AKAP7 2'5' RNA ligase-like domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AKAP7 2'5' RNA ligase-like domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WYE0_LEIDO

TriTrypDb:

LdBPK_241080.1 , LdCL_240015800 , LDHU3_24.1260

Length:

594

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WYE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYE0

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016874	ligase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	135	137	PF00675	0.661
CLV_NRD_NRD_1	307	309	PF00675	0.703
CLV_NRD_NRD_1	405	407	PF00675	0.303
CLV_NRD_NRD_1	520	522	PF00675	0.319
CLV_NRD_NRD_1	53	55	PF00675	0.506
CLV_NRD_NRD_1	532	534	PF00675	0.319
CLV_NRD_NRD_1	577	579	PF00675	0.270
CLV_PCSK_KEX2_1	112	114	PF00082	0.575
CLV_PCSK_KEX2_1	135	137	PF00082	0.626
CLV_PCSK_KEX2_1	144	146	PF00082	0.448
CLV_PCSK_KEX2_1	154	156	PF00082	0.408
CLV_PCSK_KEX2_1	307	309	PF00082	0.703
CLV_PCSK_KEX2_1	405	407	PF00082	0.303
CLV_PCSK_KEX2_1	520	522	PF00082	0.319
CLV_PCSK_KEX2_1	53	55	PF00082	0.506
CLV_PCSK_KEX2_1	577	579	PF00082	0.270
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.575
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.618
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.330
CLV_PCSK_SKI1_1	136	140	PF00082	0.680
CLV_PCSK_SKI1_1	225	229	PF00082	0.678
CLV_PCSK_SKI1_1	413	417	PF00082	0.319
CLV_PCSK_SKI1_1	520	524	PF00082	0.325
CLV_PCSK_SKI1_1	563	567	PF00082	0.401
DEG_APCC_DBOX_1	118	126	PF00400	0.588
DEG_APCC_DBOX_1	451	459	PF00400	0.519
DEG_COP1_1	291	301	PF00400	0.645
DEG_Nend_Nbox_1	1	3	PF02207	0.455
DEG_ODPH_VHL_1	447	458	PF01847	0.512
DEG_SPOP_SBC_1	62	66	PF00917	0.479
DOC_CDC14_PxL_1	565	573	PF14671	0.519
DOC_MAPK_DCC_7	563	573	PF00069	0.519
DOC_MAPK_gen_1	405	411	PF00069	0.479
DOC_MAPK_gen_1	518	527	PF00069	0.504
DOC_MAPK_MEF2A_6	393	400	PF00069	0.452
DOC_MAPK_MEF2A_6	518	527	PF00069	0.504
DOC_MAPK_NFAT4_5	393	401	PF00069	0.452
DOC_PP2B_LxvP_1	401	404	PF13499	0.452
DOC_PP2B_LxvP_1	90	93	PF13499	0.619
DOC_PP4_FxxP_1	227	230	PF00568	0.618
DOC_PP4_FxxP_1	473	476	PF00568	0.470
DOC_PP4_FxxP_1	566	569	PF00568	0.519
DOC_USP7_MATH_1	230	234	PF00917	0.590
DOC_USP7_MATH_1	239	243	PF00917	0.624
DOC_USP7_MATH_1	374	378	PF00917	0.470
DOC_USP7_MATH_1	382	386	PF00917	0.422
DOC_USP7_MATH_1	419	423	PF00917	0.504
DOC_USP7_MATH_1	516	520	PF00917	0.480
DOC_USP7_MATH_1	62	66	PF00917	0.525
DOC_USP7_MATH_1	93	97	PF00917	0.608
DOC_USP7_UBL2_3	530	534	PF12436	0.519
DOC_WW_Pin1_4	165	170	PF00397	0.527
DOC_WW_Pin1_4	297	302	PF00397	0.583
DOC_WW_Pin1_4	58	63	PF00397	0.520
LIG_14-3-3_CanoR_1	225	230	PF00244	0.596
LIG_14-3-3_CanoR_1	35	42	PF00244	0.480
LIG_14-3-3_CanoR_1	48	52	PF00244	0.464
LIG_APCC_ABBA_1	123	128	PF00400	0.591
LIG_BIR_III_2	543	547	PF00653	0.508
LIG_BRCT_BRCA1_1	323	327	PF00533	0.463
LIG_BRCT_BRCA1_1	538	542	PF00533	0.470
LIG_BRCT_BRCA1_2	323	329	PF00533	0.453
LIG_FHA_1	221	227	PF00498	0.601
LIG_FHA_1	318	324	PF00498	0.288
LIG_FHA_1	336	342	PF00498	0.477
LIG_FHA_1	389	395	PF00498	0.521
LIG_FHA_1	436	442	PF00498	0.537
LIG_FHA_2	204	210	PF00498	0.706
LIG_FHA_2	524	530	PF00498	0.579
LIG_FHA_2	66	72	PF00498	0.498
LIG_FHA_2	99	105	PF00498	0.567
LIG_LIR_Apic_2	472	476	PF02991	0.469
LIG_LIR_Apic_2	5	10	PF02991	0.456
LIG_LIR_Gen_1	102	110	PF02991	0.446
LIG_LIR_Gen_1	320	330	PF02991	0.456
LIG_LIR_Nem_3	102	108	PF02991	0.623
LIG_LIR_Nem_3	223	227	PF02991	0.603
LIG_LIR_Nem_3	320	325	PF02991	0.456
LIG_LIR_Nem_3	480	486	PF02991	0.477
LIG_PDZ_Class_2	589	594	PF00595	0.477
LIG_Pex14_2	420	424	PF04695	0.519
LIG_PTB_Apo_2	218	225	PF02174	0.537
LIG_PTB_Phospho_1	218	224	PF10480	0.536
LIG_SH2_PTP2	7	10	PF00017	0.468
LIG_SH2_SRC	352	355	PF00017	0.412
LIG_SH2_STAP1	173	177	PF00017	0.680
LIG_SH2_STAP1	352	356	PF00017	0.458
LIG_SH2_STAT5	586	589	PF00017	0.504
LIG_SH2_STAT5	7	10	PF00017	0.468
LIG_SH3_3	12	18	PF00018	0.477
LIG_SH3_3	191	197	PF00018	0.642
LIG_SH3_3	198	204	PF00018	0.689
LIG_SH3_3	295	301	PF00018	0.653
LIG_SH3_3	320	326	PF00018	0.477
LIG_SUMO_SIM_anti_2	397	402	PF11976	0.529
LIG_SUMO_SIM_par_1	396	402	PF11976	0.440
LIG_TRAF2_1	257	260	PF00917	0.560
LIG_TRAF2_1	550	553	PF00917	0.470
LIG_TRFH_1	165	169	PF08558	0.527
LIG_TYR_ITIM	481	486	PF00017	0.452
LIG_WRC_WIRS_1	344	349	PF05994	0.519
LIG_WW_3	308	312	PF00397	0.613
MOD_CDK_SPK_2	58	63	PF00069	0.520
MOD_CK1_1	24	30	PF00069	0.482
MOD_CK1_1	242	248	PF00069	0.654
MOD_CK1_1	376	382	PF00069	0.539
MOD_CK1_1	434	440	PF00069	0.504
MOD_CK1_1	47	53	PF00069	0.507
MOD_CK1_1	61	67	PF00069	0.484
MOD_CK2_1	502	508	PF00069	0.477
MOD_CK2_1	65	71	PF00069	0.506
MOD_Cter_Amidation	133	136	PF01082	0.684
MOD_Cter_Amidation	152	155	PF01082	0.324
MOD_GlcNHglycan	155	158	PF01048	0.378
MOD_GlcNHglycan	232	235	PF01048	0.668
MOD_GlcNHglycan	244	247	PF01048	0.716
MOD_GlcNHglycan	250	253	PF01048	0.726
MOD_GlcNHglycan	282	285	PF01048	0.789
MOD_GlcNHglycan	354	357	PF01048	0.246
MOD_GlcNHglycan	359	362	PF01048	0.235
MOD_GlcNHglycan	37	40	PF01048	0.476
MOD_GlcNHglycan	380	383	PF01048	0.303
MOD_GlcNHglycan	421	424	PF01048	0.303
MOD_GlcNHglycan	441	444	PF01048	0.306
MOD_GlcNHglycan	582	585	PF01048	0.302
MOD_GSK3_1	225	232	PF00069	0.665
MOD_GSK3_1	317	324	PF00069	0.330
MOD_GSK3_1	370	377	PF00069	0.538
MOD_GSK3_1	378	385	PF00069	0.499
MOD_GSK3_1	431	438	PF00069	0.489
MOD_GSK3_1	439	446	PF00069	0.523
MOD_GSK3_1	58	65	PF00069	0.528
MOD_GSK3_1	9	16	PF00069	0.469
MOD_N-GLC_1	220	225	PF02516	0.675
MOD_N-GLC_1	335	340	PF02516	0.277
MOD_NEK2_1	19	24	PF00069	0.493
MOD_NEK2_1	215	220	PF00069	0.581
MOD_NEK2_1	378	383	PF00069	0.539
MOD_NEK2_1	394	399	PF00069	0.398
MOD_NEK2_1	46	51	PF00069	0.506
MOD_NEK2_1	502	507	PF00069	0.511
MOD_NEK2_1	523	528	PF00069	0.462
MOD_NEK2_1	587	592	PF00069	0.537
MOD_NEK2_2	588	593	PF00069	0.470
MOD_OFUCOSY	200	207	PF10250	0.493
MOD_PIKK_1	302	308	PF00454	0.596
MOD_PKA_2	24	30	PF00069	0.482
MOD_PKA_2	275	281	PF00069	0.622
MOD_PKA_2	47	53	PF00069	0.507
MOD_PKA_2	62	68	PF00069	0.477
MOD_Plk_1	220	226	PF00069	0.545
MOD_Plk_1	335	341	PF00069	0.489
MOD_Plk_1	435	441	PF00069	0.487
MOD_Plk_1	443	449	PF00069	0.503
MOD_Plk_1	588	594	PF00069	0.489
MOD_Plk_2-3	288	294	PF00069	0.561
MOD_Plk_4	336	342	PF00069	0.547
MOD_Plk_4	394	400	PF00069	0.477
MOD_Plk_4	477	483	PF00069	0.502
MOD_Plk_4	523	529	PF00069	0.452
MOD_Plk_4	582	588	PF00069	0.504
MOD_ProDKin_1	165	171	PF00069	0.532
MOD_ProDKin_1	297	303	PF00069	0.581
MOD_ProDKin_1	58	64	PF00069	0.519
MOD_SUMO_for_1	143	146	PF00179	0.483
TRG_DiLeu_BaLyEn_6	210	215	PF01217	0.518
TRG_ENDOCYTIC_2	224	227	PF00928	0.537
TRG_ENDOCYTIC_2	483	486	PF00928	0.452
TRG_ER_diArg_1	135	137	PF00400	0.665
TRG_ER_diArg_1	23	26	PF00400	0.485
TRG_ER_diArg_1	307	309	PF00400	0.629
TRG_ER_diArg_1	404	406	PF00400	0.504
TRG_ER_diArg_1	520	522	PF00400	0.525
TRG_ER_diArg_1	53	55	PF00400	0.506
TRG_ER_diArg_1	576	578	PF00400	0.507
TRG_NES_CRM1_1	158	170	PF08389	0.441
TRG_NLS_Bipartite_1	520	537	PF00514	0.524
TRG_NLS_MonoExtN_4	530	537	PF00514	0.470
TRG_Pf-PMV_PEXEL_1	500	504	PF00026	0.283
TRG_Pf-PMV_PEXEL_1	545	549	PF00026	0.305
TRG_Pf-PMV_PEXEL_1	563	567	PF00026	0.372

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5X3	Leptomonas seymouri	58%	100%
A0A422MP50	Trypanosoma rangeli	27%	100%
A4HDG2	Leishmania braziliensis	77%	100%
A4I0U3	Leishmania infantum	100%	100%
C9ZVE7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AWU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QAM7	Leishmania major	92%	100%