Translationally_controlled_tumor_protein_(TCTP)_p utative/GeneDB:LmjF.24.1500/GeneDB:LmjF.24.1510

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

IgE-dependent histamine-releasing factor, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WYJ2_LEIDO

TriTrypDb:

LdBPK_241560.1 , LdCL_240020800 , LdCL_240020900 , LDHU3_24.1900 , LDHU3_24.1920

Length:

170

Annotations

Annotations by Jardim et al.

Membrane associated proteins, IgE-dependent histamine-releasing factor

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WYJ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYJ2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005509	calcium ion binding	5	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.511
CLV_NRD_NRD_1	107	109	PF00675	0.355
CLV_PCSK_SKI1_1	108	112	PF00082	0.301
CLV_PCSK_SKI1_1	120	124	PF00082	0.294
CLV_PCSK_SKI1_1	2	6	PF00082	0.326
CLV_PCSK_SKI1_1	96	100	PF00082	0.315
DEG_Nend_UBRbox_1	1	4	PF02207	0.511
DOC_CYCLIN_RxL_1	90	103	PF00134	0.519
DOC_PP4_FxxP_1	131	134	PF00568	0.511
DOC_USP7_UBL2_3	120	124	PF12436	0.516
DOC_USP7_UBL2_3	162	166	PF12436	0.519
DOC_WW_Pin1_4	152	157	PF00397	0.571
LIG_14-3-3_CanoR_1	76	82	PF00244	0.511
LIG_APCC_ABBA_1	1	6	PF00400	0.511
LIG_FHA_1	56	62	PF00498	0.571
LIG_FHA_2	7	13	PF00498	0.511
LIG_FHA_2	78	84	PF00498	0.511
LIG_Integrin_isoDGR_2	32	34	PF01839	0.316
LIG_LIR_Apic_2	128	134	PF02991	0.511
LIG_LIR_Gen_1	127	134	PF02991	0.519
LIG_LIR_Nem_3	127	132	PF02991	0.511
LIG_PDZ_Class_3	165	170	PF00595	0.580
LIG_PTB_Apo_2	29	36	PF02174	0.516
LIG_PTB_Apo_2	71	78	PF02174	0.511
LIG_PTB_Phospho_1	29	35	PF10480	0.516
LIG_PTB_Phospho_1	71	77	PF10480	0.511
LIG_SH2_NCK_1	82	86	PF00017	0.553
LIG_SH2_PTP2	35	38	PF00017	0.506
LIG_SH2_SRC	35	38	PF00017	0.511
LIG_SH2_STAT3	94	97	PF00017	0.528
LIG_SH2_STAT5	159	162	PF00017	0.573
LIG_SH2_STAT5	29	32	PF00017	0.543
LIG_SH2_STAT5	35	38	PF00017	0.526
LIG_SH2_STAT5	77	80	PF00017	0.511
MOD_CDK_SPK_2	152	157	PF00069	0.570
MOD_CK2_1	6	12	PF00069	0.511
MOD_GlcNHglycan	45	48	PF01048	0.319
MOD_N-GLC_2	17	19	PF02516	0.328
MOD_PKA_2	75	81	PF00069	0.511
MOD_Plk_1	78	84	PF00069	0.571
MOD_Plk_4	83	89	PF00069	0.544
MOD_ProDKin_1	152	158	PF00069	0.571
MOD_SUMO_for_1	165	168	PF00179	0.575
MOD_SUMO_rev_2	103	111	PF00179	0.534
TRG_DiLeu_BaEn_2	127	133	PF01217	0.520
TRG_ENDOCYTIC_2	129	132	PF00928	0.519
TRG_ENDOCYTIC_2	35	38	PF00928	0.525
TRG_Pf-PMV_PEXEL_1	96	100	PF00026	0.344

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7U9	Leptomonas seymouri	89%	100%
A0A0S4IX73	Bodo saltans	68%	99%
A0A1X0NX45	Trypanosomatidae	79%	100%
A0A1X0NXD1	Trypanosomatidae	81%	100%
A0A422N031	Trypanosoma rangeli	76%	100%
A1KXP4	Davidiella tassiana	37%	100%
A4HDJ0	Leishmania braziliensis	91%	100%
A4I0Y8	Leishmania infantum	100%	100%
A5A6K2	Pan troglodytes	34%	99%
C9ZWG0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	79%	100%
C9ZWG1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	79%	100%
D0MQ50	Alternaria alternata	37%	100%
E8NHJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
G3LU44	Loxosceles intermedia	33%	99%
J3SFJ3	Crotalus adamanteus	33%	99%
M5B4R7	Grammostola rosea	32%	98%
O03992	Fragaria ananassa	28%	100%
O18477	Lumbricus rubellus	37%	100%
P0CR82	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	38%	100%
P0CR83	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	38%	100%
P13693	Homo sapiens	34%	99%
P28014	Medicago sativa	28%	100%
P31265	Arabidopsis thaliana	33%	100%
P35681	Oryza sativa subsp. japonica	29%	100%
P35691	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
P43347	Gallus gallus	33%	99%
P43348	Oryctolagus cuniculus	33%	99%
P43349	Solanum tuberosum	30%	100%
P50906	Pisum sativum	30%	100%
P61288	Sus scrofa	34%	99%
P63028	Mus musculus	34%	99%
P63029	Rattus norvegicus	34%	99%
P84152	Plasmodium knowlesi	33%	99%
P90697	Brugia malayi	27%	94%
P91800	Schistosoma japonicum	35%	100%
Q10344	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	100%
Q1HR79	Aedes aegypti	32%	99%
Q202I6	Scophthalmus maximus	33%	100%
Q293Y0	Drosophila pseudoobscura pseudoobscura	36%	99%
Q2PS27	Cucurbita maxima	28%	100%
Q2UR29	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	32%	98%
Q4IJT5	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	35%	100%
Q4N938	Theileria parva	33%	98%
Q4PF30	Ustilago maydis (strain 521 / FGSC 9021)	34%	100%
Q4PLZ3	Ixodes scapularis	30%	98%
Q4QAI0	Leishmania major	99%	100%
Q4UGL5	Theileria annulata	28%	98%
Q4WRB8	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	28%	95%
Q4XFJ8	Plasmodium chabaudi	33%	99%
Q4YZC6	Plasmodium berghei (strain Anka)	33%	99%
Q54RX1	Dictyostelium discoideum	28%	88%
Q54RX6	Dictyostelium discoideum	33%	98%
Q56UQ5	Homo sapiens	29%	100%
Q5A860	Candida albicans (strain SC5314 / ATCC MYA-2876)	35%	100%
Q5BFN9	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	27%	95%
Q5E984	Bos taurus	34%	99%
Q5J907	Elaeis guineensis var. tenera	28%	100%
Q5MGM6	Lonomia obliqua	32%	99%
Q5MIP6	Aedes albopictus	33%	99%
Q60FS1	Plutella xylostella	34%	99%
Q66JC5	Xenopus tropicalis	35%	99%
Q6BP09	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	34%	100%
Q6C4G1	Yarrowia lipolytica (strain CLIB 122 / E 150)	37%	100%
Q6CTH3	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	36%	100%
Q6DUX3	Solanum lycopersicum	31%	100%
Q6FKB6	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	32%	100%
Q6XIN1	Drosophila yakuba	34%	99%
Q6XSH4	Lateolabrax japonicus	34%	100%
Q75VN3	Bombyx mori	35%	99%
Q7QCK2	Anopheles gambiae	33%	99%
Q7RYV5	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	36%	100%
Q7ZYF2	Xenopus laevis	34%	99%
Q8H6A5	Zea mays	29%	100%
Q8I3Z5	Plasmodium falciparum (isolate 3D7)	35%	99%
Q8I8A2	Schistosoma haematobium	26%	100%
Q8LRM8	Triticum aestivum	27%	100%
Q944T2	Glycine max	28%	100%
Q944W6	Brassica oleracea	32%	100%
Q95VY2	Branchiostoma belcheri	33%	100%
Q95WA2	Schistosoma mansoni	33%	100%
Q962A2	Wuchereria bancrofti	27%	94%
Q98SJ7	Labeo rohita	39%	99%
Q9DGK4	Danio rerio	39%	99%
Q9M5G3	Hordeum vulgare	31%	100%
Q9M9V9	Arabidopsis thaliana	23%	100%
Q9VGS2	Drosophila melanogaster	35%	99%
Q9XHL7	Nicotiana tabacum	31%	100%
Q9XYU2	Plasmodium yoelii yoelii	33%	99%
Q9ZRX0	Pseudotsuga menziesii	30%	100%
Q9ZSW9	Hevea brasiliensis	28%	100%
T1DKS4	Crotalus horridus	33%	99%
U3EQ60	Micrurus fulvius	34%	99%
V5DBM6	Trypanosoma cruzi	79%	100%