Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WYF8_LEIDO

TriTrypDb:

LdBPK_241540.1 , LdCL_240020600 , LDHU3_24.1880

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WYF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYF8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	25	29	PF00656	0.560
CLV_NRD_NRD_1	272	274	PF00675	0.637
CLV_NRD_NRD_1	36	38	PF00675	0.638
CLV_NRD_NRD_1	366	368	PF00675	0.598
CLV_NRD_NRD_1	528	530	PF00675	0.408
CLV_NRD_NRD_1	575	577	PF00675	0.619
CLV_NRD_NRD_1	606	608	PF00675	0.592
CLV_NRD_NRD_1	78	80	PF00675	0.819
CLV_PCSK_KEX2_1	272	274	PF00082	0.637
CLV_PCSK_KEX2_1	36	38	PF00082	0.638
CLV_PCSK_KEX2_1	366	368	PF00082	0.598
CLV_PCSK_KEX2_1	577	579	PF00082	0.538
CLV_PCSK_KEX2_1	606	608	PF00082	0.592
CLV_PCSK_KEX2_1	65	67	PF00082	0.835
CLV_PCSK_KEX2_1	78	80	PF00082	0.669
CLV_PCSK_PC1ET2_1	577	579	PF00082	0.538
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.796
CLV_PCSK_SKI1_1	273	277	PF00082	0.679
CLV_PCSK_SKI1_1	278	282	PF00082	0.658
CLV_PCSK_SKI1_1	319	323	PF00082	0.717
CLV_PCSK_SKI1_1	546	550	PF00082	0.558
CLV_PCSK_SKI1_1	79	83	PF00082	0.756
CLV_Separin_Metazoa	163	167	PF03568	0.415
DEG_APCC_DBOX_1	165	173	PF00400	0.431
DEG_APCC_DBOX_1	78	86	PF00400	0.552
DEG_SPOP_SBC_1	326	330	PF00917	0.528
DOC_ANK_TNKS_1	23	30	PF00023	0.476
DOC_CKS1_1	230	235	PF01111	0.497
DOC_CKS1_1	406	411	PF01111	0.417
DOC_CYCLIN_yCln2_LP_2	165	171	PF00134	0.428
DOC_CYCLIN_yCln2_LP_2	505	511	PF00134	0.411
DOC_MAPK_DCC_7	442	452	PF00069	0.432
DOC_MAPK_gen_1	422	430	PF00069	0.370
DOC_MAPK_gen_1	78	85	PF00069	0.582
DOC_MAPK_MEF2A_6	78	85	PF00069	0.582
DOC_PP2B_LxvP_1	200	203	PF13499	0.640
DOC_PP2B_LxvP_1	280	283	PF13499	0.437
DOC_PP4_FxxP_1	108	111	PF00568	0.578
DOC_PP4_FxxP_1	406	409	PF00568	0.400
DOC_USP7_MATH_1	204	208	PF00917	0.622
DOC_USP7_MATH_1	220	224	PF00917	0.346
DOC_USP7_MATH_1	304	308	PF00917	0.568
DOC_USP7_MATH_1	326	330	PF00917	0.499
DOC_USP7_MATH_1	343	347	PF00917	0.608
DOC_USP7_MATH_1	351	355	PF00917	0.518
DOC_USP7_MATH_1	418	422	PF00917	0.462
DOC_USP7_MATH_1	474	478	PF00917	0.533
DOC_WW_Pin1_4	113	118	PF00397	0.634
DOC_WW_Pin1_4	119	124	PF00397	0.569
DOC_WW_Pin1_4	129	134	PF00397	0.552
DOC_WW_Pin1_4	174	179	PF00397	0.451
DOC_WW_Pin1_4	198	203	PF00397	0.538
DOC_WW_Pin1_4	229	234	PF00397	0.484
DOC_WW_Pin1_4	248	253	PF00397	0.233
DOC_WW_Pin1_4	278	283	PF00397	0.515
DOC_WW_Pin1_4	307	312	PF00397	0.535
DOC_WW_Pin1_4	352	357	PF00397	0.556
DOC_WW_Pin1_4	374	379	PF00397	0.411
DOC_WW_Pin1_4	405	410	PF00397	0.407
DOC_WW_Pin1_4	567	572	PF00397	0.679
LIG_14-3-3_CanoR_1	136	143	PF00244	0.544
LIG_14-3-3_CanoR_1	183	187	PF00244	0.484
LIG_14-3-3_CanoR_1	272	280	PF00244	0.509
LIG_14-3-3_CanoR_1	309	315	PF00244	0.625
LIG_14-3-3_CanoR_1	36	42	PF00244	0.549
LIG_Actin_WH2_2	256	274	PF00022	0.440
LIG_BIR_II_1	1	5	PF00653	0.524
LIG_EVH1_1	169	173	PF00568	0.478
LIG_EVH1_2	212	216	PF00568	0.471
LIG_FHA_1	284	290	PF00498	0.501
LIG_FHA_1	331	337	PF00498	0.606
LIG_FHA_1	398	404	PF00498	0.384
LIG_FHA_1	591	597	PF00498	0.733
LIG_FHA_2	126	132	PF00498	0.575
LIG_FHA_2	157	163	PF00498	0.395
LIG_FHA_2	230	236	PF00498	0.502
LIG_FHA_2	279	285	PF00498	0.471
LIG_LIR_Apic_2	228	233	PF02991	0.408
LIG_LIR_Apic_2	7	13	PF02991	0.471
LIG_LIR_Gen_1	157	165	PF02991	0.408
LIG_LIR_Gen_1	384	395	PF02991	0.390
LIG_LIR_Nem_3	157	161	PF02991	0.408
LIG_LIR_Nem_3	357	362	PF02991	0.502
LIG_LIR_Nem_3	384	390	PF02991	0.383
LIG_LIR_Nem_3	501	505	PF02991	0.326
LIG_PDZ_Class_1	611	616	PF00595	0.735
LIG_SH2_CRK	10	14	PF00017	0.479
LIG_SH2_CRK	230	234	PF00017	0.415
LIG_SH2_CRK	245	249	PF00017	0.382
LIG_SH2_CRK	412	416	PF00017	0.436
LIG_SH2_NCK_1	10	14	PF00017	0.577
LIG_SH2_NCK_1	152	156	PF00017	0.332
LIG_SH2_PTP2	502	505	PF00017	0.411
LIG_SH2_SRC	361	364	PF00017	0.480
LIG_SH2_STAP1	152	156	PF00017	0.485
LIG_SH2_STAT5	158	161	PF00017	0.420
LIG_SH2_STAT5	3	6	PF00017	0.506
LIG_SH2_STAT5	361	364	PF00017	0.473
LIG_SH2_STAT5	372	375	PF00017	0.323
LIG_SH2_STAT5	402	405	PF00017	0.375
LIG_SH2_STAT5	423	426	PF00017	0.388
LIG_SH2_STAT5	497	500	PF00017	0.332
LIG_SH2_STAT5	502	505	PF00017	0.350
LIG_SH3_1	412	418	PF00018	0.447
LIG_SH3_3	120	126	PF00018	0.558
LIG_SH3_3	165	171	PF00018	0.428
LIG_SH3_3	200	206	PF00018	0.545
LIG_SH3_3	207	213	PF00018	0.514
LIG_SH3_3	246	252	PF00018	0.383
LIG_SH3_3	342	348	PF00018	0.620
LIG_SH3_3	412	418	PF00018	0.447
LIG_SH3_3	431	437	PF00018	0.215
LIG_SH3_3	443	449	PF00018	0.417
LIG_SH3_3	488	494	PF00018	0.505
LIG_SH3_3	93	99	PF00018	0.550
LIG_SH3_CIN85_PxpxPR_1	571	576	PF14604	0.687
LIG_SUMO_SIM_par_1	426	431	PF11976	0.370
LIG_SUMO_SIM_par_1	80	86	PF11976	0.481
LIG_TRAF2_1	560	563	PF00917	0.778
LIG_TYR_ITIM	500	505	PF00017	0.346
MOD_CDC14_SPxK_1	574	577	PF00782	0.797
MOD_CDK_SPK_2	113	118	PF00069	0.629
MOD_CDK_SPK_2	571	576	PF00069	0.756
MOD_CDK_SPxK_1	571	577	PF00069	0.787
MOD_CDK_SPxxK_3	129	136	PF00069	0.579
MOD_CDK_SPxxK_3	569	576	PF00069	0.770
MOD_CK1_1	190	196	PF00069	0.523
MOD_CK1_1	228	234	PF00069	0.487
MOD_CK1_1	298	304	PF00069	0.565
MOD_CK1_1	307	313	PF00069	0.526
MOD_CK1_1	315	321	PF00069	0.468
MOD_CK1_1	327	333	PF00069	0.530
MOD_CK1_1	354	360	PF00069	0.558
MOD_CK1_1	397	403	PF00069	0.446
MOD_CK1_1	475	481	PF00069	0.517
MOD_CK1_1	567	573	PF00069	0.764
MOD_CK1_1	599	605	PF00069	0.702
MOD_CK1_1	60	66	PF00069	0.594
MOD_CK1_1	71	77	PF00069	0.613
MOD_CK2_1	125	131	PF00069	0.662
MOD_CK2_1	147	153	PF00069	0.382
MOD_CK2_1	156	162	PF00069	0.370
MOD_CK2_1	229	235	PF00069	0.493
MOD_CK2_1	278	284	PF00069	0.521
MOD_GlcNHglycan	138	141	PF01048	0.814
MOD_GlcNHglycan	207	210	PF01048	0.714
MOD_GlcNHglycan	273	276	PF01048	0.710
MOD_GlcNHglycan	314	317	PF01048	0.715
MOD_GlcNHglycan	341	344	PF01048	0.802
MOD_GlcNHglycan	345	348	PF01048	0.785
MOD_GlcNHglycan	430	433	PF01048	0.571
MOD_GlcNHglycan	474	477	PF01048	0.798
MOD_GlcNHglycan	480	483	PF01048	0.741
MOD_GlcNHglycan	521	524	PF01048	0.410
MOD_GlcNHglycan	546	549	PF01048	0.509
MOD_GlcNHglycan	60	63	PF01048	0.799
MOD_GlcNHglycan	70	73	PF01048	0.729
MOD_GlcNHglycan	74	77	PF01048	0.706
MOD_GlcNHglycan	87	90	PF01048	0.766
MOD_GSK3_1	125	132	PF00069	0.617
MOD_GSK3_1	182	189	PF00069	0.526
MOD_GSK3_1	192	199	PF00069	0.522
MOD_GSK3_1	225	232	PF00069	0.473
MOD_GSK3_1	294	301	PF00069	0.572
MOD_GSK3_1	325	332	PF00069	0.577
MOD_GSK3_1	339	346	PF00069	0.616
MOD_GSK3_1	347	354	PF00069	0.523
MOD_GSK3_1	468	475	PF00069	0.489
MOD_GSK3_1	546	553	PF00069	0.745
MOD_GSK3_1	563	570	PF00069	0.749
MOD_GSK3_1	596	603	PF00069	0.748
MOD_GSK3_1	68	75	PF00069	0.588
MOD_GSK3_1	81	88	PF00069	0.485
MOD_N-GLC_1	129	134	PF02516	0.805
MOD_N-GLC_1	186	191	PF02516	0.667
MOD_NEK2_1	271	276	PF00069	0.433
MOD_NEK2_1	295	300	PF00069	0.496
MOD_NEK2_1	4	9	PF00069	0.618
MOD_NEK2_1	519	524	PF00069	0.604
MOD_NEK2_1	564	569	PF00069	0.737
MOD_NEK2_1	596	601	PF00069	0.727
MOD_NEK2_1	83	88	PF00069	0.489
MOD_NEK2_2	539	544	PF00069	0.738
MOD_PIKK_1	304	310	PF00454	0.565
MOD_PIKK_1	456	462	PF00454	0.373
MOD_PIKK_1	533	539	PF00454	0.694
MOD_PIKK_1	581	587	PF00454	0.802
MOD_PKA_1	472	478	PF00069	0.551
MOD_PKA_1	576	582	PF00069	0.833
MOD_PKA_2	182	188	PF00069	0.550
MOD_PKA_2	271	277	PF00069	0.503
MOD_PKA_2	293	299	PF00069	0.566
MOD_PKA_2	324	330	PF00069	0.578
MOD_PKA_2	50	56	PF00069	0.552
MOD_PKA_2	68	74	PF00069	0.489
MOD_PKB_1	264	272	PF00069	0.495
MOD_PKB_1	323	331	PF00069	0.608
MOD_PKB_1	544	552	PF00069	0.751
MOD_Plk_1	147	153	PF00069	0.451
MOD_Plk_1	397	403	PF00069	0.394
MOD_Plk_2-3	394	400	PF00069	0.328
MOD_Plk_4	147	153	PF00069	0.451
MOD_Plk_4	37	43	PF00069	0.479
MOD_Plk_4	600	606	PF00069	0.656
MOD_ProDKin_1	113	119	PF00069	0.634
MOD_ProDKin_1	129	135	PF00069	0.588
MOD_ProDKin_1	174	180	PF00069	0.457
MOD_ProDKin_1	198	204	PF00069	0.538
MOD_ProDKin_1	229	235	PF00069	0.493
MOD_ProDKin_1	248	254	PF00069	0.236
MOD_ProDKin_1	278	284	PF00069	0.521
MOD_ProDKin_1	307	313	PF00069	0.536
MOD_ProDKin_1	352	358	PF00069	0.551
MOD_ProDKin_1	374	380	PF00069	0.417
MOD_ProDKin_1	405	411	PF00069	0.412
MOD_ProDKin_1	567	573	PF00069	0.685
TRG_DiLeu_BaEn_1	501	506	PF01217	0.346
TRG_DiLeu_BaEn_1	97	102	PF01217	0.521
TRG_ENDOCYTIC_2	158	161	PF00928	0.476
TRG_ENDOCYTIC_2	245	248	PF00928	0.380
TRG_ENDOCYTIC_2	497	500	PF00928	0.372
TRG_ENDOCYTIC_2	502	505	PF00928	0.411
TRG_ER_diArg_1	263	266	PF00400	0.455
TRG_ER_diArg_1	271	273	PF00400	0.400
TRG_ER_diArg_1	322	325	PF00400	0.587
TRG_ER_diArg_1	35	37	PF00400	0.465
TRG_ER_diArg_1	366	368	PF00400	0.398
TRG_ER_diArg_1	543	546	PF00400	0.787
TRG_ER_diArg_1	575	578	PF00400	0.707
TRG_ER_diArg_1	605	607	PF00400	0.799
TRG_NLS_MonoExtN_4	573	580	PF00514	0.702

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM15	Leptomonas seymouri	52%	96%
A4HDJ2	Leishmania braziliensis	70%	100%
A4I0Y6	Leishmania infantum	98%	100%
E9AWZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
Q4QAI3	Leishmania major	88%	100%