Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WYK4_LEIDO

TriTrypDb:

LdBPK_242030.1 , LdCL_240026000 , LDHU3_24.2480

Length:

791

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	3
GO:0042995	cell projection	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0110165	cellular anatomical entity	1	3
GO:0120025	plasma membrane bounded cell projection	3	3

Expansion

Sequence features

A0A3S7WYK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYK4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.657
CLV_C14_Caspase3-7	163	167	PF00656	0.494
CLV_C14_Caspase3-7	294	298	PF00656	0.620
CLV_C14_Caspase3-7	36	40	PF00656	0.581
CLV_C14_Caspase3-7	461	465	PF00656	0.506
CLV_C14_Caspase3-7	552	556	PF00656	0.562
CLV_MEL_PAP_1	499	505	PF00089	0.569
CLV_NRD_NRD_1	182	184	PF00675	0.449
CLV_NRD_NRD_1	185	187	PF00675	0.441
CLV_NRD_NRD_1	501	503	PF00675	0.709
CLV_NRD_NRD_1	589	591	PF00675	0.683
CLV_NRD_NRD_1	634	636	PF00675	0.564
CLV_NRD_NRD_1	698	700	PF00675	0.642
CLV_PCSK_FUR_1	183	187	PF00082	0.446
CLV_PCSK_KEX2_1	184	186	PF00082	0.449
CLV_PCSK_KEX2_1	501	503	PF00082	0.709
CLV_PCSK_KEX2_1	589	591	PF00082	0.562
CLV_PCSK_KEX2_1	634	636	PF00082	0.697
CLV_PCSK_KEX2_1	698	700	PF00082	0.642
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.461
CLV_PCSK_SKI1_1	177	181	PF00082	0.380
CLV_PCSK_SKI1_1	186	190	PF00082	0.385
CLV_PCSK_SKI1_1	354	358	PF00082	0.592
CLV_PCSK_SKI1_1	59	63	PF00082	0.573
CLV_PCSK_SKI1_1	698	702	PF00082	0.464
CLV_PCSK_SKI1_1	706	710	PF00082	0.438
CLV_PCSK_SKI1_1	783	787	PF00082	0.585
CLV_Separin_Metazoa	695	699	PF03568	0.566
DEG_Nend_UBRbox_1	1	4	PF02207	0.494
DEG_SCF_TRCP1_1	567	573	PF00400	0.526
DEG_SPOP_SBC_1	397	401	PF00917	0.616
DEG_SPOP_SBC_1	642	646	PF00917	0.618
DOC_ANK_TNKS_1	589	596	PF00023	0.468
DOC_CDC14_PxL_1	62	70	PF14671	0.551
DOC_CDC14_PxL_1	90	98	PF14671	0.480
DOC_MAPK_gen_1	183	189	PF00069	0.470
DOC_MAPK_gen_1	452	460	PF00069	0.459
DOC_MAPK_MEF2A_6	25	34	PF00069	0.523
DOC_MAPK_MEF2A_6	354	363	PF00069	0.486
DOC_MAPK_MEF2A_6	452	460	PF00069	0.459
DOC_PP1_RVXF_1	543	549	PF00149	0.454
DOC_PP2B_LxvP_1	655	658	PF13499	0.553
DOC_PP4_FxxP_1	290	293	PF00568	0.637
DOC_USP7_MATH_1	311	315	PF00917	0.724
DOC_USP7_MATH_1	397	401	PF00917	0.782
DOC_USP7_MATH_1	565	569	PF00917	0.530
DOC_USP7_MATH_1	610	614	PF00917	0.611
DOC_USP7_MATH_1	643	647	PF00917	0.574
DOC_USP7_MATH_1	658	662	PF00917	0.497
DOC_USP7_MATH_1	773	777	PF00917	0.475
DOC_USP7_MATH_2	677	683	PF00917	0.551
DOC_WW_Pin1_4	393	398	PF00397	0.606
DOC_WW_Pin1_4	45	50	PF00397	0.727
DOC_WW_Pin1_4	479	484	PF00397	0.678
DOC_WW_Pin1_4	673	678	PF00397	0.551
LIG_14-3-3_CanoR_1	2	8	PF00244	0.422
LIG_14-3-3_CanoR_1	256	265	PF00244	0.678
LIG_14-3-3_CanoR_1	501	509	PF00244	0.585
LIG_14-3-3_CanoR_1	549	559	PF00244	0.693
LIG_Actin_WH2_2	536	553	PF00022	0.454
LIG_Actin_WH2_2	83	99	PF00022	0.398
LIG_APCC_ABBA_1	762	767	PF00400	0.474
LIG_BIR_III_2	213	217	PF00653	0.515
LIG_Clathr_ClatBox_1	209	213	PF01394	0.508
LIG_CtBP_PxDLS_1	741	745	PF00389	0.474
LIG_deltaCOP1_diTrp_1	756	765	PF00928	0.477
LIG_FHA_1	120	126	PF00498	0.505
LIG_FHA_1	2	8	PF00498	0.521
LIG_FHA_1	304	310	PF00498	0.580
LIG_FHA_1	365	371	PF00498	0.547
LIG_FHA_1	471	477	PF00498	0.580
LIG_FHA_1	520	526	PF00498	0.525
LIG_FHA_2	138	144	PF00498	0.621
LIG_FHA_2	34	40	PF00498	0.572
LIG_FHA_2	401	407	PF00498	0.532
LIG_FHA_2	431	437	PF00498	0.579
LIG_LIR_Gen_1	338	348	PF02991	0.482
LIG_LIR_Gen_1	661	670	PF02991	0.649
LIG_LIR_Gen_1	756	765	PF02991	0.492
LIG_LIR_LC3C_4	527	531	PF02991	0.434
LIG_LIR_Nem_3	338	343	PF02991	0.494
LIG_LIR_Nem_3	661	667	PF02991	0.555
LIG_LIR_Nem_3	746	750	PF02991	0.513
LIG_LIR_Nem_3	756	761	PF02991	0.497
LIG_LIR_Nem_3	767	771	PF02991	0.389
LIG_MYND_3	156	160	PF01753	0.549
LIG_MYND_3	203	207	PF01753	0.560
LIG_Pex14_1	598	602	PF04695	0.543
LIG_SH2_CRK	340	344	PF00017	0.496
LIG_SH2_CRK	492	496	PF00017	0.439
LIG_SH2_CRK	664	668	PF00017	0.560
LIG_SH2_PTP2	457	460	PF00017	0.478
LIG_SH2_SRC	726	729	PF00017	0.573
LIG_SH2_STAP1	340	344	PF00017	0.496
LIG_SH2_STAT5	124	127	PF00017	0.518
LIG_SH2_STAT5	380	383	PF00017	0.531
LIG_SH2_STAT5	457	460	PF00017	0.482
LIG_SH2_STAT5	726	729	PF00017	0.456
LIG_SH2_STAT5	750	753	PF00017	0.510
LIG_SH2_STAT5	80	83	PF00017	0.413
LIG_SH3_3	48	54	PF00018	0.721
LIG_SH3_3	604	610	PF00018	0.628
LIG_SUMO_SIM_anti_2	366	372	PF11976	0.599
LIG_SUMO_SIM_par_1	160	166	PF11976	0.505
LIG_SUMO_SIM_par_1	207	213	PF11976	0.503
LIG_TRAF2_1	677	680	PF00917	0.524
LIG_TYR_ITIM	490	495	PF00017	0.484
LIG_UBA3_1	178	184	PF00899	0.426
MOD_CK1_1	257	263	PF00069	0.656
MOD_CK1_1	338	344	PF00069	0.569
MOD_CK1_1	398	404	PF00069	0.611
MOD_CK1_1	519	525	PF00069	0.526
MOD_CK1_1	558	564	PF00069	0.610
MOD_CK1_1	568	574	PF00069	0.560
MOD_CK1_1	682	688	PF00069	0.481
MOD_CK1_1	729	735	PF00069	0.621
MOD_CK2_1	143	149	PF00069	0.598
MOD_CK2_1	16	22	PF00069	0.606
MOD_CK2_1	321	327	PF00069	0.640
MOD_CK2_1	430	436	PF00069	0.577
MOD_CK2_1	642	648	PF00069	0.683
MOD_CK2_1	673	679	PF00069	0.587
MOD_GlcNHglycan	117	120	PF01048	0.488
MOD_GlcNHglycan	145	148	PF01048	0.613
MOD_GlcNHglycan	173	176	PF01048	0.447
MOD_GlcNHglycan	256	259	PF01048	0.594
MOD_GlcNHglycan	294	297	PF01048	0.557
MOD_GlcNHglycan	324	327	PF01048	0.666
MOD_GlcNHglycan	337	340	PF01048	0.497
MOD_GlcNHglycan	4	7	PF01048	0.416
MOD_GlcNHglycan	560	563	PF01048	0.607
MOD_GlcNHglycan	567	570	PF01048	0.559
MOD_GlcNHglycan	614	617	PF01048	0.649
MOD_GlcNHglycan	679	684	PF01048	0.638
MOD_GSK3_1	115	122	PF00069	0.537
MOD_GSK3_1	137	144	PF00069	0.614
MOD_GSK3_1	299	306	PF00069	0.650
MOD_GSK3_1	311	318	PF00069	0.677
MOD_GSK3_1	335	342	PF00069	0.707
MOD_GSK3_1	391	398	PF00069	0.712
MOD_GSK3_1	430	437	PF00069	0.588
MOD_GSK3_1	497	504	PF00069	0.540
MOD_GSK3_1	551	558	PF00069	0.600
MOD_GSK3_1	598	605	PF00069	0.595
MOD_GSK3_1	669	676	PF00069	0.694
MOD_GSK3_1	678	685	PF00069	0.685
MOD_GSK3_1	72	79	PF00069	0.523
MOD_N-GLC_2	310	312	PF02516	0.591
MOD_N-GLC_2	67	69	PF02516	0.601
MOD_NEK2_1	1	6	PF00069	0.490
MOD_NEK2_1	141	146	PF00069	0.577
MOD_NEK2_1	317	322	PF00069	0.600
MOD_NEK2_1	435	440	PF00069	0.498
MOD_NEK2_1	503	508	PF00069	0.583
MOD_NEK2_1	570	575	PF00069	0.658
MOD_NEK2_1	74	79	PF00069	0.514
MOD_NEK2_1	81	86	PF00069	0.401
MOD_PIKK_1	297	303	PF00454	0.629
MOD_PIKK_1	436	442	PF00454	0.605
MOD_PIKK_1	568	574	PF00454	0.732
MOD_PIKK_1	74	80	PF00454	0.470
MOD_PKA_1	501	507	PF00069	0.581
MOD_PKA_2	1	7	PF00069	0.537
MOD_PKA_2	240	246	PF00069	0.552
MOD_PKA_2	501	507	PF00069	0.581
MOD_PKA_2	550	556	PF00069	0.666
MOD_PKB_1	547	555	PF00069	0.521
MOD_Plk_4	380	386	PF00069	0.671
MOD_Plk_4	669	675	PF00069	0.515
MOD_Plk_4	740	746	PF00069	0.666
MOD_Plk_4	76	82	PF00069	0.552
MOD_ProDKin_1	393	399	PF00069	0.604
MOD_ProDKin_1	45	51	PF00069	0.725
MOD_ProDKin_1	479	485	PF00069	0.674
MOD_ProDKin_1	673	679	PF00069	0.554
TRG_DiLeu_BaEn_1	781	786	PF01217	0.593
TRG_DiLeu_BaEn_4	130	136	PF01217	0.551
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.418
TRG_ENDOCYTIC_2	235	238	PF00928	0.705
TRG_ENDOCYTIC_2	340	343	PF00928	0.499
TRG_ENDOCYTIC_2	457	460	PF00928	0.487
TRG_ENDOCYTIC_2	491	494	PF00928	0.426
TRG_ENDOCYTIC_2	664	667	PF00928	0.558
TRG_ER_diArg_1	182	185	PF00400	0.436
TRG_ER_diArg_1	451	454	PF00400	0.484
TRG_ER_diArg_1	501	503	PF00400	0.697
TRG_ER_diArg_1	545	548	PF00400	0.575
TRG_ER_diArg_1	588	590	PF00400	0.570
TRG_ER_diArg_1	633	635	PF00400	0.562
TRG_ER_diArg_1	697	699	PF00400	0.614
TRG_ER_diArg_1	714	717	PF00400	0.358
TRG_ER_diArg_1	769	772	PF00400	0.531
TRG_NLS_MonoCore_2	182	187	PF00514	0.421
TRG_NLS_MonoExtN_4	183	188	PF00514	0.432
TRG_Pf-PMV_PEXEL_1	237	242	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	454	459	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	699	704	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	783	788	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1U0	Leptomonas seymouri	45%	100%
A0A422NX08	Trypanosoma rangeli	24%	100%
A4HDQ7	Leishmania braziliensis	78%	100%
A4I103	Leishmania infantum	100%	100%
C9ZWA6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
E9AX41	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QAD5	Leishmania major	93%	99%
V5BAG5	Trypanosoma cruzi	24%	100%