Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WYE8_LEIDO

TriTrypDb:

LdBPK_241440.1 , LdCL_240019600 , LDHU3_24.1750

Length:

200

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WYE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYE8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.494
CLV_C14_Caspase3-7	64	68	PF00656	0.556
CLV_NRD_NRD_1	115	117	PF00675	0.559
CLV_NRD_NRD_1	27	29	PF00675	0.458
CLV_NRD_NRD_1	61	63	PF00675	0.525
CLV_PCSK_KEX2_1	114	116	PF00082	0.565
CLV_PCSK_KEX2_1	159	161	PF00082	0.498
CLV_PCSK_KEX2_1	27	29	PF00082	0.436
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.511
CLV_PCSK_SKI1_1	106	110	PF00082	0.526
CLV_PCSK_SKI1_1	126	130	PF00082	0.539
CLV_PCSK_SKI1_1	133	137	PF00082	0.479
DOC_USP7_MATH_1	179	183	PF00917	0.602
DOC_USP7_MATH_1	189	193	PF00917	0.538
DOC_USP7_MATH_1	54	58	PF00917	0.594
DOC_USP7_MATH_1	68	72	PF00917	0.382
DOC_USP7_UBL2_3	69	73	PF12436	0.459
LIG_14-3-3_CanoR_1	13	17	PF00244	0.527
LIG_14-3-3_CanoR_1	27	34	PF00244	0.513
LIG_14-3-3_CanoR_1	62	70	PF00244	0.524
LIG_14-3-3_CanoR_1	83	87	PF00244	0.609
LIG_BIR_II_1	1	5	PF00653	0.630
LIG_FHA_1	107	113	PF00498	0.600
LIG_FHA_1	13	19	PF00498	0.590
LIG_FHA_2	119	125	PF00498	0.568
LIG_FHA_2	186	192	PF00498	0.547
LIG_FHA_2	45	51	PF00498	0.551
LIG_FHA_2	95	101	PF00498	0.550
LIG_LIR_Nem_3	5	10	PF02991	0.523
LIG_PDZ_Class_3	195	200	PF00595	0.658
LIG_RPA_C_Fungi	23	35	PF08784	0.554
LIG_SH2_STAT5	194	197	PF00017	0.668
LIG_SH3_1	171	177	PF00018	0.649
LIG_SH3_3	171	177	PF00018	0.626
LIG_SUMO_SIM_par_1	14	19	PF11976	0.549
LIG_TRAF2_1	135	138	PF00917	0.534
LIG_TRAF2_1	151	154	PF00917	0.573
LIG_TRAF2_1	47	50	PF00917	0.569
MOD_CK1_1	2	8	PF00069	0.564
MOD_CK2_1	118	124	PF00069	0.490
MOD_CK2_1	185	191	PF00069	0.549
MOD_CK2_1	44	50	PF00069	0.552
MOD_CK2_1	68	74	PF00069	0.519
MOD_CK2_1	82	88	PF00069	0.474
MOD_CK2_1	94	100	PF00069	0.431
MOD_GlcNHglycan	180	184	PF01048	0.622
MOD_GlcNHglycan	63	66	PF01048	0.557
MOD_GlcNHglycan	7	10	PF01048	0.532
MOD_GSK3_1	181	188	PF00069	0.570
MOD_GSK3_1	5	12	PF00069	0.552
MOD_N-GLC_1	44	49	PF02516	0.555
MOD_NEK2_1	118	123	PF00069	0.568
MOD_NEK2_1	185	190	PF00069	0.544
MOD_NEK2_1	37	42	PF00069	0.542
MOD_NEK2_1	94	99	PF00069	0.592
MOD_NEK2_2	189	194	PF00069	0.666
MOD_PIKK_1	76	82	PF00454	0.520
MOD_PKA_2	12	18	PF00069	0.478
MOD_PKA_2	26	32	PF00069	0.471
MOD_PKA_2	61	67	PF00069	0.569
MOD_PKA_2	82	88	PF00069	0.602
MOD_Plk_1	118	124	PF00069	0.551
MOD_Plk_1	2	8	PF00069	0.606
MOD_Plk_1	54	60	PF00069	0.565
MOD_Plk_4	12	18	PF00069	0.478
MOD_Plk_4	189	195	PF00069	0.556
MOD_Plk_4	82	88	PF00069	0.559
MOD_SUMO_rev_2	137	144	PF00179	0.509
MOD_SUMO_rev_2	55	65	PF00179	0.486
TRG_DiLeu_BaEn_1	191	196	PF01217	0.537
TRG_DiLeu_BaEn_4	89	95	PF01217	0.553
TRG_ER_diArg_1	114	116	PF00400	0.564
TRG_ER_diArg_1	56	59	PF00400	0.500
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1N4	Leptomonas seymouri	75%	99%
A0A0S4JQL1	Bodo saltans	29%	98%
A0A1X0NLU8	Trypanosomatidae	41%	100%
A0A3R7MNC1	Trypanosoma rangeli	47%	93%
A4HDK2	Leishmania braziliensis	88%	100%
A4I0X9	Leishmania infantum	100%	100%
C9ZUU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AWY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QAJ1	Leishmania major	96%	100%