LeishMANIAdb
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EF-hand domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
EF-hand domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7WYF3_LEIDO
TriTrypDb:
LdBPK_241170.1 , LdCL_240016800 , LDHU3_24.1380
Length:
415

Annotations

LeishMANIAdb annotations

Related to USP9X animal ubiquitin-specific proteases. Does not appear to be a TM protein.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S7WYF3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYF3

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005509 calcium ion binding 5 1
GO:0043167 ion binding 2 1
GO:0043169 cation binding 3 1
GO:0046872 metal ion binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 11 13 PF00675 0.544
CLV_NRD_NRD_1 123 125 PF00675 0.571
CLV_PCSK_KEX2_1 11 13 PF00082 0.544
CLV_PCSK_KEX2_1 123 125 PF00082 0.555
CLV_PCSK_KEX2_1 408 410 PF00082 0.663
CLV_PCSK_PC1ET2_1 408 410 PF00082 0.663
CLV_PCSK_SKI1_1 11 15 PF00082 0.542
CLV_PCSK_SKI1_1 123 127 PF00082 0.576
CLV_PCSK_SKI1_1 242 246 PF00082 0.515
CLV_PCSK_SKI1_1 278 282 PF00082 0.400
CLV_PCSK_SKI1_1 312 316 PF00082 0.426
CLV_PCSK_SKI1_1 329 333 PF00082 0.466
CLV_PCSK_SKI1_1 94 98 PF00082 0.676
DEG_APCC_DBOX_1 10 18 PF00400 0.513
DEG_APCC_DBOX_1 241 249 PF00400 0.473
DEG_SCF_FBW7_1 21 27 PF00400 0.418
DOC_CKS1_1 21 26 PF01111 0.429
DOC_CYCLIN_RxL_1 237 250 PF00134 0.523
DOC_MAPK_gen_1 11 17 PF00069 0.513
DOC_MAPK_gen_1 200 209 PF00069 0.552
DOC_MAPK_MEF2A_6 202 211 PF00069 0.553
DOC_MAPK_MEF2A_6 258 267 PF00069 0.541
DOC_PP2B_LxvP_1 229 232 PF13499 0.391
DOC_PP2B_LxvP_1 292 295 PF13499 0.545
DOC_PP2B_LxvP_1 73 76 PF13499 0.725
DOC_PP4_FxxP_1 126 129 PF00568 0.493
DOC_USP7_MATH_1 129 133 PF00917 0.608
DOC_USP7_MATH_1 186 190 PF00917 0.597
DOC_USP7_MATH_1 335 339 PF00917 0.507
DOC_USP7_MATH_1 76 80 PF00917 0.646
DOC_USP7_MATH_1 99 103 PF00917 0.769
DOC_WW_Pin1_4 114 119 PF00397 0.664
DOC_WW_Pin1_4 20 25 PF00397 0.449
DOC_WW_Pin1_4 45 50 PF00397 0.529
LIG_14-3-3_CanoR_1 108 118 PF00244 0.734
LIG_14-3-3_CanoR_1 12 18 PF00244 0.510
LIG_14-3-3_CanoR_1 135 145 PF00244 0.740
LIG_14-3-3_CanoR_1 365 372 PF00244 0.544
LIG_14-3-3_CanoR_1 77 86 PF00244 0.626
LIG_APCC_ABBA_1 304 309 PF00400 0.396
LIG_BRCT_BRCA1_1 18 22 PF00533 0.491
LIG_BRCT_BRCA1_1 337 341 PF00533 0.545
LIG_EH_1 127 131 PF12763 0.477
LIG_FHA_1 110 116 PF00498 0.734
LIG_FHA_1 25 31 PF00498 0.355
LIG_FHA_1 331 337 PF00498 0.503
LIG_FHA_1 35 41 PF00498 0.380
LIG_FHA_1 354 360 PF00498 0.483
LIG_FHA_1 63 69 PF00498 0.701
LIG_FHA_1 8 14 PF00498 0.543
LIG_LIR_Gen_1 116 126 PF02991 0.492
LIG_LIR_Gen_1 201 211 PF02991 0.458
LIG_LIR_Gen_1 220 229 PF02991 0.350
LIG_LIR_Gen_1 338 349 PF02991 0.567
LIG_LIR_Nem_3 116 122 PF02991 0.587
LIG_LIR_Nem_3 201 207 PF02991 0.453
LIG_LIR_Nem_3 220 225 PF02991 0.354
LIG_LIR_Nem_3 254 260 PF02991 0.380
LIG_LIR_Nem_3 313 318 PF02991 0.384
LIG_LIR_Nem_3 338 344 PF02991 0.558
LIG_LIR_Nem_3 87 92 PF02991 0.652
LIG_NRBOX 339 345 PF00104 0.447
LIG_NRBOX 396 402 PF00104 0.465
LIG_Pex14_2 126 130 PF04695 0.486
LIG_SH2_CRK 226 230 PF00017 0.396
LIG_SH2_CRK 394 398 PF00017 0.451
LIG_SH2_STAP1 394 398 PF00017 0.529
LIG_SH2_STAT5 226 229 PF00017 0.502
LIG_SH2_STAT5 307 310 PF00017 0.391
LIG_SH3_1 44 50 PF00018 0.511
LIG_SH3_3 43 49 PF00018 0.535
LIG_SUMO_SIM_anti_2 205 211 PF11976 0.494
LIG_SUMO_SIM_anti_2 243 250 PF11976 0.491
LIG_SUMO_SIM_anti_2 31 38 PF11976 0.410
LIG_SUMO_SIM_par_1 13 19 PF11976 0.524
LIG_SUMO_SIM_par_1 243 250 PF11976 0.397
LIG_SUMO_SIM_par_1 31 38 PF11976 0.332
LIG_SUMO_SIM_par_1 332 338 PF11976 0.510
LIG_SUMO_SIM_par_1 396 402 PF11976 0.544
LIG_TRAF2_1 299 302 PF00917 0.571
LIG_TYR_ITIM 224 229 PF00017 0.396
LIG_TYR_ITIM 392 397 PF00017 0.407
MOD_CK1_1 114 120 PF00069 0.613
MOD_CK1_1 16 22 PF00069 0.632
MOD_CK1_1 189 195 PF00069 0.533
MOD_CK1_1 26 32 PF00069 0.547
MOD_CK2_1 152 158 PF00069 0.668
MOD_CK2_1 363 369 PF00069 0.562
MOD_GlcNHglycan 101 104 PF01048 0.755
MOD_GlcNHglycan 131 134 PF01048 0.693
MOD_GlcNHglycan 138 141 PF01048 0.703
MOD_GlcNHglycan 182 185 PF01048 0.505
MOD_GlcNHglycan 188 191 PF01048 0.526
MOD_GlcNHglycan 192 195 PF01048 0.373
MOD_GlcNHglycan 79 82 PF01048 0.718
MOD_GSK3_1 109 116 PF00069 0.654
MOD_GSK3_1 134 141 PF00069 0.718
MOD_GSK3_1 16 23 PF00069 0.647
MOD_GSK3_1 186 193 PF00069 0.591
MOD_GSK3_1 24 31 PF00069 0.548
MOD_GSK3_1 371 378 PF00069 0.626
MOD_N-GLC_1 84 89 PF02516 0.739
MOD_NEK2_1 1 6 PF00069 0.759
MOD_NEK2_1 13 18 PF00069 0.588
MOD_NEK2_1 224 229 PF00069 0.430
MOD_NEK2_1 40 45 PF00069 0.486
MOD_NEK2_1 60 65 PF00069 0.618
MOD_PKA_2 109 115 PF00069 0.705
MOD_PKA_2 134 140 PF00069 0.746
MOD_PKA_2 141 147 PF00069 0.520
MOD_PKA_2 364 370 PF00069 0.507
MOD_PKA_2 76 82 PF00069 0.639
MOD_Plk_1 152 158 PF00069 0.574
MOD_Plk_1 271 277 PF00069 0.540
MOD_Plk_1 329 335 PF00069 0.415
MOD_Plk_1 84 90 PF00069 0.739
MOD_Plk_4 252 258 PF00069 0.455
MOD_Plk_4 30 36 PF00069 0.574
MOD_Plk_4 302 308 PF00069 0.543
MOD_ProDKin_1 114 120 PF00069 0.665
MOD_ProDKin_1 20 26 PF00069 0.443
MOD_ProDKin_1 45 51 PF00069 0.530
MOD_SUMO_rev_2 305 314 PF00179 0.508
MOD_SUMO_rev_2 387 393 PF00179 0.522
TRG_DiLeu_BaEn_1 167 172 PF01217 0.580
TRG_DiLeu_BaEn_1 220 225 PF01217 0.406
TRG_DiLeu_BaLyEn_6 376 381 PF01217 0.518
TRG_DiLeu_BaLyEn_6 9 14 PF01217 0.542
TRG_ENDOCYTIC_2 226 229 PF00928 0.397
TRG_ENDOCYTIC_2 257 260 PF00928 0.465
TRG_ENDOCYTIC_2 394 397 PF00928 0.415
TRG_ER_diArg_1 11 13 PF00400 0.544
TRG_ER_diArg_1 122 124 PF00400 0.648
TRG_NES_CRM1_1 201 213 PF08389 0.519
TRG_NLS_MonoExtC_3 406 411 PF00514 0.655
TRG_NLS_MonoExtN_4 404 411 PF00514 0.640
TRG_Pf-PMV_PEXEL_1 370 375 PF00026 0.481

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBQ7 Leptomonas seymouri 65% 100%
A0A0S4IZX9 Bodo saltans 30% 91%
A0A1X0NX67 Trypanosomatidae 41% 100%
A0A422NQ90 Trypanosoma rangeli 51% 100%
A4HDH1 Leishmania braziliensis 70% 100%
A4I0V2 Leishmania infantum 100% 100%
D0A781 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 100%
E9AWV6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q4QAL8 Leishmania major 83% 100%
V5BR35 Trypanosoma cruzi 49% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS