Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WYI4_LEIDO

TriTrypDb:

LdBPK_241830.1 , LdCL_240023900 , LDHU3_24.2240

Length:

270

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3S7WYI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYI4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.512
CLV_NRD_NRD_1	100	102	PF00675	0.329
CLV_NRD_NRD_1	236	238	PF00675	0.348
CLV_NRD_NRD_1	28	30	PF00675	0.423
CLV_PCSK_KEX2_1	100	102	PF00082	0.348
CLV_PCSK_KEX2_1	139	141	PF00082	0.348
CLV_PCSK_KEX2_1	236	238	PF00082	0.348
CLV_PCSK_KEX2_1	27	29	PF00082	0.423
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.348
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.423
CLV_PCSK_PC7_1	232	238	PF00082	0.373
CLV_PCSK_SKI1_1	106	110	PF00082	0.331
CLV_PCSK_SKI1_1	211	215	PF00082	0.423
CLV_PCSK_SKI1_1	228	232	PF00082	0.209
DEG_SPOP_SBC_1	129	133	PF00917	0.549
DOC_CYCLIN_yCln2_LP_2	41	47	PF00134	0.623
DOC_MAPK_MEF2A_6	253	261	PF00069	0.542
DOC_USP7_MATH_1	147	151	PF00917	0.611
DOC_USP7_MATH_1	160	164	PF00917	0.413
DOC_USP7_MATH_1	207	211	PF00917	0.549
DOC_USP7_MATH_1	226	230	PF00917	0.385
DOC_USP7_MATH_1	74	78	PF00917	0.628
DOC_USP7_MATH_1	82	86	PF00917	0.533
DOC_WW_Pin1_4	40	45	PF00397	0.549
DOC_WW_Pin1_4	67	72	PF00397	0.593
DOC_WW_Pin1_4	75	80	PF00397	0.543
DOC_WW_Pin1_4	84	89	PF00397	0.501
LIG_Clathr_ClatBox_1	51	55	PF01394	0.623
LIG_deltaCOP1_diTrp_1	196	206	PF00928	0.623
LIG_FHA_1	129	135	PF00498	0.617
LIG_FHA_1	188	194	PF00498	0.523
LIG_FHA_1	260	266	PF00498	0.685
LIG_FHA_1	97	103	PF00498	0.597
LIG_FHA_2	162	168	PF00498	0.529
LIG_FHA_2	229	235	PF00498	0.598
LIG_LIR_Gen_1	190	198	PF02991	0.523
LIG_LIR_Nem_3	190	194	PF02991	0.590
LIG_MYND_1	88	92	PF01753	0.548
LIG_NRBOX	60	66	PF00104	0.460
LIG_SH3_3	121	127	PF00018	0.555
LIG_SH3_3	85	91	PF00018	0.591
LIG_SUMO_SIM_anti_2	131	138	PF11976	0.549
LIG_WRC_WIRS_1	5	10	PF05994	0.484
MOD_CK1_1	67	73	PF00069	0.573
MOD_CK1_1	77	83	PF00069	0.509
MOD_GlcNHglycan	140	143	PF01048	0.331
MOD_GlcNHglycan	158	161	PF01048	0.427
MOD_GlcNHglycan	183	186	PF01048	0.373
MOD_GlcNHglycan	265	268	PF01048	0.605
MOD_GlcNHglycan	55	59	PF01048	0.398
MOD_GlcNHglycan	80	83	PF01048	0.305
MOD_GlcNHglycan	84	87	PF01048	0.297
MOD_GSK3_1	156	163	PF00069	0.508
MOD_GSK3_1	259	266	PF00069	0.717
MOD_GSK3_1	60	67	PF00069	0.534
MOD_GSK3_1	74	81	PF00069	0.542
MOD_GSK3_1	82	89	PF00069	0.515
MOD_GSK3_1	96	103	PF00069	0.516
MOD_LATS_1	2	8	PF00433	0.368
MOD_N-GLC_2	9	11	PF02516	0.419
MOD_NEK2_1	112	117	PF00069	0.575
MOD_NEK2_1	171	176	PF00069	0.533
MOD_NEK2_1	181	186	PF00069	0.466
MOD_NEK2_1	60	65	PF00069	0.548
MOD_PIKK_1	241	247	PF00454	0.598
MOD_PKA_1	100	106	PF00069	0.526
MOD_PKA_2	100	106	PF00069	0.623
MOD_Plk_1	171	177	PF00069	0.571
MOD_Plk_4	130	136	PF00069	0.549
MOD_Plk_4	218	224	PF00069	0.520
MOD_Plk_4	260	266	PF00069	0.721
MOD_Plk_4	60	66	PF00069	0.543
MOD_ProDKin_1	40	46	PF00069	0.549
MOD_ProDKin_1	67	73	PF00069	0.593
MOD_ProDKin_1	75	81	PF00069	0.543
MOD_ProDKin_1	84	90	PF00069	0.497
MOD_SUMO_rev_2	163	171	PF00179	0.460
TRG_DiLeu_BaLyEn_6	89	94	PF01217	0.548
TRG_ER_diArg_1	100	102	PF00400	0.548
TRG_ER_diArg_1	235	237	PF00400	0.573
TRG_NLS_MonoExtC_3	26	32	PF00514	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAV6	Leptomonas seymouri	50%	96%
A4HDN6	Leishmania braziliensis	80%	100%
A4HDN7	Leishmania braziliensis	77%	100%
E9AH83	Leishmania infantum	100%	100%
E9AX21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QAF5	Leishmania major	93%	100%