Mnd1 family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mnd1 family, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WY90_LEIDO

TriTrypDb:

LdBPK_241030.1 , LdCL_240015300 , LDHU3_24.1200

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3S7WY90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WY90

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006310	DNA recombination	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0007131	reciprocal meiotic recombination	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0022402	cell cycle process	2	1
GO:0022414	reproductive process	1	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0035825	homologous recombination	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0140527	reciprocal homologous recombination	7	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1903046	meiotic cell cycle process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003690	double-stranded DNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	297	301	PF00656	0.631
CLV_NRD_NRD_1	12	14	PF00675	0.655
CLV_NRD_NRD_1	126	128	PF00675	0.582
CLV_NRD_NRD_1	279	281	PF00675	0.589
CLV_NRD_NRD_1	8	10	PF00675	0.702
CLV_PCSK_KEX2_1	12	14	PF00082	0.578
CLV_PCSK_KEX2_1	126	128	PF00082	0.545
CLV_PCSK_KEX2_1	279	281	PF00082	0.513
CLV_PCSK_KEX2_1	418	420	PF00082	0.733
CLV_PCSK_KEX2_1	423	425	PF00082	0.701
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.578
CLV_PCSK_PC1ET2_1	418	420	PF00082	0.733
CLV_PCSK_PC1ET2_1	423	425	PF00082	0.714
CLV_PCSK_PC7_1	419	425	PF00082	0.685
CLV_PCSK_SKI1_1	126	130	PF00082	0.582
CLV_PCSK_SKI1_1	21	25	PF00082	0.485
CLV_PCSK_SKI1_1	234	238	PF00082	0.568
CLV_PCSK_SKI1_1	283	287	PF00082	0.540
CLV_PCSK_SKI1_1	407	411	PF00082	0.666
CLV_Separin_Metazoa	123	127	PF03568	0.566
DEG_APCC_DBOX_1	180	188	PF00400	0.525
DEG_APCC_DBOX_1	233	241	PF00400	0.635
DOC_CYCLIN_yCln2_LP_2	286	292	PF00134	0.548
DOC_MAPK_gen_1	279	290	PF00069	0.451
DOC_MAPK_gen_1	9	18	PF00069	0.568
DOC_MAPK_MEF2A_6	283	292	PF00069	0.570
DOC_MAPK_MEF2A_6	356	364	PF00069	0.625
DOC_MAPK_NFAT4_5	283	291	PF00069	0.546
DOC_PP1_RVXF_1	181	187	PF00149	0.644
DOC_PP2B_LxvP_1	286	289	PF13499	0.457
DOC_USP7_MATH_1	112	116	PF00917	0.725
DOC_USP7_MATH_1	173	177	PF00917	0.474
DOC_USP7_MATH_1	200	204	PF00917	0.426
DOC_USP7_MATH_1	332	336	PF00917	0.726
DOC_USP7_MATH_1	363	367	PF00917	0.546
DOC_USP7_MATH_1	387	391	PF00917	0.628
DOC_USP7_MATH_1	417	421	PF00917	0.681
DOC_USP7_MATH_1	91	95	PF00917	0.663
DOC_USP7_MATH_1	98	102	PF00917	0.678
DOC_USP7_UBL2_3	10	14	PF12436	0.676
DOC_WW_Pin1_4	151	156	PF00397	0.518
DOC_WW_Pin1_4	322	327	PF00397	0.660
DOC_WW_Pin1_4	333	338	PF00397	0.546
DOC_WW_Pin1_4	46	51	PF00397	0.355
LIG_14-3-3_CanoR_1	172	178	PF00244	0.593
LIG_14-3-3_CanoR_1	246	250	PF00244	0.450
LIG_14-3-3_CanoR_1	257	264	PF00244	0.340
LIG_14-3-3_CanoR_1	349	359	PF00244	0.665
LIG_14-3-3_CanoR_1	73	83	PF00244	0.371
LIG_14-3-3_CterR_2	424	427	PF00244	0.805
LIG_BIR_II_1	1	5	PF00653	0.715
LIG_BIR_III_2	329	333	PF00653	0.582
LIG_BIR_III_2	367	371	PF00653	0.607
LIG_CtBP_PxDLS_1	289	293	PF00389	0.512
LIG_FHA_1	152	158	PF00498	0.388
LIG_FHA_1	359	365	PF00498	0.703
LIG_FHA_1	47	53	PF00498	0.288
LIG_FHA_2	35	41	PF00498	0.284
LIG_LIR_Apic_2	78	84	PF02991	0.400
LIG_LIR_Gen_1	120	128	PF02991	0.521
LIG_LIR_Gen_1	148	157	PF02991	0.522
LIG_LIR_Gen_1	161	168	PF02991	0.368
LIG_LIR_Gen_1	248	255	PF02991	0.477
LIG_LIR_Nem_3	120	124	PF02991	0.548
LIG_LIR_Nem_3	148	153	PF02991	0.526
LIG_LIR_Nem_3	248	252	PF02991	0.494
LIG_Pex14_1	258	262	PF04695	0.494
LIG_RPA_C_Fungi	274	286	PF08784	0.468
LIG_SH2_STAP1	121	125	PF00017	0.552
LIG_SH2_STAT5	263	266	PF00017	0.448
LIG_SH2_STAT5	294	297	PF00017	0.465
LIG_SH2_STAT5	36	39	PF00017	0.284
LIG_SH3_3	331	337	PF00018	0.672
LIG_SH3_3	383	389	PF00018	0.758
LIG_SUMO_SIM_par_1	288	293	PF11976	0.546
LIG_TRAF2_1	265	268	PF00917	0.476
LIG_TRAF2_1	55	58	PF00917	0.284
LIG_TYR_ITIM	51	56	PF00017	0.416
MOD_CK1_1	108	114	PF00069	0.708
MOD_CK1_1	2	8	PF00069	0.525
MOD_CK1_1	230	236	PF00069	0.594
MOD_CK1_1	293	299	PF00069	0.620
MOD_CK1_1	92	98	PF00069	0.685
MOD_CK2_1	117	123	PF00069	0.543
MOD_CK2_1	128	134	PF00069	0.571
MOD_CK2_1	14	20	PF00069	0.453
MOD_CK2_1	198	204	PF00069	0.670
MOD_CK2_1	296	302	PF00069	0.572
MOD_CK2_1	34	40	PF00069	0.155
MOD_CK2_1	52	58	PF00069	0.259
MOD_Cter_Amidation	10	13	PF01082	0.677
MOD_Cter_Amidation	421	424	PF01082	0.818
MOD_GlcNHglycan	100	103	PF01048	0.666
MOD_GlcNHglycan	107	110	PF01048	0.681
MOD_GlcNHglycan	130	133	PF01048	0.662
MOD_GlcNHglycan	188	192	PF01048	0.600
MOD_GlcNHglycan	198	203	PF01048	0.654
MOD_GlcNHglycan	4	7	PF01048	0.689
MOD_GlcNHglycan	415	418	PF01048	0.729
MOD_GSK3_1	104	111	PF00069	0.756
MOD_GSK3_1	194	201	PF00069	0.563
MOD_GSK3_1	296	303	PF00069	0.659
MOD_GSK3_1	316	323	PF00069	0.632
MOD_GSK3_1	387	394	PF00069	0.662
MOD_GSK3_1	413	420	PF00069	0.684
MOD_N-GLC_2	343	345	PF02516	0.676
MOD_NEK2_1	128	133	PF00069	0.624
MOD_NEK2_1	187	192	PF00069	0.595
MOD_NEK2_1	275	280	PF00069	0.542
MOD_NEK2_1	290	295	PF00069	0.584
MOD_NEK2_1	320	325	PF00069	0.600
MOD_NEK2_2	316	321	PF00069	0.695
MOD_OFUCOSY	317	324	PF10250	0.689
MOD_PIKK_1	350	356	PF00454	0.694
MOD_PK_1	14	20	PF00069	0.560
MOD_PKA_1	126	132	PF00069	0.589
MOD_PKA_1	418	424	PF00069	0.729
MOD_PKA_2	103	109	PF00069	0.540
MOD_PKA_2	126	132	PF00069	0.589
MOD_PKA_2	2	8	PF00069	0.525
MOD_PKA_2	245	251	PF00069	0.447
MOD_PKA_2	256	262	PF00069	0.329
MOD_PKA_2	348	354	PF00069	0.657
MOD_PKA_2	376	382	PF00069	0.623
MOD_PKA_2	418	424	PF00069	0.679
MOD_PKA_2	92	98	PF00069	0.593
MOD_Plk_1	290	296	PF00069	0.584
MOD_Plk_2-3	194	200	PF00069	0.568
MOD_Plk_4	245	251	PF00069	0.495
MOD_Plk_4	290	296	PF00069	0.511
MOD_Plk_4	75	81	PF00069	0.400
MOD_ProDKin_1	151	157	PF00069	0.517
MOD_ProDKin_1	322	328	PF00069	0.663
MOD_ProDKin_1	333	339	PF00069	0.546
MOD_ProDKin_1	46	52	PF00069	0.355
MOD_SUMO_rev_2	17	23	PF00179	0.405
TRG_DiLeu_BaEn_1	20	25	PF01217	0.474
TRG_DiLeu_BaEn_1	40	45	PF01217	0.461
TRG_DiLeu_BaEn_1	58	63	PF01217	0.216
TRG_DiLeu_BaEn_2	181	187	PF01217	0.571
TRG_DiLeu_BaLyEn_6	355	360	PF01217	0.539
TRG_ENDOCYTIC_2	121	124	PF00928	0.488
TRG_ENDOCYTIC_2	53	56	PF00928	0.417
TRG_ER_diArg_1	125	127	PF00400	0.569
TRG_NES_CRM1_1	210	223	PF08389	0.433
TRG_NLS_Bipartite_1	407	427	PF00514	0.638
TRG_NLS_MonoExtC_3	8	13	PF00514	0.642
TRG_NLS_MonoExtN_4	405	411	PF00514	0.665
TRG_NLS_MonoExtN_4	9	16	PF00514	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBI5	Leptomonas seymouri	49%	100%
A0A1X0NVH3	Trypanosomatidae	30%	100%
A0A422N8J6	Trypanosoma rangeli	31%	100%
A4HDF7	Leishmania braziliensis	73%	100%
A4I0T8	Leishmania infantum	100%	100%
D0A770	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AWU2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QAN2	Leishmania major	89%	100%