DUF523 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF523), putative

Species:

Leishmania donovani

UniProt:

A0A3S7WY61_LEIDO

TriTrypDb:

LdBPK_240720.1 , LdCL_240012200 , LDHU3_24.0850

Length:

438

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WY61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WY61

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.557
CLV_C14_Caspase3-7	336	340	PF00656	0.425
CLV_C14_Caspase3-7	416	420	PF00656	0.533
CLV_NRD_NRD_1	187	189	PF00675	0.568
CLV_NRD_NRD_1	323	325	PF00675	0.797
CLV_NRD_NRD_1	333	335	PF00675	0.515
CLV_NRD_NRD_1	402	404	PF00675	0.624
CLV_PCSK_KEX2_1	187	189	PF00082	0.581
CLV_PCSK_KEX2_1	219	221	PF00082	0.475
CLV_PCSK_KEX2_1	323	325	PF00082	0.797
CLV_PCSK_KEX2_1	333	335	PF00082	0.515
CLV_PCSK_KEX2_1	401	403	PF00082	0.637
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.475
CLV_PCSK_PC1ET2_1	401	403	PF00082	0.636
CLV_PCSK_SKI1_1	347	351	PF00082	0.460
CLV_PCSK_SKI1_1	379	383	PF00082	0.446
DEG_APCC_DBOX_1	170	178	PF00400	0.400
DEG_APCC_DBOX_1	346	354	PF00400	0.458
DEG_Nend_UBRbox_4	1	3	PF02207	0.518
DEG_SCF_FBW7_1	93	98	PF00400	0.595
DEG_SPOP_SBC_1	95	99	PF00917	0.667
DOC_CKS1_1	62	67	PF01111	0.574
DOC_CYCLIN_yCln2_LP_2	117	123	PF00134	0.362
DOC_MAPK_DCC_7	103	112	PF00069	0.426
DOC_MAPK_MEF2A_6	103	112	PF00069	0.458
DOC_MAPK_MEF2A_6	135	142	PF00069	0.407
DOC_PP2B_LxvP_1	165	168	PF13499	0.403
DOC_PP2B_LxvP_1	249	252	PF13499	0.586
DOC_PP2B_PxIxI_1	107	113	PF00149	0.264
DOC_USP7_MATH_1	210	214	PF00917	0.510
DOC_USP7_MATH_1	3	7	PF00917	0.495
DOC_USP7_MATH_1	325	329	PF00917	0.565
DOC_WW_Pin1_4	134	139	PF00397	0.447
DOC_WW_Pin1_4	25	30	PF00397	0.563
DOC_WW_Pin1_4	275	280	PF00397	0.360
DOC_WW_Pin1_4	292	297	PF00397	0.561
DOC_WW_Pin1_4	61	66	PF00397	0.569
DOC_WW_Pin1_4	91	96	PF00397	0.660
LIG_14-3-3_CanoR_1	124	134	PF00244	0.479
LIG_14-3-3_CanoR_1	34	39	PF00244	0.541
LIG_14-3-3_CanoR_1	365	374	PF00244	0.692
LIG_BRCT_BRCA1_1	316	320	PF00533	0.565
LIG_CaM_NSCaTE_8	82	89	PF13499	0.506
LIG_deltaCOP1_diTrp_1	430	433	PF00928	0.319
LIG_FHA_1	135	141	PF00498	0.421
LIG_FHA_1	258	264	PF00498	0.376
LIG_FHA_1	341	347	PF00498	0.394
LIG_FHA_2	242	248	PF00498	0.569
LIG_FHA_2	414	420	PF00498	0.444
LIG_FHA_2	97	103	PF00498	0.605
LIG_LIR_Nem_3	144	150	PF02991	0.398
LIG_LIR_Nem_3	161	167	PF02991	0.408
LIG_LIR_Nem_3	79	85	PF02991	0.613
LIG_NRBOX	258	264	PF00104	0.430
LIG_SH2_CRK	238	242	PF00017	0.457
LIG_SH2_CRK	4	8	PF00017	0.514
LIG_SH2_NCK_1	238	242	PF00017	0.493
LIG_SH2_SRC	289	292	PF00017	0.492
LIG_SH2_STAP1	289	293	PF00017	0.467
LIG_SH2_STAP1	4	8	PF00017	0.514
LIG_SH2_STAT5	224	227	PF00017	0.462
LIG_SH2_STAT5	385	388	PF00017	0.496
LIG_SH3_2	170	175	PF14604	0.399
LIG_SH3_3	102	108	PF00018	0.695
LIG_SH3_3	154	160	PF00018	0.337
LIG_SH3_3	167	173	PF00018	0.399
LIG_SH3_3	27	33	PF00018	0.518
LIG_SH3_3	290	296	PF00018	0.708
LIG_SUMO_SIM_anti_2	6	11	PF11976	0.510
LIG_SUMO_SIM_par_1	106	113	PF11976	0.363
LIG_SUMO_SIM_par_1	6	11	PF11976	0.510
LIG_UBA3_1	262	267	PF00899	0.391
LIG_WRC_WIRS_1	418	423	PF05994	0.451
MOD_CDK_SPxxK_3	61	68	PF00069	0.566
MOD_CK1_1	180	186	PF00069	0.540
MOD_CK1_1	199	205	PF00069	0.486
MOD_CK1_1	295	301	PF00069	0.555
MOD_CK1_1	417	423	PF00069	0.451
MOD_CK1_1	96	102	PF00069	0.643
MOD_CK2_1	225	231	PF00069	0.528
MOD_CK2_1	241	247	PF00069	0.479
MOD_CK2_1	417	423	PF00069	0.416
MOD_Cter_Amidation	321	324	PF01082	0.793
MOD_GlcNHglycan	10	13	PF01048	0.550
MOD_GlcNHglycan	112	115	PF01048	0.328
MOD_GlcNHglycan	189	192	PF01048	0.709
MOD_GlcNHglycan	199	202	PF01048	0.556
MOD_GlcNHglycan	208	211	PF01048	0.478
MOD_GlcNHglycan	227	231	PF01048	0.406
MOD_GlcNHglycan	255	258	PF01048	0.598
MOD_GlcNHglycan	327	330	PF01048	0.564
MOD_GSK3_1	115	122	PF00069	0.462
MOD_GSK3_1	126	133	PF00069	0.467
MOD_GSK3_1	192	199	PF00069	0.592
MOD_GSK3_1	202	209	PF00069	0.571
MOD_GSK3_1	253	260	PF00069	0.622
MOD_GSK3_1	273	280	PF00069	0.323
MOD_GSK3_1	291	298	PF00069	0.543
MOD_GSK3_1	314	321	PF00069	0.559
MOD_GSK3_1	379	386	PF00069	0.481
MOD_GSK3_1	413	420	PF00069	0.501
MOD_GSK3_1	89	96	PF00069	0.651
MOD_N-GLC_1	23	28	PF02516	0.500
MOD_N-GLC_1	241	246	PF02516	0.598
MOD_N-GLC_1	406	411	PF02516	0.591
MOD_N-GLC_2	307	309	PF02516	0.589
MOD_NEK2_1	206	211	PF00069	0.572
MOD_NEK2_1	225	230	PF00069	0.541
MOD_NEK2_1	349	354	PF00069	0.443
MOD_NEK2_1	421	426	PF00069	0.485
MOD_PIKK_1	192	198	PF00454	0.496
MOD_PIKK_1	257	263	PF00454	0.378
MOD_PIKK_1	340	346	PF00454	0.388
MOD_PIKK_1	431	437	PF00454	0.452
MOD_PK_1	314	320	PF00069	0.543
MOD_PKA_1	187	193	PF00069	0.523
MOD_PKA_2	123	129	PF00069	0.493
MOD_PKA_2	177	183	PF00069	0.542
MOD_PKA_2	187	193	PF00069	0.586
MOD_PKA_2	33	39	PF00069	0.545
MOD_PKA_2	431	437	PF00069	0.609
MOD_Plk_1	23	29	PF00069	0.503
MOD_Plk_1	241	247	PF00069	0.563
MOD_Plk_1	89	95	PF00069	0.566
MOD_Plk_2-3	383	389	PF00069	0.483
MOD_Plk_4	3	9	PF00069	0.512
MOD_Plk_4	417	423	PF00069	0.474
MOD_ProDKin_1	134	140	PF00069	0.438
MOD_ProDKin_1	25	31	PF00069	0.564
MOD_ProDKin_1	275	281	PF00069	0.356
MOD_ProDKin_1	292	298	PF00069	0.562
MOD_ProDKin_1	61	67	PF00069	0.570
MOD_ProDKin_1	91	97	PF00069	0.664
TRG_DiLeu_BaEn_1	221	226	PF01217	0.488
TRG_DiLeu_BaEn_1	231	236	PF01217	0.435
TRG_DiLeu_BaLyEn_6	105	110	PF01217	0.322
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.423
TRG_DiLeu_BaLyEn_6	376	381	PF01217	0.376
TRG_ENDOCYTIC_2	4	7	PF00928	0.514
TRG_ER_diArg_1	323	325	PF00400	0.719
TRG_ER_diArg_1	333	335	PF00400	0.490
TRG_ER_diArg_1	402	404	PF00400	0.552
TRG_NES_CRM1_1	149	161	PF08389	0.359
TRG_NLS_MonoCore_2	399	404	PF00514	0.550
TRG_NLS_MonoExtN_4	398	405	PF00514	0.623
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	379	383	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3F4	Leptomonas seymouri	43%	100%
A4HDC8	Leishmania braziliensis	72%	100%
A4I0Q9	Leishmania infantum	98%	100%
E9AWR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QAR2	Leishmania major	90%	100%