Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WYM1_LEIDO

TriTrypDb:

LdBPK_242040.1 , LdCL_240026100 , LDHU3_24.2490

Length:

844

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WYM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYM1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	323	327	PF00656	0.603
CLV_MEL_PAP_1	830	836	PF00089	0.522
CLV_NRD_NRD_1	261	263	PF00675	0.639
CLV_NRD_NRD_1	303	305	PF00675	0.662
CLV_NRD_NRD_1	421	423	PF00675	0.509
CLV_NRD_NRD_1	440	442	PF00675	0.341
CLV_NRD_NRD_1	69	71	PF00675	0.526
CLV_NRD_NRD_1	796	798	PF00675	0.633
CLV_NRD_NRD_1	832	834	PF00675	0.535
CLV_PCSK_KEX2_1	260	262	PF00082	0.640
CLV_PCSK_KEX2_1	303	305	PF00082	0.662
CLV_PCSK_KEX2_1	421	423	PF00082	0.509
CLV_PCSK_KEX2_1	439	441	PF00082	0.351
CLV_PCSK_KEX2_1	69	71	PF00082	0.526
CLV_PCSK_KEX2_1	796	798	PF00082	0.633
CLV_PCSK_KEX2_1	832	834	PF00082	0.535
CLV_PCSK_PC7_1	257	263	PF00082	0.636
CLV_PCSK_SKI1_1	128	132	PF00082	0.446
CLV_PCSK_SKI1_1	312	316	PF00082	0.650
CLV_PCSK_SKI1_1	350	354	PF00082	0.541
CLV_PCSK_SKI1_1	514	518	PF00082	0.565
DEG_APCC_DBOX_1	349	357	PF00400	0.538
DOC_CKS1_1	680	685	PF01111	0.584
DOC_CKS1_1	717	722	PF01111	0.610
DOC_CKS1_1	789	794	PF01111	0.546
DOC_CYCLIN_yCln2_LP_2	561	567	PF00134	0.605
DOC_MAPK_DCC_7	350	358	PF00069	0.533
DOC_MAPK_MEF2A_6	44	51	PF00069	0.467
DOC_MAPK_NFAT4_5	44	52	PF00069	0.467
DOC_PP2B_LxvP_1	561	564	PF13499	0.583
DOC_PP2B_LxvP_1	574	577	PF13499	0.520
DOC_PP4_FxxP_1	680	683	PF00568	0.585
DOC_PP4_FxxP_1	717	720	PF00568	0.606
DOC_USP7_MATH_1	124	128	PF00917	0.500
DOC_USP7_MATH_1	193	197	PF00917	0.657
DOC_USP7_MATH_1	23	27	PF00917	0.507
DOC_USP7_MATH_1	239	243	PF00917	0.659
DOC_USP7_MATH_1	306	310	PF00917	0.582
DOC_USP7_MATH_1	321	325	PF00917	0.529
DOC_USP7_MATH_1	409	413	PF00917	0.506
DOC_USP7_MATH_1	588	592	PF00917	0.688
DOC_USP7_MATH_1	606	610	PF00917	0.540
DOC_USP7_MATH_1	622	626	PF00917	0.540
DOC_USP7_MATH_1	646	650	PF00917	0.607
DOC_USP7_MATH_2	642	648	PF00917	0.651
DOC_WW_Pin1_4	304	309	PF00397	0.632
DOC_WW_Pin1_4	351	356	PF00397	0.535
DOC_WW_Pin1_4	542	547	PF00397	0.674
DOC_WW_Pin1_4	554	559	PF00397	0.604
DOC_WW_Pin1_4	679	684	PF00397	0.602
DOC_WW_Pin1_4	716	721	PF00397	0.675
DOC_WW_Pin1_4	772	777	PF00397	0.645
DOC_WW_Pin1_4	788	793	PF00397	0.507
LIG_14-3-3_CanoR_1	293	297	PF00244	0.578
LIG_14-3-3_CanoR_1	467	475	PF00244	0.447
LIG_14-3-3_CanoR_1	482	490	PF00244	0.447
LIG_14-3-3_CanoR_1	592	598	PF00244	0.611
LIG_14-3-3_CanoR_1	716	720	PF00244	0.613
LIG_14-3-3_CanoR_1	783	793	PF00244	0.636
LIG_14-3-3_CanoR_1	796	800	PF00244	0.588
LIG_Actin_WH2_2	336	352	PF00022	0.581
LIG_BIR_III_4	326	330	PF00653	0.664
LIG_BRCT_BRCA1_1	204	208	PF00533	0.678
LIG_BRCT_BRCA1_1	527	531	PF00533	0.555
LIG_BRCT_BRCA1_1	815	819	PF00533	0.568
LIG_CtBP_PxDLS_1	792	796	PF00389	0.553
LIG_deltaCOP1_diTrp_1	518	524	PF00928	0.502
LIG_FHA_1	254	260	PF00498	0.679
LIG_FHA_1	332	338	PF00498	0.608
LIG_FHA_1	352	358	PF00498	0.393
LIG_FHA_1	716	722	PF00498	0.596
LIG_FHA_1	819	825	PF00498	0.525
LIG_FHA_2	201	207	PF00498	0.629
LIG_FHA_2	23	29	PF00498	0.491
LIG_FHA_2	321	327	PF00498	0.678
LIG_FHA_2	340	346	PF00498	0.431
LIG_FHA_2	680	686	PF00498	0.687
LIG_FHA_2	789	795	PF00498	0.594
LIG_LIR_Apic_2	678	683	PF02991	0.587
LIG_LIR_Apic_2	723	728	PF02991	0.654
LIG_LIR_Gen_1	205	213	PF02991	0.678
LIG_LIR_Gen_1	452	461	PF02991	0.487
LIG_LIR_Gen_1	503	513	PF02991	0.670
LIG_LIR_Gen_1	812	823	PF02991	0.553
LIG_LIR_Gen_1	95	103	PF02991	0.500
LIG_LIR_Nem_3	205	211	PF02991	0.679
LIG_LIR_Nem_3	452	457	PF02991	0.487
LIG_LIR_Nem_3	503	509	PF02991	0.676
LIG_LIR_Nem_3	95	100	PF02991	0.499
LIG_NRBOX	176	182	PF00104	0.535
LIG_PDZ_Class_2	839	844	PF00595	0.546
LIG_Pex14_2	676	680	PF04695	0.588
LIG_PTB_Apo_2	180	187	PF02174	0.541
LIG_PTB_Phospho_1	180	186	PF10480	0.538
LIG_Rb_LxCxE_1	443	462	PF01857	0.485
LIG_SH2_CRK	506	510	PF00017	0.535
LIG_SH2_CRK	513	517	PF00017	0.493
LIG_SH2_CRK	771	775	PF00017	0.556
LIG_SH2_NCK_1	771	775	PF00017	0.556
LIG_SH2_STAP1	815	819	PF00017	0.568
LIG_SH2_STAT3	186	189	PF00017	0.572
LIG_SH2_STAT5	799	802	PF00017	0.670
LIG_SH3_1	771	777	PF00018	0.604
LIG_SH3_2	298	303	PF14604	0.576
LIG_SH3_3	233	239	PF00018	0.663
LIG_SH3_3	295	301	PF00018	0.586
LIG_SH3_3	302	308	PF00018	0.673
LIG_SH3_3	543	549	PF00018	0.703
LIG_SH3_3	557	563	PF00018	0.670
LIG_SH3_3	708	714	PF00018	0.624
LIG_SH3_3	771	777	PF00018	0.641
LIG_SH3_3	786	792	PF00018	0.526
LIG_SH3_CIN85_PxpxPR_1	697	702	PF14604	0.623
LIG_SUMO_SIM_anti_2	334	342	PF11976	0.510
LIG_SUMO_SIM_anti_2	460	465	PF11976	0.490
LIG_SUMO_SIM_par_1	78	83	PF11976	0.505
LIG_TRAF2_1	25	28	PF00917	0.384
LIG_TRAF2_1	403	406	PF00917	0.499
LIG_TYR_ITIM	504	509	PF00017	0.542
LIG_UBA3_1	356	361	PF00899	0.520
LIG_WW_3	713	717	PF00397	0.609
MOD_CK1_1	242	248	PF00069	0.613
MOD_CK1_1	26	32	PF00069	0.507
MOD_CK1_1	307	313	PF00069	0.674
MOD_CK1_1	335	341	PF00069	0.635
MOD_CK1_1	348	354	PF00069	0.429
MOD_CK1_1	469	475	PF00069	0.480
MOD_CK1_1	525	531	PF00069	0.624
MOD_CK1_1	556	562	PF00069	0.614
MOD_CK1_1	591	597	PF00069	0.640
MOD_CK1_1	647	653	PF00069	0.660
MOD_CK1_1	669	675	PF00069	0.631
MOD_CK1_1	679	685	PF00069	0.627
MOD_CK1_1	730	736	PF00069	0.675
MOD_CK1_1	763	769	PF00069	0.642
MOD_CK1_1	798	804	PF00069	0.645
MOD_CK2_1	133	139	PF00069	0.521
MOD_CK2_1	200	206	PF00069	0.627
MOD_CK2_1	22	28	PF00069	0.492
MOD_CK2_1	261	267	PF00069	0.604
MOD_CK2_1	679	685	PF00069	0.687
MOD_DYRK1A_RPxSP_1	304	308	PF00069	0.648
MOD_GlcNHglycan	158	161	PF01048	0.533
MOD_GlcNHglycan	166	169	PF01048	0.497
MOD_GlcNHglycan	267	270	PF01048	0.617
MOD_GlcNHglycan	278	281	PF01048	0.490
MOD_GlcNHglycan	401	404	PF01048	0.496
MOD_GlcNHglycan	485	488	PF01048	0.534
MOD_GlcNHglycan	570	573	PF01048	0.678
MOD_GlcNHglycan	646	649	PF01048	0.707
MOD_GlcNHglycan	671	674	PF01048	0.603
MOD_GlcNHglycan	729	732	PF01048	0.635
MOD_GlcNHglycan	743	746	PF01048	0.568
MOD_GlcNHglycan	765	768	PF01048	0.592
MOD_GlcNHglycan	779	782	PF01048	0.556
MOD_GlcNHglycan	834	837	PF01048	0.515
MOD_GlcNHglycan	87	92	PF01048	0.458
MOD_GSK3_1	124	131	PF00069	0.439
MOD_GSK3_1	22	29	PF00069	0.429
MOD_GSK3_1	239	246	PF00069	0.618
MOD_GSK3_1	261	268	PF00069	0.631
MOD_GSK3_1	304	311	PF00069	0.669
MOD_GSK3_1	315	322	PF00069	0.605
MOD_GSK3_1	328	335	PF00069	0.555
MOD_GSK3_1	440	447	PF00069	0.503
MOD_GSK3_1	588	595	PF00069	0.648
MOD_GSK3_1	604	611	PF00069	0.557
MOD_GSK3_1	642	649	PF00069	0.636
MOD_GSK3_1	665	672	PF00069	0.635
MOD_GSK3_1	675	682	PF00069	0.629
MOD_GSK3_1	716	723	PF00069	0.668
MOD_GSK3_1	727	734	PF00069	0.566
MOD_GSK3_1	772	779	PF00069	0.628
MOD_GSK3_1	784	791	PF00069	0.563
MOD_GSK3_1	809	816	PF00069	0.588
MOD_LATS_1	126	132	PF00433	0.445
MOD_N-GLC_1	265	270	PF02516	0.566
MOD_N-GLC_1	809	814	PF02516	0.499
MOD_NEK2_1	253	258	PF00069	0.679
MOD_NEK2_1	265	270	PF00069	0.526
MOD_NEK2_1	315	320	PF00069	0.684
MOD_NEK2_1	444	449	PF00069	0.509
MOD_NEK2_1	598	603	PF00069	0.660
MOD_NEK2_1	741	746	PF00069	0.634
MOD_NEK2_1	752	757	PF00069	0.552
MOD_NEK2_1	762	767	PF00069	0.546
MOD_NEK2_1	795	800	PF00069	0.632
MOD_NEK2_1	838	843	PF00069	0.531
MOD_PIKK_1	222	228	PF00454	0.635
MOD_PIKK_1	292	298	PF00454	0.662
MOD_PIKK_1	321	327	PF00454	0.634
MOD_PIKK_1	332	338	PF00454	0.597
MOD_PIKK_1	401	407	PF00454	0.580
MOD_PIKK_1	667	673	PF00454	0.616
MOD_PKA_1	261	267	PF00069	0.617
MOD_PKA_1	440	446	PF00069	0.468
MOD_PKA_1	832	838	PF00069	0.527
MOD_PKA_2	164	170	PF00069	0.551
MOD_PKA_2	23	29	PF00069	0.507
MOD_PKA_2	261	267	PF00069	0.617
MOD_PKA_2	292	298	PF00069	0.576
MOD_PKA_2	440	446	PF00069	0.468
MOD_PKA_2	466	472	PF00069	0.474
MOD_PKA_2	591	597	PF00069	0.609
MOD_PKA_2	642	648	PF00069	0.608
MOD_PKA_2	715	721	PF00069	0.615
MOD_PKA_2	795	801	PF00069	0.630
MOD_PKA_2	832	838	PF00069	0.527
MOD_Plk_1	345	351	PF00069	0.542
MOD_Plk_1	520	526	PF00069	0.534
MOD_Plk_1	813	819	PF00069	0.578
MOD_Plk_1	838	844	PF00069	0.540
MOD_Plk_4	335	341	PF00069	0.511
MOD_Plk_4	362	368	PF00069	0.464
MOD_Plk_4	593	599	PF00069	0.675
MOD_Plk_4	75	81	PF00069	0.469
MOD_Plk_4	814	820	PF00069	0.568
MOD_ProDKin_1	304	310	PF00069	0.632
MOD_ProDKin_1	351	357	PF00069	0.533
MOD_ProDKin_1	542	548	PF00069	0.672
MOD_ProDKin_1	554	560	PF00069	0.600
MOD_ProDKin_1	679	685	PF00069	0.603
MOD_ProDKin_1	716	722	PF00069	0.678
MOD_ProDKin_1	772	778	PF00069	0.645
MOD_ProDKin_1	788	794	PF00069	0.507
MOD_SUMO_for_1	5	8	PF00179	0.504
MOD_SUMO_rev_2	71	78	PF00179	0.472
TRG_DiLeu_BaEn_1	452	457	PF01217	0.487
TRG_DiLeu_BaLyEn_6	352	357	PF01217	0.531
TRG_ENDOCYTIC_2	388	391	PF00928	0.502
TRG_ENDOCYTIC_2	506	509	PF00928	0.542
TRG_ENDOCYTIC_2	513	516	PF00928	0.495
TRG_ENDOCYTIC_2	815	818	PF00928	0.575
TRG_ER_diArg_1	163	166	PF00400	0.573
TRG_ER_diArg_1	259	262	PF00400	0.586
TRG_ER_diArg_1	303	305	PF00400	0.662
TRG_ER_diArg_1	33	36	PF00400	0.523
TRG_ER_diArg_1	374	377	PF00400	0.522
TRG_ER_diArg_1	421	423	PF00400	0.509
TRG_ER_diArg_1	438	441	PF00400	0.361
TRG_ER_diArg_1	795	797	PF00400	0.630
TRG_ER_diArg_1	832	834	PF00400	0.535
TRG_NES_CRM1_1	140	155	PF08389	0.477
TRG_Pf-PMV_PEXEL_1	14	18	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	190	195	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	514	518	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	738	743	PF00026	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HDQ8	Leishmania braziliensis	68%	99%
A4I104	Leishmania infantum	99%	100%
E9AX42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QAD4	Leishmania major	84%	100%