DNAJ domain protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNAJ domain protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WYG6_LEIDO

TriTrypDb:

LdBPK_241100.1 , LdCL_240016000 , LDHU3_24.1280

Length:

435

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A0A3S7WYG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYG6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	137	139	PF00675	0.404
CLV_NRD_NRD_1	29	31	PF00675	0.361
CLV_NRD_NRD_1	293	295	PF00675	0.327
CLV_NRD_NRD_1	305	307	PF00675	0.350
CLV_NRD_NRD_1	343	345	PF00675	0.500
CLV_NRD_NRD_1	37	39	PF00675	0.421
CLV_NRD_NRD_1	396	398	PF00675	0.240
CLV_NRD_NRD_1	428	430	PF00675	0.313
CLV_PCSK_FUR_1	298	302	PF00082	0.441
CLV_PCSK_FUR_1	303	307	PF00082	0.447
CLV_PCSK_KEX2_1	29	31	PF00082	0.367
CLV_PCSK_KEX2_1	293	295	PF00082	0.318
CLV_PCSK_KEX2_1	300	302	PF00082	0.338
CLV_PCSK_KEX2_1	305	307	PF00082	0.345
CLV_PCSK_KEX2_1	343	345	PF00082	0.516
CLV_PCSK_KEX2_1	37	39	PF00082	0.421
CLV_PCSK_KEX2_1	396	398	PF00082	0.295
CLV_PCSK_KEX2_1	427	429	PF00082	0.293
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.429
CLV_PCSK_PC1ET2_1	427	429	PF00082	0.331
CLV_PCSK_PC7_1	301	307	PF00082	0.453
CLV_PCSK_PC7_1	392	398	PF00082	0.332
CLV_PCSK_PC7_1	424	430	PF00082	0.267
CLV_PCSK_SKI1_1	352	356	PF00082	0.511
CLV_PCSK_SKI1_1	397	401	PF00082	0.229
CLV_PCSK_SKI1_1	54	58	PF00082	0.316
DEG_Nend_Nbox_1	1	3	PF02207	0.613
DEG_SCF_FBW7_2	49	55	PF00400	0.484
DEG_SPOP_SBC_1	318	322	PF00917	0.618
DEG_SPOP_SBC_1	354	358	PF00917	0.763
DEG_SPOP_SBC_1	78	82	PF00917	0.564
DEG_SPOP_SBC_1	88	92	PF00917	0.510
DOC_CKS1_1	12	17	PF01111	0.497
DOC_CKS1_1	49	54	PF01111	0.488
DOC_CYCLIN_RxL_1	375	386	PF00134	0.454
DOC_MAPK_gen_1	303	311	PF00069	0.617
DOC_PP1_RVXF_1	14	21	PF00149	0.528
DOC_PP4_FxxP_1	259	262	PF00568	0.210
DOC_USP7_MATH_1	318	322	PF00917	0.649
DOC_USP7_MATH_1	354	358	PF00917	0.744
DOC_USP7_MATH_1	361	365	PF00917	0.727
DOC_USP7_MATH_1	88	92	PF00917	0.510
DOC_WW_Pin1_4	11	16	PF00397	0.522
DOC_WW_Pin1_4	202	207	PF00397	0.521
DOC_WW_Pin1_4	357	362	PF00397	0.706
DOC_WW_Pin1_4	48	53	PF00397	0.599
LIG_14-3-3_CanoR_1	222	226	PF00244	0.567
LIG_14-3-3_CanoR_1	247	254	PF00244	0.328
LIG_14-3-3_CanoR_1	317	325	PF00244	0.624
LIG_14-3-3_CanoR_1	330	335	PF00244	0.569
LIG_14-3-3_CanoR_1	352	362	PF00244	0.739
LIG_14-3-3_CanoR_1	65	71	PF00244	0.503
LIG_14-3-3_CanoR_1	89	95	PF00244	0.607
LIG_APCC_ABBA_1	380	385	PF00400	0.428
LIG_BRCT_BRCA1_1	52	56	PF00533	0.506
LIG_FHA_1	144	150	PF00498	0.549
LIG_FHA_1	222	228	PF00498	0.490
LIG_FHA_1	246	252	PF00498	0.356
LIG_FHA_1	3	9	PF00498	0.678
LIG_FHA_1	90	96	PF00498	0.617
LIG_FHA_2	331	337	PF00498	0.758
LIG_FHA_2	79	85	PF00498	0.709
LIG_Integrin_RGD_1	129	131	PF01839	0.301
LIG_LIR_Gen_1	278	286	PF02991	0.422
LIG_LIR_Gen_1	359	370	PF02991	0.553
LIG_LIR_Gen_1	45	52	PF02991	0.535
LIG_LIR_Nem_3	111	117	PF02991	0.478
LIG_LIR_Nem_3	191	197	PF02991	0.484
LIG_LIR_Nem_3	221	226	PF02991	0.510
LIG_LIR_Nem_3	278	283	PF02991	0.422
LIG_LIR_Nem_3	359	365	PF02991	0.744
LIG_LIR_Nem_3	393	398	PF02991	0.467
LIG_LIR_Nem_3	418	423	PF02991	0.467
LIG_LIR_Nem_3	45	49	PF02991	0.525
LIG_LIR_Nem_3	53	59	PF02991	0.461
LIG_LYPXL_yS_3	289	292	PF13949	0.591
LIG_Pex14_2	208	212	PF04695	0.516
LIG_Pex14_2	284	288	PF04695	0.351
LIG_PTB_Apo_2	238	245	PF02174	0.500
LIG_PTB_Apo_2	70	77	PF02174	0.481
LIG_PTB_Phospho_1	238	244	PF10480	0.516
LIG_PTB_Phospho_1	70	76	PF10480	0.474
LIG_REV1ctd_RIR_1	281	289	PF16727	0.346
LIG_SH2_CRK	377	381	PF00017	0.436
LIG_SH2_CRK	395	399	PF00017	0.467
LIG_SH2_CRK	420	424	PF00017	0.453
LIG_SH2_STAP1	223	227	PF00017	0.473
LIG_SH2_STAP1	280	284	PF00017	0.334
LIG_SH2_STAT5	10	13	PF00017	0.592
LIG_SH2_STAT5	223	226	PF00017	0.517
LIG_SH2_STAT5	238	241	PF00017	0.479
LIG_SH2_STAT5	244	247	PF00017	0.294
LIG_SH2_STAT5	46	49	PF00017	0.539
LIG_SH2_STAT5	60	63	PF00017	0.461
LIG_SH2_STAT5	94	97	PF00017	0.550
LIG_SH3_3	231	237	PF00018	0.490
LIG_SH3_3	367	373	PF00018	0.607
LIG_SH3_3	9	15	PF00018	0.545
LIG_TYR_ITIM	44	49	PF00017	0.617
LIG_WRC_WIRS_1	180	185	PF05994	0.574
LIG_WRC_WIRS_1	362	367	PF05994	0.568
MOD_CDK_SPK_2	11	16	PF00069	0.522
MOD_CDK_SPxK_1	48	54	PF00069	0.493
MOD_CK1_1	156	162	PF00069	0.501
MOD_CK1_1	186	192	PF00069	0.524
MOD_CK1_1	353	359	PF00069	0.730
MOD_CK1_1	360	366	PF00069	0.723
MOD_CK1_1	77	83	PF00069	0.602
MOD_CK1_1	87	93	PF00069	0.608
MOD_CK1_1	98	104	PF00069	0.532
MOD_CK2_1	101	107	PF00069	0.566
MOD_CK2_1	384	390	PF00069	0.435
MOD_Cter_Amidation	35	38	PF01082	0.425
MOD_GlcNHglycan	185	188	PF01048	0.354
MOD_GlcNHglycan	21	25	PF01048	0.429
MOD_GlcNHglycan	227	230	PF01048	0.276
MOD_GlcNHglycan	352	355	PF01048	0.540
MOD_GlcNHglycan	365	368	PF01048	0.437
MOD_GlcNHglycan	392	395	PF01048	0.266
MOD_GlcNHglycan	62	65	PF01048	0.312
MOD_GlcNHglycan	81	84	PF01048	0.474
MOD_GlcNHglycan	85	89	PF01048	0.453
MOD_GSK3_1	175	182	PF00069	0.564
MOD_GSK3_1	221	228	PF00069	0.498
MOD_GSK3_1	246	253	PF00069	0.372
MOD_GSK3_1	330	337	PF00069	0.622
MOD_GSK3_1	350	357	PF00069	0.755
MOD_GSK3_1	74	81	PF00069	0.551
MOD_GSK3_1	84	91	PF00069	0.586
MOD_GSK3_1	94	101	PF00069	0.553
MOD_N-GLC_1	108	113	PF02516	0.292
MOD_N-GLC_1	318	323	PF02516	0.518
MOD_N-GLC_1	72	77	PF02516	0.415
MOD_N-GLC_1	78	83	PF02516	0.498
MOD_NEK2_1	133	138	PF00069	0.580
MOD_NEK2_1	153	158	PF00069	0.498
MOD_NEK2_1	179	184	PF00069	0.551
MOD_NEK2_1	2	7	PF00069	0.598
MOD_NEK2_1	225	230	PF00069	0.481
MOD_NEK2_1	239	244	PF00069	0.487
MOD_NEK2_1	269	274	PF00069	0.428
MOD_NEK2_1	355	360	PF00069	0.557
MOD_NEK2_1	8	13	PF00069	0.536
MOD_PIKK_1	108	114	PF00454	0.485
MOD_PIKK_1	319	325	PF00454	0.640
MOD_PKA_1	343	349	PF00069	0.728
MOD_PKA_2	221	227	PF00069	0.566
MOD_PKA_2	246	252	PF00069	0.336
MOD_PKA_2	329	335	PF00069	0.610
MOD_PKA_2	343	349	PF00069	0.737
MOD_PKA_2	88	94	PF00069	0.640
MOD_Plk_1	108	114	PF00069	0.486
MOD_Plk_1	384	390	PF00069	0.509
MOD_Plk_1	72	78	PF00069	0.611
MOD_Plk_2-3	188	194	PF00069	0.589
MOD_Plk_4	101	107	PF00069	0.525
MOD_Plk_4	156	162	PF00069	0.553
MOD_Plk_4	204	210	PF00069	0.554
MOD_Plk_4	221	227	PF00069	0.394
MOD_Plk_4	239	245	PF00069	0.541
MOD_Plk_4	275	281	PF00069	0.348
MOD_Plk_4	330	336	PF00069	0.607
MOD_Plk_4	66	72	PF00069	0.549
MOD_ProDKin_1	11	17	PF00069	0.515
MOD_ProDKin_1	202	208	PF00069	0.519
MOD_ProDKin_1	357	363	PF00069	0.705
MOD_ProDKin_1	48	54	PF00069	0.599
MOD_SUMO_for_1	214	217	PF00179	0.579
MOD_SUMO_rev_2	103	111	PF00179	0.610
MOD_SUMO_rev_2	188	197	PF00179	0.591
MOD_SUMO_rev_2	82	88	PF00179	0.703
TRG_ENDOCYTIC_2	280	283	PF00928	0.308
TRG_ENDOCYTIC_2	289	292	PF00928	0.506
TRG_ENDOCYTIC_2	362	365	PF00928	0.656
TRG_ENDOCYTIC_2	377	380	PF00928	0.448
TRG_ENDOCYTIC_2	395	398	PF00928	0.467
TRG_ENDOCYTIC_2	420	423	PF00928	0.453
TRG_ENDOCYTIC_2	46	49	PF00928	0.572
TRG_ER_diArg_1	28	30	PF00400	0.573
TRG_ER_diArg_1	292	294	PF00400	0.538
TRG_ER_diArg_1	3	6	PF00400	0.685
TRG_ER_diArg_1	303	306	PF00400	0.540
TRG_ER_diArg_1	37	39	PF00400	0.622
TRG_ER_diArg_1	395	397	PF00400	0.493
TRG_NLS_MonoExtN_4	424	431	PF00514	0.549
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	38	43	PF00026	0.282
TRG_Pf-PMV_PEXEL_1	421	425	PF00026	0.233

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6B2	Leptomonas seymouri	71%	100%
A0A0N1IK13	Leptomonas seymouri	23%	83%
A0A0S4IP86	Bodo saltans	45%	99%
A0A0S4ITI3	Bodo saltans	24%	85%
A0A1X0NQB1	Trypanosomatidae	25%	86%
A0A1X0NVK2	Trypanosomatidae	53%	100%
A0A3S7WSV3	Leishmania donovani	26%	100%
A0A422N8L2	Trypanosoma rangeli	52%	100%
A4H7H2	Leishmania braziliensis	24%	83%
A4HDG4	Leishmania braziliensis	88%	99%
A4HVV3	Leishmania infantum	26%	100%
A4I0U5	Leishmania infantum	99%	100%
D0A774	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9APK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AWU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QAM5	Leishmania major	94%	100%
Q4QFX4	Leishmania major	26%	100%
V5BD52	Trypanosoma cruzi	26%	85%
V5DSF1	Trypanosoma cruzi	54%	100%