PF00069	0.480
MOD_CK2_1	139	145	PF00069	0.644
MOD_GlcNHglycan	155	158	PF01048	0.515
MOD_GlcNHglycan	161	164	PF01048	0.535
MOD_GlcNHglycan	26	29	PF01048	0.463
MOD_GSK3_1	125	132	PF00069	0.431
MOD_NEK2_1	153	158	PF00069	0.717
MOD_NEK2_2	79	84	PF00069	0.430
MOD_PKA_1	7	13	PF00069	0.571
MOD_PKA_2	105	111	PF00069	0.379
MOD_PKA_2	7	13	PF00069	0.592
MOD_Plk_1	139	145	PF00069	0.644
MOD_Plk_4	79	85	PF00069	0.352
MOD_ProDKin_1	58	64	PF00069	0.439
TRG_DiLeu_BaEn_1	144	149	PF01217	0.641
TRG_ENDOCYTIC_2	18	21	PF00928	0.325
TRG_ENDOCYTIC_2	67	70	PF00928	0.563
TRG_ENDOCYTIC_2	80	83	PF00928	0.378
TRG_ER_diArg_1	6	9	PF00400	0.552
TRG_NLS_MonoExtN_4	6	11	PF00514	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C1	Leptomonas seymouri	64%	100%
A0A0S4IMU6	Bodo saltans	32%	78%
A0A1X0NWM1	Trypanosomatidae	35%	100%
A0A3R7LPV2	Trypanosoma rangeli	32%	100%
A4HDT4	Leishmania braziliensis	68%	100%
A4I132	Leishmania infantum	99%	100%
C9ZW76	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AX69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QAA7	Leishmania major	91%	100%