RNA binding protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)/RNA recognition motif (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania donovani

UniProt:

A0A3S7WYI1_LEIDO

TriTrypDb:

LdBPK_241640.1 , LdCL_240021500 , LDHU3_24.1980

Length:

689

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WYI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYI1

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.650
CLV_NRD_NRD_1	421	423	PF00675	0.530
CLV_NRD_NRD_1	428	430	PF00675	0.587
CLV_PCSK_KEX2_1	421	423	PF00082	0.555
CLV_PCSK_KEX2_1	428	430	PF00082	0.633
CLV_PCSK_SKI1_1	244	248	PF00082	0.304
CLV_PCSK_SKI1_1	260	264	PF00082	0.304
CLV_PCSK_SKI1_1	431	435	PF00082	0.606
DEG_Nend_UBRbox_3	1	3	PF02207	0.661
DEG_SCF_FBW7_1	163	168	PF00400	0.671
DEG_SCF_FBW7_1	493	500	PF00400	0.611
DEG_SCF_FBW7_1	646	652	PF00400	0.525
DEG_SPOP_SBC_1	442	446	PF00917	0.651
DOC_CDC14_PxL_1	615	623	PF14671	0.634
DOC_CKS1_1	111	116	PF01111	0.618
DOC_CKS1_1	180	185	PF01111	0.667
DOC_CKS1_1	591	596	PF01111	0.669
DOC_CKS1_1	646	651	PF01111	0.526
DOC_MAPK_FxFP_2	151	154	PF00069	0.640
DOC_MAPK_FxFP_2	28	31	PF00069	0.590
DOC_MAPK_gen_1	242	249	PF00069	0.516
DOC_MAPK_gen_1	269	278	PF00069	0.516
DOC_PP1_RVXF_1	269	276	PF00149	0.516
DOC_PP2B_LxvP_1	163	166	PF13499	0.571
DOC_PP2B_LxvP_1	499	502	PF13499	0.671
DOC_PP4_FxxP_1	151	154	PF00568	0.640
DOC_PP4_FxxP_1	28	31	PF00568	0.590
DOC_PP4_FxxP_1	457	460	PF00568	0.611
DOC_PP4_FxxP_1	616	619	PF00568	0.677
DOC_PP4_MxPP_1	471	474	PF00568	0.600
DOC_USP7_MATH_1	123	127	PF00917	0.615
DOC_USP7_MATH_1	187	191	PF00917	0.677
DOC_USP7_MATH_1	211	215	PF00917	0.672
DOC_USP7_MATH_1	217	221	PF00917	0.552
DOC_USP7_MATH_1	29	33	PF00917	0.638
DOC_USP7_MATH_1	452	456	PF00917	0.622
DOC_USP7_MATH_1	458	462	PF00917	0.566
DOC_USP7_MATH_1	549	553	PF00917	0.648
DOC_USP7_MATH_1	626	630	PF00917	0.631
DOC_USP7_MATH_1	649	653	PF00917	0.543
DOC_USP7_MATH_1	664	668	PF00917	0.608
DOC_USP7_MATH_1	77	81	PF00917	0.714
DOC_USP7_MATH_1	92	96	PF00917	0.529
DOC_USP7_UBL2_3	400	404	PF12436	0.476
DOC_WW_Pin1_4	110	115	PF00397	0.529
DOC_WW_Pin1_4	161	166	PF00397	0.669
DOC_WW_Pin1_4	179	184	PF00397	0.669
DOC_WW_Pin1_4	3	8	PF00397	0.652
DOC_WW_Pin1_4	398	403	PF00397	0.464
DOC_WW_Pin1_4	493	498	PF00397	0.660
DOC_WW_Pin1_4	564	569	PF00397	0.614
DOC_WW_Pin1_4	590	595	PF00397	0.671
DOC_WW_Pin1_4	645	650	PF00397	0.531
DOC_WW_Pin1_4	98	103	PF00397	0.612
LIG_14-3-3_CanoR_1	125	129	PF00244	0.598
LIG_14-3-3_CanoR_1	332	336	PF00244	0.474
LIG_14-3-3_CanoR_1	364	373	PF00244	0.505
LIG_14-3-3_CanoR_1	85	89	PF00244	0.675
LIG_Actin_WH2_2	502	520	PF00022	0.626
LIG_BIR_III_4	519	523	PF00653	0.567
LIG_BRCT_BRCA1_1	229	233	PF00533	0.406
LIG_BRCT_BRCA1_1	23	27	PF00533	0.552
LIG_BRCT_BRCA1_1	551	555	PF00533	0.685
LIG_EVH1_1	616	620	PF00568	0.613
LIG_EVH1_2	483	487	PF00568	0.629
LIG_FHA_1	147	153	PF00498	0.639
LIG_FHA_1	300	306	PF00498	0.594
LIG_FHA_1	437	443	PF00498	0.655
LIG_FHA_1	46	52	PF00498	0.611
LIG_FHA_1	494	500	PF00498	0.599
LIG_FHA_1	584	590	PF00498	0.603
LIG_FHA_2	332	338	PF00498	0.469
LIG_FHA_2	366	372	PF00498	0.776
LIG_FHA_2	432	438	PF00498	0.613
LIG_FHA_2	71	77	PF00498	0.616
LIG_IBAR_NPY_1	675	677	PF08397	0.606
LIG_LIR_Apic_2	148	154	PF02991	0.636
LIG_LIR_Apic_2	455	460	PF02991	0.614
LIG_LIR_Gen_1	333	342	PF02991	0.483
LIG_LIR_Gen_1	486	493	PF02991	0.588
LIG_LIR_Nem_3	150	156	PF02991	0.637
LIG_LIR_Nem_3	24	30	PF02991	0.648
LIG_LIR_Nem_3	333	339	PF02991	0.489
LIG_LIR_Nem_3	486	490	PF02991	0.621
LIG_LYPXL_S_1	152	156	PF13949	0.594
LIG_MLH1_MIPbox_1	551	555	PF16413	0.685
LIG_MYND_1	106	110	PF01753	0.553
LIG_MYND_1	619	623	PF01753	0.666
LIG_PTB_Apo_2	520	527	PF02174	0.592
LIG_PTB_Apo_2	672	679	PF02174	0.614
LIG_PTB_Phospho_1	520	526	PF10480	0.585
LIG_SH2_CRK	542	546	PF00017	0.656
LIG_SH2_NCK_1	131	135	PF00017	0.588
LIG_SH2_NCK_1	526	530	PF00017	0.614
LIG_SH2_NCK_1	542	546	PF00017	0.592
LIG_SH2_SRC	312	315	PF00017	0.511
LIG_SH2_SRC	526	529	PF00017	0.577
LIG_SH2_STAT3	338	341	PF00017	0.469
LIG_SH2_STAT5	312	315	PF00017	0.531
LIG_SH2_STAT5	338	341	PF00017	0.497
LIG_SH2_STAT5	590	593	PF00017	0.635
LIG_SH2_STAT5	677	680	PF00017	0.674
LIG_SH3_3	177	183	PF00018	0.664
LIG_SH3_3	311	317	PF00018	0.503
LIG_SH3_3	471	477	PF00018	0.567
LIG_SH3_3	485	491	PF00018	0.643
LIG_SH3_3	525	531	PF00018	0.667
LIG_SH3_3	556	562	PF00018	0.652
LIG_SH3_3	595	601	PF00018	0.599
LIG_SH3_3	614	620	PF00018	0.597
LIG_SUMO_SIM_par_1	237	243	PF11976	0.469
LIG_SUMO_SIM_par_1	245	251	PF11976	0.469
LIG_SUMO_SIM_par_1	261	267	PF11976	0.407
LIG_SUMO_SIM_par_1	326	331	PF11976	0.469
LIG_UBA3_1	246	252	PF00899	0.304
MOD_CDK_SPxK_1	398	404	PF00069	0.474
MOD_CK1_1	101	107	PF00069	0.571
MOD_CK1_1	121	127	PF00069	0.534
MOD_CK1_1	130	136	PF00069	0.583
MOD_CK1_1	146	152	PF00069	0.553
MOD_CK1_1	161	167	PF00069	0.533
MOD_CK1_1	191	197	PF00069	0.711
MOD_CK1_1	209	215	PF00069	0.524
MOD_CK1_1	331	337	PF00069	0.304
MOD_CK1_1	349	355	PF00069	0.304
MOD_CK1_1	362	368	PF00069	0.657
MOD_CK1_1	443	449	PF00069	0.635
MOD_CK1_1	489	495	PF00069	0.664
MOD_CK1_1	592	598	PF00069	0.552
MOD_CK1_1	70	76	PF00069	0.611
MOD_CK2_1	331	337	PF00069	0.284
MOD_CK2_1	364	370	PF00069	0.566
MOD_CK2_1	382	388	PF00069	0.494
MOD_CK2_1	431	437	PF00069	0.606
MOD_CK2_1	52	58	PF00069	0.576
MOD_CK2_1	70	76	PF00069	0.604
MOD_GlcNHglycan	126	129	PF01048	0.632
MOD_GlcNHglycan	132	135	PF01048	0.644
MOD_GlcNHglycan	145	148	PF01048	0.470
MOD_GlcNHglycan	167	170	PF01048	0.566
MOD_GlcNHglycan	213	216	PF01048	0.639
MOD_GlcNHglycan	219	222	PF01048	0.678
MOD_GlcNHglycan	257	260	PF01048	0.346
MOD_GlcNHglycan	31	34	PF01048	0.603
MOD_GlcNHglycan	361	364	PF01048	0.308
MOD_GlcNHglycan	37	40	PF01048	0.784
MOD_GlcNHglycan	519	523	PF01048	0.574
MOD_GlcNHglycan	555	558	PF01048	0.648
MOD_GlcNHglycan	594	597	PF01048	0.566
MOD_GlcNHglycan	635	638	PF01048	0.590
MOD_GlcNHglycan	649	652	PF01048	0.512
MOD_GlcNHglycan	69	72	PF01048	0.733
MOD_GlcNHglycan	94	97	PF01048	0.644
MOD_GSK3_1	1	8	PF00069	0.733
MOD_GSK3_1	123	130	PF00069	0.612
MOD_GSK3_1	143	150	PF00069	0.451
MOD_GSK3_1	161	168	PF00069	0.635
MOD_GSK3_1	187	194	PF00069	0.663
MOD_GSK3_1	202	209	PF00069	0.561
MOD_GSK3_1	211	218	PF00069	0.787
MOD_GSK3_1	326	333	PF00069	0.369
MOD_GSK3_1	362	369	PF00069	0.637
MOD_GSK3_1	394	401	PF00069	0.454
MOD_GSK3_1	436	443	PF00069	0.624
MOD_GSK3_1	446	453	PF00069	0.622
MOD_GSK3_1	489	496	PF00069	0.798
MOD_GSK3_1	52	59	PF00069	0.578
MOD_GSK3_1	549	556	PF00069	0.667
MOD_GSK3_1	560	567	PF00069	0.575
MOD_GSK3_1	585	592	PF00069	0.641
MOD_GSK3_1	645	652	PF00069	0.546
MOD_GSK3_1	664	671	PF00069	0.599
MOD_GSK3_1	97	104	PF00069	0.608
MOD_N-GLC_1	121	126	PF02516	0.661
MOD_N-GLC_1	188	193	PF02516	0.645
MOD_N-GLC_1	202	207	PF02516	0.570
MOD_N-GLC_1	291	296	PF02516	0.304
MOD_N-GLC_1	318	323	PF02516	0.402
MOD_N-GLC_1	564	569	PF02516	0.626
MOD_NEK2_1	188	193	PF00069	0.643
MOD_NEK2_1	291	296	PF00069	0.304
MOD_NEK2_1	328	333	PF00069	0.304
MOD_NEK2_1	589	594	PF00069	0.589
MOD_NEK2_1	86	91	PF00069	0.669
MOD_NEK2_2	416	421	PF00069	0.551
MOD_PIKK_1	1	7	PF00454	0.753
MOD_PIKK_1	101	107	PF00454	0.598
MOD_PIKK_1	206	212	PF00454	0.714
MOD_PIKK_1	52	58	PF00454	0.641
MOD_PIKK_1	583	589	PF00454	0.572
MOD_PIKK_1	604	610	PF00454	0.583
MOD_PIKK_1	626	632	PF00454	0.677
MOD_PIKK_1	668	674	PF00454	0.612
MOD_PKA_2	124	130	PF00069	0.616
MOD_PKA_2	331	337	PF00069	0.326
MOD_PKA_2	424	430	PF00069	0.544
MOD_PKA_2	84	90	PF00069	0.596
MOD_PKB_1	429	437	PF00069	0.573
MOD_Plk_1	147	153	PF00069	0.578
MOD_Plk_1	158	164	PF00069	0.593
MOD_Plk_1	188	194	PF00069	0.753
MOD_Plk_1	318	324	PF00069	0.405
MOD_Plk_1	346	352	PF00069	0.304
MOD_Plk_1	416	422	PF00069	0.555
MOD_Plk_4	147	153	PF00069	0.639
MOD_Plk_4	318	324	PF00069	0.405
MOD_Plk_4	331	337	PF00069	0.304
MOD_Plk_4	483	489	PF00069	0.728
MOD_Plk_4	500	506	PF00069	0.549
MOD_Plk_4	549	555	PF00069	0.684
MOD_Plk_4	56	62	PF00069	0.579
MOD_Plk_4	585	591	PF00069	0.605
MOD_Plk_4	649	655	PF00069	0.552
MOD_Plk_4	664	670	PF00069	0.600
MOD_ProDKin_1	110	116	PF00069	0.529
MOD_ProDKin_1	161	167	PF00069	0.672
MOD_ProDKin_1	179	185	PF00069	0.669
MOD_ProDKin_1	3	9	PF00069	0.654
MOD_ProDKin_1	398	404	PF00069	0.474
MOD_ProDKin_1	493	499	PF00069	0.661
MOD_ProDKin_1	564	570	PF00069	0.618
MOD_ProDKin_1	590	596	PF00069	0.671
MOD_ProDKin_1	645	651	PF00069	0.527
MOD_ProDKin_1	98	104	PF00069	0.613
MOD_SUMO_rev_2	370	377	PF00179	0.506
TRG_DiLeu_BaLyEn_6	407	412	PF01217	0.451
TRG_ENDOCYTIC_2	153	156	PF00928	0.594
TRG_ENDOCYTIC_2	677	680	PF00928	0.609
TRG_ER_diArg_1	420	422	PF00400	0.571
TRG_ER_diArg_1	428	431	PF00400	0.558
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1V6	Leptomonas seymouri	44%	91%
A4HDU7	Leishmania braziliensis	70%	98%
E9AH64	Leishmania infantum	99%	100%
E9AX02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QAH4	Leishmania major	92%	99%