F-box domain/F-box-like/Kelch motif/Galactose oxidase, central domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

F-box domain/Galactose oxidase, central domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WYA7_LEIDO

TriTrypDb:

LdBPK_241040.1 , LdCL_240015400 , LDHU3_24.1220

Length:

981

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WYA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYA7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	350	354	PF00656	0.669
CLV_C14_Caspase3-7	368	372	PF00656	0.581
CLV_C14_Caspase3-7	587	591	PF00656	0.686
CLV_NRD_NRD_1	248	250	PF00675	0.405
CLV_NRD_NRD_1	344	346	PF00675	0.637
CLV_NRD_NRD_1	377	379	PF00675	0.658
CLV_NRD_NRD_1	577	579	PF00675	0.686
CLV_NRD_NRD_1	606	608	PF00675	0.714
CLV_NRD_NRD_1	609	611	PF00675	0.693
CLV_NRD_NRD_1	627	629	PF00675	0.550
CLV_NRD_NRD_1	637	639	PF00675	0.663
CLV_NRD_NRD_1	689	691	PF00675	0.814
CLV_NRD_NRD_1	722	724	PF00675	0.654
CLV_PCSK_FUR_1	607	611	PF00082	0.718
CLV_PCSK_KEX2_1	112	114	PF00082	0.676
CLV_PCSK_KEX2_1	248	250	PF00082	0.405
CLV_PCSK_KEX2_1	285	287	PF00082	0.422
CLV_PCSK_KEX2_1	336	338	PF00082	0.699
CLV_PCSK_KEX2_1	344	346	PF00082	0.612
CLV_PCSK_KEX2_1	377	379	PF00082	0.658
CLV_PCSK_KEX2_1	579	581	PF00082	0.679
CLV_PCSK_KEX2_1	606	608	PF00082	0.714
CLV_PCSK_KEX2_1	609	611	PF00082	0.693
CLV_PCSK_KEX2_1	627	629	PF00082	0.550
CLV_PCSK_KEX2_1	689	691	PF00082	0.811
CLV_PCSK_KEX2_1	722	724	PF00082	0.654
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.676
CLV_PCSK_PC1ET2_1	285	287	PF00082	0.422
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.699
CLV_PCSK_PC1ET2_1	579	581	PF00082	0.725
CLV_PCSK_PC7_1	718	724	PF00082	0.624
CLV_PCSK_SKI1_1	109	113	PF00082	0.661
CLV_PCSK_SKI1_1	48	52	PF00082	0.435
CLV_PCSK_SKI1_1	667	671	PF00082	0.688
CLV_PCSK_SKI1_1	675	679	PF00082	0.620
CLV_Separin_Metazoa	918	922	PF03568	0.654
DEG_APCC_DBOX_1	47	55	PF00400	0.405
DEG_SPOP_SBC_1	132	136	PF00917	0.715
DEG_SPOP_SBC_1	856	860	PF00917	0.679
DOC_ANK_TNKS_1	835	842	PF00023	0.609
DOC_CKS1_1	454	459	PF01111	0.786
DOC_CKS1_1	697	702	PF01111	0.670
DOC_CYCLIN_RxL_1	787	795	PF00134	0.596
DOC_CYCLIN_yCln2_LP_2	79	85	PF00134	0.356
DOC_CYCLIN_yCln2_LP_2	824	830	PF00134	0.549
DOC_MAPK_FxFP_2	105	108	PF00069	0.558
DOC_MAPK_gen_1	459	468	PF00069	0.653
DOC_MAPK_gen_1	88	97	PF00069	0.550
DOC_PP1_RVXF_1	962	968	PF00149	0.628
DOC_PP2B_LxvP_1	507	510	PF13499	0.683
DOC_PP4_FxxP_1	105	108	PF00568	0.558
DOC_PP4_FxxP_1	533	536	PF00568	0.482
DOC_PP4_FxxP_1	758	761	PF00568	0.572
DOC_USP7_MATH_1	115	119	PF00917	0.789
DOC_USP7_MATH_1	120	124	PF00917	0.743
DOC_USP7_MATH_1	131	135	PF00917	0.599
DOC_USP7_MATH_1	146	150	PF00917	0.565
DOC_USP7_MATH_1	160	164	PF00917	0.584
DOC_USP7_MATH_1	185	189	PF00917	0.793
DOC_USP7_MATH_1	19	23	PF00917	0.393
DOC_USP7_MATH_1	2	6	PF00917	0.616
DOC_USP7_MATH_1	287	291	PF00917	0.478
DOC_USP7_MATH_1	449	453	PF00917	0.688
DOC_USP7_MATH_1	563	567	PF00917	0.604
DOC_USP7_MATH_1	651	655	PF00917	0.732
DOC_USP7_MATH_1	732	736	PF00917	0.656
DOC_USP7_MATH_1	777	781	PF00917	0.567
DOC_USP7_MATH_1	786	790	PF00917	0.556
DOC_USP7_MATH_1	799	803	PF00917	0.539
DOC_USP7_MATH_1	877	881	PF00917	0.626
DOC_USP7_UBL2_3	575	579	PF12436	0.704
DOC_WW_Pin1_4	121	126	PF00397	0.699
DOC_WW_Pin1_4	224	229	PF00397	0.652
DOC_WW_Pin1_4	24	29	PF00397	0.539
DOC_WW_Pin1_4	453	458	PF00397	0.785
DOC_WW_Pin1_4	494	499	PF00397	0.562
DOC_WW_Pin1_4	524	529	PF00397	0.651
DOC_WW_Pin1_4	559	564	PF00397	0.691
DOC_WW_Pin1_4	591	596	PF00397	0.643
DOC_WW_Pin1_4	696	701	PF00397	0.809
DOC_WW_Pin1_4	823	828	PF00397	0.668
DOC_WW_Pin1_4	850	855	PF00397	0.749
DOC_WW_Pin1_4	857	862	PF00397	0.711
DOC_WW_Pin1_4	865	870	PF00397	0.629
LIG_14-3-3_CanoR_1	119	125	PF00244	0.733
LIG_14-3-3_CanoR_1	165	173	PF00244	0.668
LIG_14-3-3_CanoR_1	286	294	PF00244	0.467
LIG_14-3-3_CanoR_1	322	331	PF00244	0.587
LIG_14-3-3_CanoR_1	34	43	PF00244	0.530
LIG_14-3-3_CanoR_1	487	496	PF00244	0.567
LIG_14-3-3_CanoR_1	52	58	PF00244	0.199
LIG_14-3-3_CanoR_1	607	615	PF00244	0.722
LIG_14-3-3_CanoR_1	689	696	PF00244	0.728
LIG_14-3-3_CanoR_1	953	958	PF00244	0.617
LIG_14-3-3_CanoR_1	964	968	PF00244	0.502
LIG_Actin_WH2_2	10	27	PF00022	0.565
LIG_Actin_WH2_2	39	54	PF00022	0.405
LIG_Actin_WH2_2	950	966	PF00022	0.616
LIG_Actin_WH2_2	97	114	PF00022	0.580
LIG_APCC_ABBA_1	421	426	PF00400	0.539
LIG_BIR_III_4	620	624	PF00653	0.690
LIG_EVH1_2	330	334	PF00568	0.626
LIG_FHA_1	189	195	PF00498	0.616
LIG_FHA_1	197	203	PF00498	0.568
LIG_FHA_1	311	317	PF00498	0.405
LIG_FHA_1	541	547	PF00498	0.609
LIG_FHA_1	699	705	PF00498	0.773
LIG_FHA_1	749	755	PF00498	0.593
LIG_FHA_1	777	783	PF00498	0.556
LIG_FHA_1	832	838	PF00498	0.739
LIG_FHA_1	882	888	PF00498	0.646
LIG_FHA_1	958	964	PF00498	0.595
LIG_FHA_2	348	354	PF00498	0.665
LIG_FHA_2	54	60	PF00498	0.405
LIG_FHA_2	582	588	PF00498	0.726
LIG_FHA_2	614	620	PF00498	0.672
LIG_FHA_2	689	695	PF00498	0.707
LIG_FHA_2	935	941	PF00498	0.729
LIG_LIR_Apic_2	408	413	PF02991	0.601
LIG_LIR_Apic_2	530	536	PF02991	0.489
LIG_LIR_Apic_2	795	801	PF02991	0.640
LIG_LIR_Gen_1	187	194	PF02991	0.632
LIG_LIR_Gen_1	312	319	PF02991	0.405
LIG_LIR_Gen_1	37	47	PF02991	0.547
LIG_LIR_Gen_1	446	454	PF02991	0.681
LIG_LIR_Gen_1	475	483	PF02991	0.545
LIG_LIR_Gen_1	59	67	PF02991	0.513
LIG_LIR_Gen_1	802	813	PF02991	0.516
LIG_LIR_Nem_3	187	192	PF02991	0.640
LIG_LIR_Nem_3	201	207	PF02991	0.495
LIG_LIR_Nem_3	256	261	PF02991	0.405
LIG_LIR_Nem_3	273	279	PF02991	0.230
LIG_LIR_Nem_3	312	317	PF02991	0.507
LIG_LIR_Nem_3	37	43	PF02991	0.539
LIG_LIR_Nem_3	446	450	PF02991	0.671
LIG_LIR_Nem_3	475	480	PF02991	0.546
LIG_LIR_Nem_3	56	60	PF02991	0.312
LIG_LIR_Nem_3	752	758	PF02991	0.527
LIG_LIR_Nem_3	802	808	PF02991	0.549
LIG_LIR_Nem_3	815	820	PF02991	0.537
LIG_LIR_Nem_3	880	885	PF02991	0.636
LIG_MYND_1	510	514	PF01753	0.557
LIG_NRBOX	31	37	PF00104	0.505
LIG_Pex14_2	477	481	PF04695	0.502
LIG_REV1ctd_RIR_1	332	341	PF16727	0.635
LIG_REV1ctd_RIR_1	83	92	PF16727	0.550
LIG_SH2_CRK	40	44	PF00017	0.546
LIG_SH2_CRK	447	451	PF00017	0.679
LIG_SH2_CRK	60	64	PF00017	0.199
LIG_SH2_CRK	805	809	PF00017	0.610
LIG_SH2_NCK_1	447	451	PF00017	0.679
LIG_SH2_NCK_1	60	64	PF00017	0.429
LIG_SH2_PTP2	534	537	PF00017	0.539
LIG_SH2_PTP2	769	772	PF00017	0.616
LIG_SH2_SRC	708	711	PF00017	0.565
LIG_SH2_STAP1	246	250	PF00017	0.405
LIG_SH2_STAT5	106	109	PF00017	0.682
LIG_SH2_STAT5	366	369	PF00017	0.638
LIG_SH2_STAT5	518	521	PF00017	0.499
LIG_SH2_STAT5	53	56	PF00017	0.405
LIG_SH2_STAT5	534	537	PF00017	0.539
LIG_SH2_STAT5	708	711	PF00017	0.565
LIG_SH2_STAT5	769	772	PF00017	0.616
LIG_SH2_STAT5	805	808	PF00017	0.612
LIG_SH3_3	125	131	PF00018	0.635
LIG_SH3_3	222	228	PF00018	0.651
LIG_SH3_3	451	457	PF00018	0.603
LIG_SH3_3	490	496	PF00018	0.578
LIG_SH3_3	508	514	PF00018	0.372
LIG_SH3_3	767	773	PF00018	0.633
LIG_SH3_3	851	857	PF00018	0.676
LIG_SH3_3	929	935	PF00018	0.724
LIG_SUMO_SIM_anti_2	779	785	PF11976	0.559
LIG_SUMO_SIM_par_1	190	196	PF11976	0.609
LIG_SUMO_SIM_par_1	315	321	PF11976	0.405
LIG_TRAF2_1	616	619	PF00917	0.684
LIG_TRAF2_1	938	941	PF00917	0.729
LIG_TYR_ITIM	445	450	PF00017	0.670
LIG_TYR_ITIM	58	63	PF00017	0.453
LIG_TYR_ITIM	803	808	PF00017	0.604
LIG_WRC_WIRS_1	54	59	PF05994	0.405
MOD_CDC14_SPxK_1	567	570	PF00782	0.582
MOD_CDK_SPK_2	494	499	PF00069	0.562
MOD_CDK_SPxK_1	453	459	PF00069	0.700
MOD_CDK_SPxK_1	564	570	PF00069	0.582
MOD_CDK_SPxxK_3	696	703	PF00069	0.588
MOD_CK1_1	124	130	PF00069	0.681
MOD_CK1_1	134	140	PF00069	0.628
MOD_CK1_1	142	148	PF00069	0.559
MOD_CK1_1	163	169	PF00069	0.661
MOD_CK1_1	188	194	PF00069	0.582
MOD_CK1_1	61	67	PF00069	0.405
MOD_CK1_1	681	687	PF00069	0.699
MOD_CK1_1	826	832	PF00069	0.720
MOD_CK1_1	860	866	PF00069	0.750
MOD_CK1_1	881	887	PF00069	0.649
MOD_CK2_1	2	8	PF00069	0.594
MOD_CK2_1	581	587	PF00069	0.725
MOD_CK2_1	613	619	PF00069	0.791
MOD_CK2_1	623	629	PF00069	0.750
MOD_CK2_1	660	666	PF00069	0.779
MOD_CK2_1	688	694	PF00069	0.705
MOD_CK2_1	709	715	PF00069	0.702
MOD_CK2_1	934	940	PF00069	0.727
MOD_Cter_Amidation	604	607	PF01082	0.675
MOD_Cter_Amidation	687	690	PF01082	0.623
MOD_GlcNHglycan	139	142	PF01048	0.818
MOD_GlcNHglycan	148	151	PF01048	0.699
MOD_GlcNHglycan	166	169	PF01048	0.677
MOD_GlcNHglycan	179	182	PF01048	0.532
MOD_GlcNHglycan	289	292	PF01048	0.489
MOD_GlcNHglycan	382	385	PF01048	0.638
MOD_GlcNHglycan	389	392	PF01048	0.605
MOD_GlcNHglycan	399	402	PF01048	0.563
MOD_GlcNHglycan	403	406	PF01048	0.570
MOD_GlcNHglycan	447	450	PF01048	0.673
MOD_GlcNHglycan	63	66	PF01048	0.405
MOD_GlcNHglycan	682	686	PF01048	0.630
MOD_GlcNHglycan	711	714	PF01048	0.623
MOD_GlcNHglycan	730	733	PF01048	0.801
MOD_GlcNHglycan	734	737	PF01048	0.778
MOD_GlcNHglycan	8	12	PF01048	0.642
MOD_GlcNHglycan	828	831	PF01048	0.756
MOD_GlcNHglycan	921	924	PF01048	0.664
MOD_GSK3_1	120	127	PF00069	0.741
MOD_GSK3_1	131	138	PF00069	0.587
MOD_GSK3_1	142	149	PF00069	0.608
MOD_GSK3_1	160	167	PF00069	0.511
MOD_GSK3_1	184	191	PF00069	0.787
MOD_GSK3_1	3	10	PF00069	0.617
MOD_GSK3_1	365	372	PF00069	0.597
MOD_GSK3_1	376	383	PF00069	0.658
MOD_GSK3_1	397	404	PF00069	0.664
MOD_GSK3_1	445	452	PF00069	0.674
MOD_GSK3_1	559	566	PF00069	0.621
MOD_GSK3_1	59	66	PF00069	0.400
MOD_GSK3_1	591	598	PF00069	0.713
MOD_GSK3_1	699	706	PF00069	0.699
MOD_GSK3_1	728	735	PF00069	0.650
MOD_GSK3_1	788	795	PF00069	0.641
MOD_GSK3_1	822	829	PF00069	0.741
MOD_GSK3_1	856	863	PF00069	0.704
MOD_GSK3_1	877	884	PF00069	0.621
MOD_GSK3_1	953	960	PF00069	0.606
MOD_N-GLC_1	369	374	PF02516	0.614
MOD_N-GLC_1	450	455	PF02516	0.560
MOD_N-GLC_1	718	723	PF02516	0.648
MOD_N-GLC_1	957	962	PF02516	0.596
MOD_NEK2_1	18	23	PF00069	0.443
MOD_NEK2_1	58	63	PF00069	0.405
MOD_NEK2_1	608	613	PF00069	0.764
MOD_NEK2_1	7	12	PF00069	0.588
MOD_NEK2_1	709	714	PF00069	0.666
MOD_NEK2_1	792	797	PF00069	0.591
MOD_NEK2_1	957	962	PF00069	0.621
MOD_NEK2_1	963	968	PF00069	0.587
MOD_PIKK_1	193	199	PF00454	0.617
MOD_PIKK_1	236	242	PF00454	0.555
MOD_PIKK_1	323	329	PF00454	0.441
MOD_PIKK_1	34	40	PF00454	0.523
MOD_PIKK_1	347	353	PF00454	0.656
MOD_PIKK_1	405	411	PF00454	0.647
MOD_PK_1	462	468	PF00069	0.654
MOD_PKA_2	164	170	PF00069	0.669
MOD_PKA_2	376	382	PF00069	0.701
MOD_PKA_2	608	614	PF00069	0.721
MOD_PKA_2	688	694	PF00069	0.729
MOD_PKA_2	963	969	PF00069	0.623
MOD_Plk_1	440	446	PF00069	0.659
MOD_Plk_1	450	456	PF00069	0.590
MOD_Plk_1	58	64	PF00069	0.422
MOD_Plk_1	749	755	PF00069	0.578
MOD_Plk_1	842	848	PF00069	0.650
MOD_Plk_4	185	191	PF00069	0.784
MOD_Plk_4	19	25	PF00069	0.535
MOD_Plk_4	473	479	PF00069	0.557
MOD_Plk_4	53	59	PF00069	0.332
MOD_Plk_4	749	755	PF00069	0.532
MOD_Plk_4	777	783	PF00069	0.556
MOD_Plk_4	958	964	PF00069	0.644
MOD_ProDKin_1	121	127	PF00069	0.700
MOD_ProDKin_1	224	230	PF00069	0.654
MOD_ProDKin_1	24	30	PF00069	0.537
MOD_ProDKin_1	453	459	PF00069	0.787
MOD_ProDKin_1	494	500	PF00069	0.557
MOD_ProDKin_1	524	530	PF00069	0.644
MOD_ProDKin_1	559	565	PF00069	0.688
MOD_ProDKin_1	591	597	PF00069	0.643
MOD_ProDKin_1	696	702	PF00069	0.810
MOD_ProDKin_1	823	829	PF00069	0.671
MOD_ProDKin_1	850	856	PF00069	0.741
MOD_ProDKin_1	857	863	PF00069	0.714
MOD_ProDKin_1	865	871	PF00069	0.629
MOD_SUMO_rev_2	312	321	PF00179	0.272
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.501
TRG_DiLeu_BaLyEn_6	816	821	PF01217	0.694
TRG_ENDOCYTIC_2	222	225	PF00928	0.645
TRG_ENDOCYTIC_2	258	261	PF00928	0.405
TRG_ENDOCYTIC_2	269	272	PF00928	0.292
TRG_ENDOCYTIC_2	314	317	PF00928	0.363
TRG_ENDOCYTIC_2	40	43	PF00928	0.537
TRG_ENDOCYTIC_2	447	450	PF00928	0.673
TRG_ENDOCYTIC_2	534	537	PF00928	0.539
TRG_ENDOCYTIC_2	60	63	PF00928	0.247
TRG_ENDOCYTIC_2	769	772	PF00928	0.616
TRG_ENDOCYTIC_2	805	808	PF00928	0.612
TRG_ER_diArg_1	248	250	PF00400	0.405
TRG_ER_diArg_1	606	609	PF00400	0.718
TRG_ER_diArg_1	722	724	PF00400	0.650
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.607
TRG_Pf-PMV_PEXEL_1	544	548	PF00026	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HDF8	Leishmania braziliensis	71%	100%
A4I0T9	Leishmania infantum	100%	100%
E9AWU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QAN1	Leishmania major	88%	100%