Ring-box_protein_putative/GeneDB:LmjF.24.1610

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ring-box protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WYG9_LEIDO

TriTrypDb:

LdBPK_241680.1 , LdCL_240021900 , LDHU3_24.2050

Length:

119

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0005634	nucleus	5	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	1

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Expansion

Sequence features

A0A3S7WYG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYG9

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0005488	binding	1	7
GO:0005515	protein binding	2	1
GO:0008270	zinc ion binding	6	7
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	26	30	PF00082	0.502
CLV_PCSK_SKI1_1	92	96	PF00082	0.283
DEG_SPOP_SBC_1	5	9	PF00917	0.684
DOC_USP7_MATH_1	10	14	PF00917	0.767
DOC_USP7_MATH_1	72	76	PF00917	0.591
LIG_14-3-3_CanoR_1	26	32	PF00244	0.562
LIG_BIR_II_1	1	5	PF00653	0.767
LIG_Clathr_ClatBox_1	28	32	PF01394	0.626
LIG_deltaCOP1_diTrp_1	106	113	PF00928	0.528
LIG_FHA_1	85	91	PF00498	0.480

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7V1	Leptomonas seymouri	87%	100%
A0A0S4IYF9	Bodo saltans	44%	86%
A0A0S4J7B6	Bodo saltans	37%	81%
A0A0S4JR26	Bodo saltans	33%	100%
A0A1X0NQI6	Trypanosomatidae	31%	100%
A0A1X0NXY1	Trypanosomatidae	42%	100%
A0A3S7WTW3	Leishmania donovani	32%	100%
A0A3S7WW78	Leishmania donovani	47%	100%
A0A422MZP5	Trypanosoma rangeli	48%	91%
A4HBJ7	Leishmania braziliensis	45%	100%

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