Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WYF6_LEIDO

TriTrypDb:

LdBPK_241620.1 , LdCL_240021300 , LDHU3_24.1960

Length:

953

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WYF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYF6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	306	310	PF00656	0.648
CLV_NRD_NRD_1	131	133	PF00675	0.699
CLV_NRD_NRD_1	201	203	PF00675	0.595
CLV_NRD_NRD_1	411	413	PF00675	0.648
CLV_NRD_NRD_1	561	563	PF00675	0.613
CLV_NRD_NRD_1	638	640	PF00675	0.628
CLV_NRD_NRD_1	718	720	PF00675	0.557
CLV_NRD_NRD_1	73	75	PF00675	0.538
CLV_NRD_NRD_1	763	765	PF00675	0.709
CLV_NRD_NRD_1	785	787	PF00675	0.579
CLV_NRD_NRD_1	875	877	PF00675	0.728
CLV_NRD_NRD_1	96	98	PF00675	0.515
CLV_PCSK_FUR_1	409	413	PF00082	0.544
CLV_PCSK_KEX2_1	131	133	PF00082	0.699
CLV_PCSK_KEX2_1	201	203	PF00082	0.595
CLV_PCSK_KEX2_1	411	413	PF00082	0.545
CLV_PCSK_KEX2_1	560	562	PF00082	0.619
CLV_PCSK_KEX2_1	638	640	PF00082	0.628
CLV_PCSK_KEX2_1	718	720	PF00082	0.557
CLV_PCSK_KEX2_1	73	75	PF00082	0.538
CLV_PCSK_KEX2_1	763	765	PF00082	0.700
CLV_PCSK_KEX2_1	785	787	PF00082	0.670
CLV_PCSK_KEX2_1	875	877	PF00082	0.611
CLV_PCSK_KEX2_1	95	97	PF00082	0.523
CLV_PCSK_SKI1_1	160	164	PF00082	0.606
CLV_PCSK_SKI1_1	185	189	PF00082	0.714
CLV_PCSK_SKI1_1	572	576	PF00082	0.502
CLV_PCSK_SKI1_1	620	624	PF00082	0.600
CLV_PCSK_SKI1_1	63	67	PF00082	0.542
CLV_PCSK_SKI1_1	686	690	PF00082	0.546
CLV_PCSK_SKI1_1	934	938	PF00082	0.524
CLV_Separin_Metazoa	602	606	PF03568	0.505
DEG_APCC_DBOX_1	184	192	PF00400	0.686
DEG_APCC_DBOX_1	525	533	PF00400	0.566
DEG_APCC_DBOX_1	933	941	PF00400	0.633
DEG_Nend_Nbox_1	1	3	PF02207	0.534
DEG_SCF_FBW7_1	288	294	PF00400	0.714
DOC_ANK_TNKS_1	111	118	PF00023	0.588
DOC_CDC14_PxL_1	467	475	PF14671	0.660
DOC_CKS1_1	288	293	PF01111	0.668
DOC_CYCLIN_RxL_1	182	190	PF00134	0.626
DOC_CYCLIN_yCln2_LP_2	468	474	PF00134	0.549
DOC_MAPK_gen_1	605	612	PF00069	0.493
DOC_MAPK_gen_1	638	645	PF00069	0.559
DOC_MAPK_gen_1	725	733	PF00069	0.570
DOC_MAPK_MEF2A_6	638	645	PF00069	0.696
DOC_MAPK_MEF2A_6	727	735	PF00069	0.590
DOC_PP2B_LxvP_1	379	382	PF13499	0.596
DOC_PP2B_LxvP_1	468	471	PF13499	0.597
DOC_PP2B_LxvP_1	680	683	PF13499	0.535
DOC_PP4_MxPP_1	461	464	PF00568	0.592
DOC_USP7_MATH_1	121	125	PF00917	0.664
DOC_USP7_MATH_1	221	225	PF00917	0.689
DOC_USP7_MATH_1	227	231	PF00917	0.664
DOC_USP7_MATH_1	291	295	PF00917	0.645
DOC_USP7_MATH_1	346	350	PF00917	0.672
DOC_USP7_MATH_1	474	478	PF00917	0.584
DOC_USP7_MATH_1	481	485	PF00917	0.596
DOC_USP7_MATH_1	653	657	PF00917	0.624
DOC_USP7_MATH_1	849	853	PF00917	0.660
DOC_USP7_MATH_1	856	860	PF00917	0.630
DOC_USP7_MATH_2	431	437	PF00917	0.704
DOC_WW_Pin1_4	208	213	PF00397	0.640
DOC_WW_Pin1_4	214	219	PF00397	0.645
DOC_WW_Pin1_4	228	233	PF00397	0.517
DOC_WW_Pin1_4	287	292	PF00397	0.649
DOC_WW_Pin1_4	335	340	PF00397	0.823
DOC_WW_Pin1_4	356	361	PF00397	0.661
DOC_WW_Pin1_4	452	457	PF00397	0.665
DOC_WW_Pin1_4	665	670	PF00397	0.689
DOC_WW_Pin1_4	764	769	PF00397	0.786
DOC_WW_Pin1_4	898	903	PF00397	0.568
LIG_14-3-3_CanoR_1	109	115	PF00244	0.552
LIG_14-3-3_CanoR_1	283	289	PF00244	0.703
LIG_14-3-3_CanoR_1	311	320	PF00244	0.566
LIG_14-3-3_CanoR_1	567	575	PF00244	0.533
LIG_14-3-3_CanoR_1	620	627	PF00244	0.696
LIG_14-3-3_CanoR_1	638	644	PF00244	0.437
LIG_14-3-3_CanoR_1	73	78	PF00244	0.536
LIG_14-3-3_CanoR_1	757	765	PF00244	0.576
LIG_14-3-3_CanoR_1	785	791	PF00244	0.559
LIG_14-3-3_CanoR_1	883	887	PF00244	0.588
LIG_BRCT_BRCA1_1	631	635	PF00533	0.606
LIG_CaM_IQ_9	88	104	PF13499	0.571
LIG_CtBP_PxDLS_1	868	872	PF00389	0.541
LIG_FHA_1	223	229	PF00498	0.681
LIG_FHA_1	60	66	PF00498	0.532
LIG_FHA_1	621	627	PF00498	0.581
LIG_FHA_1	674	680	PF00498	0.588
LIG_FHA_1	86	92	PF00498	0.639
LIG_FHA_1	908	914	PF00498	0.633
LIG_FHA_1	920	926	PF00498	0.508
LIG_FHA_2	156	162	PF00498	0.601
LIG_FHA_2	263	269	PF00498	0.612
LIG_FHA_2	346	352	PF00498	0.800
LIG_FHA_2	793	799	PF00498	0.675
LIG_LIR_Apic_2	448	454	PF02991	0.683
LIG_LIR_Gen_1	155	163	PF02991	0.592
LIG_LIR_Gen_1	376	386	PF02991	0.588
LIG_LIR_Gen_1	542	553	PF02991	0.558
LIG_LIR_Gen_1	598	608	PF02991	0.514
LIG_LIR_Gen_1	729	737	PF02991	0.618
LIG_LIR_Gen_1	841	850	PF02991	0.574
LIG_LIR_LC3C_4	642	645	PF02991	0.505
LIG_LIR_Nem_3	155	159	PF02991	0.589
LIG_LIR_Nem_3	376	381	PF02991	0.609
LIG_LIR_Nem_3	542	548	PF02991	0.499
LIG_LIR_Nem_3	598	603	PF02991	0.530
LIG_LIR_Nem_3	687	692	PF02991	0.432
LIG_LIR_Nem_3	729	733	PF02991	0.616
LIG_LIR_Nem_3	841	845	PF02991	0.550
LIG_NRBOX	183	189	PF00104	0.626
LIG_NRBOX	254	260	PF00104	0.559
LIG_Pex14_1	793	797	PF04695	0.518
LIG_RPA_C_Fungi	714	726	PF08784	0.547
LIG_SH2_PTP2	451	454	PF00017	0.680
LIG_SH2_PTP2	842	845	PF00017	0.547
LIG_SH2_SRC	31	34	PF00017	0.506
LIG_SH2_STAP1	608	612	PF00017	0.496
LIG_SH2_STAT3	2	5	PF00017	0.595
LIG_SH2_STAT3	261	264	PF00017	0.652
LIG_SH2_STAT5	2	5	PF00017	0.595
LIG_SH2_STAT5	31	34	PF00017	0.506
LIG_SH2_STAT5	390	393	PF00017	0.621
LIG_SH2_STAT5	405	408	PF00017	0.699
LIG_SH2_STAT5	424	427	PF00017	0.518
LIG_SH2_STAT5	451	454	PF00017	0.680
LIG_SH2_STAT5	467	470	PF00017	0.495
LIG_SH2_STAT5	690	693	PF00017	0.482
LIG_SH2_STAT5	694	697	PF00017	0.470
LIG_SH2_STAT5	730	733	PF00017	0.618
LIG_SH2_STAT5	801	804	PF00017	0.618
LIG_SH2_STAT5	842	845	PF00017	0.510
LIG_SH3_3	170	176	PF00018	0.566
LIG_SH3_3	549	555	PF00018	0.600
LIG_SH3_3	74	80	PF00018	0.527
LIG_SH3_3	762	768	PF00018	0.565
LIG_SH3_3	843	849	PF00018	0.516
LIG_Sin3_3	893	900	PF02671	0.631
LIG_SUMO_SIM_anti_2	841	847	PF11976	0.555
LIG_SUMO_SIM_par_1	731	736	PF11976	0.594
LIG_SUMO_SIM_par_1	841	847	PF11976	0.531
LIG_SUMO_SIM_par_1	867	873	PF11976	0.543
LIG_TRAF2_1	371	374	PF00917	0.691
LIG_TRAF2_1	520	523	PF00917	0.658
LIG_TRAF2_1	777	780	PF00917	0.575
MOD_CDK_SPK_2	228	233	PF00069	0.650
MOD_CDK_SPxxK_3	335	342	PF00069	0.583
MOD_CK1_1	122	128	PF00069	0.630
MOD_CK1_1	217	223	PF00069	0.715
MOD_CK1_1	243	249	PF00069	0.782
MOD_CK1_1	284	290	PF00069	0.722
MOD_CK1_1	315	321	PF00069	0.551
MOD_CK1_1	345	351	PF00069	0.676
MOD_CK1_1	359	365	PF00069	0.679
MOD_CK1_1	477	483	PF00069	0.651
MOD_CK1_1	484	490	PF00069	0.549
MOD_CK1_1	629	635	PF00069	0.648
MOD_CK1_1	822	828	PF00069	0.542
MOD_CK1_1	898	904	PF00069	0.569
MOD_CK2_1	155	161	PF00069	0.600
MOD_CK2_1	262	268	PF00069	0.557
MOD_CK2_1	345	351	PF00069	0.827
MOD_CK2_1	480	486	PF00069	0.682
MOD_CK2_1	517	523	PF00069	0.673
MOD_CK2_1	792	798	PF00069	0.704
MOD_Cter_Amidation	716	719	PF01082	0.557
MOD_DYRK1A_RPxSP_1	764	768	PF00069	0.648
MOD_GlcNHglycan	112	115	PF01048	0.575
MOD_GlcNHglycan	124	127	PF01048	0.676
MOD_GlcNHglycan	136	139	PF01048	0.631
MOD_GlcNHglycan	179	182	PF01048	0.662
MOD_GlcNHglycan	196	199	PF01048	0.571
MOD_GlcNHglycan	242	245	PF01048	0.752
MOD_GlcNHglycan	283	286	PF01048	0.711
MOD_GlcNHglycan	293	296	PF01048	0.619
MOD_GlcNHglycan	344	347	PF01048	0.693
MOD_GlcNHglycan	348	351	PF01048	0.682
MOD_GlcNHglycan	365	368	PF01048	0.644
MOD_GlcNHglycan	435	438	PF01048	0.665
MOD_GlcNHglycan	479	482	PF01048	0.615
MOD_GlcNHglycan	483	486	PF01048	0.582
MOD_GlcNHglycan	49	52	PF01048	0.503
MOD_GlcNHglycan	519	522	PF01048	0.687
MOD_GlcNHglycan	537	540	PF01048	0.543
MOD_GlcNHglycan	569	572	PF01048	0.541
MOD_GlcNHglycan	582	585	PF01048	0.721
MOD_GlcNHglycan	655	658	PF01048	0.619
MOD_GlcNHglycan	68	71	PF01048	0.483
MOD_GlcNHglycan	768	771	PF01048	0.648
MOD_GlcNHglycan	816	819	PF01048	0.604
MOD_GlcNHglycan	852	855	PF01048	0.635
MOD_GlcNHglycan	858	861	PF01048	0.600
MOD_GlcNHglycan	898	901	PF01048	0.572
MOD_GlcNHglycan	917	920	PF01048	0.427
MOD_GlcNHglycan	940	943	PF01048	0.640
MOD_GSK3_1	217	224	PF00069	0.645
MOD_GSK3_1	287	294	PF00069	0.696
MOD_GSK3_1	342	349	PF00069	0.696
MOD_GSK3_1	352	359	PF00069	0.746
MOD_GSK3_1	477	484	PF00069	0.595
MOD_GSK3_1	563	570	PF00069	0.526
MOD_GSK3_1	819	826	PF00069	0.544
MOD_GSK3_1	915	922	PF00069	0.563
MOD_NEK2_1	1	6	PF00069	0.461
MOD_NEK2_1	136	141	PF00069	0.702
MOD_NEK2_1	152	157	PF00069	0.458
MOD_NEK2_1	240	245	PF00069	0.586
MOD_NEK2_1	66	71	PF00069	0.530
MOD_NEK2_1	675	680	PF00069	0.563
MOD_NEK2_1	72	77	PF00069	0.531
MOD_NEK2_1	895	900	PF00069	0.585
MOD_NEK2_1	926	931	PF00069	0.661
MOD_NEK2_1	938	943	PF00069	0.530
MOD_NEK2_2	792	797	PF00069	0.547
MOD_PIKK_1	1	7	PF00454	0.461
MOD_PIKK_1	359	365	PF00454	0.601
MOD_PIKK_1	595	601	PF00454	0.611
MOD_PKA_1	73	79	PF00069	0.606
MOD_PKA_2	152	158	PF00069	0.581
MOD_PKA_2	262	268	PF00069	0.690
MOD_PKA_2	403	409	PF00069	0.649
MOD_PKA_2	658	664	PF00069	0.634
MOD_PKA_2	72	78	PF00069	0.530
MOD_PKA_2	756	762	PF00069	0.708
MOD_PKA_2	882	888	PF00069	0.576
MOD_PKB_1	560	568	PF00069	0.551
MOD_PKB_1	764	772	PF00069	0.614
MOD_Plk_1	267	273	PF00069	0.572
MOD_Plk_1	373	379	PF00069	0.616
MOD_Plk_1	524	530	PF00069	0.551
MOD_Plk_1	548	554	PF00069	0.592
MOD_Plk_1	629	635	PF00069	0.608
MOD_Plk_2-3	324	330	PF00069	0.599
MOD_Plk_4	36	42	PF00069	0.441
MOD_Plk_4	373	379	PF00069	0.689
MOD_Plk_4	484	490	PF00069	0.656
MOD_Plk_4	548	554	PF00069	0.592
MOD_Plk_4	629	635	PF00069	0.608
MOD_Plk_4	639	645	PF00069	0.517
MOD_Plk_4	675	681	PF00069	0.584
MOD_Plk_4	73	79	PF00069	0.620
MOD_Plk_4	792	798	PF00069	0.546
MOD_Plk_4	819	825	PF00069	0.605
MOD_Plk_4	882	888	PF00069	0.522
MOD_ProDKin_1	208	214	PF00069	0.645
MOD_ProDKin_1	219	225	PF00069	0.639
MOD_ProDKin_1	228	234	PF00069	0.516
MOD_ProDKin_1	287	293	PF00069	0.649
MOD_ProDKin_1	335	341	PF00069	0.823
MOD_ProDKin_1	356	362	PF00069	0.661
MOD_ProDKin_1	452	458	PF00069	0.662
MOD_ProDKin_1	665	671	PF00069	0.688
MOD_ProDKin_1	764	770	PF00069	0.783
MOD_ProDKin_1	898	904	PF00069	0.569
MOD_SUMO_rev_2	161	170	PF00179	0.517
TRG_DiLeu_BaEn_1	892	897	PF01217	0.626
TRG_DiLeu_BaEn_4	524	530	PF01217	0.579
TRG_DiLeu_BaLyEn_6	77	82	PF01217	0.602
TRG_ENDOCYTIC_2	730	733	PF00928	0.618
TRG_ENDOCYTIC_2	832	835	PF00928	0.575
TRG_ENDOCYTIC_2	842	845	PF00928	0.468
TRG_ER_diArg_1	130	132	PF00400	0.699
TRG_ER_diArg_1	201	203	PF00400	0.593
TRG_ER_diArg_1	560	562	PF00400	0.619
TRG_ER_diArg_1	604	607	PF00400	0.508
TRG_ER_diArg_1	638	640	PF00400	0.628
TRG_ER_diArg_1	72	74	PF00400	0.543
TRG_ER_diArg_1	762	764	PF00400	0.706
TRG_ER_diArg_1	875	877	PF00400	0.535
TRG_ER_diArg_1	95	97	PF00400	0.523
TRG_NES_CRM1_1	316	329	PF08389	0.644
TRG_Pf-PMV_PEXEL_1	185	190	PF00026	0.704
TRG_Pf-PMV_PEXEL_1	63	68	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I728	Leptomonas seymouri	39%	100%
A4HDI6	Leishmania braziliensis	75%	100%
E9AH62	Leishmania infantum	100%	100%
E9AX00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QAH6	Leishmania major	90%	100%