Ssl1-like, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Ssl1-like, putative

Gene product:

Ssl1-like, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WYH8_LEIDO

TriTrypDb:

LdBPK_241750.1 , LdCL_240023100 , LDHU3_24.2160

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005667	transcription regulator complex	2	1
GO:0005675	transcription factor TFIIH holo complex	4	1
GO:0032806	carboxy-terminal domain protein kinase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	1
GO:0090575	RNA polymerase II transcription regulator complex	3	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1902554	serine/threonine protein kinase complex	6	1
GO:1902911	protein kinase complex	5	1
GO:1990234	transferase complex	3	1
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WYH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYH8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006259	DNA metabolic process	4	3
GO:0006281	DNA repair	5	3
GO:0006289	nucleotide-excision repair	6	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0006950	response to stress	2	3
GO:0006974	DNA damage response	4	3
GO:0008152	metabolic process	1	3
GO:0009889	regulation of biosynthetic process	4	1
GO:0009987	cellular process	1	3
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0033554	cellular response to stress	3	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044260	obsolete cellular macromolecule metabolic process	3	3
GO:0046483	heterocycle metabolic process	3	3
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0050896	response to stimulus	1	3
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051716	cellular response to stimulus	2	3
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	3
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0008270	zinc ion binding	6	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046914	transition metal ion binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	248	252	PF00656	0.662
CLV_C14_Caspase3-7	9	13	PF00656	0.330
CLV_NRD_NRD_1	218	220	PF00675	0.591
CLV_PCSK_FUR_1	219	223	PF00082	0.665
CLV_PCSK_FUR_1	231	235	PF00082	0.659
CLV_PCSK_KEX2_1	221	223	PF00082	0.639
CLV_PCSK_KEX2_1	233	235	PF00082	0.620
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.636
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.629
CLV_PCSK_SKI1_1	3	7	PF00082	0.281
CLV_PCSK_SKI1_1	308	312	PF00082	0.357
CLV_PCSK_SKI1_1	77	81	PF00082	0.461
DEG_APCC_DBOX_1	28	36	PF00400	0.316
DEG_Nend_Nbox_1	1	3	PF02207	0.372
DEG_SCF_FBW7_1	40	47	PF00400	0.330
DEG_SPOP_SBC_1	353	357	PF00917	0.446
DOC_CDC14_PxL_1	311	319	PF14671	0.445
DOC_CYCLIN_RxL_1	305	313	PF00134	0.342
DOC_CYCLIN_yCln2_LP_2	191	197	PF00134	0.297
DOC_CYCLIN_yCln2_LP_2	327	330	PF00134	0.521
DOC_PP2B_LxvP_1	267	270	PF13499	0.517
DOC_PP2B_LxvP_1	298	301	PF13499	0.505
DOC_PP2B_LxvP_1	327	330	PF13499	0.456
DOC_PP4_MxPP_1	28	31	PF00568	0.330
DOC_USP7_MATH_1	115	119	PF00917	0.633
DOC_USP7_MATH_1	13	17	PF00917	0.278
DOC_USP7_MATH_1	275	279	PF00917	0.664
DOC_USP7_MATH_1	280	284	PF00917	0.572
DOC_USP7_MATH_1	396	400	PF00917	0.713
DOC_USP7_MATH_1	417	421	PF00917	0.488
DOC_USP7_MATH_1	44	48	PF00917	0.247
DOC_WW_Pin1_4	338	343	PF00397	0.575
DOC_WW_Pin1_4	392	397	PF00397	0.650
DOC_WW_Pin1_4	40	45	PF00397	0.300
LIG_14-3-3_CanoR_1	167	171	PF00244	0.369
LIG_14-3-3_CanoR_1	95	104	PF00244	0.239
LIG_Actin_WH2_2	18	36	PF00022	0.330
LIG_BIR_III_2	339	343	PF00653	0.549
LIG_BRCT_BRCA1_1	117	121	PF00533	0.461
LIG_BRCT_BRCA1_1	282	286	PF00533	0.579
LIG_EH1_1	154	162	PF00400	0.274
LIG_eIF4E_1	20	26	PF01652	0.235
LIG_FHA_1	141	147	PF00498	0.402
LIG_FHA_1	2	8	PF00498	0.290
LIG_FHA_1	318	324	PF00498	0.486
LIG_FHA_1	353	359	PF00498	0.502
LIG_FHA_1	376	382	PF00498	0.480
LIG_FHA_1	400	406	PF00498	0.387
LIG_FHA_1	431	437	PF00498	0.479
LIG_FHA_2	145	151	PF00498	0.297
LIG_FHA_2	355	361	PF00498	0.694
LIG_FHA_2	86	92	PF00498	0.343
LIG_LIR_Apic_2	254	260	PF02991	0.509
LIG_LIR_Gen_1	152	163	PF02991	0.344
LIG_LIR_LC3C_4	402	407	PF02991	0.457
LIG_LIR_Nem_3	152	158	PF02991	0.320
LIG_LIR_Nem_3	190	195	PF02991	0.418
LIG_MYND_1	256	260	PF01753	0.569
LIG_SH2_CRK	192	196	PF00017	0.418
LIG_SH2_SRC	257	260	PF00017	0.457
LIG_SH2_SRC	266	269	PF00017	0.447
LIG_SH2_SRC	39	42	PF00017	0.261
LIG_SH2_STAP1	197	201	PF00017	0.399
LIG_SH2_STAP1	318	322	PF00017	0.506
LIG_SH2_STAT5	192	195	PF00017	0.317
LIG_SH2_STAT5	20	23	PF00017	0.241
LIG_SH2_STAT5	24	27	PF00017	0.244
LIG_SH2_STAT5	257	260	PF00017	0.457
LIG_SH2_STAT5	266	269	PF00017	0.330
LIG_SH2_STAT5	287	290	PF00017	0.350
LIG_SH2_STAT5	39	42	PF00017	0.237
LIG_SH2_STAT5	439	442	PF00017	0.472
LIG_SH3_3	390	396	PF00018	0.666
LIG_SUMO_SIM_anti_2	145	150	PF11976	0.287
LIG_SUMO_SIM_anti_2	169	175	PF11976	0.445
LIG_SUMO_SIM_anti_2	4	9	PF11976	0.247
LIG_SUMO_SIM_anti_2	70	76	PF11976	0.330
LIG_SUMO_SIM_par_1	138	143	PF11976	0.311
LIG_SUMO_SIM_par_1	3	9	PF11976	0.300
LIG_SUMO_SIM_par_1	70	76	PF11976	0.330
LIG_TRAF2_1	357	360	PF00917	0.594
LIG_TYR_ITIM	195	200	PF00017	0.413
LIG_WRC_WIRS_1	318	323	PF05994	0.514
LIG_WRC_WIRS_1	377	382	PF05994	0.412
MOD_CK1_1	169	175	PF00069	0.378
MOD_CK1_1	279	285	PF00069	0.601
MOD_CK1_1	399	405	PF00069	0.535
MOD_CK1_1	85	91	PF00069	0.418
MOD_CK2_1	354	360	PF00069	0.685
MOD_CK2_1	397	403	PF00069	0.497
MOD_CK2_1	85	91	PF00069	0.402
MOD_GlcNHglycan	132	135	PF01048	0.562
MOD_GlcNHglycan	273	276	PF01048	0.624
MOD_GlcNHglycan	278	281	PF01048	0.496
MOD_GlcNHglycan	312	315	PF01048	0.396
MOD_GlcNHglycan	350	353	PF01048	0.702
MOD_GlcNHglycan	399	402	PF01048	0.679
MOD_GlcNHglycan	415	418	PF01048	0.481
MOD_GlcNHglycan	84	87	PF01048	0.281
MOD_GSK3_1	111	118	PF00069	0.547
MOD_GSK3_1	140	147	PF00069	0.279
MOD_GSK3_1	162	169	PF00069	0.371
MOD_GSK3_1	271	278	PF00069	0.639
MOD_GSK3_1	296	303	PF00069	0.373
MOD_GSK3_1	338	345	PF00069	0.565
MOD_GSK3_1	348	355	PF00069	0.640
MOD_GSK3_1	392	399	PF00069	0.709
MOD_GSK3_1	40	47	PF00069	0.411
MOD_GSK3_1	413	420	PF00069	0.435
MOD_GSK3_1	82	89	PF00069	0.281
MOD_N-GLC_1	14	19	PF02516	0.281
MOD_N-GLC_1	348	353	PF02516	0.593
MOD_N-GLC_2	424	426	PF02516	0.424
MOD_NEK2_1	1	6	PF00069	0.332
MOD_NEK2_1	142	147	PF00069	0.297
MOD_NEK2_1	310	315	PF00069	0.396
MOD_NEK2_1	316	321	PF00069	0.381
MOD_NEK2_1	323	328	PF00069	0.425
MOD_NEK2_1	375	380	PF00069	0.475
MOD_NEK2_1	385	390	PF00069	0.677
MOD_NEK2_2	162	167	PF00069	0.413
MOD_PIKK_1	132	138	PF00454	0.413
MOD_PKA_1	116	122	PF00069	0.676
MOD_PKA_2	166	172	PF00069	0.418
MOD_Plk_2-3	181	187	PF00069	0.348
MOD_Plk_4	144	150	PF00069	0.281
MOD_Plk_4	169	175	PF00069	0.417
MOD_Plk_4	187	193	PF00069	0.341
MOD_Plk_4	317	323	PF00069	0.384
MOD_Plk_4	376	382	PF00069	0.513
MOD_ProDKin_1	338	344	PF00069	0.580
MOD_ProDKin_1	392	398	PF00069	0.648
MOD_ProDKin_1	40	46	PF00069	0.372
TRG_DiLeu_BaEn_2	75	81	PF01217	0.297
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.413
TRG_DiLeu_BaLyEn_6	305	310	PF01217	0.410
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.372
TRG_ENDOCYTIC_2	192	195	PF00928	0.289
TRG_ENDOCYTIC_2	197	200	PF00928	0.272
TRG_ENDOCYTIC_2	318	321	PF00928	0.517
TRG_NLS_MonoCore_2	218	223	PF00514	0.578
TRG_NLS_MonoExtN_4	219	224	PF00514	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8I5	Leptomonas seymouri	63%	97%
A0A0S4JM00	Bodo saltans	33%	100%
A0A1X0NX76	Trypanosomatidae	38%	100%
A0A422MXM9	Trypanosoma rangeli	40%	100%
A0JN27	Rattus norvegicus	24%	100%
A4HDM8	Leishmania braziliensis	79%	98%
C9ZWD7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AH75	Leishmania infantum	99%	100%
E9AX13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	95%
Q13888	Homo sapiens	25%	100%
Q2TBV5	Bos taurus	24%	100%
Q4QAG3	Leishmania major	93%	100%
Q6P1K8	Homo sapiens	24%	100%
Q9JIB4	Mus musculus	25%	100%
V5BAZ0	Trypanosoma cruzi	40%	100%