Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical predicted transmembrane protein

Species:

Leishmania donovani

UniProt:

A0A3S7WY91_LEIDO

TriTrypDb:

LdBPK_240590.1 , LdCL_240010700 , LDHU3_24.0700

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3S7WY91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WY91

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.534
CLV_C14_Caspase3-7	66	70	PF00656	0.532
CLV_NRD_NRD_1	226	228	PF00675	0.675
CLV_PCSK_KEX2_1	226	228	PF00082	0.717
CLV_PCSK_SKI1_1	18	22	PF00082	0.419
CLV_PCSK_SKI1_1	42	46	PF00082	0.736
DEG_APCC_DBOX_1	84	92	PF00400	0.412
DEG_Nend_UBRbox_2	1	3	PF02207	0.745
DEG_SPOP_SBC_1	207	211	PF00917	0.490
DEG_SPOP_SBC_1	233	237	PF00917	0.502
DEG_SPOP_SBC_1	263	267	PF00917	0.484
DOC_MAPK_FxFP_2	312	315	PF00069	0.534
DOC_MAPK_gen_1	83	91	PF00069	0.415
DOC_MAPK_MEF2A_6	123	131	PF00069	0.390
DOC_MAPK_MEF2A_6	73	82	PF00069	0.391
DOC_PP1_RVXF_1	147	153	PF00149	0.428
DOC_PP2B_LxvP_1	243	246	PF13499	0.554
DOC_PP2B_LxvP_1	313	316	PF13499	0.534
DOC_PP4_FxxP_1	258	261	PF00568	0.522
DOC_PP4_FxxP_1	312	315	PF00568	0.534
DOC_USP7_MATH_1	261	265	PF00917	0.472
DOC_USP7_MATH_1	43	47	PF00917	0.442
DOC_WW_Pin1_4	159	164	PF00397	0.405
DOC_WW_Pin1_4	189	194	PF00397	0.521
DOC_WW_Pin1_4	229	234	PF00397	0.533
LIG_14-3-3_CanoR_1	110	116	PF00244	0.363
LIG_14-3-3_CanoR_1	42	51	PF00244	0.541
LIG_BRCT_BRCA1_1	255	259	PF00533	0.526
LIG_deltaCOP1_diTrp_1	171	179	PF00928	0.454
LIG_deltaCOP1_diTrp_1	292	297	PF00928	0.466
LIG_EH1_1	22	30	PF00400	0.348
LIG_EH1_1	32	40	PF00400	0.338
LIG_FHA_1	107	113	PF00498	0.470
LIG_FHA_1	263	269	PF00498	0.485
LIG_FHA_1	328	334	PF00498	0.569
LIG_FHA_2	207	213	PF00498	0.501
LIG_FHA_2	217	223	PF00498	0.392
LIG_FHA_2	43	49	PF00498	0.487
LIG_FHA_2	99	105	PF00498	0.423
LIG_LIR_Apic_2	256	261	PF02991	0.523
LIG_LIR_Apic_2	285	291	PF02991	0.533
LIG_LIR_Apic_2	309	315	PF02991	0.524
LIG_LIR_Gen_1	292	298	PF02991	0.466
LIG_LIR_Nem_3	292	297	PF02991	0.500
LIG_LYPXL_S_1	313	317	PF13949	0.732
LIG_LYPXL_yS_3	314	317	PF13949	0.530
LIG_MLH1_MIPbox_1	255	259	PF16413	0.526
LIG_NRBOX	180	186	PF00104	0.489
LIG_Pex14_2	269	273	PF04695	0.513
LIG_Rb_LxCxE_1	318	340	PF01857	0.520
LIG_SH2_CRK	158	162	PF00017	0.420
LIG_SH2_GRB2like	158	161	PF00017	0.492
LIG_SH2_NCK_1	158	162	PF00017	0.490
LIG_SH2_NCK_1	288	292	PF00017	0.540
LIG_SH2_NCK_1	56	60	PF00017	0.400
LIG_SH2_SRC	158	161	PF00017	0.492
LIG_SH2_STAP1	120	124	PF00017	0.492
LIG_SH2_STAP1	153	157	PF00017	0.424
LIG_SH2_STAT3	194	197	PF00017	0.441
LIG_SH2_STAT5	56	59	PF00017	0.535
LIG_SH3_3	140	146	PF00018	0.419
LIG_SH3_3	160	166	PF00018	0.550
LIG_SH3_3	169	175	PF00018	0.391
LIG_SH3_3	342	348	PF00018	0.520
LIG_TRAF2_1	324	327	PF00917	0.548
LIG_WRC_WIRS_1	255	260	PF05994	0.602
MOD_CK1_1	114	120	PF00069	0.459
MOD_CK1_1	138	144	PF00069	0.527
MOD_CK1_1	210	216	PF00069	0.668
MOD_CK1_1	232	238	PF00069	0.655
MOD_CK1_1	264	270	PF00069	0.557
MOD_CK1_1	299	305	PF00069	0.641
MOD_CK1_1	54	60	PF00069	0.626
MOD_CK2_1	174	180	PF00069	0.555
MOD_CK2_1	206	212	PF00069	0.615
MOD_CK2_1	42	48	PF00069	0.570
MOD_CK2_1	98	104	PF00069	0.425
MOD_CMANNOS	195	198	PF00535	0.514
MOD_GlcNHglycan	137	140	PF01048	0.587
MOD_GlcNHglycan	187	190	PF01048	0.641
MOD_GlcNHglycan	200	203	PF01048	0.401
MOD_GlcNHglycan	222	225	PF01048	0.736
MOD_GlcNHglycan	238	241	PF01048	0.513
MOD_GlcNHglycan	349	352	PF01048	0.590
MOD_GlcNHglycan	53	56	PF01048	0.540
MOD_GSK3_1	114	121	PF00069	0.475
MOD_GSK3_1	185	192	PF00069	0.528
MOD_GSK3_1	206	213	PF00069	0.659
MOD_GSK3_1	216	223	PF00069	0.621
MOD_GSK3_1	229	236	PF00069	0.529
MOD_GSK3_1	263	270	PF00069	0.635
MOD_N-GLC_1	106	111	PF02516	0.594
MOD_N-GLC_1	118	123	PF02516	0.395
MOD_N-GLC_1	135	140	PF02516	0.311
MOD_N-GLC_1	159	164	PF02516	0.605
MOD_NEK2_1	183	188	PF00069	0.622
MOD_NEK2_1	234	239	PF00069	0.570
MOD_NEK2_1	269	274	PF00069	0.621
MOD_NEK2_1	297	302	PF00069	0.658
MOD_NEK2_2	254	259	PF00069	0.584
MOD_OFUCOSY	325	331	PF10250	0.556
MOD_PIKK_1	118	124	PF00454	0.538
MOD_Plk_1	106	112	PF00069	0.611
MOD_Plk_1	135	141	PF00069	0.644
MOD_Plk_1	211	217	PF00069	0.635
MOD_Plk_2-3	216	222	PF00069	0.614
MOD_Plk_4	138	144	PF00069	0.527
MOD_Plk_4	254	260	PF00069	0.742
MOD_Plk_4	264	270	PF00069	0.611
MOD_ProDKin_1	159	165	PF00069	0.487
MOD_ProDKin_1	189	195	PF00069	0.647
MOD_ProDKin_1	229	235	PF00069	0.668
TRG_DiLeu_BaEn_1	180	185	PF01217	0.608
TRG_DiLeu_BaEn_1	340	345	PF01217	0.693
TRG_DiLeu_BaEn_1	48	53	PF01217	0.578
TRG_DiLeu_BaEn_1	76	81	PF01217	0.658
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.670
TRG_ENDOCYTIC_2	158	161	PF00928	0.593
TRG_ENDOCYTIC_2	314	317	PF00928	0.668
TRG_ER_diArg_1	226	229	PF00400	0.717
TRG_ER_diArg_1	82	85	PF00400	0.587
TRG_ER_diArg_1	92	95	PF00400	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9U7	Leptomonas seymouri	40%	99%
A4HDB6	Leishmania braziliensis	59%	100%
A4I0P6	Leishmania infantum	99%	100%
E9AWP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QAS5	Leishmania major	86%	100%