Rab-GTPase-TBC_domain_containing_protein_putative /Pfam:PF00566

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rab-GTPase-TBC domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WY95_LEIDO

TriTrypDb:

LdBPK_240970.1 , LdCL_240014700 , LDHU3_24.1140

Length:

398

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WY95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WY95

Function

Biological processes
Term	Name	Level	Count
GO:0043085	positive regulation of catalytic activity	4	1
GO:0043087	regulation of GTPase activity	5	1
GO:0043547	positive regulation of GTPase activity	6	1
GO:0044093	positive regulation of molecular function	3	1
GO:0050790	regulation of catalytic activity	3	1
GO:0051336	regulation of hydrolase activity	4	1
GO:0051345	positive regulation of hydrolase activity	5	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0090630	activation of GTPase activity	7	1

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	1
GO:0008047	enzyme activator activity	3	1
GO:0030234	enzyme regulator activity	2	1
GO:0030695	GTPase regulator activity	4	1
GO:0060589	nucleoside-triphosphatase regulator activity	3	1
GO:0098772	molecular function regulator activity	1	1
GO:0140677	molecular function activator activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.449
CLV_NRD_NRD_1	380	382	PF00675	0.515
CLV_PCSK_SKI1_1	110	114	PF00082	0.652
CLV_PCSK_SKI1_1	283	287	PF00082	0.459
CLV_PCSK_SKI1_1	382	386	PF00082	0.507
CLV_PCSK_SKI1_1	393	397	PF00082	0.416
CLV_PCSK_SKI1_1	41	45	PF00082	0.400
DEG_APCC_DBOX_1	282	290	PF00400	0.459
DOC_AGCK_PIF_2	322	327	PF00069	0.267
DOC_CDC14_PxL_1	368	376	PF14671	0.512
DOC_CKS1_1	161	166	PF01111	0.604
DOC_CYCLIN_RxL_1	107	117	PF00134	0.608
DOC_MAPK_gen_1	22	31	PF00069	0.559
DOC_MAPK_MEF2A_6	41	48	PF00069	0.378
DOC_USP7_MATH_1	122	126	PF00917	0.679
DOC_USP7_MATH_1	330	334	PF00917	0.459
DOC_WW_Pin1_4	160	165	PF00397	0.617
LIG_14-3-3_CanoR_1	239	249	PF00244	0.459
LIG_Actin_WH2_2	9	26	PF00022	0.429
LIG_BIR_II_1	1	5	PF00653	0.581
LIG_BIR_III_4	146	150	PF00653	0.663
LIG_BRCT_BRCA1_1	135	139	PF00533	0.687
LIG_EH1_1	106	114	PF00400	0.638
LIG_FHA_1	161	167	PF00498	0.653
LIG_FHA_1	351	357	PF00498	0.323
LIG_FHA_1	374	380	PF00498	0.500
LIG_FHA_1	71	77	PF00498	0.538
LIG_FHA_2	106	112	PF00498	0.580
LIG_FHA_2	297	303	PF00498	0.421
LIG_FHA_2	54	60	PF00498	0.589
LIG_LIR_Gen_1	299	308	PF02991	0.459
LIG_LIR_Gen_1	62	72	PF02991	0.423
LIG_LIR_Nem_3	136	142	PF02991	0.686
LIG_LIR_Nem_3	246	251	PF02991	0.344
LIG_LIR_Nem_3	299	304	PF02991	0.421
LIG_LIR_Nem_3	62	68	PF02991	0.425
LIG_MYND_1	174	178	PF01753	0.492
LIG_NRBOX	228	234	PF00104	0.475
LIG_Pex14_2	278	282	PF04695	0.323
LIG_PTB_Apo_2	66	73	PF02174	0.588
LIG_PTB_Phospho_1	66	72	PF10480	0.582
LIG_Rb_LxCxE_1	363	376	PF01857	0.511
LIG_Rb_pABgroove_1	249	257	PF01858	0.355
LIG_REV1ctd_RIR_1	309	317	PF16727	0.459
LIG_SH2_CRK	167	171	PF00017	0.604
LIG_SH2_CRK	219	223	PF00017	0.521
LIG_SH2_CRK	343	347	PF00017	0.459
LIG_SH2_CRK	35	39	PF00017	0.378
LIG_SH2_CRK	40	44	PF00017	0.341
LIG_SH2_STAP1	343	347	PF00017	0.459
LIG_SH2_STAP1	391	395	PF00017	0.563
LIG_SH2_STAP1	72	76	PF00017	0.627
LIG_SH2_STAT5	194	197	PF00017	0.443
LIG_SH2_STAT5	219	222	PF00017	0.484
LIG_SH2_STAT5	328	331	PF00017	0.323
LIG_SH2_STAT5	366	369	PF00017	0.509
LIG_SH2_STAT5	42	45	PF00017	0.371
LIG_SH2_STAT5	72	75	PF00017	0.601
LIG_SH3_3	158	164	PF00018	0.741
LIG_SH3_3	282	288	PF00018	0.459
LIG_TRAF2_1	184	187	PF00917	0.525
LIG_TRAF2_1	56	59	PF00917	0.595
LIG_TYR_ITIM	38	43	PF00017	0.492
LIG_WRC_WIRS_1	112	117	PF05994	0.570
LIG_WW_1	32	35	PF00397	0.429
MOD_CK1_1	116	122	PF00069	0.706
MOD_CK1_1	306	312	PF00069	0.459
MOD_CK1_1	350	356	PF00069	0.459
MOD_CK1_1	389	395	PF00069	0.409
MOD_CK1_1	53	59	PF00069	0.525
MOD_CK1_1	96	102	PF00069	0.570
MOD_CK2_1	105	111	PF00069	0.621
MOD_CK2_1	122	128	PF00069	0.621
MOD_CK2_1	296	302	PF00069	0.346
MOD_CK2_1	348	354	PF00069	0.459
MOD_CK2_1	53	59	PF00069	0.609
MOD_GlcNHglycan	118	121	PF01048	0.674
MOD_GlcNHglycan	124	127	PF01048	0.740
MOD_GlcNHglycan	128	132	PF01048	0.721
MOD_GlcNHglycan	136	139	PF01048	0.615
MOD_GlcNHglycan	143	146	PF01048	0.557
MOD_GlcNHglycan	155	158	PF01048	0.481
MOD_GlcNHglycan	170	173	PF01048	0.468
MOD_GlcNHglycan	178	181	PF01048	0.497
MOD_GlcNHglycan	209	212	PF01048	0.452
MOD_GlcNHglycan	242	245	PF01048	0.459
MOD_GlcNHglycan	93	96	PF01048	0.756
MOD_GSK3_1	111	118	PF00069	0.607
MOD_GSK3_1	148	155	PF00069	0.801
MOD_GSK3_1	240	247	PF00069	0.377
MOD_GSK3_1	46	53	PF00069	0.452
MOD_GSK3_1	91	98	PF00069	0.696
MOD_N-GLC_1	220	225	PF02516	0.525
MOD_NEK2_1	113	118	PF00069	0.679
MOD_NEK2_1	133	138	PF00069	0.779
MOD_NEK2_1	281	286	PF00069	0.314
MOD_NEK2_1	348	353	PF00069	0.459
MOD_NEK2_1	67	72	PF00069	0.461
MOD_NEK2_2	105	110	PF00069	0.645
MOD_NEK2_2	244	249	PF00069	0.459
MOD_PIKK_1	256	262	PF00454	0.393
MOD_PKA_2	244	250	PF00069	0.459
MOD_PKA_2	386	392	PF00069	0.521
MOD_Plk_1	220	226	PF00069	0.522
MOD_Plk_1	24	30	PF00069	0.499
MOD_Plk_1	53	59	PF00069	0.462
MOD_Plk_2-3	291	297	PF00069	0.382
MOD_Plk_4	244	250	PF00069	0.382
MOD_Plk_4	303	309	PF00069	0.354
MOD_Plk_4	386	392	PF00069	0.402
MOD_ProDKin_1	160	166	PF00069	0.611
TRG_ENDOCYTIC_2	219	222	PF00928	0.537
TRG_ENDOCYTIC_2	290	293	PF00928	0.323
TRG_ENDOCYTIC_2	343	346	PF00928	0.335
TRG_ENDOCYTIC_2	35	38	PF00928	0.394
TRG_ENDOCYTIC_2	40	43	PF00928	0.331
TRG_ENDOCYTIC_2	72	75	PF00928	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A422NHQ9	Trypanosoma rangeli	38%	100%
A4HDF1	Leishmania braziliensis	87%	100%
A4I0T4	Leishmania infantum	100%	100%
D0A763	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AWT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QAN8	Leishmania major	98%	100%
V5BAM9	Trypanosoma cruzi	38%	92%