SET domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WYH5_LEIDO

TriTrypDb:

LdBPK_241820.1 , LdCL_240023800 , LDHU3_24.2230

Length:

738

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WYH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYH5

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	1
GO:0042054	histone methyltransferase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	366	370	PF00656	0.492
CLV_C14_Caspase3-7	572	576	PF00656	0.647
CLV_NRD_NRD_1	379	381	PF00675	0.562
CLV_NRD_NRD_1	705	707	PF00675	0.453
CLV_PCSK_KEX2_1	289	291	PF00082	0.720
CLV_PCSK_KEX2_1	379	381	PF00082	0.562
CLV_PCSK_KEX2_1	394	396	PF00082	0.540
CLV_PCSK_KEX2_1	503	505	PF00082	0.621
CLV_PCSK_KEX2_1	704	706	PF00082	0.430
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.700
CLV_PCSK_PC1ET2_1	394	396	PF00082	0.291
CLV_PCSK_PC1ET2_1	503	505	PF00082	0.547
CLV_PCSK_SKI1_1	290	294	PF00082	0.644
CLV_PCSK_SKI1_1	452	456	PF00082	0.431
CLV_PCSK_SKI1_1	520	524	PF00082	0.596
CLV_PCSK_SKI1_1	706	710	PF00082	0.517
DEG_APCC_DBOX_1	383	391	PF00400	0.479
DEG_APCC_DBOX_1	428	436	PF00400	0.591
DEG_SPOP_SBC_1	404	408	PF00917	0.617
DOC_ANK_TNKS_1	567	574	PF00023	0.616
DOC_CKS1_1	274	279	PF01111	0.609
DOC_CYCLIN_RxL_1	391	402	PF00134	0.592
DOC_MAPK_gen_1	379	387	PF00069	0.498
DOC_MAPK_MEF2A_6	384	392	PF00069	0.447
DOC_PP1_RVXF_1	392	399	PF00149	0.562
DOC_PP1_RVXF_1	413	420	PF00149	0.531
DOC_PP1_RVXF_1	58	64	PF00149	0.488
DOC_PP4_FxxP_1	274	277	PF00568	0.558
DOC_PP4_FxxP_1	658	661	PF00568	0.438
DOC_USP7_MATH_1	117	121	PF00917	0.700
DOC_USP7_MATH_1	131	135	PF00917	0.738
DOC_USP7_MATH_1	334	338	PF00917	0.499
DOC_USP7_MATH_1	370	374	PF00917	0.503
DOC_USP7_MATH_1	404	408	PF00917	0.638
DOC_USP7_MATH_1	507	511	PF00917	0.694
DOC_USP7_MATH_1	571	575	PF00917	0.656
DOC_USP7_MATH_1	595	599	PF00917	0.612
DOC_USP7_MATH_2	80	86	PF00917	0.675
DOC_USP7_UBL2_3	94	98	PF12436	0.686
DOC_WW_Pin1_4	118	123	PF00397	0.681
DOC_WW_Pin1_4	127	132	PF00397	0.586
DOC_WW_Pin1_4	198	203	PF00397	0.775
DOC_WW_Pin1_4	207	212	PF00397	0.714
DOC_WW_Pin1_4	229	234	PF00397	0.741
DOC_WW_Pin1_4	252	257	PF00397	0.665
DOC_WW_Pin1_4	273	278	PF00397	0.569
DOC_WW_Pin1_4	292	297	PF00397	0.436
DOC_WW_Pin1_4	405	410	PF00397	0.630
DOC_WW_Pin1_4	505	510	PF00397	0.712
DOC_WW_Pin1_4	554	559	PF00397	0.542
DOC_WW_Pin1_4	625	630	PF00397	0.547
LIG_14-3-3_CanoR_1	191	197	PF00244	0.719
LIG_14-3-3_CanoR_1	257	266	PF00244	0.649
LIG_14-3-3_CanoR_1	290	296	PF00244	0.690
LIG_14-3-3_CanoR_1	395	401	PF00244	0.504
LIG_14-3-3_CanoR_1	456	460	PF00244	0.424
LIG_Actin_WH2_1	384	399	PF00022	0.485
LIG_Actin_WH2_2	381	399	PF00022	0.532
LIG_Actin_WH2_2	440	458	PF00022	0.566
LIG_BIR_III_4	575	579	PF00653	0.727
LIG_BRCT_BRCA1_1	30	34	PF00533	0.604
LIG_BRCT_BRCA1_1	530	534	PF00533	0.533
LIG_Clathr_ClatBox_1	446	450	PF01394	0.490
LIG_FAT_LD_1	182	190	PF03623	0.641
LIG_FHA_1	11	17	PF00498	0.651
LIG_FHA_1	128	134	PF00498	0.744
LIG_FHA_1	211	217	PF00498	0.786
LIG_FHA_1	279	285	PF00498	0.615
LIG_FHA_1	521	527	PF00498	0.588
LIG_FHA_1	682	688	PF00498	0.514
LIG_FHA_1	726	732	PF00498	0.504
LIG_FHA_2	230	236	PF00498	0.634
LIG_FHA_2	243	249	PF00498	0.741
LIG_FHA_2	259	265	PF00498	0.601
LIG_FHA_2	364	370	PF00498	0.488
LIG_FHA_2	510	516	PF00498	0.679
LIG_FHA_2	97	103	PF00498	0.678
LIG_GBD_Chelix_1	388	396	PF00786	0.444
LIG_HP1_1	334	338	PF01393	0.480
LIG_LIR_Gen_1	212	222	PF02991	0.711
LIG_LIR_Gen_1	458	467	PF02991	0.466
LIG_LIR_Gen_1	472	481	PF02991	0.527
LIG_LIR_Gen_1	684	692	PF02991	0.552
LIG_LIR_Nem_3	106	111	PF02991	0.687
LIG_LIR_Nem_3	212	217	PF02991	0.706
LIG_LIR_Nem_3	458	462	PF02991	0.393
LIG_LIR_Nem_3	463	468	PF02991	0.401
LIG_LIR_Nem_3	680	686	PF02991	0.500
LIG_LIR_Nem_3	710	714	PF02991	0.411
LIG_NRBOX	181	187	PF00104	0.627
LIG_NRBOX	386	392	PF00104	0.539
LIG_PCNA_yPIPBox_3	332	340	PF02747	0.497
LIG_PDZ_Class_2	733	738	PF00595	0.624
LIG_PTB_Apo_2	653	660	PF02174	0.551
LIG_Rb_LxCxE_1	463	485	PF01857	0.513
LIG_SH2_CRK	108	112	PF00017	0.687
LIG_SH2_NCK_1	643	647	PF00017	0.490
LIG_SH2_PTP2	686	689	PF00017	0.398
LIG_SH2_SRC	439	442	PF00017	0.593
LIG_SH2_STAT5	15	18	PF00017	0.556
LIG_SH2_STAT5	242	245	PF00017	0.762
LIG_SH2_STAT5	259	262	PF00017	0.602
LIG_SH2_STAT5	273	276	PF00017	0.420
LIG_SH2_STAT5	539	542	PF00017	0.437
LIG_SH2_STAT5	553	556	PF00017	0.527
LIG_SH2_STAT5	560	563	PF00017	0.582
LIG_SH2_STAT5	686	689	PF00017	0.401
LIG_SH2_STAT5	707	710	PF00017	0.431
LIG_SH3_3	494	500	PF00018	0.649
LIG_SH3_3	552	558	PF00018	0.529
LIG_SUMO_SIM_anti_2	261	267	PF11976	0.531
LIG_SUMO_SIM_anti_2	597	603	PF11976	0.676
LIG_SUMO_SIM_par_1	445	450	PF11976	0.501
LIG_TYR_ITSM	682	689	PF00017	0.559
LIG_UBA3_1	387	394	PF00899	0.541
LIG_UBA3_1	601	607	PF00899	0.602
LIG_WRC_WIRS_1	347	352	PF05994	0.475
MOD_CDK_SPK_2	118	123	PF00069	0.681
MOD_CDK_SPK_2	198	203	PF00069	0.717
MOD_CDK_SPK_2	252	257	PF00069	0.717
MOD_CDK_SPxxK_3	118	125	PF00069	0.685
MOD_CDK_SPxxK_3	405	412	PF00069	0.381
MOD_CK1_1	132	138	PF00069	0.746
MOD_CK1_1	142	148	PF00069	0.797
MOD_CK1_1	29	35	PF00069	0.628
MOD_CK1_1	373	379	PF00069	0.497
MOD_CK1_1	4	10	PF00069	0.671
MOD_CK1_1	427	433	PF00069	0.513
MOD_CK1_1	482	488	PF00069	0.587
MOD_CK1_1	510	516	PF00069	0.643
MOD_CK1_1	72	78	PF00069	0.622
MOD_CK2_1	190	196	PF00069	0.686
MOD_CK2_1	209	215	PF00069	0.661
MOD_CK2_1	242	248	PF00069	0.673
MOD_CK2_1	280	286	PF00069	0.607
MOD_CK2_1	427	433	PF00069	0.591
MOD_CK2_1	435	441	PF00069	0.505
MOD_CK2_1	509	515	PF00069	0.632
MOD_CK2_1	566	572	PF00069	0.532
MOD_CK2_1	96	102	PF00069	0.678
MOD_CMANNOS	563	566	PF00535	0.622
MOD_Cter_Amidation	287	290	PF01082	0.700
MOD_GlcNHglycan	238	241	PF01048	0.770
MOD_GlcNHglycan	3	6	PF01048	0.630
MOD_GlcNHglycan	316	319	PF01048	0.588
MOD_GlcNHglycan	329	332	PF01048	0.526
MOD_GlcNHglycan	401	404	PF01048	0.584
MOD_GlcNHglycan	484	487	PF01048	0.689
MOD_GlcNHglycan	509	512	PF01048	0.639
MOD_GSK3_1	127	134	PF00069	0.696
MOD_GSK3_1	26	33	PF00069	0.656
MOD_GSK3_1	323	330	PF00069	0.664
MOD_GSK3_1	369	376	PF00069	0.554
MOD_GSK3_1	399	406	PF00069	0.541
MOD_GSK3_1	480	487	PF00069	0.625
MOD_GSK3_1	505	512	PF00069	0.713
MOD_GSK3_1	554	561	PF00069	0.522
MOD_GSK3_1	584	591	PF00069	0.650
MOD_GSK3_1	631	638	PF00069	0.571
MOD_LATS_1	732	738	PF00433	0.581
MOD_N-GLC_1	649	654	PF02516	0.290
MOD_N-GLC_2	77	79	PF02516	0.644
MOD_NEK2_1	1	6	PF00069	0.680
MOD_NEK2_1	291	296	PF00069	0.714
MOD_NEK2_1	323	328	PF00069	0.666
MOD_NEK2_1	396	401	PF00069	0.529
MOD_NEK2_1	435	440	PF00069	0.615
MOD_NEK2_1	455	460	PF00069	0.283
MOD_NEK2_1	477	482	PF00069	0.412
MOD_NEK2_1	608	613	PF00069	0.710
MOD_NEK2_1	635	640	PF00069	0.587
MOD_NEK2_1	649	654	PF00069	0.527
MOD_NEK2_1	682	687	PF00069	0.581
MOD_NEK2_1	69	74	PF00069	0.526
MOD_NEK2_2	370	375	PF00069	0.541
MOD_PIKK_1	80	86	PF00454	0.647
MOD_PKA_2	145	151	PF00069	0.749
MOD_PKA_2	190	196	PF00069	0.713
MOD_PKA_2	396	402	PF00069	0.503
MOD_PKA_2	455	461	PF00069	0.394
MOD_Plk_1	631	637	PF00069	0.581
MOD_Plk_1	649	655	PF00069	0.483
MOD_Plk_2-3	190	196	PF00069	0.686
MOD_Plk_2-3	280	286	PF00069	0.607
MOD_Plk_4	280	286	PF00069	0.611
MOD_Plk_4	334	340	PF00069	0.552
MOD_Plk_4	460	466	PF00069	0.488
MOD_Plk_4	487	493	PF00069	0.736
MOD_Plk_4	558	564	PF00069	0.529
MOD_Plk_4	595	601	PF00069	0.684
MOD_Plk_4	64	70	PF00069	0.567
MOD_Plk_4	666	672	PF00069	0.542
MOD_Plk_4	682	688	PF00069	0.412
MOD_ProDKin_1	118	124	PF00069	0.684
MOD_ProDKin_1	127	133	PF00069	0.587
MOD_ProDKin_1	198	204	PF00069	0.774
MOD_ProDKin_1	207	213	PF00069	0.714
MOD_ProDKin_1	229	235	PF00069	0.741
MOD_ProDKin_1	252	258	PF00069	0.664
MOD_ProDKin_1	273	279	PF00069	0.567
MOD_ProDKin_1	292	298	PF00069	0.438
MOD_ProDKin_1	405	411	PF00069	0.624
MOD_ProDKin_1	505	511	PF00069	0.709
MOD_ProDKin_1	554	560	PF00069	0.541
MOD_ProDKin_1	625	631	PF00069	0.547
MOD_SUMO_rev_2	283	291	PF00179	0.651
MOD_SUMO_rev_2	575	585	PF00179	0.624
TRG_DiLeu_BaEn_1	280	285	PF01217	0.562
TRG_DiLeu_BaEn_1	383	388	PF01217	0.476
TRG_DiLeu_BaEn_1	450	455	PF01217	0.560
TRG_DiLeu_BaEn_3	286	292	PF01217	0.742
TRG_DiLeu_BaEn_3	472	478	PF01217	0.391
TRG_DiLeu_BaEn_4	177	183	PF01217	0.570
TRG_DiLeu_BaLyEn_6	167	172	PF01217	0.610
TRG_ENDOCYTIC_2	108	111	PF00928	0.688
TRG_ENDOCYTIC_2	474	477	PF00928	0.603
TRG_ENDOCYTIC_2	539	542	PF00928	0.522
TRG_ENDOCYTIC_2	686	689	PF00928	0.423
TRG_ENDOCYTIC_2	711	714	PF00928	0.496
TRG_ER_diArg_1	395	398	PF00400	0.396
TRG_ER_diArg_1	428	431	PF00400	0.554
TRG_ER_diArg_1	704	706	PF00400	0.496
TRG_NLS_Bipartite_1	379	398	PF00514	0.299
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.731
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	706	710	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I099	Leptomonas seymouri	41%	100%
A0A3R7RB97	Trypanosoma rangeli	30%	100%
A4HDN5	Leishmania braziliensis	73%	100%
C9ZWC8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AH82	Leishmania infantum	99%	100%
E9AX20	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QAF6	Leishmania major	90%	100%
V5CZP8	Trypanosoma cruzi	30%	100%