Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical predicted multi-pass transmembrane protein

Species:

Leishmania donovani

UniProt:

A0A3S7WYI6_LEIDO

TriTrypDb:

LdBPK_241920.1 , LdCL_240024800 , LDHU3_24.2350

Length:

413

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 3
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3S7WYI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYI6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.508
CLV_C14_Caspase3-7	301	305	PF00656	0.476
CLV_NRD_NRD_1	144	146	PF00675	0.652
CLV_NRD_NRD_1	220	222	PF00675	0.696
CLV_NRD_NRD_1	223	225	PF00675	0.687
CLV_NRD_NRD_1	306	308	PF00675	0.611
CLV_NRD_NRD_1	320	322	PF00675	0.551
CLV_NRD_NRD_1	392	394	PF00675	0.391
CLV_NRD_NRD_1	7	9	PF00675	0.441
CLV_PCSK_FUR_1	221	225	PF00082	0.672
CLV_PCSK_KEX2_1	144	146	PF00082	0.634
CLV_PCSK_KEX2_1	219	221	PF00082	0.699
CLV_PCSK_KEX2_1	223	225	PF00082	0.684
CLV_PCSK_KEX2_1	306	308	PF00082	0.611
CLV_PCSK_KEX2_1	7	9	PF00082	0.449
CLV_PCSK_PC7_1	219	225	PF00082	0.683
CLV_PCSK_PC7_1	3	9	PF00082	0.459
CLV_PCSK_SKI1_1	177	181	PF00082	0.622
CLV_PCSK_SKI1_1	213	217	PF00082	0.662
DEG_Nend_UBRbox_3	1	3	PF02207	0.687
DOC_CKS1_1	67	72	PF01111	0.401
DOC_MAPK_gen_1	306	315	PF00069	0.414
DOC_MAPK_MEF2A_6	20	27	PF00069	0.306
DOC_MAPK_MEF2A_6	306	315	PF00069	0.490
DOC_MAPK_MEF2A_6	368	376	PF00069	0.294
DOC_PP1_RVXF_1	386	393	PF00149	0.518
DOC_PP2B_LxvP_1	102	105	PF13499	0.439
DOC_PP4_FxxP_1	100	103	PF00568	0.412
DOC_PP4_MxPP_1	101	104	PF00568	0.396
DOC_USP7_MATH_1	19	23	PF00917	0.446
DOC_USP7_MATH_1	237	241	PF00917	0.573
DOC_USP7_MATH_1	243	247	PF00917	0.535
DOC_USP7_MATH_1	256	260	PF00917	0.442
DOC_USP7_MATH_1	305	309	PF00917	0.433
DOC_USP7_MATH_1	323	327	PF00917	0.369
DOC_USP7_MATH_1	361	365	PF00917	0.404
DOC_USP7_MATH_1	73	77	PF00917	0.515
DOC_USP7_MATH_1	91	95	PF00917	0.474
DOC_WW_Pin1_4	231	236	PF00397	0.507
DOC_WW_Pin1_4	66	71	PF00397	0.406
LIG_14-3-3_CanoR_1	20	24	PF00244	0.313
LIG_14-3-3_CanoR_1	224	232	PF00244	0.494
LIG_14-3-3_CanoR_1	251	261	PF00244	0.495
LIG_14-3-3_CanoR_1	362	366	PF00244	0.397
LIG_14-3-3_CanoR_1	393	400	PF00244	0.669
LIG_BRCT_BRCA1_1	96	100	PF00533	0.375
LIG_FHA_1	261	267	PF00498	0.461
LIG_FHA_1	353	359	PF00498	0.405
LIG_FHA_1	384	390	PF00498	0.502
LIG_FHA_1	62	68	PF00498	0.419
LIG_FHA_2	292	298	PF00498	0.517
LIG_GBD_Chelix_1	23	31	PF00786	0.369
LIG_LIR_Apic_2	97	103	PF02991	0.402
LIG_LIR_Gen_1	344	351	PF02991	0.433
LIG_LIR_Gen_1	377	387	PF02991	0.504
LIG_LIR_Gen_1	76	87	PF02991	0.391
LIG_LIR_Nem_3	154	158	PF02991	0.459
LIG_LIR_Nem_3	186	192	PF02991	0.398
LIG_LIR_Nem_3	364	370	PF02991	0.344
LIG_LIR_Nem_3	377	383	PF02991	0.369
LIG_NRBOX	26	32	PF00104	0.369
LIG_NRBOX	51	57	PF00104	0.387
LIG_Pex14_1	371	375	PF04695	0.325
LIG_Pex14_2	365	369	PF04695	0.374
LIG_REV1ctd_RIR_1	177	186	PF16727	0.423
LIG_REV1ctd_RIR_1	363	371	PF16727	0.363
LIG_RPA_C_Fungi	15	27	PF08784	0.248
LIG_RPA_C_Fungi	383	395	PF08784	0.472
LIG_SH2_CRK	380	384	PF00017	0.284
LIG_SH2_STAP1	347	351	PF00017	0.541
LIG_SH2_STAP1	380	384	PF00017	0.360
LIG_SH2_STAT3	192	195	PF00017	0.508
LIG_SH2_STAT5	298	301	PF00017	0.588
LIG_SH3_3	229	235	PF00018	0.637
LIG_SUMO_SIM_anti_2	22	28	PF11976	0.325
LIG_SUMO_SIM_anti_2	51	57	PF11976	0.462
LIG_SUMO_SIM_par_1	63	69	PF11976	0.467
LIG_TRAF2_1	115	118	PF00917	0.576
LIG_TRAF2_1	159	162	PF00917	0.451
LIG_TRAF2_1	283	286	PF00917	0.653
LIG_TRFH_1	100	104	PF08558	0.515
MOD_CDK_SPK_2	231	236	PF00069	0.637
MOD_CK1_1	396	402	PF00069	0.568
MOD_CK1_1	66	72	PF00069	0.488
MOD_CK1_1	94	100	PF00069	0.523
MOD_CK2_1	156	162	PF00069	0.441
MOD_CK2_1	201	207	PF00069	0.637
MOD_CK2_1	238	244	PF00069	0.684
MOD_CK2_1	291	297	PF00069	0.703
MOD_GlcNHglycan	130	133	PF01048	0.631
MOD_GlcNHglycan	227	230	PF01048	0.577
MOD_GlcNHglycan	241	244	PF01048	0.632
MOD_GlcNHglycan	245	248	PF01048	0.623
MOD_GlcNHglycan	254	257	PF01048	0.612
MOD_GlcNHglycan	258	261	PF01048	0.577
MOD_GlcNHglycan	270	273	PF01048	0.659
MOD_GlcNHglycan	278	282	PF01048	0.625
MOD_GlcNHglycan	325	328	PF01048	0.572
MOD_GlcNHglycan	401	404	PF01048	0.564
MOD_GlcNHglycan	93	96	PF01048	0.539
MOD_GSK3_1	124	131	PF00069	0.704
MOD_GSK3_1	15	22	PF00069	0.355
MOD_GSK3_1	199	206	PF00069	0.588
MOD_GSK3_1	231	238	PF00069	0.813
MOD_GSK3_1	239	246	PF00069	0.677
MOD_GSK3_1	252	259	PF00069	0.593
MOD_GSK3_1	401	408	PF00069	0.523
MOD_GSK3_1	73	80	PF00069	0.620
MOD_NEK2_1	139	144	PF00069	0.637
MOD_NEK2_1	151	156	PF00069	0.434
MOD_NEK2_1	268	273	PF00069	0.632
MOD_NEK2_1	374	379	PF00069	0.411
MOD_NEK2_1	383	388	PF00069	0.318
MOD_NEK2_1	48	53	PF00069	0.578
MOD_NEK2_2	361	366	PF00069	0.491
MOD_PIKK_1	139	145	PF00454	0.616
MOD_PIKK_1	393	399	PF00454	0.506
MOD_PIKK_1	86	92	PF00454	0.572
MOD_PKA_1	219	225	PF00069	0.564
MOD_PKA_1	393	399	PF00069	0.485
MOD_PKA_2	19	25	PF00069	0.304
MOD_PKA_2	219	225	PF00069	0.584
MOD_PKA_2	305	311	PF00069	0.511
MOD_PKA_2	352	358	PF00069	0.594
MOD_PKA_2	361	367	PF00069	0.453
MOD_Plk_1	291	297	PF00069	0.703
MOD_Plk_2-3	201	207	PF00069	0.587
MOD_Plk_4	19	25	PF00069	0.446
MOD_Plk_4	361	367	PF00069	0.467
MOD_Plk_4	48	54	PF00069	0.439
MOD_Plk_4	73	79	PF00069	0.464
MOD_Plk_4	94	100	PF00069	0.484
MOD_ProDKin_1	231	237	PF00069	0.636
MOD_ProDKin_1	66	72	PF00069	0.493
TRG_ENDOCYTIC_2	347	350	PF00928	0.542
TRG_ENDOCYTIC_2	367	370	PF00928	0.183
TRG_ENDOCYTIC_2	380	383	PF00928	0.304
TRG_ER_diArg_1	108	111	PF00400	0.599
TRG_ER_diArg_1	218	221	PF00400	0.627
TRG_ER_diArg_1	223	226	PF00400	0.611
TRG_ER_diArg_1	7	9	PF00400	0.548
TRG_ER_diLys_1	409	413	PF00400	0.598
TRG_NLS_Bipartite_1	393	413	PF00514	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P420	Leptomonas seymouri	38%	98%
A4HDP6	Leishmania braziliensis	64%	98%
E9AH92	Leishmania infantum	100%	100%
E9AX30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QAE6	Leishmania major	89%	100%