Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WYL2_LEIDO

TriTrypDb:

LdBPK_241770.1 , LdCL_240023300 , LDHU3_24.2180

Length:

469

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7WYL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYL2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	90	94	PF00656	0.732
CLV_NRD_NRD_1	129	131	PF00675	0.470
CLV_NRD_NRD_1	145	147	PF00675	0.371
CLV_NRD_NRD_1	174	176	PF00675	0.518
CLV_NRD_NRD_1	224	226	PF00675	0.577
CLV_NRD_NRD_1	441	443	PF00675	0.435
CLV_PCSK_FUR_1	127	131	PF00082	0.384
CLV_PCSK_FUR_1	143	147	PF00082	0.359
CLV_PCSK_KEX2_1	126	128	PF00082	0.412
CLV_PCSK_KEX2_1	129	131	PF00082	0.417
CLV_PCSK_KEX2_1	145	147	PF00082	0.408
CLV_PCSK_KEX2_1	174	176	PF00082	0.532
CLV_PCSK_KEX2_1	224	226	PF00082	0.510
CLV_PCSK_KEX2_1	441	443	PF00082	0.435
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.396
CLV_PCSK_SKI1_1	355	359	PF00082	0.333
DOC_CYCLIN_yCln2_LP_2	240	246	PF00134	0.624
DOC_MAPK_MEF2A_6	289	296	PF00069	0.529
DOC_MAPK_MEF2A_6	302	311	PF00069	0.443
DOC_PP2B_LxvP_1	240	243	PF13499	0.691
DOC_USP7_MATH_1	158	162	PF00917	0.626
DOC_USP7_MATH_1	182	186	PF00917	0.757
DOC_USP7_MATH_1	4	8	PF00917	0.774
DOC_USP7_MATH_1	96	100	PF00917	0.617
DOC_WW_Pin1_4	148	153	PF00397	0.646
DOC_WW_Pin1_4	198	203	PF00397	0.796
DOC_WW_Pin1_4	32	37	PF00397	0.692
DOC_WW_Pin1_4	92	97	PF00397	0.609
LIG_14-3-3_CanoR_1	177	182	PF00244	0.745
LIG_14-3-3_CanoR_1	210	220	PF00244	0.670
LIG_14-3-3_CanoR_1	355	361	PF00244	0.572
LIG_14-3-3_CanoR_1	370	377	PF00244	0.547
LIG_14-3-3_CanoR_1	458	468	PF00244	0.692
LIG_14-3-3_CanoR_1	64	72	PF00244	0.691
LIG_Actin_WH2_2	300	317	PF00022	0.552
LIG_AP2alpha_2	274	276	PF02296	0.551
LIG_APCC_ABBA_1	273	278	PF00400	0.562
LIG_CaM_IQ_9	119	135	PF13499	0.636
LIG_FHA_1	211	217	PF00498	0.683
LIG_FHA_1	234	240	PF00498	0.630
LIG_FHA_1	428	434	PF00498	0.590
LIG_FHA_2	19	25	PF00498	0.617
LIG_FHA_2	88	94	PF00498	0.661
LIG_FHA_2	96	102	PF00498	0.623
LIG_LIR_Apic_2	359	363	PF02991	0.607
LIG_LIR_Gen_1	241	251	PF02991	0.682
LIG_LIR_Gen_1	328	334	PF02991	0.337
LIG_LIR_Gen_1	53	59	PF02991	0.669
LIG_LIR_Nem_3	241	247	PF02991	0.634
LIG_LIR_Nem_3	269	273	PF02991	0.567
LIG_LIR_Nem_3	328	333	PF02991	0.337
LIG_LIR_Nem_3	53	58	PF02991	0.624
LIG_Pex14_1	108	112	PF04695	0.573
LIG_Pex14_1	356	360	PF04695	0.496
LIG_Pex14_2	343	347	PF04695	0.258
LIG_RPA_C_Fungi	427	439	PF08784	0.568
LIG_SH2_CRK	33	37	PF00017	0.594
LIG_SH2_CRK	360	364	PF00017	0.494
LIG_SH2_NCK_1	33	37	PF00017	0.585
LIG_SH2_NCK_1	360	364	PF00017	0.456
LIG_SH2_STAP1	443	447	PF00017	0.500
LIG_SH2_STAP1	55	59	PF00017	0.535
LIG_SH2_STAP1	67	71	PF00017	0.519
LIG_SH2_STAT5	147	150	PF00017	0.608
LIG_SH2_STAT5	33	36	PF00017	0.612
LIG_SH2_STAT5	360	363	PF00017	0.470
LIG_SH2_STAT5	375	378	PF00017	0.253
LIG_SH2_STAT5	461	464	PF00017	0.596
LIG_SH2_STAT5	466	469	PF00017	0.583
LIG_SH2_STAT5	57	60	PF00017	0.565
LIG_SH3_5	266	270	PF00018	0.547
LIG_SUMO_SIM_par_1	424	430	PF11976	0.463
LIG_TRAF2_1	121	124	PF00917	0.534
LIG_TRFH_1	148	152	PF08558	0.538
LIG_TRFH_1	271	275	PF08558	0.511
LIG_TRFH_1	360	364	PF08558	0.459
LIG_TYR_ITIM	268	273	PF00017	0.526
LIG_UBA3_1	353	358	PF00899	0.489
MOD_CK1_1	18	24	PF00069	0.631
MOD_CK1_1	250	256	PF00069	0.505
MOD_CK1_1	279	285	PF00069	0.409
MOD_CK1_1	459	465	PF00069	0.540
MOD_CK1_1	66	72	PF00069	0.646
MOD_CK1_1	95	101	PF00069	0.566
MOD_CK2_1	158	164	PF00069	0.620
MOD_CK2_1	182	188	PF00069	0.648
MOD_CK2_1	50	56	PF00069	0.629
MOD_CK2_1	95	101	PF00069	0.534
MOD_GlcNHglycan	16	20	PF01048	0.631
MOD_GlcNHglycan	278	281	PF01048	0.537
MOD_GlcNHglycan	316	319	PF01048	0.279
MOD_GlcNHglycan	381	384	PF01048	0.297
MOD_GlcNHglycan	405	408	PF01048	0.297
MOD_GlcNHglycan	47	50	PF01048	0.563
MOD_GSK3_1	158	165	PF00069	0.498
MOD_GSK3_1	325	332	PF00069	0.357
MOD_GSK3_1	456	463	PF00069	0.603
MOD_GSK3_1	63	70	PF00069	0.659
MOD_GSK3_1	92	99	PF00069	0.665
MOD_N-GLC_1	210	215	PF02516	0.614
MOD_N-GLC_1	325	330	PF02516	0.279
MOD_N-GLC_1	394	399	PF02516	0.463
MOD_N-GLC_1	4	9	PF02516	0.641
MOD_NEK2_1	15	20	PF00069	0.699
MOD_NEK2_1	176	181	PF00069	0.600
MOD_NEK2_1	276	281	PF00069	0.425
MOD_NEK2_1	314	319	PF00069	0.313
MOD_NEK2_1	325	330	PF00069	0.332
MOD_NEK2_1	377	382	PF00069	0.287
MOD_NEK2_1	394	399	PF00069	0.445
MOD_NEK2_1	403	408	PF00069	0.240
MOD_NEK2_1	50	55	PF00069	0.667
MOD_NEK2_2	107	112	PF00069	0.463
MOD_NEK2_2	4	9	PF00069	0.616
MOD_PIKK_1	158	164	PF00454	0.462
MOD_PKA_2	176	182	PF00069	0.696
MOD_PKA_2	223	229	PF00069	0.765
MOD_PKA_2	233	239	PF00069	0.650
MOD_PKA_2	369	375	PF00069	0.407
MOD_PKA_2	63	69	PF00069	0.630
MOD_PKB_1	175	183	PF00069	0.598
MOD_Plk_1	325	331	PF00069	0.279
MOD_Plk_4	107	113	PF00069	0.488
MOD_Plk_4	279	285	PF00069	0.435
MOD_Plk_4	320	326	PF00069	0.306
MOD_Plk_4	329	335	PF00069	0.314
MOD_Plk_4	462	468	PF00069	0.509
MOD_Plk_4	67	73	PF00069	0.614
MOD_ProDKin_1	148	154	PF00069	0.558
MOD_ProDKin_1	198	204	PF00069	0.770
MOD_ProDKin_1	32	38	PF00069	0.627
MOD_ProDKin_1	92	98	PF00069	0.508
TRG_ENDOCYTIC_2	147	150	PF00928	0.601
TRG_ENDOCYTIC_2	270	273	PF00928	0.521
TRG_ENDOCYTIC_2	443	446	PF00928	0.505
TRG_ENDOCYTIC_2	55	58	PF00928	0.641
TRG_ER_diArg_1	127	130	PF00400	0.564
TRG_ER_diArg_1	143	146	PF00400	0.570
TRG_ER_diArg_1	166	169	PF00400	0.509
TRG_ER_diArg_1	174	177	PF00400	0.512
TRG_ER_diArg_1	264	267	PF00400	0.545
TRG_ER_diArg_1	440	442	PF00400	0.547
TRG_NLS_Bipartite_1	113	130	PF00514	0.513
TRG_NLS_MonoExtC_3	125	130	PF00514	0.477
TRG_Pf-PMV_PEXEL_1	52	56	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7U8	Leptomonas seymouri	64%	99%
A0A0S4JPE5	Bodo saltans	43%	100%
A0A1X0NW21	Trypanosomatidae	52%	100%
A4HDN0	Leishmania braziliensis	85%	100%
C9ZWD5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AH77	Leishmania infantum	99%	100%
E9AX15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QAG1	Leishmania major	95%	100%
V5DBL9	Trypanosoma cruzi	48%	100%