Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical predicted transmembrane protein

Species:

Leishmania donovani

UniProt:

A0A3S7WYC5_LEIDO

TriTrypDb:

LdBPK_240700.1 , LdCL_240012000 , LDHU3_24.0830

Length:

152

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3S7WYC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYC5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	108	110	PF00082	0.685
CLV_PCSK_KEX2_1	116	118	PF00082	0.762
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.685
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.762
CLV_PCSK_SKI1_1	103	107	PF00082	0.665
CLV_PCSK_SKI1_1	22	26	PF00082	0.516
CLV_PCSK_SKI1_1	29	33	PF00082	0.463
CLV_PCSK_SKI1_1	66	70	PF00082	0.481
CLV_Separin_Metazoa	19	23	PF03568	0.719
DEG_APCC_DBOX_1	131	139	PF00400	0.520
DEG_Nend_Nbox_1	1	3	PF02207	0.709
DEG_SPOP_SBC_1	12	16	PF00917	0.720
DOC_CYCLIN_RxL_1	60	72	PF00134	0.679
DOC_PP4_FxxP_1	10	13	PF00568	0.750
DOC_SPAK_OSR1_1	9	13	PF12202	0.723
DOC_USP7_MATH_1	13	17	PF00917	0.711
DOC_USP7_MATH_1	58	62	PF00917	0.633
DOC_WW_Pin1_4	133	138	PF00397	0.574
DOC_WW_Pin1_4	14	19	PF00397	0.695
DOC_WW_Pin1_4	54	59	PF00397	0.661
DOC_WW_Pin1_4	69	74	PF00397	0.552
LIG_14-3-3_CanoR_1	22	31	PF00244	0.723
LIG_14-3-3_CanoR_1	48	52	PF00244	0.629
LIG_APCC_ABBAyCdc20_2	56	62	PF00400	0.603
LIG_BRCT_BRCA1_1	60	64	PF00533	0.665
LIG_FHA_1	6	12	PF00498	0.775
LIG_FHA_2	23	29	PF00498	0.702
LIG_FHA_2	32	38	PF00498	0.750
LIG_LIR_Apic_2	8	13	PF02991	0.694
LIG_LIR_Gen_1	139	147	PF02991	0.593
LIG_LIR_Gen_1	37	45	PF02991	0.697
LIG_LIR_Nem_3	139	144	PF02991	0.593
LIG_LIR_Nem_3	37	42	PF02991	0.666
LIG_LIR_Nem_3	61	67	PF02991	0.721
LIG_MLH1_MIPbox_1	60	64	PF16413	0.665
LIG_Pex14_2	86	90	PF04695	0.389
LIG_REV1ctd_RIR_1	103	113	PF16727	0.413
LIG_REV1ctd_RIR_1	61	70	PF16727	0.724
LIG_SH2_CRK	39	43	PF00017	0.658
LIG_SH2_STAP1	39	43	PF00017	0.691
LIG_SH2_STAT5	67	70	PF00017	0.674
LIG_SH3_3	15	21	PF00018	0.742
LIG_SH3_3	91	97	PF00018	0.465
LIG_TRAF2_1	126	129	PF00917	0.592
LIG_TRAF2_1	137	140	PF00917	0.482
LIG_WRC_WIRS_1	87	92	PF05994	0.389
MOD_CK1_1	118	124	PF00069	0.542
MOD_CK1_1	14	20	PF00069	0.655
MOD_CK1_1	5	11	PF00069	0.735
MOD_CK2_1	13	19	PF00069	0.718
MOD_CK2_1	133	139	PF00069	0.598
MOD_CK2_1	22	28	PF00069	0.646
MOD_Cter_Amidation	114	117	PF01082	0.715
MOD_GlcNHglycan	117	120	PF01048	0.684
MOD_GlcNHglycan	34	37	PF01048	0.476
MOD_GlcNHglycan	69	72	PF01048	0.519
MOD_GSK3_1	115	122	PF00069	0.552
MOD_GSK3_1	54	61	PF00069	0.691
MOD_NEK2_1	2	7	PF00069	0.691
MOD_NEK2_1	86	91	PF00069	0.475
MOD_PKA_2	131	137	PF00069	0.457
MOD_PKA_2	47	53	PF00069	0.687
MOD_PKA_2	5	11	PF00069	0.693
MOD_ProDKin_1	133	139	PF00069	0.573
MOD_ProDKin_1	14	20	PF00069	0.694
MOD_ProDKin_1	54	60	PF00069	0.657
MOD_ProDKin_1	69	75	PF00069	0.552
MOD_SUMO_for_1	147	150	PF00179	0.509
TRG_DiLeu_BaEn_1	140	145	PF01217	0.505
TRG_DiLeu_BaEn_2	18	24	PF01217	0.692
TRG_ENDOCYTIC_2	39	42	PF00928	0.660
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5G4	Leptomonas seymouri	42%	100%
A4HDC7	Leishmania braziliensis	64%	100%
A4I0Q7	Leishmania infantum	99%	100%
E9AWQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QAR4	Leishmania major	92%	100%