Phospholipase/Carboxylesterase family protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

lysophospholipase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WYH3_LEIDO

TriTrypDb:

LdBPK_241910.1 , LdCL_240024700 , LDHU3_24.2340

Length:

278

Annotations

Annotations by Jardim et al.

Lipid Metabolism, lysophospholipase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WYH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYH3

Function

Biological processes
Term	Name	Level	Count
GO:0002084	protein depalmitoylation	6	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0019538	protein metabolic process	3	1
GO:0030163	protein catabolic process	4	1
GO:0035601	protein deacylation	5	1
GO:0036211	protein modification process	4	1
GO:0042157	lipoprotein metabolic process	4	1
GO:0042159	lipoprotein catabolic process	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0098732	macromolecule deacylation	5	1
GO:0098734	macromolecule depalmitoylation	6	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004620	phospholipase activity	5	6
GO:0004622	lysophospholipase activity	5	6
GO:0016298	lipase activity	4	6
GO:0016787	hydrolase activity	2	13
GO:0016788	hydrolase activity, acting on ester bonds	3	6
GO:0052689	carboxylic ester hydrolase activity	4	6
GO:0102545	phosphatidyl phospholipase B activity	5	6
GO:0008474	palmitoyl-(protein) hydrolase activity	3	1
GO:0016790	thiolester hydrolase activity	4	1
GO:0098599	palmitoyl hydrolase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	91	93	PF00675	0.465
CLV_PCSK_KEX2_1	91	93	PF00082	0.465
CLV_PCSK_SKI1_1	106	110	PF00082	0.435
CLV_PCSK_SKI1_1	235	239	PF00082	0.444
CLV_Separin_Metazoa	88	92	PF03568	0.545
DOC_CDC14_PxL_1	90	98	PF14671	0.545
DOC_MAPK_DCC_7	240	249	PF00069	0.545
DOC_MAPK_gen_1	91	99	PF00069	0.465
DOC_MAPK_MEF2A_6	221	228	PF00069	0.486
DOC_MAPK_MEF2A_6	91	98	PF00069	0.458
DOC_PP4_FxxP_1	98	101	PF00568	0.396
DOC_USP7_MATH_1	104	108	PF00917	0.529
DOC_USP7_MATH_1	174	178	PF00917	0.470
DOC_USP7_MATH_1	192	196	PF00917	0.431
DOC_WW_Pin1_4	43	48	PF00397	0.547
DOC_WW_Pin1_4	61	66	PF00397	0.215
LIG_14-3-3_CanoR_1	141	147	PF00244	0.545
LIG_FHA_1	181	187	PF00498	0.439
LIG_FHA_1	200	206	PF00498	0.443
LIG_FHA_1	232	238	PF00498	0.545
LIG_FHA_1	265	271	PF00498	0.468
LIG_FHA_1	47	53	PF00498	0.531
LIG_FHA_1	64	70	PF00498	0.262
LIG_FHA_2	54	60	PF00498	0.634
LIG_LIR_Nem_3	248	252	PF02991	0.513
LIG_PDZ_Class_3	273	278	PF00595	0.605
LIG_PTAP_UEV_1	100	105	PF05743	0.425
LIG_SH2_CRK	54	58	PF00017	0.489
LIG_SH2_NCK_1	120	124	PF00017	0.331
LIG_SH2_SRC	120	123	PF00017	0.331
LIG_SH2_STAT5	146	149	PF00017	0.392
LIG_SH2_STAT5	197	200	PF00017	0.390
LIG_SH3_1	221	227	PF00018	0.524
LIG_SH3_2	101	106	PF14604	0.443
LIG_SH3_3	221	227	PF00018	0.524
LIG_SH3_3	98	104	PF00018	0.425
LIG_TYR_ITIM	52	57	PF00017	0.505
LIG_UBA3_1	57	63	PF00899	0.581
LIG_WRC_WIRS_1	266	271	PF05994	0.465
MOD_CK1_1	168	174	PF00069	0.499
MOD_CK1_1	177	183	PF00069	0.481
MOD_CK1_1	268	274	PF00069	0.524
MOD_CK2_1	245	251	PF00069	0.542
MOD_CK2_1	53	59	PF00069	0.636
MOD_GlcNHglycan	127	130	PF01048	0.451
MOD_GlcNHglycan	131	134	PF01048	0.398
MOD_GlcNHglycan	167	170	PF01048	0.496
MOD_GlcNHglycan	194	197	PF01048	0.421
MOD_GlcNHglycan	228	231	PF01048	0.524
MOD_GlcNHglycan	77	80	PF01048	0.413
MOD_GSK3_1	102	109	PF00069	0.491
MOD_GSK3_1	125	132	PF00069	0.409
MOD_GSK3_1	136	143	PF00069	0.472
MOD_GSK3_1	264	271	PF00069	0.468
MOD_GSK3_1	42	49	PF00069	0.514
MOD_GSK3_1	63	70	PF00069	0.414
MOD_N-GLC_1	61	66	PF02516	0.421
MOD_NEK2_1	125	130	PF00069	0.528
MOD_NEK2_1	254	259	PF00069	0.386
MOD_NEK2_1	75	80	PF00069	0.396
MOD_PIKK_1	168	174	PF00454	0.432
MOD_PKA_2	140	146	PF00069	0.545
MOD_PKA_2	42	48	PF00069	0.505
MOD_Plk_1	254	260	PF00069	0.468
MOD_Plk_1	264	270	PF00069	0.341
MOD_Plk_4	265	271	PF00069	0.487
MOD_Plk_4	53	59	PF00069	0.644
MOD_Plk_4	67	73	PF00069	0.443
MOD_ProDKin_1	43	49	PF00069	0.545
MOD_ProDKin_1	61	67	PF00069	0.215
MOD_SUMO_for_1	13	16	PF00179	0.478
MOD_SUMO_rev_2	229	237	PF00179	0.506
TRG_DiLeu_BaEn_4	15	21	PF01217	0.559
TRG_ENDOCYTIC_2	120	123	PF00928	0.545
TRG_ENDOCYTIC_2	167	170	PF00928	0.425
TRG_ENDOCYTIC_2	54	57	PF00928	0.482
TRG_ER_diArg_1	90	92	PF00400	0.469
TRG_Pf-PMV_PEXEL_1	272	276	PF00026	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3M9	Leptomonas seymouri	73%	100%
A0A0S4IM79	Bodo saltans	39%	73%
A0A0S4IVW5	Bodo saltans	32%	89%
A0A0S4J016	Bodo saltans	44%	77%
A0A1X0NWA4	Trypanosomatidae	58%	100%
A0A3R7LLR7	Trypanosoma rangeli	60%	99%
A4HDP5	Leishmania braziliensis	88%	100%
C9ZWB8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	99%
E9AH91	Leishmania infantum	100%	100%
E9AX29	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O75608	Homo sapiens	31%	100%
O77821	Oryctolagus cuniculus	31%	100%
O95372	Homo sapiens	32%	100%
P0CL94	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	32%	100%
P0CL95	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	32%	100%
P70470	Rattus norvegicus	31%	100%
P97823	Mus musculus	31%	100%
Q0J969	Oryza sativa subsp. japonica	31%	100%
Q12354	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
Q3MHR0	Bos taurus	33%	100%
Q3UFF7	Mus musculus	28%	100%
Q4I8Q4	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	35%	100%
Q4PID3	Ustilago maydis (strain 521 / FGSC 9021)	37%	100%
Q4QAE7	Leishmania major	96%	100%
Q4WCX7	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	34%	100%
Q51758	Pseudomonas fluorescens	33%	100%
Q53547	Pseudomonas fluorescens	34%	100%
Q54T49	Dictyostelium discoideum	34%	100%
Q55FK4	Dictyostelium discoideum	31%	100%
Q5AGD1	Candida albicans (strain SC5314 / ATCC MYA-2876)	32%	100%
Q5ASI2	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	36%	100%
Q5R8C2	Pongo abelii	26%	100%
Q5RBR7	Pongo abelii	32%	100%
Q5VWZ2	Homo sapiens	28%	100%
Q6BSS8	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	31%	100%
Q6CGL4	Yarrowia lipolytica (strain CLIB 122 / E 150)	31%	100%
Q6CJK6	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	36%	100%
Q6FW75	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	33%	100%
Q750X7	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	31%	100%
Q7XR62	Oryza sativa subsp. japonica	27%	100%
Q84WK4	Arabidopsis thaliana	28%	100%
Q8GYK2	Arabidopsis thaliana	29%	100%
Q9HFJ5	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	37%	100%
Q9QYL8	Rattus norvegicus	32%	100%
Q9WTL7	Mus musculus	32%	100%
V5AV05	Trypanosoma cruzi	59%	99%