Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WYG5_LEIDO

TriTrypDb:

LdBPK_241200.1 , LdCL_240017100 , LDHU3_24.1420

Length:

1235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 6
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WYG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYG5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1003	1007	PF00656	0.735
CLV_C14_Caspase3-7	313	317	PF00656	0.708
CLV_NRD_NRD_1	1219	1221	PF00675	0.528
CLV_NRD_NRD_1	229	231	PF00675	0.746
CLV_NRD_NRD_1	311	313	PF00675	0.634
CLV_NRD_NRD_1	404	406	PF00675	0.622
CLV_NRD_NRD_1	432	434	PF00675	0.678
CLV_NRD_NRD_1	496	498	PF00675	0.606
CLV_NRD_NRD_1	531	533	PF00675	0.629
CLV_NRD_NRD_1	638	640	PF00675	0.652
CLV_NRD_NRD_1	651	653	PF00675	0.681
CLV_NRD_NRD_1	924	926	PF00675	0.486
CLV_PCSK_FUR_1	348	352	PF00082	0.425
CLV_PCSK_KEX2_1	1209	1211	PF00082	0.580
CLV_PCSK_KEX2_1	311	313	PF00082	0.621
CLV_PCSK_KEX2_1	350	352	PF00082	0.466
CLV_PCSK_KEX2_1	404	406	PF00082	0.622
CLV_PCSK_KEX2_1	432	434	PF00082	0.678
CLV_PCSK_KEX2_1	495	497	PF00082	0.613
CLV_PCSK_KEX2_1	531	533	PF00082	0.629
CLV_PCSK_KEX2_1	638	640	PF00082	0.652
CLV_PCSK_KEX2_1	650	652	PF00082	0.679
CLV_PCSK_KEX2_1	734	736	PF00082	0.649
CLV_PCSK_KEX2_1	924	926	PF00082	0.486
CLV_PCSK_PC1ET2_1	1209	1211	PF00082	0.597
CLV_PCSK_PC1ET2_1	350	352	PF00082	0.466
CLV_PCSK_PC1ET2_1	650	652	PF00082	0.639
CLV_PCSK_PC1ET2_1	734	736	PF00082	0.550
CLV_PCSK_SKI1_1	1044	1048	PF00082	0.625
CLV_PCSK_SKI1_1	222	226	PF00082	0.559
CLV_PCSK_SKI1_1	322	326	PF00082	0.772
CLV_PCSK_SKI1_1	370	374	PF00082	0.681
CLV_PCSK_SKI1_1	405	409	PF00082	0.663
CLV_PCSK_SKI1_1	459	463	PF00082	0.605
CLV_PCSK_SKI1_1	499	503	PF00082	0.536
CLV_PCSK_SKI1_1	534	538	PF00082	0.583
CLV_PCSK_SKI1_1	768	772	PF00082	0.723
CLV_PCSK_SKI1_1	784	788	PF00082	0.501
DEG_APCC_DBOX_1	767	775	PF00400	0.720
DEG_SPOP_SBC_1	592	596	PF00917	0.579
DEG_SPOP_SBC_1	777	781	PF00917	0.704
DOC_ANK_TNKS_1	860	867	PF00023	0.561
DOC_CKS1_1	829	834	PF01111	0.574
DOC_CYCLIN_RxL_1	456	465	PF00134	0.493
DOC_MAPK_gen_1	138	147	PF00069	0.754
DOC_MAPK_gen_1	531	537	PF00069	0.595
DOC_MAPK_gen_1	638	646	PF00069	0.576
DOC_MAPK_HePTP_8	636	648	PF00069	0.637
DOC_MAPK_MEF2A_6	623	631	PF00069	0.596
DOC_MAPK_MEF2A_6	639	648	PF00069	0.580
DOC_MAPK_MEF2A_6	822	829	PF00069	0.608
DOC_PP2B_LxvP_1	205	208	PF13499	0.593
DOC_PP2B_LxvP_1	408	411	PF13499	0.684
DOC_PP2B_LxvP_1	590	593	PF13499	0.566
DOC_PP2B_LxvP_1	698	701	PF13499	0.733
DOC_PP2B_LxvP_1	796	799	PF13499	0.651
DOC_PP4_FxxP_1	320	323	PF00568	0.611
DOC_USP7_MATH_1	1081	1085	PF00917	0.713
DOC_USP7_MATH_1	129	133	PF00917	0.731
DOC_USP7_MATH_1	159	163	PF00917	0.775
DOC_USP7_MATH_1	216	220	PF00917	0.691
DOC_USP7_MATH_1	310	314	PF00917	0.719
DOC_USP7_MATH_1	413	417	PF00917	0.494
DOC_USP7_MATH_1	436	440	PF00917	0.694
DOC_USP7_MATH_1	593	597	PF00917	0.641
DOC_USP7_MATH_1	600	604	PF00917	0.627
DOC_USP7_MATH_1	655	659	PF00917	0.696
DOC_USP7_MATH_1	776	780	PF00917	0.696
DOC_USP7_MATH_1	786	790	PF00917	0.622
DOC_USP7_MATH_1	990	994	PF00917	0.803
DOC_USP7_UBL2_3	346	350	PF12436	0.641
DOC_WW_Pin1_4	1077	1082	PF00397	0.804
DOC_WW_Pin1_4	1101	1106	PF00397	0.772
DOC_WW_Pin1_4	125	130	PF00397	0.765
DOC_WW_Pin1_4	214	219	PF00397	0.737
DOC_WW_Pin1_4	44	49	PF00397	0.517
DOC_WW_Pin1_4	756	761	PF00397	0.685
DOC_WW_Pin1_4	828	833	PF00397	0.573
DOC_WW_Pin1_4	951	956	PF00397	0.611
LIG_14-3-3_CanoR_1	1055	1065	PF00244	0.732
LIG_14-3-3_CanoR_1	1118	1124	PF00244	0.681
LIG_14-3-3_CanoR_1	370	379	PF00244	0.681
LIG_14-3-3_CanoR_1	499	505	PF00244	0.589
LIG_14-3-3_CanoR_1	623	627	PF00244	0.676
LIG_14-3-3_CanoR_1	735	740	PF00244	0.638
LIG_14-3-3_CanoR_1	746	754	PF00244	0.560
LIG_14-3-3_CanoR_1	79	84	PF00244	0.749
LIG_BIR_III_4	1004	1008	PF00653	0.672
LIG_BIR_III_4	616	620	PF00653	0.730
LIG_CSL_BTD_1	590	593	PF09270	0.513
LIG_CtBP_PxDLS_1	1010	1014	PF00389	0.606
LIG_CtBP_PxDLS_1	302	306	PF00389	0.802
LIG_deltaCOP1_diTrp_1	347	352	PF00928	0.639
LIG_deltaCOP1_diTrp_1	475	483	PF00928	0.655
LIG_eIF4E_1	1008	1014	PF01652	0.611
LIG_FHA_1	1038	1044	PF00498	0.726
LIG_FHA_1	1125	1131	PF00498	0.679
LIG_FHA_1	1167	1173	PF00498	0.789
LIG_FHA_1	194	200	PF00498	0.661
LIG_FHA_1	223	229	PF00498	0.728
LIG_FHA_1	338	344	PF00498	0.676
LIG_FHA_1	35	41	PF00498	0.534
LIG_FHA_1	500	506	PF00498	0.637
LIG_FHA_1	51	57	PF00498	0.621
LIG_FHA_1	728	734	PF00498	0.598
LIG_FHA_2	1089	1095	PF00498	0.621
LIG_FHA_2	288	294	PF00498	0.732
LIG_FHA_2	332	338	PF00498	0.680
LIG_FHA_2	659	665	PF00498	0.616
LIG_FHA_2	757	763	PF00498	0.616
LIG_GBD_Chelix_1	1227	1235	PF00786	0.495
LIG_GBD_Chelix_1	974	982	PF00786	0.647
LIG_HP1_1	955	959	PF01393	0.574
LIG_LIR_Apic_2	1131	1137	PF02991	0.776
LIG_LIR_Apic_2	318	323	PF02991	0.609
LIG_LIR_Apic_2	66	72	PF02991	0.731
LIG_LIR_Apic_2	848	853	PF02991	0.650
LIG_LIR_Gen_1	142	151	PF02991	0.682
LIG_LIR_Gen_1	355	364	PF02991	0.630
LIG_LIR_Gen_1	416	426	PF02991	0.487
LIG_LIR_Gen_1	661	667	PF02991	0.536
LIG_LIR_Gen_1	791	801	PF02991	0.688
LIG_LIR_Gen_1	872	882	PF02991	0.600
LIG_LIR_Nem_3	1006	1011	PF02991	0.706
LIG_LIR_Nem_3	1029	1035	PF02991	0.625
LIG_LIR_Nem_3	142	147	PF02991	0.679
LIG_LIR_Nem_3	251	255	PF02991	0.682
LIG_LIR_Nem_3	347	352	PF02991	0.637
LIG_LIR_Nem_3	355	361	PF02991	0.598
LIG_LIR_Nem_3	416	422	PF02991	0.481
LIG_LIR_Nem_3	477	483	PF02991	0.620
LIG_LIR_Nem_3	625	629	PF02991	0.542
LIG_LIR_Nem_3	661	666	PF02991	0.545
LIG_LIR_Nem_3	791	796	PF02991	0.676
LIG_LIR_Nem_3	872	877	PF02991	0.575
LIG_LYPXL_yS_3	626	629	PF13949	0.578
LIG_NRBOX	11	17	PF00104	0.555
LIG_NRBOX	717	723	PF00104	0.626
LIG_PCNA_PIPBox_1	561	570	PF02747	0.617
LIG_PCNA_yPIPBox_3	559	568	PF02747	0.690
LIG_PTB_Apo_2	187	194	PF02174	0.544
LIG_PTB_Apo_2	536	543	PF02174	0.530
LIG_PTB_Phospho_1	536	542	PF10480	0.533
LIG_Rb_LxCxE_1	661	679	PF01857	0.549
LIG_REV1ctd_RIR_1	553	563	PF16727	0.678
LIG_SH2_CRK	144	148	PF00017	0.814
LIG_SH2_CRK	252	256	PF00017	0.670
LIG_SH2_CRK	419	423	PF00017	0.629
LIG_SH2_CRK	542	546	PF00017	0.494
LIG_SH2_CRK	850	854	PF00017	0.658
LIG_SH2_GRB2like	833	836	PF00017	0.685
LIG_SH2_NCK_1	358	362	PF00017	0.626
LIG_SH2_NCK_1	850	854	PF00017	0.650
LIG_SH2_PTP2	1008	1011	PF00017	0.697
LIG_SH2_PTP2	874	877	PF00017	0.612
LIG_SH2_SRC	1008	1011	PF00017	0.697
LIG_SH2_SRC	177	180	PF00017	0.731
LIG_SH2_STAP1	358	362	PF00017	0.591
LIG_SH2_STAP1	542	546	PF00017	0.508
LIG_SH2_STAP1	663	667	PF00017	0.562
LIG_SH2_STAT3	567	570	PF00017	0.629
LIG_SH2_STAT5	1008	1011	PF00017	0.697
LIG_SH2_STAT5	1147	1150	PF00017	0.523
LIG_SH2_STAT5	177	180	PF00017	0.716
LIG_SH2_STAT5	192	195	PF00017	0.403
LIG_SH2_STAT5	63	66	PF00017	0.665
LIG_SH2_STAT5	69	72	PF00017	0.664
LIG_SH2_STAT5	793	796	PF00017	0.675
LIG_SH2_STAT5	833	836	PF00017	0.632
LIG_SH2_STAT5	874	877	PF00017	0.612
LIG_SH2_STAT5	960	963	PF00017	0.566
LIG_SH3_3	166	172	PF00018	0.767
LIG_SH3_3	201	207	PF00018	0.663
LIG_SH3_3	502	508	PF00018	0.651
LIG_SH3_3	542	548	PF00018	0.516
LIG_SH3_3	580	586	PF00018	0.591
LIG_SH3_3	672	678	PF00018	0.557
LIG_SH3_3	826	832	PF00018	0.524
LIG_SH3_3	896	902	PF00018	0.674
LIG_SUMO_SIM_anti_2	194	201	PF11976	0.622
LIG_SUMO_SIM_anti_2	533	539	PF11976	0.553
LIG_SUMO_SIM_anti_2	643	649	PF11976	0.561
LIG_SUMO_SIM_anti_2	953	960	PF11976	0.590
LIG_SUMO_SIM_par_1	1126	1131	PF11976	0.628
LIG_SUMO_SIM_par_1	14	20	PF11976	0.462
LIG_SUMO_SIM_par_1	194	201	PF11976	0.619
LIG_SUMO_SIM_par_1	52	57	PF11976	0.661
LIG_SUMO_SIM_par_1	63	68	PF11976	0.621
LIG_SUMO_SIM_par_1	643	649	PF11976	0.510
LIG_TRAF2_1	1074	1077	PF00917	0.789
LIG_TRAF2_1	760	763	PF00917	0.564
LIG_TRAF2_1	882	885	PF00917	0.575
LIG_UBA3_1	1201	1209	PF00899	0.502
LIG_UBA3_1	342	350	PF00899	0.679
MOD_CDK_SPK_2	1077	1082	PF00069	0.686
MOD_CK1_1	234	240	PF00069	0.727
MOD_CK1_1	378	384	PF00069	0.782
MOD_CK1_1	399	405	PF00069	0.647
MOD_CK1_1	47	53	PF00069	0.482
MOD_CK1_1	503	509	PF00069	0.667
MOD_CK1_1	595	601	PF00069	0.676
MOD_CK1_1	658	664	PF00069	0.637
MOD_CK1_1	738	744	PF00069	0.628
MOD_CK1_1	780	786	PF00069	0.784
MOD_CK1_1	911	917	PF00069	0.696
MOD_CK2_1	121	127	PF00069	0.718
MOD_CK2_1	600	606	PF00069	0.572
MOD_CK2_1	658	664	PF00069	0.618
MOD_CK2_1	756	762	PF00069	0.613
MOD_CK2_1	900	906	PF00069	0.733
MOD_CK2_1	990	996	PF00069	0.691
MOD_Cter_Amidation	402	405	PF01082	0.648
MOD_GlcNHglycan	1000	1003	PF01048	0.761
MOD_GlcNHglycan	1119	1122	PF01048	0.738
MOD_GlcNHglycan	1183	1187	PF01048	0.802
MOD_GlcNHglycan	123	126	PF01048	0.793
MOD_GlcNHglycan	131	134	PF01048	0.724
MOD_GlcNHglycan	183	186	PF01048	0.584
MOD_GlcNHglycan	233	236	PF01048	0.727
MOD_GlcNHglycan	238	241	PF01048	0.765
MOD_GlcNHglycan	274	277	PF01048	0.626
MOD_GlcNHglycan	380	383	PF01048	0.779
MOD_GlcNHglycan	388	391	PF01048	0.704
MOD_GlcNHglycan	398	401	PF01048	0.402
MOD_GlcNHglycan	438	441	PF01048	0.726
MOD_GlcNHglycan	464	467	PF01048	0.683
MOD_GlcNHglycan	595	598	PF01048	0.671
MOD_GlcNHglycan	657	660	PF01048	0.666
MOD_GlcNHglycan	784	787	PF01048	0.727
MOD_GlcNHglycan	788	791	PF01048	0.650
MOD_GlcNHglycan	811	815	PF01048	0.812
MOD_GlcNHglycan	857	860	PF01048	0.740
MOD_GlcNHglycan	908	911	PF01048	0.787
MOD_GSK3_1	1077	1084	PF00069	0.734
MOD_GSK3_1	1113	1120	PF00069	0.765
MOD_GSK3_1	112	119	PF00069	0.663
MOD_GSK3_1	1126	1133	PF00069	0.633
MOD_GSK3_1	121	128	PF00069	0.676
MOD_GSK3_1	129	136	PF00069	0.525
MOD_GSK3_1	191	198	PF00069	0.546
MOD_GSK3_1	30	37	PF00069	0.532
MOD_GSK3_1	40	47	PF00069	0.480
MOD_GSK3_1	436	443	PF00069	0.746
MOD_GSK3_1	499	506	PF00069	0.646
MOD_GSK3_1	50	57	PF00069	0.659
MOD_GSK3_1	591	598	PF00069	0.596
MOD_GSK3_1	600	607	PF00069	0.690
MOD_GSK3_1	776	783	PF00069	0.660
MOD_GSK3_1	906	913	PF00069	0.681
MOD_GSK3_1	914	921	PF00069	0.634
MOD_GSK3_1	941	948	PF00069	0.705
MOD_N-GLC_1	604	609	PF02516	0.715
MOD_N-GLC_1	996	1001	PF02516	0.732
MOD_N-GLC_2	749	751	PF02516	0.555
MOD_N-GLC_2	936	938	PF02516	0.499
MOD_NEK2_1	1037	1042	PF00069	0.615
MOD_NEK2_1	17	22	PF00069	0.497
MOD_NEK2_1	193	198	PF00069	0.506
MOD_NEK2_1	362	367	PF00069	0.723
MOD_NEK2_1	375	380	PF00069	0.567
MOD_NEK2_1	386	391	PF00069	0.515
MOD_NEK2_1	412	417	PF00069	0.629
MOD_NEK2_1	422	427	PF00069	0.452
MOD_NEK2_1	500	505	PF00069	0.603
MOD_NEK2_1	550	555	PF00069	0.578
MOD_NEK2_1	65	70	PF00069	0.657
MOD_NEK2_1	691	696	PF00069	0.787
MOD_NEK2_2	133	138	PF00069	0.576
MOD_PIKK_1	258	264	PF00454	0.652
MOD_PIKK_1	452	458	PF00454	0.743
MOD_PIKK_1	706	712	PF00454	0.705
MOD_PIKK_1	852	858	PF00454	0.694
MOD_PIKK_1	941	947	PF00454	0.675
MOD_PK_1	35	41	PF00069	0.497
MOD_PK_1	684	690	PF00069	0.642
MOD_PKA_2	1054	1060	PF00069	0.794
MOD_PKA_2	1063	1069	PF00069	0.672
MOD_PKA_2	1081	1087	PF00069	0.512
MOD_PKA_2	1117	1123	PF00069	0.731
MOD_PKA_2	1124	1130	PF00069	0.709
MOD_PKA_2	145	151	PF00069	0.664
MOD_PKA_2	310	316	PF00069	0.716
MOD_PKA_2	530	536	PF00069	0.613
MOD_PKA_2	622	628	PF00069	0.672
MOD_PKA_2	745	751	PF00069	0.570
MOD_PKA_2	983	989	PF00069	0.726
MOD_PKB_1	497	505	PF00069	0.636
MOD_Plk_1	1130	1136	PF00069	0.782
MOD_Plk_1	325	331	PF00069	0.790
MOD_Plk_1	65	71	PF00069	0.658
MOD_Plk_1	691	697	PF00069	0.656
MOD_Plk_2-3	1126	1132	PF00069	0.628
MOD_Plk_4	1130	1136	PF00069	0.712
MOD_Plk_4	160	166	PF00069	0.688
MOD_Plk_4	195	201	PF00069	0.674
MOD_Plk_4	338	344	PF00069	0.676
MOD_Plk_4	35	41	PF00069	0.532
MOD_Plk_4	422	428	PF00069	0.588
MOD_Plk_4	50	56	PF00069	0.576
MOD_Plk_4	500	506	PF00069	0.615
MOD_Plk_4	65	71	PF00069	0.648
MOD_Plk_4	845	851	PF00069	0.614
MOD_Plk_4	914	920	PF00069	0.635
MOD_ProDKin_1	1077	1083	PF00069	0.803
MOD_ProDKin_1	1101	1107	PF00069	0.769
MOD_ProDKin_1	125	131	PF00069	0.767
MOD_ProDKin_1	214	220	PF00069	0.732
MOD_ProDKin_1	44	50	PF00069	0.515
MOD_ProDKin_1	756	762	PF00069	0.686
MOD_ProDKin_1	828	834	PF00069	0.573
MOD_ProDKin_1	951	957	PF00069	0.601
MOD_SUMO_rev_2	516	525	PF00179	0.633
TRG_DiLeu_BaEn_1	662	667	PF01217	0.462
TRG_ENDOCYTIC_2	1008	1011	PF00928	0.697
TRG_ENDOCYTIC_2	1032	1035	PF00928	0.660
TRG_ENDOCYTIC_2	144	147	PF00928	0.690
TRG_ENDOCYTIC_2	252	255	PF00928	0.615
TRG_ENDOCYTIC_2	358	361	PF00928	0.641
TRG_ENDOCYTIC_2	419	422	PF00928	0.633
TRG_ENDOCYTIC_2	542	545	PF00928	0.497
TRG_ENDOCYTIC_2	626	629	PF00928	0.578
TRG_ENDOCYTIC_2	663	666	PF00928	0.535
TRG_ENDOCYTIC_2	793	796	PF00928	0.675
TRG_ENDOCYTIC_2	874	877	PF00928	0.612
TRG_ER_diArg_1	311	314	PF00400	0.629
TRG_ER_diArg_1	431	433	PF00400	0.707
TRG_ER_diArg_1	494	497	PF00400	0.615
TRG_ER_diArg_1	531	534	PF00400	0.671
TRG_ER_diArg_1	924	927	PF00400	0.485
TRG_NLS_Bipartite_1	638	654	PF00514	0.552
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.678
TRG_Pf-PMV_PEXEL_1	405	409	PF00026	0.663
TRG_Pf-PMV_PEXEL_1	79	83	PF00026	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I480	Leptomonas seymouri	36%	100%
A0A422NQA5	Trypanosoma rangeli	25%	100%
A4HDH4	Leishmania braziliensis	68%	99%
A4I0V5	Leishmania infantum	99%	100%
E9AWV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QAL5	Leishmania major	88%	100%