Cyclophilin 8, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidyl-prolyl cis-trans isomerase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WYD9_LEIDO

TriTrypDb:

LdBPK_241350.1 , LdCL_240018600 , LDHU3_24.1630

Length:

242

Annotations

Annotations by Jardim et al.

Chaperone/Protein Folding, cyclophilin 8 CYP8

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S7WYD9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYD9

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	15
GO:0006807	nitrogen compound metabolic process	2	15
GO:0008152	metabolic process	1	15
GO:0018193	peptidyl-amino acid modification	5	15
GO:0018208	peptidyl-proline modification	6	15
GO:0019538	protein metabolic process	3	15
GO:0036211	protein modification process	4	15
GO:0043170	macromolecule metabolic process	3	15
GO:0043412	macromolecule modification	4	15
GO:0044238	primary metabolic process	2	15
GO:0071704	organic substance metabolic process	2	15
GO:1901564	organonitrogen compound metabolic process	3	15
GO:0006457	protein folding	2	7
GO:0009987	cellular process	1	7

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	15
GO:0003824	catalytic activity	1	15
GO:0016853	isomerase activity	2	15
GO:0016859	cis-trans isomerase activity	3	15
GO:0140096	catalytic activity, acting on a protein	2	15
GO:0005488	binding	1	2
GO:0016018	cyclosporin A binding	4	2
GO:0033218	amide binding	2	2
GO:0042277	peptide binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	226	228	PF00675	0.340
CLV_NRD_NRD_1	48	50	PF00675	0.641
CLV_PCSK_SKI1_1	50	54	PF00082	0.507
CLV_PCSK_SKI1_1	8	12	PF00082	0.409
DEG_Nend_Nbox_1	1	3	PF02207	0.470
DEG_SPOP_SBC_1	9	13	PF00917	0.438
DOC_MAPK_gen_1	49	57	PF00069	0.538
DOC_PP1_RVXF_1	193	200	PF00149	0.303
DOC_PP2B_LxvP_1	44	47	PF13499	0.528
DOC_PP4_FxxP_1	14	17	PF00568	0.361
DOC_PP4_FxxP_1	6	9	PF00568	0.412
DOC_USP7_MATH_1	211	215	PF00917	0.407
DOC_USP7_UBL2_3	112	116	PF12436	0.304
DOC_USP7_UBL2_3	50	54	PF12436	0.586
DOC_WW_Pin1_4	90	95	PF00397	0.293
LIG_14-3-3_CanoR_1	168	174	PF00244	0.363
LIG_14-3-3_CanoR_1	8	18	PF00244	0.413
LIG_BRCT_BRCA1_1	169	173	PF00533	0.289
LIG_BRCT_BRCA1_1	175	179	PF00533	0.285
LIG_Clathr_ClatBox_1	71	75	PF01394	0.346
LIG_DCNL_PONY_1	1	4	PF03556	0.453
LIG_FHA_1	133	139	PF00498	0.387
LIG_FHA_2	169	175	PF00498	0.367
LIG_HCF-1_HBM_1	22	25	PF13415	0.408
LIG_LIR_Apic_2	11	17	PF02991	0.412
LIG_LIR_Gen_1	176	187	PF02991	0.387
LIG_LIR_Gen_1	22	29	PF02991	0.459
LIG_LIR_Gen_1	236	242	PF02991	0.468
LIG_LIR_LC3C_4	33	38	PF02991	0.472
LIG_LIR_Nem_3	12	18	PF02991	0.466
LIG_LIR_Nem_3	176	182	PF02991	0.301
LIG_LIR_Nem_3	22	28	PF02991	0.405
LIG_LIR_Nem_3	78	84	PF02991	0.298
LIG_MLH1_MIPbox_1	175	179	PF16413	0.287
LIG_Pex14_2	15	19	PF04695	0.451
LIG_PTB_Apo_2	119	126	PF02174	0.364
LIG_SH2_CRK	161	165	PF00017	0.293
LIG_SH2_CRK	81	85	PF00017	0.394
LIG_SH2_STAT5	232	235	PF00017	0.312
LIG_SH3_3	34	40	PF00018	0.505
LIG_SUMO_SIM_par_1	35	41	PF11976	0.475
LIG_SUMO_SIM_par_1	82	87	PF11976	0.293
LIG_UBA3_1	71	76	PF00899	0.351
LIG_WW_3	46	50	PF00397	0.566
MOD_CDK_SPK_2	90	95	PF00069	0.293
MOD_CK1_1	107	113	PF00069	0.255
MOD_CK1_1	169	175	PF00069	0.391
MOD_CK1_1	59	65	PF00069	0.668
MOD_CK1_1	90	96	PF00069	0.437
MOD_GlcNHglycan	218	222	PF01048	0.448
MOD_GlcNHglycan	25	28	PF01048	0.510
MOD_GlcNHglycan	58	61	PF01048	0.592
MOD_GlcNHglycan	89	92	PF01048	0.334
MOD_GSK3_1	106	113	PF00069	0.385
MOD_GSK3_1	162	169	PF00069	0.301
MOD_N-GLC_1	107	112	PF02516	0.279
MOD_NEK2_1	10	15	PF00069	0.427
MOD_NEK2_1	166	171	PF00069	0.293
MOD_NEK2_1	173	178	PF00069	0.287
MOD_PIKK_1	173	179	PF00454	0.322
MOD_PKA_2	123	129	PF00069	0.334
MOD_PKA_2	167	173	PF00069	0.341
MOD_PKA_2	23	29	PF00069	0.495
MOD_Plk_1	235	241	PF00069	0.366
MOD_Plk_4	10	16	PF00069	0.486
MOD_ProDKin_1	90	96	PF00069	0.293
TRG_DiLeu_BaEn_1	32	37	PF01217	0.489
TRG_ENDOCYTIC_2	161	164	PF00928	0.293
TRG_ENDOCYTIC_2	239	242	PF00928	0.582
TRG_ENDOCYTIC_2	25	28	PF00928	0.510
TRG_ENDOCYTIC_2	81	84	PF00928	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D1	Leptomonas seymouri	68%	100%
A0A0N0P523	Leptomonas seymouri	32%	88%
A0A0S4J351	Bodo saltans	28%	91%
A0A1X0ND98	Trypanosomatidae	40%	100%
A0A1X0NJS0	Trypanosomatidae	29%	100%
A0A1X0NXG7	Trypanosomatidae	28%	93%
A0A3R7RE54	Trypanosoma rangeli	31%	94%
A0A3S5H7U6	Leishmania donovani	26%	100%
A0A3S7WXF4	Leishmania donovani	31%	82%
A4HCL8	Leishmania braziliensis	29%	82%
A4HDL1	Leishmania braziliensis	80%	100%
A4HE26	Leishmania braziliensis	27%	100%
A4HLM4	Leishmania braziliensis	27%	100%
A4I042	Leishmania infantum	31%	82%
A4I0X0	Leishmania infantum	100%	100%
A4I935	Leishmania infantum	26%	100%
C9ZUX8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	80%
C9ZWH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AWX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9B400	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	95%
P25007	Drosophila melanogaster	29%	100%
P29117	Rattus norvegicus	30%	100%
P52011	Caenorhabditis elegans	30%	100%
Q1RMP7	Bos taurus	29%	79%
Q26548	Schistosoma mansoni	29%	89%
Q38867	Arabidopsis thaliana	30%	100%
Q38900	Arabidopsis thaliana	29%	100%
Q4G338	Haemonchus contortus	30%	75%
Q4Q424	Leishmania major	26%	100%
Q4QAK0	Leishmania major	93%	100%
Q4QBH1	Leishmania major	31%	82%
Q99KR7	Mus musculus	29%	100%
V5B2A0	Trypanosoma cruzi	33%	94%