Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WYH2_LEIDO

TriTrypDb:

LdBPK_241370.1 , LdCL_240018800 , LDHU3_24.1650

Length:

Annotations

Annotations by Jardim et al.

Tricarboxylic acid cycle, Succinate dehydrogenase subunit 11(SDH11) Complex II Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A0A3S7WYH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYH2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.440
CLV_PCSK_KEX2_1	15	17	PF00082	0.420
DOC_MAPK_gen_1	52	61	PF00069	0.522
DOC_MAPK_MEF2A_6	54	63	PF00069	0.488
DOC_USP7_MATH_1	25	29	PF00917	0.647
LIG_14-3-3_CanoR_1	15	21	PF00244	0.641
LIG_BIR_II_1	1	5	PF00653	0.621
LIG_FHA_1	56	62	PF00498	0.446
LIG_LIR_Apic_2	40	46	PF02991	0.592
LIG_LIR_Gen_1	58	66	PF02991	0.361
LIG_LIR_Gen_1	68	79	PF02991	0.406
LIG_LIR_Nem_3	58	63	PF02991	0.339
LIG_LIR_Nem_3	68	74	PF02991	0.348
LIG_PDZ_Class_2	80	85	PF00595	0.343
LIG_Pex14_2	74	78	PF04695	0.428
LIG_REV1ctd_RIR_1	80	85	PF16727	0.360
LIG_SH2_NCK_1	43	47	PF00017	0.651
LIG_SH2_STAT5	43	46	PF00017	0.600
LIG_SH2_STAT5	48	51	PF00017	0.566
LIG_SH2_STAT5	71	74	PF00017	0.320
LIG_SH2_STAT5	81	84	PF00017	0.334
LIG_SH3_3	31	37	PF00018	0.637
LIG_SH3_3	69	75	PF00018	0.342
LIG_TRFH_1	71	75	PF08558	0.398
MOD_CK1_1	19	25	PF00069	0.672
MOD_GSK3_1	37	44	PF00069	0.631
MOD_NEK2_1	55	60	PF00069	0.518
MOD_Plk_4	37	43	PF00069	0.582
MOD_Plk_4	44	50	PF00069	0.563
MOD_Plk_4	55	61	PF00069	0.414
MOD_Plk_4	8	14	PF00069	0.554
TRG_ENDOCYTIC_2	71	74	PF00928	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCA5	Leptomonas seymouri	83%	93%
A0A0S4J5H3	Bodo saltans	52%	69%
A4HDK9	Leishmania braziliensis	81%	100%
A4I0X2	Leishmania infantum	100%	100%
C9ZWH5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	97%
E9AWX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QAJ8	Leishmania major	96%	100%
V5BB00	Trypanosoma cruzi	59%	97%