PHD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WYC3_LEIDO

TriTrypDb:

LdBPK_241260.1 , LdCL_240017700 , LDHU3_24.1480

Length:

762

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WYC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYC3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	308	312	PF00656	0.699
CLV_C14_Caspase3-7	742	746	PF00656	0.677
CLV_C14_Caspase3-7	756	760	PF00656	0.530
CLV_NRD_NRD_1	169	171	PF00675	0.638
CLV_NRD_NRD_1	226	228	PF00675	0.520
CLV_NRD_NRD_1	433	435	PF00675	0.485
CLV_NRD_NRD_1	494	496	PF00675	0.469
CLV_NRD_NRD_1	577	579	PF00675	0.473
CLV_NRD_NRD_1	646	648	PF00675	0.476
CLV_NRD_NRD_1	729	731	PF00675	0.652
CLV_PCSK_FUR_1	166	170	PF00082	0.759
CLV_PCSK_KEX2_1	166	168	PF00082	0.650
CLV_PCSK_KEX2_1	169	171	PF00082	0.624
CLV_PCSK_KEX2_1	226	228	PF00082	0.520
CLV_PCSK_KEX2_1	433	435	PF00082	0.485
CLV_PCSK_KEX2_1	494	496	PF00082	0.469
CLV_PCSK_KEX2_1	609	611	PF00082	0.528
CLV_PCSK_KEX2_1	627	629	PF00082	0.355
CLV_PCSK_KEX2_1	731	733	PF00082	0.635
CLV_PCSK_PC1ET2_1	609	611	PF00082	0.509
CLV_PCSK_PC1ET2_1	627	629	PF00082	0.355
CLV_PCSK_PC1ET2_1	731	733	PF00082	0.635
CLV_PCSK_SKI1_1	133	137	PF00082	0.607
CLV_PCSK_SKI1_1	285	289	PF00082	0.551
CLV_PCSK_SKI1_1	540	544	PF00082	0.481
CLV_PCSK_SKI1_1	600	604	PF00082	0.419
DEG_APCC_DBOX_1	577	585	PF00400	0.416
DEG_SPOP_SBC_1	387	391	PF00917	0.734
DOC_CYCLIN_RxL_1	133	143	PF00134	0.584
DOC_CYCLIN_RxL_1	404	418	PF00134	0.578
DOC_CYCLIN_RxL_1	535	546	PF00134	0.563
DOC_MAPK_gen_1	598	607	PF00069	0.383
DOC_MAPK_gen_1	75	85	PF00069	0.684
DOC_PP1_RVXF_1	615	621	PF00149	0.452
DOC_PP2B_LxvP_1	159	162	PF13499	0.759
DOC_PP2B_LxvP_1	185	188	PF13499	0.549
DOC_PP2B_LxvP_1	325	328	PF13499	0.705
DOC_PP2B_LxvP_1	451	454	PF13499	0.416
DOC_PP4_FxxP_1	287	290	PF00568	0.546
DOC_PP4_FxxP_1	320	323	PF00568	0.710
DOC_PP4_FxxP_1	620	623	PF00568	0.395
DOC_USP7_MATH_1	107	111	PF00917	0.697
DOC_USP7_MATH_1	176	180	PF00917	0.659
DOC_USP7_MATH_1	197	201	PF00917	0.698
DOC_USP7_MATH_1	221	225	PF00917	0.751
DOC_USP7_MATH_1	309	313	PF00917	0.674
DOC_USP7_MATH_1	378	382	PF00917	0.765
DOC_USP7_MATH_1	400	404	PF00917	0.614
DOC_USP7_MATH_1	503	507	PF00917	0.361
DOC_USP7_MATH_1	623	627	PF00917	0.427
DOC_USP7_MATH_1	94	98	PF00917	0.618
DOC_WW_Pin1_4	112	117	PF00397	0.624
DOC_WW_Pin1_4	154	159	PF00397	0.629
DOC_WW_Pin1_4	179	184	PF00397	0.632
DOC_WW_Pin1_4	226	231	PF00397	0.608
DOC_WW_Pin1_4	248	253	PF00397	0.502
DOC_WW_Pin1_4	294	299	PF00397	0.688
DOC_WW_Pin1_4	31	36	PF00397	0.643
DOC_WW_Pin1_4	319	324	PF00397	0.767
DOC_WW_Pin1_4	346	351	PF00397	0.610
DOC_WW_Pin1_4	420	425	PF00397	0.614
DOC_WW_Pin1_4	546	551	PF00397	0.544
DOC_WW_Pin1_4	619	624	PF00397	0.440
DOC_WW_Pin1_4	684	689	PF00397	0.663
DOC_WW_Pin1_4	99	104	PF00397	0.731
LIG_14-3-3_CanoR_1	109	113	PF00244	0.616
LIG_14-3-3_CanoR_1	141	147	PF00244	0.696
LIG_14-3-3_CanoR_1	202	209	PF00244	0.728
LIG_14-3-3_CanoR_1	318	323	PF00244	0.711
LIG_14-3-3_CanoR_1	511	516	PF00244	0.489
LIG_14-3-3_CanoR_1	583	589	PF00244	0.481
LIG_14-3-3_CanoR_1	650	658	PF00244	0.473
LIG_14-3-3_CanoR_1	80	86	PF00244	0.631
LIG_Actin_WH2_2	228	244	PF00022	0.679
LIG_Actin_WH2_2	520	537	PF00022	0.539
LIG_Actin_WH2_2	577	594	PF00022	0.385
LIG_BIR_III_4	153	157	PF00653	0.679
LIG_BRCT_BRCA1_1	631	635	PF00533	0.391
LIG_Clathr_ClatBox_1	585	589	PF01394	0.353
LIG_FHA_1	134	140	PF00498	0.575
LIG_FHA_1	141	147	PF00498	0.578
LIG_FHA_1	335	341	PF00498	0.592
LIG_FHA_1	349	355	PF00498	0.598
LIG_FHA_1	378	384	PF00498	0.692
LIG_FHA_1	462	468	PF00498	0.447
LIG_FHA_1	585	591	PF00498	0.470
LIG_FHA_2	253	259	PF00498	0.401
LIG_FHA_2	306	312	PF00498	0.702
LIG_FHA_2	455	461	PF00498	0.541
LIG_FHA_2	644	650	PF00498	0.499
LIG_FHA_2	754	760	PF00498	0.655
LIG_Integrin_isoDGR_2	164	166	PF01839	0.732
LIG_Integrin_isoDGR_2	509	511	PF01839	0.444
LIG_Integrin_RGD_1	372	374	PF01839	0.595
LIG_LIR_Apic_2	286	290	PF02991	0.515
LIG_LIR_Apic_2	619	623	PF02991	0.416
LIG_LIR_Gen_1	274	280	PF02991	0.495
LIG_LIR_Gen_1	563	571	PF02991	0.403
LIG_LIR_Gen_1	632	642	PF02991	0.397
LIG_LIR_Nem_3	274	278	PF02991	0.493
LIG_LIR_Nem_3	397	402	PF02991	0.779
LIG_LIR_Nem_3	480	486	PF02991	0.433
LIG_LIR_Nem_3	522	527	PF02991	0.550
LIG_LIR_Nem_3	563	567	PF02991	0.394
LIG_LIR_Nem_3	632	638	PF02991	0.382
LIG_LYPXL_yS_3	399	402	PF13949	0.690
LIG_MYND_1	323	327	PF01753	0.660
LIG_MYND_1	384	388	PF01753	0.707
LIG_NRBOX	580	586	PF00104	0.384
LIG_PCNA_yPIPBox_3	509	521	PF02747	0.403
LIG_Pex14_2	287	291	PF04695	0.525
LIG_PTB_Apo_2	661	668	PF02174	0.397
LIG_SH2_CRK	448	452	PF00017	0.416
LIG_SH2_CRK	524	528	PF00017	0.544
LIG_SH2_CRK	642	646	PF00017	0.484
LIG_SH2_NCK_1	642	646	PF00017	0.484
LIG_SH2_SRC	642	645	PF00017	0.483
LIG_SH2_STAT5	486	489	PF00017	0.421
LIG_SH2_STAT5	498	501	PF00017	0.403
LIG_SH3_3	118	124	PF00018	0.624
LIG_SH3_3	180	186	PF00018	0.675
LIG_SH3_3	311	317	PF00018	0.720
LIG_SH3_3	320	326	PF00018	0.655
LIG_SH3_3	381	387	PF00018	0.750
LIG_SH3_3	403	409	PF00018	0.726
LIG_SH3_3	421	427	PF00018	0.417
LIG_SUMO_SIM_par_1	41	49	PF11976	0.597
LIG_TRAF2_1	704	707	PF00917	0.681
LIG_TYR_ITIM	273	278	PF00017	0.485
LIG_TYR_ITIM	446	451	PF00017	0.392
LIG_UBA3_1	584	592	PF00899	0.356
LIG_ULM_U2AF65_1	647	652	PF00076	0.463
LIG_WRC_WIRS_1	630	635	PF05994	0.389
LIG_WW_2	323	326	PF00397	0.664
MOD_CDC14_SPxK_1	106	109	PF00782	0.608
MOD_CDK_SPK_2	31	36	PF00069	0.604
MOD_CDK_SPxK_1	103	109	PF00069	0.609
MOD_CK1_1	115	121	PF00069	0.629
MOD_CK1_1	142	148	PF00069	0.711
MOD_CK1_1	179	185	PF00069	0.617
MOD_CK1_1	204	210	PF00069	0.658
MOD_CK1_1	229	235	PF00069	0.593
MOD_CK1_1	300	306	PF00069	0.767
MOD_CK1_1	312	318	PF00069	0.773
MOD_CK1_1	335	341	PF00069	0.706
MOD_CK1_1	392	398	PF00069	0.706
MOD_CK1_1	546	552	PF00069	0.545
MOD_CK1_1	710	716	PF00069	0.682
MOD_CK1_1	735	741	PF00069	0.694
MOD_CK1_1	84	90	PF00069	0.724
MOD_CK1_1	92	98	PF00069	0.641
MOD_CK1_1	99	105	PF00069	0.591
MOD_CK2_1	107	113	PF00069	0.755
MOD_CK2_1	248	254	PF00069	0.496
MOD_CK2_1	336	342	PF00069	0.755
MOD_CK2_1	454	460	PF00069	0.537
MOD_CK2_1	613	619	PF00069	0.482
MOD_CK2_1	643	649	PF00069	0.492
MOD_CK2_1	701	707	PF00069	0.800
MOD_CK2_1	710	716	PF00069	0.585
MOD_Cter_Amidation	164	167	PF01082	0.763
MOD_Cter_Amidation	224	227	PF01082	0.520
MOD_GlcNHglycan	117	120	PF01048	0.676
MOD_GlcNHglycan	172	175	PF01048	0.745
MOD_GlcNHglycan	195	198	PF01048	0.704
MOD_GlcNHglycan	204	207	PF01048	0.552
MOD_GlcNHglycan	210	213	PF01048	0.516
MOD_GlcNHglycan	222	226	PF01048	0.669
MOD_GlcNHglycan	267	270	PF01048	0.478
MOD_GlcNHglycan	299	302	PF01048	0.655
MOD_GlcNHglycan	369	372	PF01048	0.697
MOD_GlcNHglycan	380	383	PF01048	0.712
MOD_GlcNHglycan	391	394	PF01048	0.599
MOD_GlcNHglycan	479	482	PF01048	0.446
MOD_GlcNHglycan	518	521	PF01048	0.524
MOD_GlcNHglycan	544	548	PF01048	0.498
MOD_GlcNHglycan	569	572	PF01048	0.394
MOD_GlcNHglycan	684	687	PF01048	0.657
MOD_GlcNHglycan	703	706	PF01048	0.516
MOD_GlcNHglycan	721	724	PF01048	0.632
MOD_GlcNHglycan	734	737	PF01048	0.684
MOD_GlcNHglycan	745	748	PF01048	0.577
MOD_GlcNHglycan	88	91	PF01048	0.801
MOD_GlcNHglycan	98	101	PF01048	0.685
MOD_GSK3_1	103	110	PF00069	0.577
MOD_GSK3_1	135	142	PF00069	0.612
MOD_GSK3_1	189	196	PF00069	0.655
MOD_GSK3_1	197	204	PF00069	0.753
MOD_GSK3_1	217	224	PF00069	0.594
MOD_GSK3_1	248	255	PF00069	0.471
MOD_GSK3_1	290	297	PF00069	0.647
MOD_GSK3_1	300	307	PF00069	0.687
MOD_GSK3_1	332	339	PF00069	0.724
MOD_GSK3_1	363	370	PF00069	0.684
MOD_GSK3_1	373	380	PF00069	0.573
MOD_GSK3_1	387	394	PF00069	0.720
MOD_GSK3_1	42	49	PF00069	0.668
MOD_GSK3_1	511	518	PF00069	0.435
MOD_GSK3_1	529	536	PF00069	0.417
MOD_GSK3_1	565	572	PF00069	0.382
MOD_GSK3_1	619	626	PF00069	0.441
MOD_GSK3_1	706	713	PF00069	0.589
MOD_GSK3_1	715	722	PF00069	0.564
MOD_GSK3_1	84	91	PF00069	0.719
MOD_GSK3_1	92	99	PF00069	0.674
MOD_N-GLC_1	149	154	PF02516	0.584
MOD_N-GLC_1	176	181	PF02516	0.694
MOD_N-GLC_1	682	687	PF02516	0.745
MOD_N-GLC_1	714	719	PF02516	0.599
MOD_N-GLC_2	264	266	PF02516	0.419
MOD_NEK2_1	139	144	PF00069	0.684
MOD_NEK2_1	193	198	PF00069	0.689
MOD_NEK2_1	340	345	PF00069	0.590
MOD_NEK2_1	515	520	PF00069	0.377
MOD_NEK2_1	534	539	PF00069	0.420
MOD_NEK2_1	569	574	PF00069	0.404
MOD_NEK2_1	591	596	PF00069	0.485
MOD_NEK2_1	629	634	PF00069	0.392
MOD_PIKK_1	229	235	PF00454	0.604
MOD_PIKK_1	327	333	PF00454	0.761
MOD_PIKK_1	503	509	PF00454	0.518
MOD_PIKK_1	529	535	PF00454	0.415
MOD_PK_1	332	338	PF00069	0.672
MOD_PKA_1	168	174	PF00069	0.753
MOD_PKA_2	108	114	PF00069	0.614
MOD_PKA_2	140	146	PF00069	0.716
MOD_PKA_2	168	174	PF00069	0.704
MOD_PKA_2	201	207	PF00069	0.753
MOD_PKA_2	649	655	PF00069	0.474
MOD_PKA_2	66	72	PF00069	0.641
MOD_PKA_2	707	713	PF00069	0.682
MOD_PKB_1	166	174	PF00069	0.756
MOD_PKB_1	730	738	PF00069	0.633
MOD_Plk_1	176	182	PF00069	0.691
MOD_Plk_1	189	195	PF00069	0.568
MOD_Plk_1	373	379	PF00069	0.665
MOD_Plk_1	475	481	PF00069	0.446
MOD_Plk_1	706	712	PF00069	0.734
MOD_Plk_4	142	148	PF00069	0.580
MOD_Plk_4	252	258	PF00069	0.427
MOD_Plk_4	42	48	PF00069	0.597
MOD_Plk_4	511	517	PF00069	0.356
MOD_ProDKin_1	112	118	PF00069	0.622
MOD_ProDKin_1	154	160	PF00069	0.630
MOD_ProDKin_1	179	185	PF00069	0.631
MOD_ProDKin_1	226	232	PF00069	0.604
MOD_ProDKin_1	248	254	PF00069	0.496
MOD_ProDKin_1	294	300	PF00069	0.696
MOD_ProDKin_1	31	37	PF00069	0.638
MOD_ProDKin_1	319	325	PF00069	0.766
MOD_ProDKin_1	346	352	PF00069	0.609
MOD_ProDKin_1	420	426	PF00069	0.613
MOD_ProDKin_1	546	552	PF00069	0.534
MOD_ProDKin_1	619	625	PF00069	0.444
MOD_ProDKin_1	684	690	PF00069	0.667
MOD_ProDKin_1	99	105	PF00069	0.732
TRG_DiLeu_BaEn_1	431	436	PF01217	0.539
TRG_DiLeu_BaLyEn_6	580	585	PF01217	0.507
TRG_DiLeu_LyEn_5	431	436	PF01217	0.475
TRG_ENDOCYTIC_2	275	278	PF00928	0.491
TRG_ENDOCYTIC_2	399	402	PF00928	0.722
TRG_ENDOCYTIC_2	448	451	PF00928	0.415
TRG_ENDOCYTIC_2	524	527	PF00928	0.423
TRG_ENDOCYTIC_2	630	633	PF00928	0.393
TRG_ENDOCYTIC_2	642	645	PF00928	0.483
TRG_ER_diArg_1	166	169	PF00400	0.711
TRG_ER_diArg_1	2	5	PF00400	0.629
TRG_ER_diArg_1	226	228	PF00400	0.520
TRG_ER_diArg_1	278	281	PF00400	0.549
TRG_ER_diArg_1	432	434	PF00400	0.489
TRG_ER_diArg_1	50	53	PF00400	0.755
TRG_ER_diArg_1	595	598	PF00400	0.384
TRG_ER_diArg_1	62	65	PF00400	0.599
TRG_Pf-PMV_PEXEL_1	36	41	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	540	544	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	627	631	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYY8	Leptomonas seymouri	51%	91%
A4HDI0	Leishmania braziliensis	77%	100%
A4I0W1	Leishmania infantum	99%	100%
E9AWW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QAK9	Leishmania major	92%	100%