CID domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WYL9_LEIDO

TriTrypDb:

LdBPK_242190.1 , LdCL_240027500 , LDHU3_24.2670

Length:

308

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WYL9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYL9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	72	76	PF00656	0.564
CLV_NRD_NRD_1	294	296	PF00675	0.630
CLV_NRD_NRD_1	299	301	PF00675	0.621
CLV_NRD_NRD_1	64	66	PF00675	0.427
CLV_PCSK_KEX2_1	292	294	PF00082	0.638
CLV_PCSK_KEX2_1	298	300	PF00082	0.628
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.715
CLV_PCSK_PC7_1	294	300	PF00082	0.620
CLV_PCSK_SKI1_1	202	206	PF00082	0.682
CLV_PCSK_SKI1_1	208	212	PF00082	0.679
CLV_PCSK_SKI1_1	65	69	PF00082	0.440
DOC_CKS1_1	235	240	PF01111	0.740
DOC_MAPK_DCC_7	279	288	PF00069	0.698
DOC_MAPK_gen_1	279	288	PF00069	0.698
DOC_MAPK_MEF2A_6	279	288	PF00069	0.698
DOC_MAPK_MEF2A_6	91	100	PF00069	0.409
DOC_PP2B_LxvP_1	100	103	PF13499	0.450
DOC_PP2B_LxvP_1	286	289	PF13499	0.704
DOC_USP7_MATH_1	151	155	PF00917	0.564
DOC_USP7_MATH_1	167	171	PF00917	0.657
DOC_USP7_MATH_1	200	204	PF00917	0.652
DOC_USP7_MATH_1	248	252	PF00917	0.743
DOC_WW_Pin1_4	12	17	PF00397	0.664
DOC_WW_Pin1_4	172	177	PF00397	0.670
DOC_WW_Pin1_4	223	228	PF00397	0.797
DOC_WW_Pin1_4	234	239	PF00397	0.543
DOC_WW_Pin1_4	268	273	PF00397	0.771
LIG_14-3-3_CanoR_1	121	126	PF00244	0.635
LIG_14-3-3_CanoR_1	208	217	PF00244	0.711
LIG_BIR_II_1	1	5	PF00653	0.597
LIG_Clathr_ClatBox_1	125	129	PF01394	0.544
LIG_eIF4E_1	84	90	PF01652	0.373
LIG_FHA_1	209	215	PF00498	0.678
LIG_FHA_1	23	29	PF00498	0.560
LIG_Integrin_isoDGR_2	242	244	PF01839	0.668
LIG_LIR_Apic_2	232	238	PF02991	0.732
LIG_LIR_Gen_1	134	143	PF02991	0.490
LIG_LIR_Gen_1	187	195	PF02991	0.488
LIG_LIR_Gen_1	59	69	PF02991	0.413
LIG_LIR_Nem_3	134	138	PF02991	0.408
LIG_LIR_Nem_3	187	192	PF02991	0.486
LIG_LIR_Nem_3	59	64	PF02991	0.399
LIG_LIR_Nem_3	81	86	PF02991	0.438
LIG_NRBOX	159	165	PF00104	0.606
LIG_PALB2_WD40_1	123	131	PF16756	0.537
LIG_PTAP_UEV_1	226	231	PF05743	0.597
LIG_SH2_CRK	144	148	PF00017	0.526
LIG_SH2_CRK	235	239	PF00017	0.770
LIG_SH2_CRK	30	34	PF00017	0.536
LIG_SH2_STAP1	24	28	PF00017	0.594
LIG_SH2_STAT3	108	111	PF00017	0.426
LIG_SH2_STAT5	108	111	PF00017	0.426
LIG_SH2_STAT5	24	27	PF00017	0.590
LIG_SH2_STAT5	270	273	PF00017	0.639
LIG_SH2_STAT5	84	87	PF00017	0.380
LIG_SH3_3	13	19	PF00018	0.676
LIG_SH3_3	173	179	PF00018	0.615
LIG_SH3_3	224	230	PF00018	0.797
LIG_SH3_3	93	99	PF00018	0.403
LIG_SUMO_SIM_anti_2	213	220	PF11976	0.614
LIG_SUMO_SIM_par_1	213	220	PF11976	0.544
LIG_TYR_ITIM	28	33	PF00017	0.531
MOD_CDK_SPK_2	12	17	PF00069	0.715
MOD_CK1_1	223	229	PF00069	0.760
MOD_CK1_1	3	9	PF00069	0.464
MOD_CK1_1	57	63	PF00069	0.510
MOD_CK2_1	153	159	PF00069	0.482
MOD_Cter_Amidation	296	299	PF01082	0.762
MOD_GlcNHglycan	144	147	PF01048	0.440
MOD_GlcNHglycan	155	158	PF01048	0.414
MOD_GlcNHglycan	20	23	PF01048	0.389
MOD_GlcNHglycan	227	230	PF01048	0.721
MOD_GlcNHglycan	231	234	PF01048	0.784
MOD_GlcNHglycan	250	253	PF01048	0.754
MOD_GlcNHglycan	5	8	PF01048	0.643
MOD_GlcNHglycan	56	59	PF01048	0.452
MOD_GSK3_1	18	25	PF00069	0.558
MOD_GSK3_1	221	228	PF00069	0.736
MOD_LATS_1	206	212	PF00433	0.606
MOD_N-GLC_1	78	83	PF02516	0.487
MOD_NEK2_1	106	111	PF00069	0.523
MOD_NEK2_2	200	205	PF00069	0.718
MOD_PIKK_1	255	261	PF00454	0.782
MOD_Plk_1	106	112	PF00069	0.522
MOD_Plk_1	167	173	PF00069	0.620
MOD_Plk_1	78	84	PF00069	0.491
MOD_Plk_4	121	127	PF00069	0.558
MOD_Plk_4	200	206	PF00069	0.697
MOD_ProDKin_1	12	18	PF00069	0.658
MOD_ProDKin_1	172	178	PF00069	0.661
MOD_ProDKin_1	223	229	PF00069	0.796
MOD_ProDKin_1	234	240	PF00069	0.544
MOD_ProDKin_1	268	274	PF00069	0.770
MOD_SUMO_rev_2	218	224	PF00179	0.557
TRG_DiLeu_BaEn_1	159	164	PF01217	0.605
TRG_DiLeu_BaLyEn_6	101	106	PF01217	0.464
TRG_ENDOCYTIC_2	144	147	PF00928	0.516
TRG_ENDOCYTIC_2	30	33	PF00928	0.527
TRG_ER_diArg_1	293	295	PF00400	0.666
TRG_ER_diArg_1	298	300	PF00400	0.612
TRG_NES_CRM1_1	123	136	PF08389	0.558
TRG_Pf-PMV_PEXEL_1	66	70	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0R9	Leptomonas seymouri	65%	100%
A0A1X0NWE2	Trypanosomatidae	39%	100%
A0A3R7MR43	Trypanosoma rangeli	38%	100%
A4HDS1	Leishmania braziliensis	86%	100%
A4I119	Leishmania infantum	99%	100%
C9ZW91	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AX56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QAC0	Leishmania major	95%	100%
V5AV25	Trypanosoma cruzi	41%	100%