Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WYA2_LEIDO

TriTrypDb:

LdBPK_240510.1 , LdCL_240009900 , LDHU3_24.0620

Length:

238

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WYA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYA2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.625
CLV_NRD_NRD_1	17	19	PF00675	0.432
CLV_NRD_NRD_1	174	176	PF00675	0.709
CLV_NRD_NRD_1	185	187	PF00675	0.717
CLV_NRD_NRD_1	212	214	PF00675	0.576
CLV_NRD_NRD_1	228	230	PF00675	0.556
CLV_NRD_NRD_1	24	26	PF00675	0.427
CLV_NRD_NRD_1	90	92	PF00675	0.524
CLV_PCSK_KEX2_1	174	176	PF00082	0.709
CLV_PCSK_KEX2_1	185	187	PF00082	0.717
CLV_PCSK_KEX2_1	212	214	PF00082	0.578
CLV_PCSK_KEX2_1	226	228	PF00082	0.543
CLV_PCSK_KEX2_1	23	25	PF00082	0.452
CLV_PCSK_KEX2_1	90	92	PF00082	0.524
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.502
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.452
CLV_PCSK_SKI1_1	11	15	PF00082	0.517
CLV_PCSK_SKI1_1	25	29	PF00082	0.500
CLV_PCSK_SKI1_1	38	42	PF00082	0.557
CLV_PCSK_SKI1_1	91	95	PF00082	0.520
CLV_Separin_Metazoa	8	12	PF03568	0.499
DEG_APCC_DBOX_1	123	131	PF00400	0.625
DEG_Nend_UBRbox_2	1	3	PF02207	0.458
DOC_CYCLIN_RxL_1	33	45	PF00134	0.523
DOC_SPAK_OSR1_1	198	202	PF12202	0.594
DOC_USP7_MATH_1	120	124	PF00917	0.652
DOC_USP7_UBL2_3	19	23	PF12436	0.418
DOC_USP7_UBL2_3	222	226	PF12436	0.582
LIG_14-3-3_CanoR_1	124	128	PF00244	0.577
LIG_14-3-3_CanoR_1	72	76	PF00244	0.485
LIG_14-3-3_CanoR_1	90	94	PF00244	0.475
LIG_BIR_III_2	101	105	PF00653	0.509
LIG_FHA_1	92	98	PF00498	0.584
LIG_FHA_2	133	139	PF00498	0.593
LIG_Integrin_RGD_1	186	188	PF01839	0.665
LIG_SH2_SRC	77	80	PF00017	0.550
LIG_SH2_STAP1	77	81	PF00017	0.550
LIG_SH3_2	208	213	PF14604	0.571
LIG_SH3_3	162	168	PF00018	0.603
LIG_SH3_3	205	211	PF00018	0.518
LIG_TRAF2_1	148	151	PF00917	0.693
LIG_TRAF2_1	217	220	PF00917	0.516
LIG_TRAF2_1	230	233	PF00917	0.623
LIG_UBA3_1	9	14	PF00899	0.432
MOD_CK1_1	123	129	PF00069	0.603
MOD_CK1_1	48	54	PF00069	0.582
MOD_CK1_1	80	86	PF00069	0.602
MOD_CK1_1	89	95	PF00069	0.588
MOD_CK2_1	145	151	PF00069	0.602
MOD_CK2_1	214	220	PF00069	0.589
MOD_GlcNHglycan	135	138	PF01048	0.644
MOD_GlcNHglycan	147	150	PF01048	0.520
MOD_GlcNHglycan	47	50	PF01048	0.574
MOD_GlcNHglycan	59	62	PF01048	0.609
MOD_GSK3_1	128	135	PF00069	0.622
MOD_GSK3_1	44	51	PF00069	0.559
MOD_GSK3_1	52	59	PF00069	0.541
MOD_GSK3_1	80	87	PF00069	0.657
MOD_GSK3_1	89	96	PF00069	0.573
MOD_N-GLC_2	192	194	PF02516	0.500
MOD_NEK2_1	71	76	PF00069	0.531
MOD_NEK2_1	93	98	PF00069	0.587
MOD_PIKK_1	201	207	PF00454	0.471
MOD_PKA_2	123	129	PF00069	0.576
MOD_PKA_2	71	77	PF00069	0.506
MOD_PKA_2	89	95	PF00069	0.502
MOD_Plk_1	77	83	PF00069	0.552
MOD_Plk_4	71	77	PF00069	0.498
TRG_DiLeu_BaEn_4	150	156	PF01217	0.587
TRG_ER_diArg_1	211	213	PF00400	0.569
TRG_ER_diArg_1	227	229	PF00400	0.553
TRG_NLS_Bipartite_1	212	230	PF00514	0.556
TRG_NLS_MonoCore_2	225	230	PF00514	0.475
TRG_NLS_MonoExtC_3	225	231	PF00514	0.508
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZZ3	Leptomonas seymouri	47%	100%
A4HDA7	Leishmania braziliensis	72%	100%
A4I0P0	Leishmania infantum	100%	100%
E9AWP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QAT1	Leishmania major	86%	98%
V5C0P2	Trypanosoma cruzi	31%	100%