Surfeit locus protein 6, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Surfeit locus protein 6, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WYB0_LEIDO

TriTrypDb:

LdBPK_241210.1 , LdCL_240017200 , LDHU3_24.1430

Length:

248

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	8
GO:0005730	nucleolus	5	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7WYB0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYB0

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0022613	ribonucleoprotein complex biogenesis	4	1
GO:0042273	ribosomal large subunit biogenesis	5	1
GO:0042274	ribosomal small subunit biogenesis	5	1
GO:0044085	cellular component biogenesis	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.345
CLV_NRD_NRD_1	159	161	PF00675	0.337
CLV_NRD_NRD_1	16	18	PF00675	0.680
CLV_NRD_NRD_1	172	174	PF00675	0.346
CLV_NRD_NRD_1	197	199	PF00675	0.337
CLV_NRD_NRD_1	237	239	PF00675	0.677
CLV_NRD_NRD_1	50	52	PF00675	0.417
CLV_PCSK_KEX2_1	109	111	PF00082	0.306
CLV_PCSK_KEX2_1	158	160	PF00082	0.357
CLV_PCSK_KEX2_1	16	18	PF00082	0.680
CLV_PCSK_KEX2_1	163	165	PF00082	0.329
CLV_PCSK_KEX2_1	168	170	PF00082	0.348
CLV_PCSK_KEX2_1	172	174	PF00082	0.306
CLV_PCSK_KEX2_1	209	211	PF00082	0.609
CLV_PCSK_KEX2_1	52	54	PF00082	0.445
CLV_PCSK_KEX2_1	93	95	PF00082	0.326
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.307
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.340
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.364
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.609
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.376
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.309
CLV_PCSK_PC7_1	159	165	PF00082	0.306
CLV_PCSK_SKI1_1	111	115	PF00082	0.315
CLV_PCSK_SKI1_1	151	155	PF00082	0.356
CLV_PCSK_SKI1_1	199	203	PF00082	0.311
CLV_PCSK_SKI1_1	210	214	PF00082	0.551
CLV_PCSK_SKI1_1	53	57	PF00082	0.384
DEG_Nend_UBRbox_1	1	4	PF02207	0.661
DOC_AGCK_PIF_2	80	85	PF00069	0.300
DOC_MAPK_MEF2A_6	53	62	PF00069	0.359
DOC_MAPK_MEF2A_6	71	80	PF00069	0.313
DOC_USP7_MATH_1	58	62	PF00917	0.390
DOC_USP7_UBL2_3	154	158	PF12436	0.301
DOC_USP7_UBL2_3	192	196	PF12436	0.411
DOC_USP7_UBL2_3	202	206	PF12436	0.257
DOC_USP7_UBL2_3	223	227	PF12436	0.650
DOC_USP7_UBL2_3	235	239	PF12436	0.475
DOC_USP7_UBL2_3	89	93	PF12436	0.360
DOC_WW_Pin1_4	33	38	PF00397	0.640
LIG_14-3-3_CanoR_1	110	119	PF00244	0.315
LIG_14-3-3_CanoR_1	164	170	PF00244	0.300
LIG_14-3-3_CanoR_1	57	63	PF00244	0.510
LIG_14-3-3_CterR_2	243	248	PF00244	0.609
LIG_CtBP_PxDLS_1	75	79	PF00389	0.300
LIG_FHA_2	112	118	PF00498	0.267
LIG_LIR_Gen_1	84	91	PF02991	0.360
LIG_LIR_Nem_3	77	83	PF02991	0.304
LIG_NRBOX	100	106	PF00104	0.360
LIG_NRP_CendR_1	245	248	PF00754	0.684
LIG_PTB_Apo_2	79	86	PF02174	0.300
LIG_SH3_3	31	37	PF00018	0.628
LIG_SUMO_SIM_par_1	74	79	PF11976	0.360
MOD_CDK_SPxxK_3	33	40	PF00069	0.544
MOD_CK1_1	20	26	PF00069	0.568
MOD_CK1_1	45	51	PF00069	0.619
MOD_CK1_1	7	13	PF00069	0.637
MOD_Cter_Amidation	14	17	PF01082	0.702
MOD_Cter_Amidation	220	223	PF01082	0.733
MOD_Cter_Amidation	91	94	PF01082	0.360
MOD_DYRK1A_RPxSP_1	33	37	PF00069	0.541
MOD_GlcNHglycan	133	136	PF01048	0.357
MOD_GlcNHglycan	139	142	PF01048	0.382
MOD_GlcNHglycan	165	168	PF01048	0.311
MOD_GlcNHglycan	19	22	PF01048	0.650
MOD_GlcNHglycan	219	222	PF01048	0.765
MOD_GlcNHglycan	9	12	PF01048	0.778
MOD_GSK3_1	20	27	PF00069	0.667
MOD_GSK3_1	217	224	PF00069	0.696
MOD_GSK3_1	239	246	PF00069	0.636
MOD_GSK3_1	3	10	PF00069	0.632
MOD_GSK3_1	43	50	PF00069	0.800
MOD_N-GLC_1	17	22	PF02516	0.632
MOD_N-GLC_1	7	12	PF02516	0.603
MOD_NEK2_1	118	123	PF00069	0.458
MOD_NEK2_1	137	142	PF00069	0.196
MOD_NEK2_1	76	81	PF00069	0.300
MOD_PK_1	186	192	PF00069	0.360
MOD_PKA_1	158	164	PF00069	0.295
MOD_PKA_2	158	164	PF00069	0.318
MOD_PKA_2	3	9	PF00069	0.616
MOD_PKA_2	58	64	PF00069	0.346
MOD_PKB_1	51	59	PF00069	0.423
MOD_Plk_1	177	183	PF00069	0.360
MOD_Plk_1	186	192	PF00069	0.360
MOD_Plk_1	76	82	PF00069	0.320
MOD_Plk_1	99	105	PF00069	0.360
MOD_Plk_2-3	126	132	PF00069	0.328
MOD_Plk_4	100	106	PF00069	0.394
MOD_ProDKin_1	33	39	PF00069	0.639
MOD_SUMO_rev_2	84	91	PF00179	0.300
TRG_DiLeu_BaEn_1	100	105	PF01217	0.360
TRG_ER_diArg_1	172	174	PF00400	0.283
TRG_ER_diArg_1	57	60	PF00400	0.304
TRG_NES_CRM1_1	64	77	PF08389	0.328
TRG_NLS_Bipartite_1	209	231	PF00514	0.747
TRG_NLS_MonoExtC_3	157	162	PF00514	0.247
TRG_NLS_MonoExtN_4	159	166	PF00514	0.290

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5P3	Leptomonas seymouri	72%	100%
A4HDH5	Leishmania braziliensis	77%	100%
A4I0V6	Leishmania infantum	100%	100%
D0A787	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AWW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QAL4	Leishmania major	91%	100%