Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WYA9_LEIDO

TriTrypDb:

LdBPK_241060.1 , LdCL_240015600 , LDHU3_24.1240

Length:

920

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WYA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYA9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	28	32	PF00656	0.621
CLV_NRD_NRD_1	114	116	PF00675	0.677
CLV_NRD_NRD_1	160	162	PF00675	0.678
CLV_NRD_NRD_1	163	165	PF00675	0.666
CLV_NRD_NRD_1	283	285	PF00675	0.578
CLV_NRD_NRD_1	501	503	PF00675	0.587
CLV_NRD_NRD_1	552	554	PF00675	0.655
CLV_NRD_NRD_1	570	572	PF00675	0.511
CLV_NRD_NRD_1	617	619	PF00675	0.786
CLV_NRD_NRD_1	620	622	PF00675	0.731
CLV_PCSK_FUR_1	158	162	PF00082	0.614
CLV_PCSK_FUR_1	281	285	PF00082	0.589
CLV_PCSK_FUR_1	618	622	PF00082	0.656
CLV_PCSK_KEX2_1	114	116	PF00082	0.773
CLV_PCSK_KEX2_1	160	162	PF00082	0.651
CLV_PCSK_KEX2_1	163	165	PF00082	0.631
CLV_PCSK_KEX2_1	283	285	PF00082	0.699
CLV_PCSK_KEX2_1	619	621	PF00082	0.782
CLV_PCSK_KEX2_1	753	755	PF00082	0.429
CLV_PCSK_PC1ET2_1	619	621	PF00082	0.782
CLV_PCSK_PC1ET2_1	753	755	PF00082	0.429
CLV_PCSK_PC7_1	156	162	PF00082	0.654
CLV_PCSK_PC7_1	615	621	PF00082	0.621
CLV_PCSK_SKI1_1	134	138	PF00082	0.645
CLV_PCSK_SKI1_1	554	558	PF00082	0.645
CLV_PCSK_SKI1_1	584	588	PF00082	0.634
CLV_PCSK_SKI1_1	678	682	PF00082	0.619
CLV_Separin_Metazoa	756	760	PF03568	0.517
DEG_APCC_DBOX_1	294	302	PF00400	0.633
DEG_APCC_DBOX_1	879	887	PF00400	0.552
DEG_SCF_FBW7_1	803	810	PF00400	0.512
DEG_SPOP_SBC_1	211	215	PF00917	0.590
DEG_SPOP_SBC_1	223	227	PF00917	0.546
DEG_SPOP_SBC_1	36	40	PF00917	0.667
DEG_SPOP_SBC_1	515	519	PF00917	0.625
DEG_SPOP_SBC_1	874	878	PF00917	0.564
DOC_CDC14_PxL_1	302	310	PF14671	0.536
DOC_CDC14_PxL_1	713	721	PF14671	0.526
DOC_CKS1_1	522	527	PF01111	0.664
DOC_CKS1_1	804	809	PF01111	0.523
DOC_CKS1_1	849	854	PF01111	0.583
DOC_CKS1_1	879	884	PF01111	0.572
DOC_CYCLIN_yCln2_LP_2	471	477	PF00134	0.600
DOC_CYCLIN_yCln2_LP_2	542	548	PF00134	0.687
DOC_CYCLIN_yCln2_LP_2	56	62	PF00134	0.656
DOC_CYCLIN_yCln2_LP_2	699	705	PF00134	0.684
DOC_MAPK_MEF2A_6	455	462	PF00069	0.613
DOC_MAPK_MEF2A_6	698	705	PF00069	0.675
DOC_MAPK_MEF2A_6	855	863	PF00069	0.573
DOC_MAPK_MEF2A_6	884	892	PF00069	0.498
DOC_MAPK_MEF2A_6	910	917	PF00069	0.571
DOC_MAPK_RevD_3	739	754	PF00069	0.430
DOC_PP2B_LxvP_1	143	146	PF13499	0.579
DOC_PP2B_LxvP_1	471	474	PF13499	0.644
DOC_PP2B_LxvP_1	542	545	PF13499	0.681
DOC_PP2B_LxvP_1	699	702	PF13499	0.682
DOC_PP2B_LxvP_1	839	842	PF13499	0.620
DOC_PP2B_PxIxI_1	75	81	PF00149	0.576
DOC_PP4_FxxP_1	182	185	PF00568	0.513
DOC_USP7_MATH_1	116	120	PF00917	0.788
DOC_USP7_MATH_1	211	215	PF00917	0.650
DOC_USP7_MATH_1	322	326	PF00917	0.533
DOC_USP7_MATH_1	348	352	PF00917	0.705
DOC_USP7_MATH_1	36	40	PF00917	0.633
DOC_USP7_MATH_1	42	46	PF00917	0.588
DOC_USP7_MATH_1	440	444	PF00917	0.708
DOC_USP7_MATH_1	514	518	PF00917	0.673
DOC_USP7_MATH_1	576	580	PF00917	0.627
DOC_USP7_MATH_1	74	78	PF00917	0.672
DOC_USP7_MATH_1	874	878	PF00917	0.564
DOC_WW_Pin1_4	144	149	PF00397	0.645
DOC_WW_Pin1_4	429	434	PF00397	0.788
DOC_WW_Pin1_4	521	526	PF00397	0.707
DOC_WW_Pin1_4	55	60	PF00397	0.630
DOC_WW_Pin1_4	61	66	PF00397	0.589
DOC_WW_Pin1_4	70	75	PF00397	0.537
DOC_WW_Pin1_4	773	778	PF00397	0.652
DOC_WW_Pin1_4	803	808	PF00397	0.668
DOC_WW_Pin1_4	833	838	PF00397	0.782
DOC_WW_Pin1_4	848	853	PF00397	0.525
DOC_WW_Pin1_4	85	90	PF00397	0.585
DOC_WW_Pin1_4	878	883	PF00397	0.572
LIG_14-3-3_CanoR_1	177	185	PF00244	0.465
LIG_14-3-3_CanoR_1	236	244	PF00244	0.481
LIG_14-3-3_CanoR_1	288	298	PF00244	0.729
LIG_14-3-3_CanoR_1	333	341	PF00244	0.585
LIG_14-3-3_CanoR_1	391	396	PF00244	0.652
LIG_14-3-3_CanoR_1	431	439	PF00244	0.693
LIG_14-3-3_CanoR_1	442	449	PF00244	0.634
LIG_14-3-3_CanoR_1	590	598	PF00244	0.585
LIG_14-3-3_CanoR_1	678	687	PF00244	0.739
LIG_14-3-3_CanoR_1	690	696	PF00244	0.656
LIG_14-3-3_CanoR_1	740	745	PF00244	0.423
LIG_Actin_WH2_2	709	725	PF00022	0.463
LIG_APCC_ABBA_1	302	307	PF00400	0.570
LIG_APCC_ABBA_1	701	706	PF00400	0.683
LIG_BIR_II_1	1	5	PF00653	0.541
LIG_BIR_III_2	47	51	PF00653	0.555
LIG_BIR_III_2	69	73	PF00653	0.628
LIG_BIR_III_2	832	836	PF00653	0.648
LIG_BRCT_BRCA1_1	191	195	PF00533	0.590
LIG_BRCT_BRCA1_1	213	217	PF00533	0.604
LIG_Clathr_ClatBox_1	585	589	PF01394	0.571
LIG_deltaCOP1_diTrp_1	736	739	PF00928	0.429
LIG_DLG_GKlike_1	391	399	PF00625	0.658
LIG_eIF4E_1	529	535	PF01652	0.656
LIG_FHA_1	103	109	PF00498	0.481
LIG_FHA_1	128	134	PF00498	0.519
LIG_FHA_1	218	224	PF00498	0.587
LIG_FHA_1	22	28	PF00498	0.647
LIG_FHA_1	225	231	PF00498	0.557
LIG_FHA_1	236	242	PF00498	0.367
LIG_FHA_1	51	57	PF00498	0.631
LIG_FHA_1	516	522	PF00498	0.652
LIG_FHA_1	556	562	PF00498	0.743
LIG_FHA_1	581	587	PF00498	0.630
LIG_FHA_1	690	696	PF00498	0.703
LIG_FHA_1	786	792	PF00498	0.527
LIG_FHA_1	849	855	PF00498	0.645
LIG_FHA_1	91	97	PF00498	0.606
LIG_FHA_2	277	283	PF00498	0.582
LIG_FHA_2	860	866	PF00498	0.569
LIG_LIR_Apic_2	180	185	PF02991	0.474
LIG_LIR_Apic_2	31	36	PF02991	0.650
LIG_LIR_Gen_1	58	67	PF02991	0.753
LIG_LIR_Gen_1	708	718	PF02991	0.615
LIG_LIR_Nem_3	166	172	PF02991	0.657
LIG_LIR_Nem_3	240	246	PF02991	0.584
LIG_LIR_Nem_3	254	258	PF02991	0.502
LIG_LIR_Nem_3	330	335	PF02991	0.619
LIG_LIR_Nem_3	58	63	PF02991	0.763
LIG_LIR_Nem_3	708	713	PF02991	0.654
LIG_LYPXL_S_1	304	308	PF13949	0.506
LIG_LYPXL_yS_3	305	308	PF13949	0.527
LIG_MYND_3	716	720	PF01753	0.555
LIG_NRBOX	297	303	PF00104	0.612
LIG_PALB2_WD40_1	465	473	PF16756	0.498
LIG_PCNA_PIPBox_1	261	270	PF02747	0.556
LIG_PCNA_yPIPBox_3	481	489	PF02747	0.534
LIG_Pex14_1	488	492	PF04695	0.651
LIG_Rb_LxCxE_1	878	900	PF01857	0.511
LIG_RPA_C_Fungi	409	421	PF08784	0.585
LIG_SH2_CRK	906	910	PF00017	0.604
LIG_SH2_CRK	911	915	PF00017	0.497
LIG_SH2_NCK_1	29	33	PF00017	0.628
LIG_SH2_PTP2	33	36	PF00017	0.653
LIG_SH2_SRC	267	270	PF00017	0.564
LIG_SH2_SRC	29	32	PF00017	0.569
LIG_SH2_SRC	492	495	PF00017	0.652
LIG_SH2_SRC	529	532	PF00017	0.657
LIG_SH2_STAP1	244	248	PF00017	0.506
LIG_SH2_STAP1	29	33	PF00017	0.654
LIG_SH2_STAP1	341	345	PF00017	0.589
LIG_SH2_STAT5	267	270	PF00017	0.564
LIG_SH2_STAT5	33	36	PF00017	0.643
LIG_SH2_STAT5	529	532	PF00017	0.778
LIG_SH2_STAT5	548	551	PF00017	0.479
LIG_SH2_STAT5	721	724	PF00017	0.593
LIG_SH2_STAT5	751	754	PF00017	0.674
LIG_SH3_3	758	764	PF00018	0.660
LIG_SH3_3	765	771	PF00018	0.610
LIG_SH3_3	796	802	PF00018	0.592
LIG_SH3_3	832	838	PF00018	0.751
LIG_SUMO_SIM_anti_2	459	464	PF11976	0.536
LIG_SUMO_SIM_anti_2	583	589	PF11976	0.576
LIG_SUMO_SIM_par_1	104	109	PF11976	0.592
LIG_SUMO_SIM_par_1	583	589	PF11976	0.576
LIG_SUMO_SIM_par_1	800	806	PF11976	0.506
LIG_SUMO_SIM_par_1	836	843	PF11976	0.593
LIG_SUMO_SIM_par_1	887	894	PF11976	0.544
LIG_SUMO_SIM_par_1	913	919	PF11976	0.488
LIG_TRAF2_1	594	597	PF00917	0.527
LIG_TRAF2_1	810	813	PF00917	0.574
LIG_TYR_ITIM	241	246	PF00017	0.448
LIG_TYR_ITIM	909	914	PF00017	0.512
MOD_CDK_SPK_2	803	808	PF00069	0.516
MOD_CDK_SPxK_1	878	884	PF00069	0.567
MOD_CDK_SPxxK_3	848	855	PF00069	0.633
MOD_CK1_1	102	108	PF00069	0.603
MOD_CK1_1	215	221	PF00069	0.587
MOD_CK1_1	222	228	PF00069	0.582
MOD_CK1_1	229	235	PF00069	0.490
MOD_CK1_1	349	355	PF00069	0.749
MOD_CK1_1	443	449	PF00069	0.675
MOD_CK1_1	484	490	PF00069	0.566
MOD_CK1_1	632	638	PF00069	0.705
MOD_CK1_1	673	679	PF00069	0.869
MOD_CK1_1	694	700	PF00069	0.646
MOD_CK1_1	711	717	PF00069	0.420
MOD_CK1_1	792	798	PF00069	0.564
MOD_CK1_1	840	846	PF00069	0.733
MOD_CK1_1	875	881	PF00069	0.544
MOD_CK2_1	16	22	PF00069	0.626
MOD_CK2_1	276	282	PF00069	0.579
MOD_CK2_1	571	577	PF00069	0.616
MOD_CK2_1	591	597	PF00069	0.451
MOD_CK2_1	619	625	PF00069	0.764
MOD_CK2_1	807	813	PF00069	0.629
MOD_CK2_1	894	900	PF00069	0.566
MOD_GlcNHglycan	336	339	PF01048	0.597
MOD_GlcNHglycan	342	346	PF01048	0.738
MOD_GlcNHglycan	358	361	PF01048	0.600
MOD_GlcNHglycan	44	47	PF01048	0.640
MOD_GlcNHglycan	445	448	PF01048	0.765
MOD_GlcNHglycan	452	455	PF01048	0.609
MOD_GlcNHglycan	518	521	PF01048	0.681
MOD_GlcNHglycan	526	529	PF01048	0.572
MOD_GlcNHglycan	573	576	PF01048	0.663
MOD_GlcNHglycan	6	9	PF01048	0.656
MOD_GlcNHglycan	637	640	PF01048	0.589
MOD_GlcNHglycan	709	713	PF01048	0.705
MOD_GlcNHglycan	723	726	PF01048	0.431
MOD_GlcNHglycan	727	730	PF01048	0.672
MOD_GlcNHglycan	780	783	PF01048	0.597
MOD_GlcNHglycan	865	869	PF01048	0.633
MOD_GSK3_1	121	128	PF00069	0.776
MOD_GSK3_1	18	25	PF00069	0.546
MOD_GSK3_1	189	196	PF00069	0.615
MOD_GSK3_1	203	210	PF00069	0.540
MOD_GSK3_1	211	218	PF00069	0.611
MOD_GSK3_1	219	226	PF00069	0.548
MOD_GSK3_1	346	353	PF00069	0.699
MOD_GSK3_1	38	45	PF00069	0.495
MOD_GSK3_1	4	11	PF00069	0.674
MOD_GSK3_1	441	448	PF00069	0.759
MOD_GSK3_1	477	484	PF00069	0.623
MOD_GSK3_1	576	583	PF00069	0.616
MOD_GSK3_1	629	636	PF00069	0.770
MOD_GSK3_1	689	696	PF00069	0.672
MOD_GSK3_1	70	77	PF00069	0.744
MOD_GSK3_1	721	728	PF00069	0.630
MOD_GSK3_1	78	85	PF00069	0.673
MOD_GSK3_1	785	792	PF00069	0.521
MOD_GSK3_1	803	810	PF00069	0.545
MOD_GSK3_1	833	840	PF00069	0.729
MOD_GSK3_1	859	866	PF00069	0.638
MOD_GSK3_1	874	881	PF00069	0.605
MOD_N-GLC_2	918	920	PF02516	0.571
MOD_NEK2_1	137	142	PF00069	0.654
MOD_NEK2_1	216	221	PF00069	0.615
MOD_NEK2_1	224	229	PF00069	0.617
MOD_NEK2_1	778	783	PF00069	0.710
MOD_NEK2_1	791	796	PF00069	0.394
MOD_NEK2_1	847	852	PF00069	0.652
MOD_NEK2_1	859	864	PF00069	0.375
MOD_NEK2_1	913	918	PF00069	0.567
MOD_NEK2_2	212	217	PF00069	0.554
MOD_PIKK_1	224	230	PF00454	0.707
MOD_PIKK_1	322	328	PF00454	0.663
MOD_PIKK_1	350	356	PF00454	0.734
MOD_PIKK_1	397	403	PF00454	0.691
MOD_PIKK_1	420	426	PF00454	0.550
MOD_PIKK_1	463	469	PF00454	0.670
MOD_PIKK_1	670	676	PF00454	0.745
MOD_PIKK_1	866	872	PF00454	0.629
MOD_PK_1	481	487	PF00069	0.572
MOD_PKA_1	571	577	PF00069	0.616
MOD_PKA_1	619	625	PF00069	0.608
MOD_PKA_2	121	127	PF00069	0.599
MOD_PKA_2	235	241	PF00069	0.483
MOD_PKA_2	441	447	PF00069	0.698
MOD_PKA_2	589	595	PF00069	0.504
MOD_PKA_2	619	625	PF00069	0.608
MOD_PKA_2	689	695	PF00069	0.652
MOD_PKA_2	863	869	PF00069	0.566
MOD_Plk_1	458	464	PF00069	0.489
MOD_Plk_1	576	582	PF00069	0.619
MOD_Plk_1	708	714	PF00069	0.571
MOD_Plk_2-3	121	127	PF00069	0.560
MOD_Plk_2-3	589	595	PF00069	0.504
MOD_Plk_4	212	218	PF00069	0.630
MOD_Plk_4	219	225	PF00069	0.592
MOD_Plk_4	391	397	PF00069	0.655
MOD_Plk_4	458	464	PF00069	0.585
MOD_Plk_4	484	490	PF00069	0.590
MOD_Plk_4	52	58	PF00069	0.681
MOD_Plk_4	529	535	PF00069	0.670
MOD_Plk_4	840	846	PF00069	0.625
MOD_ProDKin_1	144	150	PF00069	0.645
MOD_ProDKin_1	429	435	PF00069	0.791
MOD_ProDKin_1	521	527	PF00069	0.703
MOD_ProDKin_1	55	61	PF00069	0.632
MOD_ProDKin_1	70	76	PF00069	0.535
MOD_ProDKin_1	773	779	PF00069	0.652
MOD_ProDKin_1	803	809	PF00069	0.668
MOD_ProDKin_1	833	839	PF00069	0.782
MOD_ProDKin_1	848	854	PF00069	0.516
MOD_ProDKin_1	85	91	PF00069	0.579
MOD_ProDKin_1	878	884	PF00069	0.561
MOD_SUMO_for_1	152	155	PF00179	0.652
MOD_SUMO_rev_2	269	277	PF00179	0.556
TRG_ENDOCYTIC_2	243	246	PF00928	0.626
TRG_ENDOCYTIC_2	255	258	PF00928	0.481
TRG_ENDOCYTIC_2	305	308	PF00928	0.709
TRG_ENDOCYTIC_2	906	909	PF00928	0.603
TRG_ENDOCYTIC_2	911	914	PF00928	0.507
TRG_ER_diArg_1	113	115	PF00400	0.655
TRG_ER_diArg_1	156	159	PF00400	0.661
TRG_ER_diArg_1	550	553	PF00400	0.599
TRG_ER_diArg_1	618	621	PF00400	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HDG0	Leishmania braziliensis	70%	100%
A4I0U1	Leishmania infantum	99%	100%
E9AWU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QAM9	Leishmania major	89%	99%