Ubiquitin carboxyl-terminal hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin carboxyl-terminal hydrolase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WY54_LEIDO

TriTrypDb:

LdBPK_240630.1 , LdCL_240011300 , LDHU3_24.0750

Length:

810

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WY54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WY54

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0016579	protein deubiquitination	6	12
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043632	modification-dependent macromolecule catabolic process	5	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044265	obsolete cellular macromolecule catabolic process	4	12
GO:0051603	proteolysis involved in protein catabolic process	5	12
GO:0070646	protein modification by small protein removal	5	12
GO:0070647	protein modification by small protein conjugation or removal	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004843	cysteine-type deubiquitinase activity	5	12
GO:0008233	peptidase activity	3	12
GO:0008234	cysteine-type peptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0019783	ubiquitin-like protein peptidase activity	4	12
GO:0101005	deubiquitinase activity	5	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	342	346	PF00656	0.385
CLV_C14_Caspase3-7	468	472	PF00656	0.413
CLV_C14_Caspase3-7	588	592	PF00656	0.676
CLV_C14_Caspase3-7	624	628	PF00656	0.780
CLV_C14_Caspase3-7	651	655	PF00656	0.651
CLV_C14_Caspase3-7	703	707	PF00656	0.663
CLV_NRD_NRD_1	174	176	PF00675	0.363
CLV_NRD_NRD_1	18	20	PF00675	0.618
CLV_NRD_NRD_1	26	28	PF00675	0.572
CLV_NRD_NRD_1	493	495	PF00675	0.488
CLV_NRD_NRD_1	557	559	PF00675	0.618
CLV_NRD_NRD_1	667	669	PF00675	0.820
CLV_NRD_NRD_1	719	721	PF00675	0.808
CLV_NRD_NRD_1	737	739	PF00675	0.607
CLV_NRD_NRD_1	748	750	PF00675	0.644
CLV_NRD_NRD_1	77	79	PF00675	0.786
CLV_NRD_NRD_1	808	810	PF00675	0.641
CLV_PCSK_FUR_1	804	808	PF00082	0.606
CLV_PCSK_KEX2_1	296	298	PF00082	0.475
CLV_PCSK_KEX2_1	377	379	PF00082	0.315
CLV_PCSK_KEX2_1	431	433	PF00082	0.475
CLV_PCSK_KEX2_1	556	558	PF00082	0.607
CLV_PCSK_KEX2_1	616	618	PF00082	0.732
CLV_PCSK_KEX2_1	667	669	PF00082	0.820
CLV_PCSK_KEX2_1	698	700	PF00082	0.640
CLV_PCSK_KEX2_1	748	750	PF00082	0.711
CLV_PCSK_KEX2_1	77	79	PF00082	0.786
CLV_PCSK_KEX2_1	806	808	PF00082	0.609
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.475
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.328
CLV_PCSK_PC1ET2_1	431	433	PF00082	0.475
CLV_PCSK_PC1ET2_1	556	558	PF00082	0.601
CLV_PCSK_PC1ET2_1	616	618	PF00082	0.767
CLV_PCSK_PC1ET2_1	698	700	PF00082	0.682
CLV_PCSK_PC7_1	804	810	PF00082	0.735
CLV_PCSK_SKI1_1	14	18	PF00082	0.668
CLV_PCSK_SKI1_1	229	233	PF00082	0.330
CLV_PCSK_SKI1_1	377	381	PF00082	0.398
CLV_PCSK_SKI1_1	388	392	PF00082	0.474
CLV_PCSK_SKI1_1	683	687	PF00082	0.733
CLV_PCSK_SKI1_1	695	699	PF00082	0.648
CLV_PCSK_SKI1_1	738	742	PF00082	0.735
CLV_PCSK_SKI1_1	775	779	PF00082	0.769
CLV_PCSK_SKI1_1	798	802	PF00082	0.676
DEG_Nend_UBRbox_2	1	3	PF02207	0.647
DOC_CKS1_1	741	746	PF01111	0.751
DOC_CYCLIN_RxL_1	4	15	PF00134	0.711
DOC_CYCLIN_yCln2_LP_2	160	166	PF00134	0.413
DOC_CYCLIN_yCln2_LP_2	641	647	PF00134	0.556
DOC_MAPK_DCC_7	388	396	PF00069	0.398
DOC_MAPK_gen_1	276	286	PF00069	0.449
DOC_MAPK_gen_1	358	367	PF00069	0.383
DOC_MAPK_gen_1	634	643	PF00069	0.566
DOC_MAPK_HePTP_8	355	367	PF00069	0.437
DOC_MAPK_MEF2A_6	279	288	PF00069	0.449
DOC_MAPK_MEF2A_6	358	367	PF00069	0.337
DOC_MAPK_RevD_3	363	378	PF00069	0.342
DOC_PP1_RVXF_1	17	24	PF00149	0.550
DOC_PP1_RVXF_1	386	393	PF00149	0.339
DOC_PP1_RVXF_1	5	12	PF00149	0.661
DOC_PP2B_LxvP_1	160	163	PF13499	0.413
DOC_PP2B_LxvP_1	641	644	PF13499	0.696
DOC_PP4_MxPP_1	503	506	PF00568	0.678
DOC_USP7_MATH_1	381	385	PF00917	0.390
DOC_USP7_MATH_1	519	523	PF00917	0.780
DOC_USP7_MATH_1	623	627	PF00917	0.742
DOC_USP7_MATH_1	663	667	PF00917	0.698
DOC_USP7_MATH_1	685	689	PF00917	0.741
DOC_USP7_UBL2_3	287	291	PF12436	0.449
DOC_USP7_UBL2_3	698	702	PF12436	0.735
DOC_USP7_UBL2_3	776	780	PF12436	0.735
DOC_WW_Pin1_4	114	119	PF00397	0.577
DOC_WW_Pin1_4	139	144	PF00397	0.305
DOC_WW_Pin1_4	348	353	PF00397	0.328
DOC_WW_Pin1_4	377	382	PF00397	0.437
DOC_WW_Pin1_4	407	412	PF00397	0.471
DOC_WW_Pin1_4	423	428	PF00397	0.398
DOC_WW_Pin1_4	719	724	PF00397	0.691
DOC_WW_Pin1_4	740	745	PF00397	0.715
LIG_14-3-3_CanoR_1	212	219	PF00244	0.449
LIG_14-3-3_CanoR_1	244	254	PF00244	0.396
LIG_14-3-3_CanoR_1	400	405	PF00244	0.391
LIG_14-3-3_CanoR_1	476	482	PF00244	0.369
LIG_14-3-3_CanoR_1	611	616	PF00244	0.785
LIG_14-3-3_CanoR_1	748	754	PF00244	0.719
LIG_Actin_WH2_2	686	704	PF00022	0.682
LIG_AP2alpha_2	317	319	PF02296	0.328
LIG_AP2alpha_2	785	787	PF02296	0.776
LIG_APCC_ABBA_1	790	795	PF00400	0.771
LIG_BRCT_BRCA1_1	204	208	PF00533	0.363
LIG_BRCT_BRCA1_1	7	11	PF00533	0.695
LIG_BRCT_BRCA1_1	721	725	PF00533	0.687
LIG_Clathr_ClatBox_1	391	395	PF01394	0.262
LIG_EH_1	790	794	PF12763	0.744
LIG_EVH1_2	368	372	PF00568	0.262
LIG_FHA_1	140	146	PF00498	0.354
LIG_FHA_1	246	252	PF00498	0.323
LIG_FHA_1	44	50	PF00498	0.623
LIG_FHA_2	531	537	PF00498	0.751
LIG_FHA_2	575	581	PF00498	0.783
LIG_FHA_2	586	592	PF00498	0.682
LIG_FHA_2	622	628	PF00498	0.752
LIG_FHA_2	649	655	PF00498	0.561
LIG_LIR_Apic_2	24	29	PF02991	0.620
LIG_LIR_Apic_2	348	352	PF02991	0.449
LIG_LIR_Gen_1	317	327	PF02991	0.328
LIG_LIR_Gen_1	336	344	PF02991	0.328
LIG_LIR_Gen_1	399	405	PF02991	0.463
LIG_LIR_Nem_3	15	21	PF02991	0.632
LIG_LIR_Nem_3	22	26	PF02991	0.623
LIG_LIR_Nem_3	313	319	PF02991	0.328
LIG_LIR_Nem_3	336	341	PF02991	0.449
LIG_LIR_Nem_3	399	404	PF02991	0.407
LIG_LIR_Nem_3	449	455	PF02991	0.378
LIG_LIR_Nem_3	688	693	PF02991	0.656
LIG_LIR_Nem_3	785	790	PF02991	0.770
LIG_PCNA_yPIPBox_3	267	275	PF02747	0.392
LIG_Pex14_2	149	153	PF04695	0.363
LIG_Pex14_2	164	168	PF04695	0.363
LIG_PTB_Apo_2	125	132	PF02174	0.328
LIG_SH2_CRK	26	30	PF00017	0.605
LIG_SH2_CRK	401	405	PF00017	0.475
LIG_SH2_CRK	690	694	PF00017	0.614
LIG_SH2_STAP1	437	441	PF00017	0.321
LIG_SH2_STAT5	148	151	PF00017	0.351
LIG_SH2_STAT5	258	261	PF00017	0.340
LIG_SH2_STAT5	349	352	PF00017	0.326
LIG_SH2_STAT5	401	404	PF00017	0.402
LIG_SH2_STAT5	456	459	PF00017	0.415
LIG_SH2_STAT5	639	642	PF00017	0.708
LIG_SH3_3	29	35	PF00018	0.623
LIG_SH3_3	364	370	PF00018	0.435
LIG_SH3_3	37	43	PF00018	0.561
LIG_SH3_3	387	393	PF00018	0.385
LIG_SH3_3	408	414	PF00018	0.444
LIG_SH3_3	744	750	PF00018	0.603
LIG_SUMO_SIM_par_1	320	325	PF11976	0.344
LIG_SUMO_SIM_par_1	392	397	PF11976	0.417
LIG_TRAF2_1	266	269	PF00917	0.385
LIG_TRAF2_1	340	343	PF00917	0.398
LIG_TRAF2_1	534	537	PF00917	0.690
LIG_TRAF2_1	792	795	PF00917	0.714
LIG_UBA3_1	197	206	PF00899	0.385
LIG_UBA3_1	231	240	PF00899	0.402
LIG_UBA3_1	693	702	PF00899	0.693
LIG_WRC_WIRS_1	150	155	PF05994	0.449
MOD_CDK_SPK_2	348	353	PF00069	0.328
MOD_CDK_SPxxK_3	719	726	PF00069	0.726
MOD_CK1_1	155	161	PF00069	0.396
MOD_CK1_1	261	267	PF00069	0.364
MOD_CK1_1	348	354	PF00069	0.449
MOD_CK1_1	406	412	PF00069	0.423
MOD_CK1_1	426	432	PF00069	0.449
MOD_CK1_1	472	478	PF00069	0.418
MOD_CK1_1	520	526	PF00069	0.700
MOD_CK1_1	572	578	PF00069	0.797
MOD_CK1_1	586	592	PF00069	0.748
MOD_CK1_1	603	609	PF00069	0.637
MOD_CK1_1	710	716	PF00069	0.803
MOD_CK2_1	263	269	PF00069	0.344
MOD_CK2_1	530	536	PF00069	0.675
MOD_CK2_1	543	549	PF00069	0.557
MOD_CK2_1	574	580	PF00069	0.720
MOD_CK2_1	589	595	PF00069	0.561
MOD_CK2_1	627	633	PF00069	0.680
MOD_CK2_1	652	658	PF00069	0.728
MOD_Cter_Amidation	294	297	PF01082	0.398
MOD_Cter_Amidation	804	807	PF01082	0.600
MOD_GlcNHglycan	154	157	PF01048	0.421
MOD_GlcNHglycan	36	39	PF01048	0.676
MOD_GlcNHglycan	381	384	PF01048	0.262
MOD_GlcNHglycan	515	518	PF01048	0.735
MOD_GlcNHglycan	523	526	PF01048	0.542
MOD_GlcNHglycan	574	577	PF01048	0.787
MOD_GlcNHglycan	588	591	PF01048	0.713
MOD_GlcNHglycan	608	611	PF01048	0.449
MOD_GlcNHglycan	751	754	PF01048	0.783
MOD_GSK3_1	202	209	PF00069	0.367
MOD_GSK3_1	223	230	PF00069	0.434
MOD_GSK3_1	377	384	PF00069	0.390
MOD_GSK3_1	396	403	PF00069	0.377
MOD_GSK3_1	422	429	PF00069	0.437
MOD_GSK3_1	490	497	PF00069	0.516
MOD_GSK3_1	513	520	PF00069	0.747
MOD_GSK3_1	570	577	PF00069	0.765
MOD_GSK3_1	585	592	PF00069	0.650
MOD_GSK3_1	599	606	PF00069	0.712
MOD_GSK3_1	621	628	PF00069	0.734
MOD_GSK3_1	648	655	PF00069	0.634
MOD_GSK3_1	707	714	PF00069	0.759
MOD_GSK3_1	94	101	PF00069	0.547
MOD_N-GLC_1	469	474	PF02516	0.404
MOD_N-GLC_1	5	10	PF02516	0.679
MOD_N-GLC_1	586	591	PF02516	0.698
MOD_N-GLC_1	62	67	PF02516	0.661
MOD_N-GLC_2	128	130	PF02516	0.335
MOD_N-GLC_2	568	570	PF02516	0.573
MOD_N-GLC_2	648	650	PF02516	0.766
MOD_NEK2_1	105	110	PF00069	0.533
MOD_NEK2_1	126	131	PF00069	0.335
MOD_NEK2_1	149	154	PF00069	0.361
MOD_NEK2_1	170	175	PF00069	0.317
MOD_NEK2_1	223	228	PF00069	0.434
MOD_NEK2_1	235	240	PF00069	0.344
MOD_NEK2_1	396	401	PF00069	0.407
MOD_NEK2_1	404	409	PF00069	0.344
MOD_NEK2_1	469	474	PF00069	0.437
MOD_NEK2_1	490	495	PF00069	0.374
MOD_NEK2_1	585	590	PF00069	0.706
MOD_NEK2_1	604	609	PF00069	0.717
MOD_NEK2_2	685	690	PF00069	0.756
MOD_PIKK_1	155	161	PF00454	0.469
MOD_PIKK_1	258	264	PF00454	0.413
MOD_PIKK_1	52	58	PF00454	0.733
MOD_PIKK_1	94	100	PF00454	0.549
MOD_PK_1	206	212	PF00069	0.437
MOD_PK_1	361	367	PF00069	0.475
MOD_PKA_1	361	367	PF00069	0.475
MOD_PKA_1	494	500	PF00069	0.593
MOD_PKA_1	77	83	PF00069	0.588
MOD_PKA_2	105	111	PF00069	0.546
MOD_PKA_2	211	217	PF00069	0.449
MOD_PKA_2	299	305	PF00069	0.381
MOD_PKA_2	475	481	PF00069	0.393
MOD_PKA_2	513	519	PF00069	0.695
MOD_PKA_2	570	576	PF00069	0.654
MOD_PKA_2	77	83	PF00069	0.588
MOD_Plk_1	396	402	PF00069	0.406
MOD_Plk_1	469	475	PF00069	0.396
MOD_Plk_1	5	11	PF00069	0.755
MOD_Plk_2-3	446	452	PF00069	0.475
MOD_Plk_2-3	627	633	PF00069	0.709
MOD_Plk_4	131	137	PF00069	0.344
MOD_Plk_4	227	233	PF00069	0.413
MOD_Plk_4	400	406	PF00069	0.458
MOD_Plk_4	685	691	PF00069	0.754
MOD_ProDKin_1	114	120	PF00069	0.569
MOD_ProDKin_1	139	145	PF00069	0.305
MOD_ProDKin_1	348	354	PF00069	0.328
MOD_ProDKin_1	377	383	PF00069	0.437
MOD_ProDKin_1	407	413	PF00069	0.471
MOD_ProDKin_1	423	429	PF00069	0.398
MOD_ProDKin_1	719	725	PF00069	0.690
MOD_ProDKin_1	740	746	PF00069	0.718
MOD_SUMO_for_1	286	289	PF00179	0.425
MOD_SUMO_rev_2	282	288	PF00179	0.385
MOD_SUMO_rev_2	289	298	PF00179	0.385
TRG_DiLeu_BaEn_1	270	275	PF01217	0.385
TRG_DiLeu_BaEn_1	549	554	PF01217	0.637
TRG_DiLeu_BaEn_1	580	585	PF01217	0.726
TRG_DiLeu_BaLyEn_6	199	204	PF01217	0.449
TRG_ENDOCYTIC_2	316	319	PF00928	0.328
TRG_ENDOCYTIC_2	401	404	PF00928	0.407
TRG_ENDOCYTIC_2	455	458	PF00928	0.328
TRG_ENDOCYTIC_2	488	491	PF00928	0.348
TRG_ENDOCYTIC_2	690	693	PF00928	0.614
TRG_ER_diArg_1	747	749	PF00400	0.682
TRG_ER_diArg_1	76	78	PF00400	0.780
TRG_ER_diArg_1	803	806	PF00400	0.612
TRG_ER_diArg_1	807	809	PF00400	0.613
TRG_NES_CRM1_1	159	172	PF08389	0.475
TRG_NES_CRM1_1	758	770	PF08389	0.715
TRG_NLS_MonoExtN_4	358	364	PF00514	0.449
TRG_NLS_MonoExtN_4	773	779	PF00514	0.643
TRG_Pf-PMV_PEXEL_1	47	51	PF00026	0.685
TRG_Pf-PMV_PEXEL_1	699	703	PF00026	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Z2	Leptomonas seymouri	62%	100%
A0A0S4JHR5	Bodo saltans	35%	100%
A0A1X0NIL8	Trypanosomatidae	38%	100%
A0A422P3Z4	Trypanosoma rangeli	39%	100%
A4HDC0	Leishmania braziliensis	76%	99%
A4I0Q0	Leishmania infantum	100%	100%
D0A726	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AWQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QAS1	Leishmania major	92%	100%
V5BR83	Trypanosoma cruzi	37%	100%