Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WYF1_LEIDO

TriTrypDb:

LdBPK_241340.1 , LdCL_240018500 , LDHU3_24.1620

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WYF1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYF1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	227	231	PF00656	0.360
CLV_NRD_NRD_1	3	5	PF00675	0.568
CLV_PCSK_KEX2_1	52	54	PF00082	0.575
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.573
CLV_PCSK_SKI1_1	127	131	PF00082	0.463
CLV_PCSK_SKI1_1	192	196	PF00082	0.416
CLV_PCSK_SKI1_1	44	48	PF00082	0.411
DOC_MAPK_gen_1	4	12	PF00069	0.438
DOC_MAPK_JIP1_4	19	25	PF00069	0.444
DOC_MAPK_MEF2A_6	19	27	PF00069	0.489
DOC_MAPK_MEF2A_6	205	212	PF00069	0.446
DOC_PP1_RVXF_1	125	131	PF00149	0.457
DOC_PP4_FxxP_1	232	235	PF00568	0.452
DOC_USP7_MATH_1	159	163	PF00917	0.601
DOC_USP7_MATH_1	8	12	PF00917	0.638
DOC_USP7_UBL2_3	205	209	PF12436	0.440
LIG_14-3-3_CanoR_1	190	195	PF00244	0.462
LIG_14-3-3_CanoR_1	53	57	PF00244	0.595
LIG_AP2alpha_1	228	232	PF02296	0.408
LIG_BRCT_BRCA1_1	218	222	PF00533	0.367
LIG_EH_1	74	78	PF12763	0.576
LIG_FHA_1	121	127	PF00498	0.498
LIG_FHA_1	136	142	PF00498	0.373
LIG_FHA_1	161	167	PF00498	0.546
LIG_FHA_2	142	148	PF00498	0.460
LIG_FHA_2	222	228	PF00498	0.319
LIG_FHA_2	52	58	PF00498	0.641
LIG_GBD_Chelix_1	170	178	PF00786	0.295
LIG_IRF3_LxIS_1	150	157	PF10401	0.446
LIG_LIR_Apic_2	230	235	PF02991	0.452
LIG_LIR_Gen_1	57	67	PF02991	0.564
LIG_LIR_Gen_1	95	104	PF02991	0.355
LIG_LIR_Nem_3	219	225	PF02991	0.344
LIG_LIR_Nem_3	57	63	PF02991	0.578
LIG_LIR_Nem_3	92	96	PF02991	0.339
LIG_LYPXL_yS_3	203	206	PF13949	0.462
LIG_MYND_1	204	208	PF01753	0.363
LIG_Pex14_2	228	232	PF04695	0.488
LIG_PTB_Apo_2	72	79	PF02174	0.484
LIG_SH2_GRB2like	216	219	PF00017	0.336
LIG_SH2_NCK_1	35	39	PF00017	0.478
LIG_SH2_SRC	216	219	PF00017	0.395
LIG_SH2_STAP1	35	39	PF00017	0.456
LIG_SH2_STAT3	96	99	PF00017	0.356
LIG_SH2_STAT5	107	110	PF00017	0.308
LIG_SH2_STAT5	216	219	PF00017	0.339
LIG_SH2_STAT5	96	99	PF00017	0.352
LIG_SH3_3	14	20	PF00018	0.477
LIG_SH3_3	198	204	PF00018	0.441
LIG_SH3_3	98	104	PF00018	0.416
LIG_SUMO_SIM_par_1	175	182	PF11976	0.389
LIG_SUMO_SIM_par_1	21	26	PF11976	0.440
LIG_TRAF2_1	162	165	PF00917	0.470
LIG_TYR_ITIM	201	206	PF00017	0.470
LIG_WW_3	1	5	PF00397	0.577
MOD_CK1_1	221	227	PF00069	0.528
MOD_CK1_1	81	87	PF00069	0.484
MOD_CK2_1	154	160	PF00069	0.576
MOD_CK2_1	173	179	PF00069	0.446
MOD_CK2_1	221	227	PF00069	0.329
MOD_CK2_1	52	58	PF00069	0.609
MOD_CK2_1	8	14	PF00069	0.615
MOD_Cter_Amidation	48	51	PF01082	0.361
MOD_GlcNHglycan	157	160	PF01048	0.595
MOD_GSK3_1	150	157	PF00069	0.537
MOD_GSK3_1	160	167	PF00069	0.562
MOD_GSK3_1	179	186	PF00069	0.373
MOD_GSK3_1	52	59	PF00069	0.427
MOD_GSK3_1	81	88	PF00069	0.484
MOD_N-GLC_2	231	233	PF02516	0.489
MOD_NEK2_1	120	125	PF00069	0.546
MOD_NEK2_1	154	159	PF00069	0.642
MOD_NEK2_1	23	28	PF00069	0.449
MOD_NEK2_1	78	83	PF00069	0.560
MOD_PIKK_1	164	170	PF00454	0.577
MOD_PIKK_1	179	185	PF00454	0.398
MOD_PIKK_1	78	84	PF00454	0.606
MOD_PK_1	190	196	PF00069	0.525
MOD_PKA_1	51	57	PF00069	0.557
MOD_PKA_2	18	24	PF00069	0.572
MOD_PKA_2	52	58	PF00069	0.573
MOD_Plk_1	172	178	PF00069	0.480
MOD_Plk_1	23	29	PF00069	0.509
MOD_Plk_1	56	62	PF00069	0.409
MOD_Plk_2-3	160	166	PF00069	0.432
MOD_Plk_2-3	173	179	PF00069	0.318
MOD_Plk_2-3	18	24	PF00069	0.486
MOD_Plk_4	150	156	PF00069	0.569
MOD_Plk_4	173	179	PF00069	0.516
MOD_Plk_4	18	24	PF00069	0.431
MOD_Plk_4	190	196	PF00069	0.341
MOD_Plk_4	218	224	PF00069	0.506
MOD_Plk_4	8	14	PF00069	0.561
MOD_Plk_4	85	91	PF00069	0.455
MOD_SUMO_for_1	208	211	PF00179	0.358
MOD_SUMO_rev_2	113	118	PF00179	0.546
MOD_SUMO_rev_2	61	69	PF00179	0.455
TRG_ENDOCYTIC_2	203	206	PF00928	0.462
TRG_ER_diArg_1	41	44	PF00400	0.354
TRG_NLS_MonoCore_2	49	54	PF00514	0.429
TRG_NLS_MonoExtN_4	50	55	PF00514	0.442
TRG_Pf-PMV_PEXEL_1	127	132	PF00026	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHY5	Leptomonas seymouri	54%	100%
A0A0S4J677	Bodo saltans	22%	77%
A0A0S4JEV4	Bodo saltans	22%	77%
A0A1X0NX29	Trypanosomatidae	32%	96%
A4HDL2	Leishmania braziliensis	79%	100%
A4I0W9	Leishmania infantum	100%	100%
C9ZWH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	96%
E9AWX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QAK1	Leishmania major	93%	100%
V5BAW4	Trypanosoma cruzi	32%	81%