Ubiquitin-conjugating_enzyme_E2_putative/GeneDB:L mjF.24.2130

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin-conjugating enzyme E2, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WYK3_LEIDO

TriTrypDb:

LdBPK_242220.1 , LdCL_240027800 , LDHU3_24.2710

Length:

155

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3S7WYK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYK3

PDB structure(s): 1yf9_A , 1yf9_B , 1yf9_C

Function

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Biological processes
Term	Name	Level	Count
GO:0000209	protein polyubiquitination	8	1
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0007346	regulation of mitotic cell cycle	5	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	9
GO:0004842	ubiquitin-protein transferase activity	4	2
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0016740	transferase activity	2	9
GO:0016746	acyltransferase activity	3	1
GO:0016874	ligase activity	2	2
GO:0017076	purine nucleotide binding	4	10
GO:0019787	ubiquitin-like protein transferase activity	3	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
DEG_SCF_FBW7_2	48	55	PF00400	0.339
DOC_CKS1_1	49	54	PF01111	0.375
DOC_CKS1_1	77	82	PF01111	0.259
DOC_MAPK_gen_1	13	21	PF00069	0.283
DOC_MAPK_MEF2A_6	16	23	PF00069	0.283
DOC_MAPK_MEF2A_6	89	96	PF00069	0.375
DOC_MAPK_NFAT4_5	89	97	PF00069	0.375
DOC_PP4_FxxP_1	77	80	PF00568	0.275
DOC_WW_Pin1_4	122	127	PF00397	0.259
DOC_WW_Pin1_4	48	53	PF00397	0.319

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P683	Leptomonas seymouri	36%	69%
A0A0N0P6R4	Leptomonas seymouri	44%	85%
A0A0N1I1I8	Leptomonas seymouri	31%	68%
A0A0N1I1Z1	Leptomonas seymouri	88%	100%
A0A0N1I707	Leptomonas seymouri	38%	100%
A0A0N1PB60	Leptomonas seymouri	39%	100%
A0A0S4IJE0	Bodo saltans	41%	70%
A0A0S4IWQ9	Bodo saltans	31%	80%
A0A0S4J8W6	Bodo saltans	41%	100%
A0A0S4JGV6	Bodo saltans	35%	100%

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