Crinkler (CRN) family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WY82_LEIDO

TriTrypDb:

LdBPK_240410.1 , LdCL_240009000 , LDHU3_24.0520

Length:

756

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WY82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WY82

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	484	488	PF00656	0.350
CLV_C14_Caspase3-7	79	83	PF00656	0.407
CLV_NRD_NRD_1	132	134	PF00675	0.694
CLV_NRD_NRD_1	207	209	PF00675	0.627
CLV_NRD_NRD_1	365	367	PF00675	0.408
CLV_NRD_NRD_1	396	398	PF00675	0.515
CLV_NRD_NRD_1	700	702	PF00675	0.525
CLV_NRD_NRD_1	97	99	PF00675	0.548
CLV_PCSK_KEX2_1	132	134	PF00082	0.668
CLV_PCSK_KEX2_1	207	209	PF00082	0.632
CLV_PCSK_KEX2_1	97	99	PF00082	0.548
CLV_PCSK_SKI1_1	265	269	PF00082	0.629
CLV_PCSK_SKI1_1	328	332	PF00082	0.466
CLV_PCSK_SKI1_1	453	457	PF00082	0.396
CLV_PCSK_SKI1_1	469	473	PF00082	0.404
CLV_PCSK_SKI1_1	493	497	PF00082	0.528
CLV_PCSK_SKI1_1	659	663	PF00082	0.539
DEG_APCC_DBOX_1	427	435	PF00400	0.420
DEG_SPOP_SBC_1	172	176	PF00917	0.727
DEG_SPOP_SBC_1	300	304	PF00917	0.721
DEG_SPOP_SBC_1	99	103	PF00917	0.658
DOC_CYCLIN_RxL_1	428	439	PF00134	0.452
DOC_CYCLIN_yClb3_PxF_3	517	523	PF00134	0.518
DOC_CYCLIN_yCln2_LP_2	275	281	PF00134	0.589
DOC_CYCLIN_yCln2_LP_2	734	740	PF00134	0.550
DOC_MAPK_gen_1	674	682	PF00069	0.498
DOC_MAPK_gen_1	698	706	PF00069	0.528
DOC_MAPK_MEF2A_6	565	573	PF00069	0.382
DOC_MAPK_MEF2A_6	676	684	PF00069	0.456
DOC_PP1_RVXF_1	430	437	PF00149	0.439
DOC_PP1_RVXF_1	451	457	PF00149	0.376
DOC_PP2B_LxvP_1	275	278	PF13499	0.661
DOC_PP2B_LxvP_1	704	707	PF13499	0.535
DOC_PP2B_LxvP_1	734	737	PF13499	0.506
DOC_PP4_FxxP_1	297	300	PF00568	0.585
DOC_USP7_MATH_1	108	112	PF00917	0.616
DOC_USP7_MATH_1	125	129	PF00917	0.696
DOC_USP7_MATH_1	173	177	PF00917	0.717
DOC_USP7_MATH_1	183	187	PF00917	0.646
DOC_USP7_MATH_1	202	206	PF00917	0.648
DOC_USP7_MATH_1	237	241	PF00917	0.709
DOC_USP7_MATH_1	246	250	PF00917	0.755
DOC_USP7_MATH_1	257	261	PF00917	0.705
DOC_USP7_MATH_1	279	283	PF00917	0.677
DOC_USP7_MATH_1	333	337	PF00917	0.557
DOC_USP7_MATH_1	632	636	PF00917	0.591
DOC_USP7_MATH_1	99	103	PF00917	0.649
DOC_USP7_MATH_2	577	583	PF00917	0.434
DOC_WW_Pin1_4	113	118	PF00397	0.678
DOC_WW_Pin1_4	132	137	PF00397	0.673
DOC_WW_Pin1_4	219	224	PF00397	0.695
DOC_WW_Pin1_4	258	263	PF00397	0.726
DOC_WW_Pin1_4	320	325	PF00397	0.451
DOC_WW_Pin1_4	375	380	PF00397	0.509
DOC_WW_Pin1_4	555	560	PF00397	0.416
DOC_WW_Pin1_4	635	640	PF00397	0.481
DOC_WW_Pin1_4	9	14	PF00397	0.521
LIG_14-3-3_CanoR_1	265	271	PF00244	0.646
LIG_14-3-3_CanoR_1	280	286	PF00244	0.601
LIG_14-3-3_CanoR_1	29	33	PF00244	0.421
LIG_14-3-3_CanoR_1	373	379	PF00244	0.564
LIG_14-3-3_CanoR_1	416	426	PF00244	0.501
LIG_14-3-3_CanoR_1	659	668	PF00244	0.378
LIG_14-3-3_CanoR_1	701	705	PF00244	0.552
LIG_14-3-3_CanoR_1	97	107	PF00244	0.643
LIG_Actin_WH2_2	39	55	PF00022	0.550
LIG_Actin_WH2_2	482	499	PF00022	0.366
LIG_Actin_WH2_2	569	587	PF00022	0.440
LIG_APCC_ABBAyCdc20_2	313	319	PF00400	0.523
LIG_BIR_II_1	1	5	PF00653	0.601
LIG_BIR_III_3	1	5	PF00653	0.601
LIG_BRCT_BRCA1_1	247	251	PF00533	0.595
LIG_BRCT_BRCA1_1	293	297	PF00533	0.577
LIG_BRCT_BRCA1_1	388	392	PF00533	0.446
LIG_BRCT_BRCA1_1	582	586	PF00533	0.362
LIG_Clathr_ClatBox_1	447	451	PF01394	0.436
LIG_CSL_BTD_1	199	202	PF09270	0.665
LIG_FHA_1	272	278	PF00498	0.717
LIG_FHA_1	286	292	PF00498	0.562
LIG_FHA_1	313	319	PF00498	0.501
LIG_FHA_1	45	51	PF00498	0.441
LIG_FHA_1	556	562	PF00498	0.427
LIG_FHA_1	625	631	PF00498	0.353
LIG_FHA_1	646	652	PF00498	0.445
LIG_FHA_1	701	707	PF00498	0.628
LIG_FHA_1	83	89	PF00498	0.406
LIG_FHA_2	36	42	PF00498	0.430
LIG_FHA_2	376	382	PF00498	0.441
LIG_LIR_Apic_2	294	300	PF02991	0.580
LIG_LIR_Gen_1	359	370	PF02991	0.400
LIG_LIR_Gen_1	389	400	PF02991	0.465
LIG_LIR_Gen_1	540	549	PF02991	0.554
LIG_LIR_Nem_3	216	221	PF02991	0.553
LIG_LIR_Nem_3	248	254	PF02991	0.590
LIG_LIR_Nem_3	359	365	PF02991	0.356
LIG_LIR_Nem_3	389	395	PF02991	0.485
LIG_LIR_Nem_3	451	455	PF02991	0.389
LIG_LIR_Nem_3	540	544	PF02991	0.422
LIG_LIR_Nem_3	570	576	PF02991	0.343
LIG_LIR_Nem_3	583	589	PF02991	0.362
LIG_LIR_Nem_3	665	670	PF02991	0.423
LIG_LIR_Nem_3	708	714	PF02991	0.665
LIG_LYPXL_S_1	548	552	PF13949	0.456
LIG_LYPXL_yS_3	549	552	PF13949	0.460
LIG_NRBOX	359	365	PF00104	0.480
LIG_NRBOX	742	748	PF00104	0.438
LIG_PCNA_yPIPBox_3	472	486	PF02747	0.402
LIG_Pex14_2	452	456	PF04695	0.377
LIG_Pex14_2	586	590	PF04695	0.394
LIG_SH2_CRK	371	375	PF00017	0.431
LIG_SH2_CRK	443	447	PF00017	0.401
LIG_SH2_CRK	478	482	PF00017	0.377
LIG_SH2_CRK	574	578	PF00017	0.338
LIG_SH2_CRK	63	67	PF00017	0.430
LIG_SH2_GRB2like	17	20	PF00017	0.407
LIG_SH2_NCK_1	574	578	PF00017	0.338
LIG_SH2_SRC	17	20	PF00017	0.407
LIG_SH2_SRC	574	577	PF00017	0.338
LIG_SH2_SRC	643	646	PF00017	0.534
LIG_SH2_STAP1	603	607	PF00017	0.521
LIG_SH2_STAP1	730	734	PF00017	0.474
LIG_SH2_STAT3	714	717	PF00017	0.495
LIG_SH2_STAT5	17	20	PF00017	0.407
LIG_SH2_STAT5	362	365	PF00017	0.355
LIG_SH2_STAT5	430	433	PF00017	0.616
LIG_SH2_STAT5	45	48	PF00017	0.519
LIG_SH2_STAT5	643	646	PF00017	0.534
LIG_SH2_STAT5	689	692	PF00017	0.471
LIG_SH3_1	321	327	PF00018	0.552
LIG_SH3_3	114	120	PF00018	0.639
LIG_SH3_3	196	202	PF00018	0.618
LIG_SH3_3	203	209	PF00018	0.757
LIG_SH3_3	231	237	PF00018	0.688
LIG_SH3_3	256	262	PF00018	0.746
LIG_SH3_3	321	327	PF00018	0.504
LIG_SH3_3	408	414	PF00018	0.411
LIG_SH3_3	435	441	PF00018	0.543
LIG_SH3_3	48	54	PF00018	0.507
LIG_SH3_3	512	518	PF00018	0.504
LIG_SH3_3	604	610	PF00018	0.499
LIG_SH3_4	512	519	PF00018	0.582
LIG_SUMO_SIM_par_1	445	451	PF11976	0.347
LIG_SUMO_SIM_par_1	702	709	PF11976	0.561
LIG_SUMO_SIM_par_1	84	89	PF11976	0.393
LIG_TYR_ITIM	360	365	PF00017	0.354
LIG_UBA3_1	391	398	PF00899	0.569
LIG_WW_3	325	329	PF00397	0.426
LIG_WW_3	413	417	PF00397	0.454
LIG_WW_3	466	470	PF00397	0.578
MOD_CDK_SPK_2	219	224	PF00069	0.601
MOD_CDK_SPxK_1	113	119	PF00069	0.562
MOD_CDK_SPxxK_3	136	143	PF00069	0.655
MOD_CDK_SPxxK_3	258	265	PF00069	0.560
MOD_CK1_1	307	313	PF00069	0.565
MOD_CK1_1	35	41	PF00069	0.434
MOD_CK1_1	352	358	PF00069	0.475
MOD_CK1_1	417	423	PF00069	0.406
MOD_CK1_1	635	641	PF00069	0.483
MOD_CK1_1	691	697	PF00069	0.635
MOD_CK1_1	705	711	PF00069	0.474
MOD_CK2_1	207	213	PF00069	0.723
MOD_CK2_1	257	263	PF00069	0.706
MOD_CK2_1	35	41	PF00069	0.446
MOD_CK2_1	355	361	PF00069	0.453
MOD_Cter_Amidation	130	133	PF01082	0.697
MOD_Cter_Amidation	395	398	PF01082	0.501
MOD_GlcNHglycan	110	113	PF01048	0.560
MOD_GlcNHglycan	127	130	PF01048	0.855
MOD_GlcNHglycan	136	139	PF01048	0.636
MOD_GlcNHglycan	185	188	PF01048	0.698
MOD_GlcNHglycan	248	251	PF01048	0.737
MOD_GlcNHglycan	255	258	PF01048	0.711
MOD_GlcNHglycan	291	294	PF01048	0.704
MOD_GlcNHglycan	306	309	PF01048	0.644
MOD_GlcNHglycan	341	344	PF01048	0.487
MOD_GlcNHglycan	351	354	PF01048	0.469
MOD_GlcNHglycan	411	414	PF01048	0.439
MOD_GlcNHglycan	416	419	PF01048	0.472
MOD_GlcNHglycan	586	589	PF01048	0.368
MOD_GlcNHglycan	662	665	PF01048	0.378
MOD_GlcNHglycan	69	72	PF01048	0.495
MOD_GlcNHglycan	693	696	PF01048	0.493
MOD_GlcNHglycan	711	714	PF01048	0.480
MOD_GlcNHglycan	720	724	PF01048	0.540
MOD_GSK3_1	132	139	PF00069	0.686
MOD_GSK3_1	173	180	PF00069	0.805
MOD_GSK3_1	237	244	PF00069	0.829
MOD_GSK3_1	253	260	PF00069	0.794
MOD_GSK3_1	28	35	PF00069	0.437
MOD_GSK3_1	285	292	PF00069	0.663
MOD_GSK3_1	299	306	PF00069	0.727
MOD_GSK3_1	333	340	PF00069	0.675
MOD_GSK3_1	352	359	PF00069	0.386
MOD_GSK3_1	414	421	PF00069	0.597
MOD_GSK3_1	5	12	PF00069	0.548
MOD_GSK3_1	580	587	PF00069	0.359
MOD_GSK3_1	645	652	PF00069	0.571
MOD_GSK3_1	702	709	PF00069	0.546
MOD_GSK3_1	82	89	PF00069	0.435
MOD_N-GLC_1	521	526	PF02516	0.428
MOD_NEK2_1	266	271	PF00069	0.722
MOD_NEK2_1	291	296	PF00069	0.629
MOD_NEK2_1	337	342	PF00069	0.607
MOD_NEK2_1	354	359	PF00069	0.348
MOD_NEK2_1	374	379	PF00069	0.458
MOD_NEK2_1	391	396	PF00069	0.517
MOD_NEK2_1	442	447	PF00069	0.372
MOD_NEK2_1	523	528	PF00069	0.369
MOD_NEK2_1	580	585	PF00069	0.374
MOD_NEK2_1	662	667	PF00069	0.463
MOD_NEK2_1	700	705	PF00069	0.622
MOD_NEK2_2	312	317	PF00069	0.533
MOD_PIKK_1	207	213	PF00454	0.611
MOD_PIKK_1	237	243	PF00454	0.668
MOD_PIKK_1	462	468	PF00454	0.470
MOD_PIKK_1	524	530	PF00454	0.398
MOD_PK_1	217	223	PF00069	0.619
MOD_PK_1	230	236	PF00069	0.668
MOD_PK_1	702	708	PF00069	0.574
MOD_PKA_1	207	213	PF00069	0.601
MOD_PKA_1	97	103	PF00069	0.571
MOD_PKA_2	192	198	PF00069	0.637
MOD_PKA_2	207	213	PF00069	0.576
MOD_PKA_2	279	285	PF00069	0.723
MOD_PKA_2	28	34	PF00069	0.435
MOD_PKA_2	312	318	PF00069	0.526
MOD_PKA_2	605	611	PF00069	0.529
MOD_PKA_2	700	706	PF00069	0.659
MOD_PKA_2	97	103	PF00069	0.571
MOD_PKB_1	215	223	PF00069	0.649
MOD_PKB_1	228	236	PF00069	0.694
MOD_Plk_4	312	318	PF00069	0.583
MOD_Plk_4	421	427	PF00069	0.549
MOD_Plk_4	442	448	PF00069	0.368
MOD_Plk_4	638	644	PF00069	0.545
MOD_Plk_4	688	694	PF00069	0.542
MOD_Plk_4	82	88	PF00069	0.396
MOD_ProDKin_1	113	119	PF00069	0.691
MOD_ProDKin_1	132	138	PF00069	0.675
MOD_ProDKin_1	219	225	PF00069	0.698
MOD_ProDKin_1	258	264	PF00069	0.727
MOD_ProDKin_1	320	326	PF00069	0.440
MOD_ProDKin_1	375	381	PF00069	0.507
MOD_ProDKin_1	555	561	PF00069	0.418
MOD_ProDKin_1	635	641	PF00069	0.483
MOD_ProDKin_1	9	15	PF00069	0.511
TRG_DiLeu_BaEn_1	498	503	PF01217	0.467
TRG_DiLeu_BaEn_1	742	747	PF01217	0.469
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.469
TRG_DiLeu_BaLyEn_6	450	455	PF01217	0.360
TRG_DiLeu_BaLyEn_6	466	471	PF01217	0.392
TRG_DiLeu_BaLyEn_6	613	618	PF01217	0.489
TRG_ENDOCYTIC_2	362	365	PF00928	0.375
TRG_ENDOCYTIC_2	371	374	PF00928	0.444
TRG_ENDOCYTIC_2	443	446	PF00928	0.406
TRG_ENDOCYTIC_2	478	481	PF00928	0.382
TRG_ENDOCYTIC_2	549	552	PF00928	0.527
TRG_ENDOCYTIC_2	63	66	PF00928	0.439
TRG_ENDOCYTIC_2	689	692	PF00928	0.476
TRG_ER_diArg_1	206	208	PF00400	0.642
TRG_ER_diArg_1	227	230	PF00400	0.714
TRG_ER_diArg_1	671	674	PF00400	0.496
TRG_ER_diArg_1	97	99	PF00400	0.527
TRG_Pf-PMV_PEXEL_1	432	437	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	469	473	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I868	Leptomonas seymouri	53%	96%
A4HD97	Leishmania braziliensis	77%	100%
E9AH52	Leishmania infantum	99%	100%
E9AWN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4QAU0	Leishmania major	91%	100%