RNA-binding protein 38, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein 38, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WYC8_LEIDO

TriTrypDb:

LdBPK_241250.1 , LdCL_240017600 , LDHU3_24.1470

Length:

543

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WYC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYC8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	6
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.608
CLV_C14_Caspase3-7	90	94	PF00656	0.654
CLV_NRD_NRD_1	110	112	PF00675	0.617
CLV_NRD_NRD_1	176	178	PF00675	0.558
CLV_NRD_NRD_1	298	300	PF00675	0.535
CLV_NRD_NRD_1	465	467	PF00675	0.538
CLV_PCSK_KEX2_1	110	112	PF00082	0.636
CLV_PCSK_KEX2_1	298	300	PF00082	0.500
CLV_PCSK_KEX2_1	410	412	PF00082	0.610
CLV_PCSK_KEX2_1	465	467	PF00082	0.512
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.741
CLV_PCSK_PC1ET2_1	410	412	PF00082	0.610
CLV_PCSK_SKI1_1	14	18	PF00082	0.548
CLV_PCSK_SKI1_1	172	176	PF00082	0.525
CLV_PCSK_SKI1_1	291	295	PF00082	0.502
CLV_PCSK_SKI1_1	312	316	PF00082	0.459
CLV_PCSK_SKI1_1	354	358	PF00082	0.418
CLV_PCSK_SKI1_1	380	384	PF00082	0.436
CLV_PCSK_SKI1_1	386	390	PF00082	0.404
CLV_PCSK_SKI1_1	438	442	PF00082	0.452
CLV_PCSK_SKI1_1	465	469	PF00082	0.572
CLV_PCSK_SKI1_1	532	536	PF00082	0.719
CLV_Separin_Metazoa	415	419	PF03568	0.578
DEG_SPOP_SBC_1	117	121	PF00917	0.638
DEG_SPOP_SBC_1	62	66	PF00917	0.669
DOC_CKS1_1	159	164	PF01111	0.588
DOC_CKS1_1	341	346	PF01111	0.548
DOC_CKS1_1	493	498	PF01111	0.549
DOC_CYCLIN_yCln2_LP_2	80	83	PF00134	0.690
DOC_PP1_RVXF_1	170	176	PF00149	0.531
DOC_PP1_RVXF_1	289	296	PF00149	0.522
DOC_PP1_RVXF_1	356	363	PF00149	0.364
DOC_PP1_RVXF_1	387	393	PF00149	0.404
DOC_PP2B_LxvP_1	80	83	PF13499	0.630
DOC_USP7_MATH_1	117	121	PF00917	0.788
DOC_USP7_MATH_1	124	128	PF00917	0.709
DOC_USP7_MATH_1	162	166	PF00917	0.625
DOC_USP7_MATH_1	18	22	PF00917	0.587
DOC_USP7_MATH_1	194	198	PF00917	0.635
DOC_USP7_MATH_1	236	240	PF00917	0.674
DOC_USP7_MATH_1	247	251	PF00917	0.583
DOC_USP7_MATH_1	266	270	PF00917	0.710
DOC_USP7_MATH_1	303	307	PF00917	0.483
DOC_USP7_MATH_1	308	312	PF00917	0.493
DOC_USP7_MATH_1	36	40	PF00917	0.635
DOC_USP7_MATH_1	398	402	PF00917	0.642
DOC_USP7_MATH_1	76	80	PF00917	0.748
DOC_USP7_MATH_1	88	92	PF00917	0.633
DOC_USP7_MATH_1	94	98	PF00917	0.714
DOC_USP7_UBL2_3	108	112	PF12436	0.756
DOC_USP7_UBL2_3	389	393	PF12436	0.421
DOC_USP7_UBL2_3	438	442	PF12436	0.433
DOC_USP7_UBL2_3	92	96	PF12436	0.734
DOC_WW_Pin1_4	158	163	PF00397	0.493
DOC_WW_Pin1_4	204	209	PF00397	0.684
DOC_WW_Pin1_4	22	27	PF00397	0.592
DOC_WW_Pin1_4	28	33	PF00397	0.618
DOC_WW_Pin1_4	340	345	PF00397	0.493
DOC_WW_Pin1_4	38	43	PF00397	0.607
DOC_WW_Pin1_4	476	481	PF00397	0.605
DOC_WW_Pin1_4	492	497	PF00397	0.578
LIG_14-3-3_CanoR_1	310	315	PF00244	0.454
LIG_14-3-3_CanoR_1	348	357	PF00244	0.485
LIG_14-3-3_CanoR_1	421	429	PF00244	0.508
LIG_14-3-3_CanoR_1	483	488	PF00244	0.647
LIG_14-3-3_CanoR_1	514	523	PF00244	0.642
LIG_Actin_WH2_2	149	166	PF00022	0.570
LIG_BRCT_BRCA1_1	279	283	PF00533	0.426
LIG_EH1_1	136	144	PF00400	0.491
LIG_eIF4E_1	277	283	PF01652	0.496
LIG_FHA_1	158	164	PF00498	0.468
LIG_FHA_1	190	196	PF00498	0.704
LIG_FHA_1	300	306	PF00498	0.411
LIG_FHA_1	316	322	PF00498	0.425
LIG_FHA_1	328	334	PF00498	0.436
LIG_FHA_1	517	523	PF00498	0.704
LIG_FHA_1	68	74	PF00498	0.743
LIG_FHA_2	471	477	PF00498	0.666
LIG_LIR_Gen_1	135	144	PF02991	0.408
LIG_LIR_Gen_1	343	350	PF02991	0.426
LIG_LIR_Nem_3	135	141	PF02991	0.410
LIG_LIR_Nem_3	343	349	PF02991	0.433
LIG_LIR_Nem_3	450	454	PF02991	0.550
LIG_LIR_Nem_3	503	507	PF02991	0.563
LIG_LIR_Nem_3	508	513	PF02991	0.533
LIG_LIR_Nem_3	6	10	PF02991	0.547
LIG_MYND_1	480	484	PF01753	0.617
LIG_SH2_CRK	451	455	PF00017	0.535
LIG_SH2_GRB2like	365	368	PF00017	0.471
LIG_SH2_NCK_1	60	64	PF00017	0.561
LIG_SH2_PTP2	346	349	PF00017	0.413
LIG_SH2_PTP2	7	10	PF00017	0.663
LIG_SH2_STAT5	346	349	PF00017	0.414
LIG_SH2_STAT5	7	10	PF00017	0.663
LIG_SH3_3	165	171	PF00018	0.483
LIG_SH3_3	173	179	PF00018	0.528
LIG_SH3_3	202	208	PF00018	0.682
LIG_SH3_3	338	344	PF00018	0.484
LIG_SH3_3	490	496	PF00018	0.637
LIG_SH3_3	522	528	PF00018	0.581
LIG_SH3_3	80	86	PF00018	0.626
LIG_SUMO_SIM_anti_2	222	227	PF11976	0.442
LIG_TRAF2_1	412	415	PF00917	0.583
MOD_CDK_SPxK_1	158	164	PF00069	0.515
MOD_CDK_SPxxK_3	476	483	PF00069	0.602
MOD_CK1_1	115	121	PF00069	0.768
MOD_CK1_1	145	151	PF00069	0.517
MOD_CK1_1	188	194	PF00069	0.642
MOD_CK1_1	206	212	PF00069	0.645
MOD_CK1_1	239	245	PF00069	0.796
MOD_CK1_1	306	312	PF00069	0.515
MOD_CK1_1	409	415	PF00069	0.578
MOD_CK1_1	470	476	PF00069	0.558
MOD_CK1_1	515	521	PF00069	0.684
MOD_CK2_1	409	415	PF00069	0.537
MOD_CK2_1	470	476	PF00069	0.660
MOD_Cter_Amidation	105	108	PF01082	0.704
MOD_GlcNHglycan	114	117	PF01048	0.772
MOD_GlcNHglycan	122	125	PF01048	0.720
MOD_GlcNHglycan	126	129	PF01048	0.659
MOD_GlcNHglycan	196	199	PF01048	0.663
MOD_GlcNHglycan	200	203	PF01048	0.679
MOD_GlcNHglycan	249	252	PF01048	0.677
MOD_GlcNHglycan	268	271	PF01048	0.615
MOD_GlcNHglycan	38	41	PF01048	0.722
MOD_GlcNHglycan	422	425	PF01048	0.473
MOD_GlcNHglycan	535	538	PF01048	0.708
MOD_GSK3_1	112	119	PF00069	0.684
MOD_GSK3_1	120	127	PF00069	0.643
MOD_GSK3_1	158	165	PF00069	0.579
MOD_GSK3_1	18	25	PF00069	0.577
MOD_GSK3_1	185	192	PF00069	0.644
MOD_GSK3_1	194	201	PF00069	0.580
MOD_GSK3_1	299	306	PF00069	0.484
MOD_GSK3_1	310	317	PF00069	0.447
MOD_GSK3_1	394	401	PF00069	0.591
MOD_GSK3_1	472	479	PF00069	0.663
MOD_GSK3_1	512	519	PF00069	0.588
MOD_GSK3_1	61	68	PF00069	0.726
MOD_N-GLC_1	28	33	PF02516	0.700
MOD_N-GLC_1	315	320	PF02516	0.412
MOD_N-GLC_1	470	475	PF02516	0.623
MOD_NEK2_1	221	226	PF00069	0.437
MOD_NEK2_1	315	320	PF00069	0.398
MOD_NEK2_1	429	434	PF00069	0.566
MOD_NEK2_1	447	452	PF00069	0.314
MOD_PIKK_1	512	518	PF00454	0.621
MOD_PK_1	310	316	PF00069	0.476
MOD_PKA_1	393	399	PF00069	0.569
MOD_PKA_2	420	426	PF00069	0.503
MOD_Plk_1	185	191	PF00069	0.676
MOD_Plk_1	219	225	PF00069	0.617
MOD_Plk_1	289	295	PF00069	0.525
MOD_Plk_1	315	321	PF00069	0.409
MOD_Plk_4	221	227	PF00069	0.439
MOD_Plk_4	277	283	PF00069	0.514
MOD_Plk_4	291	297	PF00069	0.422
MOD_Plk_4	315	321	PF00069	0.421
MOD_Plk_4	329	335	PF00069	0.443
MOD_Plk_4	342	348	PF00069	0.389
MOD_Plk_4	76	82	PF00069	0.647
MOD_ProDKin_1	158	164	PF00069	0.491
MOD_ProDKin_1	204	210	PF00069	0.686
MOD_ProDKin_1	22	28	PF00069	0.593
MOD_ProDKin_1	340	346	PF00069	0.493
MOD_ProDKin_1	38	44	PF00069	0.606
MOD_ProDKin_1	476	482	PF00069	0.603
MOD_ProDKin_1	492	498	PF00069	0.578
MOD_SUMO_for_1	328	331	PF00179	0.486
MOD_SUMO_for_1	388	391	PF00179	0.408
MOD_SUMO_rev_2	369	376	PF00179	0.379
MOD_SUMO_rev_2	529	534	PF00179	0.710
MOD_SUMO_rev_2	89	94	PF00179	0.716
TRG_DiLeu_BaLyEn_6	345	350	PF01217	0.544
TRG_ENDOCYTIC_2	346	349	PF00928	0.413
TRG_ENDOCYTIC_2	451	454	PF00928	0.563
TRG_ENDOCYTIC_2	7	10	PF00928	0.663
TRG_ER_diArg_1	298	300	PF00400	0.536
TRG_ER_diArg_1	464	466	PF00400	0.499
TRG_ER_diArg_1	539	542	PF00400	0.609
TRG_NLS_MonoCore_2	106	111	PF00514	0.742
TRG_NLS_MonoExtC_3	106	111	PF00514	0.742
TRG_NLS_MonoExtN_4	107	114	PF00514	0.693
TRG_Pf-PMV_PEXEL_1	348	353	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	386	391	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	411	415	PF00026	0.589
TRG_Pf-PMV_PEXEL_1	524	529	PF00026	0.692

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC49	Leptomonas seymouri	67%	100%
A0A0S4J510	Bodo saltans	38%	100%
A0A1X0NW66	Trypanosomatidae	45%	100%
A0A422NQ46	Trypanosoma rangeli	44%	100%
A4HDH9	Leishmania braziliensis	79%	98%
A4I0W0	Leishmania infantum	100%	100%
D0A792	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AWW4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	99%
Q4QAL0	Leishmania major	95%	100%