Separase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Separase

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WY64_LEIDO

TriTrypDb:

LdBPK_240670.1 , LdCL_240011700 , LDHU3_24.0800

Length:

762

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WY64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WY64

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.529
CLV_C14_Caspase3-7	188	192	PF00656	0.694
CLV_C14_Caspase3-7	648	652	PF00656	0.608
CLV_C14_Caspase3-7	722	726	PF00656	0.631
CLV_NRD_NRD_1	136	138	PF00675	0.462
CLV_NRD_NRD_1	379	381	PF00675	0.489
CLV_NRD_NRD_1	394	396	PF00675	0.365
CLV_NRD_NRD_1	711	713	PF00675	0.570
CLV_PCSK_KEX2_1	141	143	PF00082	0.452
CLV_PCSK_KEX2_1	379	381	PF00082	0.441
CLV_PCSK_KEX2_1	394	396	PF00082	0.397
CLV_PCSK_KEX2_1	404	406	PF00082	0.407
CLV_PCSK_KEX2_1	710	712	PF00082	0.523
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.500
CLV_PCSK_PC1ET2_1	404	406	PF00082	0.531
CLV_PCSK_PC1ET2_1	710	712	PF00082	0.603
CLV_PCSK_PC7_1	137	143	PF00082	0.494
CLV_PCSK_SKI1_1	138	142	PF00082	0.466
CLV_PCSK_SKI1_1	16	20	PF00082	0.697
CLV_PCSK_SKI1_1	179	183	PF00082	0.546
CLV_PCSK_SKI1_1	317	321	PF00082	0.587
CLV_PCSK_SKI1_1	353	357	PF00082	0.485
CLV_PCSK_SKI1_1	380	384	PF00082	0.424
CLV_PCSK_SKI1_1	387	391	PF00082	0.428
CLV_PCSK_SKI1_1	405	409	PF00082	0.461
DEG_APCC_DBOX_1	379	387	PF00400	0.343
DEG_Nend_Nbox_1	1	3	PF02207	0.696
DEG_SCF_FBW7_1	611	618	PF00400	0.602
DEG_SCF_FBW7_1	740	745	PF00400	0.595
DEG_SCF_SKP2-CKS1_1	573	580	PF00560	0.578
DOC_CKS1_1	612	617	PF01111	0.608
DOC_CKS1_1	739	744	PF01111	0.598
DOC_CYCLIN_RxL_1	137	149	PF00134	0.484
DOC_CYCLIN_RxL_1	311	324	PF00134	0.584
DOC_CYCLIN_RxL_1	616	626	PF00134	0.475
DOC_MAPK_gen_1	12	21	PF00069	0.522
DOC_MAPK_gen_1	126	135	PF00069	0.623
DOC_MAPK_gen_1	379	385	PF00069	0.560
DOC_MAPK_gen_1	476	484	PF00069	0.562
DOC_MAPK_gen_1	672	680	PF00069	0.613
DOC_MAPK_JIP1_4	129	135	PF00069	0.620
DOC_MAPK_MEF2A_6	476	484	PF00069	0.562
DOC_MAPK_MEF2A_6	674	683	PF00069	0.596
DOC_PP1_RVXF_1	456	462	PF00149	0.388
DOC_PP1_SILK_1	380	385	PF00149	0.339
DOC_PP2B_LxvP_1	201	204	PF13499	0.467
DOC_USP7_MATH_1	177	181	PF00917	0.559
DOC_USP7_MATH_1	204	208	PF00917	0.504
DOC_USP7_MATH_1	516	520	PF00917	0.444
DOC_USP7_MATH_1	615	619	PF00917	0.570
DOC_USP7_MATH_1	649	653	PF00917	0.611
DOC_USP7_MATH_1	694	698	PF00917	0.602
DOC_USP7_MATH_1	742	746	PF00917	0.673
DOC_USP7_UBL2_3	672	676	PF12436	0.491
DOC_WW_Pin1_4	411	416	PF00397	0.399
DOC_WW_Pin1_4	574	579	PF00397	0.601
DOC_WW_Pin1_4	611	616	PF00397	0.558
DOC_WW_Pin1_4	738	743	PF00397	0.599
LIG_14-3-3_CanoR_1	120	125	PF00244	0.548
LIG_14-3-3_CanoR_1	146	152	PF00244	0.437
LIG_14-3-3_CanoR_1	246	255	PF00244	0.555
LIG_14-3-3_CanoR_1	373	379	PF00244	0.487
LIG_14-3-3_CanoR_1	515	524	PF00244	0.566
LIG_14-3-3_CanoR_1	569	578	PF00244	0.550
LIG_14-3-3_CanoR_1	661	669	PF00244	0.676
LIG_14-3-3_CanoR_1	82	90	PF00244	0.548
LIG_Actin_WH2_2	375	392	PF00022	0.522
LIG_BRCT_BRCA1_1	550	554	PF00533	0.543
LIG_Clathr_ClatBox_1	236	240	PF01394	0.459
LIG_deltaCOP1_diTrp_1	682	686	PF00928	0.607
LIG_eIF4E_1	257	263	PF01652	0.532
LIG_eIF4E_1	508	514	PF01652	0.490
LIG_FHA_1	208	214	PF00498	0.430
LIG_FHA_1	250	256	PF00498	0.452
LIG_FHA_1	275	281	PF00498	0.619
LIG_FHA_1	294	300	PF00498	0.410
LIG_FHA_1	416	422	PF00498	0.498
LIG_FHA_1	439	445	PF00498	0.451
LIG_FHA_1	469	475	PF00498	0.457
LIG_FHA_1	655	661	PF00498	0.693
LIG_FHA_1	739	745	PF00498	0.672
LIG_FHA_1	756	762	PF00498	0.669
LIG_FHA_2	148	154	PF00498	0.527
LIG_FHA_2	186	192	PF00498	0.657
LIG_FHA_2	293	299	PF00498	0.537
LIG_FHA_2	3	9	PF00498	0.532
LIG_FHA_2	624	630	PF00498	0.603
LIG_FHA_2	646	652	PF00498	0.548
LIG_GBD_Chelix_1	727	735	PF00786	0.564
LIG_IRF3_LxIS_1	29	36	PF10401	0.635
LIG_IRF3_LxIS_1	407	414	PF10401	0.508
LIG_LIR_Apic_2	525	531	PF02991	0.480
LIG_LIR_Apic_2	736	742	PF02991	0.629
LIG_LIR_Gen_1	104	112	PF02991	0.513
LIG_LIR_Gen_1	292	302	PF02991	0.540
LIG_LIR_Gen_1	331	341	PF02991	0.511
LIG_LIR_Gen_1	481	492	PF02991	0.453
LIG_LIR_Gen_1	69	80	PF02991	0.688
LIG_LIR_Gen_1	699	709	PF02991	0.521
LIG_LIR_Nem_3	104	109	PF02991	0.486
LIG_LIR_Nem_3	122	127	PF02991	0.370
LIG_LIR_Nem_3	143	148	PF02991	0.430
LIG_LIR_Nem_3	292	297	PF02991	0.519
LIG_LIR_Nem_3	331	336	PF02991	0.427
LIG_LIR_Nem_3	481	487	PF02991	0.455
LIG_LIR_Nem_3	502	508	PF02991	0.507
LIG_LIR_Nem_3	69	75	PF02991	0.665
LIG_LIR_Nem_3	699	705	PF02991	0.505
LIG_LIR_Nem_3	747	752	PF02991	0.608
LIG_LIR_Nem_3	95	100	PF02991	0.556
LIG_MYND_1	282	286	PF01753	0.528
LIG_NRBOX	258	264	PF00104	0.539
LIG_PCNA_yPIPBox_3	633	647	PF02747	0.631
LIG_Rb_LxCxE_1	725	747	PF01857	0.648
LIG_REV1ctd_RIR_1	666	676	PF16727	0.693
LIG_SH2_CRK	127	131	PF00017	0.591
LIG_SH2_CRK	508	512	PF00017	0.495
LIG_SH2_CRK	528	532	PF00017	0.465
LIG_SH2_CRK	72	76	PF00017	0.683
LIG_SH2_NCK_1	453	457	PF00017	0.443
LIG_SH2_SRC	453	456	PF00017	0.448
LIG_SH2_STAP1	101	105	PF00017	0.496
LIG_SH2_STAP1	453	457	PF00017	0.524
LIG_SH2_STAP1	501	505	PF00017	0.492
LIG_SH2_STAT3	595	598	PF00017	0.657
LIG_SH2_STAT5	294	297	PF00017	0.540
LIG_SH2_STAT5	309	312	PF00017	0.483
LIG_SH2_STAT5	422	425	PF00017	0.533
LIG_SH2_STAT5	528	531	PF00017	0.473
LIG_SH2_STAT5	595	598	PF00017	0.638
LIG_SH2_STAT5	62	65	PF00017	0.676
LIG_SH2_STAT5	739	742	PF00017	0.600
LIG_SH3_2	282	287	PF14604	0.598
LIG_SH3_3	279	285	PF00018	0.610
LIG_SH3_3	360	366	PF00018	0.518
LIG_SUMO_SIM_anti_2	234	240	PF11976	0.523
LIG_SUMO_SIM_anti_2	295	301	PF11976	0.504
LIG_SUMO_SIM_anti_2	510	515	PF11976	0.370
LIG_SUMO_SIM_par_1	162	169	PF11976	0.528
LIG_SUMO_SIM_par_1	234	240	PF11976	0.463
LIG_SUMO_SIM_par_1	298	304	PF11976	0.473
LIG_SUMO_SIM_par_1	485	490	PF11976	0.503
LIG_SUMO_SIM_par_1	5	10	PF11976	0.596
LIG_TRAF2_1	150	153	PF00917	0.568
LIG_TRAF2_1	170	173	PF00917	0.207
LIG_UBA3_1	336	345	PF00899	0.602
LIG_UBA3_1	356	365	PF00899	0.224
LIG_UBA3_1	382	390	PF00899	0.514
LIG_UBA3_1	407	412	PF00899	0.467
LIG_WRC_WIRS_1	121	126	PF05994	0.532
LIG_WRC_WIRS_1	423	428	PF05994	0.432
LIG_WRC_WIRS_1	749	754	PF05994	0.557
MOD_CDK_SPxK_1	574	580	PF00069	0.623
MOD_CDK_SPxK_1	611	617	PF00069	0.610
MOD_CK1_1	207	213	PF00069	0.529
MOD_CK1_1	248	254	PF00069	0.508
MOD_CK1_1	292	298	PF00069	0.547
MOD_CK1_1	331	337	PF00069	0.591
MOD_CK1_1	374	380	PF00069	0.402
MOD_CK1_1	40	46	PF00069	0.655
MOD_CK1_1	414	420	PF00069	0.486
MOD_CK1_1	425	431	PF00069	0.405
MOD_CK1_1	663	669	PF00069	0.710
MOD_CK1_1	698	704	PF00069	0.579
MOD_CK1_1	715	721	PF00069	0.715
MOD_CK1_1	73	79	PF00069	0.689
MOD_CK1_1	751	757	PF00069	0.697
MOD_CK2_1	146	152	PF00069	0.479
MOD_CK2_1	2	8	PF00069	0.537
MOD_CK2_1	300	306	PF00069	0.459
MOD_CK2_1	569	575	PF00069	0.575
MOD_CK2_1	623	629	PF00069	0.577
MOD_CK2_1	649	655	PF00069	0.594
MOD_CK2_1	694	700	PF00069	0.605
MOD_Cter_Amidation	13	16	PF01082	0.670
MOD_GlcNHglycan	168	171	PF01048	0.537
MOD_GlcNHglycan	179	182	PF01048	0.611
MOD_GlcNHglycan	248	251	PF01048	0.570
MOD_GlcNHglycan	39	42	PF01048	0.645
MOD_GlcNHglycan	48	51	PF01048	0.598
MOD_GlcNHglycan	518	521	PF01048	0.451
MOD_GlcNHglycan	75	78	PF01048	0.599
MOD_GlcNHglycan	754	757	PF01048	0.646
MOD_GlcNHglycan	758	761	PF01048	0.647
MOD_GlcNHglycan	92	95	PF01048	0.516
MOD_GSK3_1	183	190	PF00069	0.547
MOD_GSK3_1	241	248	PF00069	0.484
MOD_GSK3_1	289	296	PF00069	0.442
MOD_GSK3_1	33	40	PF00069	0.662
MOD_GSK3_1	369	376	PF00069	0.593
MOD_GSK3_1	411	418	PF00069	0.488
MOD_GSK3_1	428	435	PF00069	0.473
MOD_GSK3_1	462	469	PF00069	0.500
MOD_GSK3_1	518	525	PF00069	0.456
MOD_GSK3_1	548	555	PF00069	0.537
MOD_GSK3_1	61	68	PF00069	0.546
MOD_GSK3_1	611	618	PF00069	0.588
MOD_GSK3_1	625	632	PF00069	0.624
MOD_GSK3_1	645	652	PF00069	0.291
MOD_GSK3_1	694	701	PF00069	0.502
MOD_GSK3_1	738	745	PF00069	0.673
MOD_GSK3_1	748	755	PF00069	0.710
MOD_GSK3_1	86	93	PF00069	0.672
MOD_N-GLC_1	694	699	PF02516	0.484
MOD_NEK2_1	119	124	PF00069	0.445
MOD_NEK2_1	144	149	PF00069	0.434
MOD_NEK2_1	205	210	PF00069	0.434
MOD_NEK2_1	300	305	PF00069	0.518
MOD_NEK2_1	33	38	PF00069	0.717
MOD_NEK2_1	341	346	PF00069	0.525
MOD_NEK2_1	55	60	PF00069	0.611
MOD_NEK2_1	623	628	PF00069	0.585
MOD_NEK2_1	645	650	PF00069	0.577
MOD_NEK2_1	66	71	PF00069	0.502
MOD_NEK2_1	660	665	PF00069	0.559
MOD_NEK2_1	752	757	PF00069	0.600
MOD_NEK2_2	422	427	PF00069	0.460
MOD_OFUCOSY	330	335	PF10250	0.551
MOD_PIKK_1	660	666	PF00454	0.678
MOD_PK_1	241	247	PF00069	0.506
MOD_PKA_1	499	505	PF00069	0.543
MOD_PKA_1	712	718	PF00069	0.674
MOD_PKA_2	119	125	PF00069	0.523
MOD_PKA_2	245	251	PF00069	0.399
MOD_PKA_2	378	384	PF00069	0.484
MOD_PKA_2	55	61	PF00069	0.620
MOD_PKA_2	649	655	PF00069	0.602
MOD_PKA_2	660	666	PF00069	0.642
MOD_PKA_2	752	758	PF00069	0.676
MOD_PKA_2	81	87	PF00069	0.700
MOD_Plk_1	155	161	PF00069	0.530
MOD_Plk_1	31	37	PF00069	0.640
MOD_Plk_1	466	472	PF00069	0.553
MOD_Plk_1	654	660	PF00069	0.673
MOD_Plk_1	698	704	PF00069	0.564
MOD_Plk_4	120	126	PF00069	0.536
MOD_Plk_4	2	8	PF00069	0.616
MOD_Plk_4	43	49	PF00069	0.649
MOD_Plk_4	522	528	PF00069	0.515
MOD_Plk_4	591	597	PF00069	0.589
MOD_Plk_4	649	655	PF00069	0.563
MOD_Plk_4	67	73	PF00069	0.613
MOD_Plk_4	698	704	PF00069	0.509
MOD_Plk_4	86	92	PF00069	0.338
MOD_ProDKin_1	411	417	PF00069	0.402
MOD_ProDKin_1	574	580	PF00069	0.608
MOD_ProDKin_1	611	617	PF00069	0.561
MOD_ProDKin_1	738	744	PF00069	0.597
MOD_SUMO_for_1	140	143	PF00179	0.478
MOD_SUMO_rev_2	149	157	PF00179	0.502
MOD_SUMO_rev_2	269	277	PF00179	0.587
TRG_DiLeu_BaEn_1	351	356	PF01217	0.459
TRG_DiLeu_BaEn_1	86	91	PF01217	0.669
TRG_DiLeu_BaEn_2	654	660	PF01217	0.557
TRG_DiLeu_BaEn_2	94	100	PF01217	0.572
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.536
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.442
TRG_DiLeu_BaLyEn_6	336	341	PF01217	0.586
TRG_DiLeu_BaLyEn_6	381	386	PF01217	0.431
TRG_DiLeu_BaLyEn_6	676	681	PF01217	0.599
TRG_ENDOCYTIC_2	199	202	PF00928	0.462
TRG_ENDOCYTIC_2	260	263	PF00928	0.507
TRG_ENDOCYTIC_2	294	297	PF00928	0.506
TRG_ENDOCYTIC_2	508	511	PF00928	0.497
TRG_ENDOCYTIC_2	72	75	PF00928	0.678
TRG_ENDOCYTIC_2	749	752	PF00928	0.732
TRG_ER_diArg_1	378	380	PF00400	0.413
TRG_ER_diArg_1	393	395	PF00400	0.405
TRG_NES_CRM1_1	228	240	PF08389	0.564
TRG_NLS_MonoCore_2	709	714	PF00514	0.634
TRG_NLS_MonoExtC_3	136	141	PF00514	0.493
TRG_NLS_MonoExtC_3	709	714	PF00514	0.590
TRG_NLS_MonoExtN_4	134	141	PF00514	0.561
TRG_Pf-PMV_PEXEL_1	317	321	PF00026	0.637

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5G6	Leptomonas seymouri	46%	100%
A0A1X0NK62	Trypanosomatidae	27%	92%
A0A3S5IQT2	Trypanosoma rangeli	27%	100%
A4HDC4	Leishmania braziliensis	72%	100%
A4I0Q4	Leishmania infantum	99%	100%
D0A732	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	99%
E9AWQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QAR7	Leishmania major	90%	100%
V5C0M8	Trypanosoma cruzi	28%	100%