HpcH/HpaI_aldolase/citrate_lyase_family_putative/ Pfam:PF03328

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HpcH/HpaI aldolase/citrate lyase family, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WYJ5_LEIDO

TriTrypDb:

LdBPK_241490.1 , LdCL_240020100 , LDHU3_24.1820

Length:

537

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WYJ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYJ5

Function

Biological processes
Term	Name	Level	Count
GO:0019222	regulation of metabolic process	3	1
GO:0030656	regulation of vitamin metabolic process	5	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0062012	regulation of small molecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0106064	regulation of cobalamin metabolic process	6	1
GO:1901401	regulation of tetrapyrrole metabolic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016829	lyase activity	2	4
GO:0016830	carbon-carbon lyase activity	3	1
GO:0016833	oxo-acid-lyase activity	4	1
GO:0047777	(S)-citramalyl-CoA lyase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	236	240	PF00656	0.616
CLV_C14_Caspase3-7	456	460	PF00656	0.382
CLV_NRD_NRD_1	146	148	PF00675	0.726
CLV_NRD_NRD_1	198	200	PF00675	0.346
CLV_NRD_NRD_1	2	4	PF00675	0.714
CLV_NRD_NRD_1	402	404	PF00675	0.443
CLV_NRD_NRD_1	47	49	PF00675	0.708
CLV_NRD_NRD_1	487	489	PF00675	0.648
CLV_PCSK_FUR_1	144	148	PF00082	0.693
CLV_PCSK_KEX2_1	146	148	PF00082	0.726
CLV_PCSK_KEX2_1	197	199	PF00082	0.359
CLV_PCSK_KEX2_1	2	4	PF00082	0.721
CLV_PCSK_KEX2_1	402	404	PF00082	0.443
CLV_PCSK_KEX2_1	47	49	PF00082	0.708
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.359
CLV_PCSK_SKI1_1	160	164	PF00082	0.290
CLV_PCSK_SKI1_1	472	476	PF00082	0.410
DEG_Nend_UBRbox_1	1	4	PF02207	0.765
DOC_CDC14_PxL_1	173	181	PF14671	0.590
DOC_CKS1_1	25	30	PF01111	0.697
DOC_CKS1_1	338	343	PF01111	0.658
DOC_CYCLIN_yCln2_LP_2	418	424	PF00134	0.340
DOC_MAPK_DCC_7	416	424	PF00069	0.278
DOC_MAPK_gen_1	469	477	PF00069	0.400
DOC_PP1_RVXF_1	158	165	PF00149	0.443
DOC_PP2B_LxvP_1	163	166	PF13499	0.504
DOC_PP2B_LxvP_1	334	337	PF13499	0.529
DOC_PP4_FxxP_1	302	305	PF00568	0.376
DOC_PP4_FxxP_1	392	395	PF00568	0.509
DOC_USP7_MATH_1	227	231	PF00917	0.624
DOC_USP7_MATH_1	46	50	PF00917	0.753
DOC_USP7_MATH_1	70	74	PF00917	0.731
DOC_USP7_UBL2_3	485	489	PF12436	0.629
DOC_WW_Pin1_4	145	150	PF00397	0.748
DOC_WW_Pin1_4	24	29	PF00397	0.736
DOC_WW_Pin1_4	247	252	PF00397	0.389
DOC_WW_Pin1_4	301	306	PF00397	0.370
DOC_WW_Pin1_4	337	342	PF00397	0.609
DOC_WW_Pin1_4	42	47	PF00397	0.778
DOC_WW_Pin1_4	429	434	PF00397	0.400
DOC_WW_Pin1_4	526	531	PF00397	0.814
DOC_WW_Pin1_4	53	58	PF00397	0.712
DOC_WW_Pin1_4	61	66	PF00397	0.657
LIG_14-3-3_CanoR_1	402	406	PF00244	0.443
LIG_14-3-3_CanoR_1	47	57	PF00244	0.749
LIG_14-3-3_CterR_2	534	537	PF00244	0.826
LIG_APCC_ABBA_1	89	94	PF00400	0.597
LIG_BIR_III_2	239	243	PF00653	0.550
LIG_BRCT_BRCA1_1	160	164	PF00533	0.561
LIG_BRCT_BRCA1_1	57	61	PF00533	0.752
LIG_CaM_IQ_9	208	224	PF13499	0.561
LIG_Clathr_ClatBox_1	410	414	PF01394	0.422
LIG_FHA_1	25	31	PF00498	0.764
LIG_FHA_1	255	261	PF00498	0.509
LIG_FHA_1	282	288	PF00498	0.434
LIG_FHA_1	371	377	PF00498	0.489
LIG_FHA_1	494	500	PF00498	0.719
LIG_FHA_2	430	436	PF00498	0.408
LIG_FHA_2	454	460	PF00498	0.438
LIG_LIR_Apic_2	290	294	PF02991	0.442
LIG_LIR_Apic_2	389	395	PF02991	0.488
LIG_LIR_Nem_3	239	244	PF02991	0.561
LIG_LIR_Nem_3	88	92	PF02991	0.566
LIG_LYPXL_yS_3	241	244	PF13949	0.535
LIG_MYND_1	155	159	PF01753	0.571
LIG_NRBOX	263	269	PF00104	0.453
LIG_SH2_NCK_1	253	257	PF00017	0.571
LIG_SH2_NCK_1	431	435	PF00017	0.484
LIG_SH2_PTP2	291	294	PF00017	0.489
LIG_SH2_SRC	253	256	PF00017	0.578
LIG_SH2_SRC	291	294	PF00017	0.457
LIG_SH2_SRC	320	323	PF00017	0.394
LIG_SH2_STAT5	291	294	PF00017	0.457
LIG_SH2_STAT5	431	434	PF00017	0.443
LIG_SH2_STAT5	86	89	PF00017	0.614
LIG_SH3_3	174	180	PF00018	0.546
LIG_SH3_3	6	12	PF00018	0.609
LIG_SUMO_SIM_anti_2	303	310	PF11976	0.438
LIG_SUMO_SIM_par_1	184	191	PF11976	0.512
LIG_TRAF2_1	101	104	PF00917	0.636
LIG_TRAF2_1	404	407	PF00917	0.484
LIG_TRAF2_1	433	436	PF00917	0.289
LIG_UBA3_1	410	416	PF00899	0.422
MOD_CDK_SPK_2	42	47	PF00069	0.647
MOD_CDK_SPK_2	61	66	PF00069	0.714
MOD_CDK_SPxK_1	42	48	PF00069	0.651
MOD_CDK_SPxK_1	526	532	PF00069	0.816
MOD_CK1_1	304	310	PF00069	0.482
MOD_CK1_1	360	366	PF00069	0.422
MOD_CK1_1	49	55	PF00069	0.792
MOD_CK1_1	56	62	PF00069	0.746
MOD_CK2_1	349	355	PF00069	0.514
MOD_CK2_1	401	407	PF00069	0.484
MOD_CK2_1	429	435	PF00069	0.353
MOD_CK2_1	458	464	PF00069	0.443
MOD_Cter_Amidation	144	147	PF01082	0.771
MOD_GlcNHglycan	122	125	PF01048	0.761
MOD_GlcNHglycan	229	232	PF01048	0.615
MOD_GlcNHglycan	329	333	PF01048	0.489
MOD_GlcNHglycan	450	453	PF01048	0.491
MOD_GlcNHglycan	479	482	PF01048	0.615
MOD_GlcNHglycan	58	61	PF01048	0.785
MOD_GlcNHglycan	68	71	PF01048	0.675
MOD_GlcNHglycan	72	75	PF01048	0.589
MOD_GSK3_1	114	121	PF00069	0.573
MOD_GSK3_1	145	152	PF00069	0.761
MOD_GSK3_1	277	284	PF00069	0.493
MOD_GSK3_1	340	347	PF00069	0.554
MOD_GSK3_1	36	43	PF00069	0.704
MOD_GSK3_1	454	461	PF00069	0.382
MOD_GSK3_1	46	53	PF00069	0.765
MOD_GSK3_1	483	490	PF00069	0.686
MOD_GSK3_1	55	62	PF00069	0.687
MOD_GSK3_1	66	73	PF00069	0.650
MOD_N-GLC_1	70	75	PF02516	0.639
MOD_NEK2_1	188	193	PF00069	0.351
MOD_NEK2_1	35	40	PF00069	0.783
MOD_NEK2_1	369	374	PF00069	0.475
MOD_NEK2_1	401	406	PF00069	0.387
MOD_NEK2_1	483	488	PF00069	0.604
MOD_NEK2_1	50	55	PF00069	0.708
MOD_NEK2_2	278	283	PF00069	0.436
MOD_NEK2_2	357	362	PF00069	0.576
MOD_PIKK_1	138	144	PF00454	0.602
MOD_PIKK_1	214	220	PF00454	0.620
MOD_PKA_2	35	41	PF00069	0.761
MOD_PKA_2	401	407	PF00069	0.498
MOD_PKA_2	46	52	PF00069	0.695
MOD_PKA_2	487	493	PF00069	0.705
MOD_PKA_2	509	515	PF00069	0.609
MOD_Plk_1	188	194	PF00069	0.443
MOD_Plk_1	453	459	PF00069	0.423
MOD_Plk_1	483	489	PF00069	0.677
MOD_Plk_2-3	349	355	PF00069	0.551
MOD_Plk_2-3	454	460	PF00069	0.422
MOD_Plk_4	26	32	PF00069	0.696
MOD_Plk_4	304	310	PF00069	0.397
MOD_Plk_4	414	420	PF00069	0.443
MOD_ProDKin_1	145	151	PF00069	0.741
MOD_ProDKin_1	24	30	PF00069	0.735
MOD_ProDKin_1	247	253	PF00069	0.397
MOD_ProDKin_1	301	307	PF00069	0.367
MOD_ProDKin_1	337	343	PF00069	0.611
MOD_ProDKin_1	42	48	PF00069	0.782
MOD_ProDKin_1	429	435	PF00069	0.400
MOD_ProDKin_1	526	532	PF00069	0.816
MOD_ProDKin_1	53	59	PF00069	0.712
MOD_ProDKin_1	61	67	PF00069	0.655
TRG_DiLeu_BaLyEn_6	146	151	PF01217	0.740
TRG_DiLeu_BaLyEn_6	240	245	PF01217	0.536
TRG_DiLeu_BaLyEn_6	309	314	PF01217	0.535
TRG_DiLeu_BaLyEn_6	406	411	PF01217	0.422
TRG_ENDOCYTIC_2	241	244	PF00928	0.535
TRG_ENDOCYTIC_2	295	298	PF00928	0.384
TRG_ENDOCYTIC_2	322	325	PF00928	0.340
TRG_ENDOCYTIC_2	327	330	PF00928	0.376
TRG_ENDOCYTIC_2	86	89	PF00928	0.561
TRG_ER_diArg_1	1	3	PF00400	0.728
TRG_ER_diArg_1	144	147	PF00400	0.729
TRG_ER_diArg_1	198	201	PF00400	0.422
TRG_ER_diArg_1	401	403	PF00400	0.443
TRG_ER_diArg_1	46	48	PF00400	0.702
TRG_NLS_MonoExtC_3	196	201	PF00514	0.422
TRG_Pf-PMV_PEXEL_1	403	407	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	409	414	PF00026	0.386
TRG_Pf-PMV_PEXEL_1	83	88	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHZ0	Leptomonas seymouri	57%	100%
A0A1X0NVS5	Trypanosomatidae	31%	100%
A4HDJ6	Leishmania braziliensis	74%	99%
C9ZWG8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AH59	Leishmania infantum	100%	100%
E9AWY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q4QAI7	Leishmania major	89%	100%
V5DBJ5	Trypanosoma cruzi	35%	100%