Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WY45_LEIDO

TriTrypDb:

LdBPK_240480.1 , LdCL_240009600 , LDHU3_24.0590

Length:

421

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WY45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WY45

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.769
CLV_NRD_NRD_1	230	232	PF00675	0.758
CLV_NRD_NRD_1	328	330	PF00675	0.721
CLV_NRD_NRD_1	372	374	PF00675	0.760
CLV_PCSK_KEX2_1	230	232	PF00082	0.758
CLV_PCSK_KEX2_1	328	330	PF00082	0.721
CLV_PCSK_KEX2_1	354	356	PF00082	0.645
CLV_PCSK_KEX2_1	372	374	PF00082	0.655
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.631
CLV_PCSK_SKI1_1	234	238	PF00082	0.739
CLV_PCSK_SKI1_1	385	389	PF00082	0.740
CLV_PCSK_SKI1_1	66	70	PF00082	0.557
DEG_SPOP_SBC_1	314	318	PF00917	0.713
DOC_CDC14_PxL_1	258	266	PF14671	0.608
DOC_CKS1_1	284	289	PF01111	0.741
DOC_MAPK_gen_1	230	239	PF00069	0.744
DOC_MAPK_gen_1	64	71	PF00069	0.665
DOC_MAPK_MEF2A_6	361	370	PF00069	0.588
DOC_MAPK_MEF2A_6	64	71	PF00069	0.592
DOC_MAPK_MEF2A_6	95	103	PF00069	0.484
DOC_PP4_FxxP_1	246	249	PF00568	0.763
DOC_USP7_MATH_1	271	275	PF00917	0.787
DOC_USP7_MATH_1	279	283	PF00917	0.708
DOC_USP7_MATH_1	310	314	PF00917	0.821
DOC_USP7_MATH_1	417	421	PF00917	0.670
DOC_WW_Pin1_4	105	110	PF00397	0.672
DOC_WW_Pin1_4	269	274	PF00397	0.659
DOC_WW_Pin1_4	280	285	PF00397	0.708
DOC_WW_Pin1_4	294	299	PF00397	0.725
DOC_WW_Pin1_4	327	332	PF00397	0.775
DOC_WW_Pin1_4	360	365	PF00397	0.768
DOC_WW_Pin1_4	7	12	PF00397	0.717
LIG_14-3-3_CanoR_1	119	124	PF00244	0.669
LIG_14-3-3_CanoR_1	138	148	PF00244	0.508
LIG_14-3-3_CanoR_1	231	239	PF00244	0.830
LIG_14-3-3_CanoR_1	355	364	PF00244	0.630
LIG_14-3-3_CanoR_1	385	394	PF00244	0.786
LIG_14-3-3_CanoR_1	401	405	PF00244	0.626
LIG_Actin_WH2_2	54	72	PF00022	0.581
LIG_APCC_ABBA_1	97	102	PF00400	0.617
LIG_BRCT_BRCA1_1	249	253	PF00533	0.712
LIG_BRCT_BRCA1_1	271	275	PF00533	0.676
LIG_BRCT_BRCA1_1	398	402	PF00533	0.593
LIG_Clathr_ClatBox_1	43	47	PF01394	0.603
LIG_DLG_GKlike_1	373	381	PF00625	0.733
LIG_FHA_1	150	156	PF00498	0.612
LIG_FHA_1	77	83	PF00498	0.517
LIG_LIR_Apic_2	199	205	PF02991	0.782
LIG_LIR_Apic_2	274	279	PF02991	0.682
LIG_LIR_Apic_2	294	299	PF02991	0.710
LIG_LIR_Gen_1	118	128	PF02991	0.586
LIG_LIR_Gen_1	38	48	PF02991	0.644
LIG_LIR_Nem_3	118	123	PF02991	0.566
LIG_LIR_Nem_3	272	278	PF02991	0.692
LIG_LIR_Nem_3	38	43	PF02991	0.647
LIG_LIR_Nem_3	47	53	PF02991	0.649
LIG_MLH1_MIPbox_1	249	253	PF16413	0.576
LIG_MYND_1	382	386	PF01753	0.537
LIG_SH2_CRK	202	206	PF00017	0.780
LIG_SH2_NCK_1	175	179	PF00017	0.696
LIG_SH2_PTP2	268	271	PF00017	0.771
LIG_SH2_STAP1	139	143	PF00017	0.492
LIG_SH2_STAT5	268	271	PF00017	0.669
LIG_SH3_1	328	334	PF00018	0.748
LIG_SH3_3	267	273	PF00018	0.727
LIG_SH3_3	281	287	PF00018	0.578
LIG_SH3_3	328	334	PF00018	0.742
LIG_SH3_3	98	104	PF00018	0.613
LIG_SUMO_SIM_anti_2	42	47	PF11976	0.615
LIG_SUMO_SIM_par_1	42	47	PF11976	0.615
LIG_SUMO_SIM_par_1	57	63	PF11976	0.611
LIG_TRAF2_1	108	111	PF00917	0.544
LIG_TRAF2_1	162	165	PF00917	0.745
LIG_WW_3	297	301	PF00397	0.607
MOD_CDK_SPxK_1	294	300	PF00069	0.783
MOD_CK1_1	163	169	PF00069	0.718
MOD_CK1_1	209	215	PF00069	0.598
MOD_CK1_1	235	241	PF00069	0.737
MOD_CK1_1	282	288	PF00069	0.807
MOD_CK1_1	31	37	PF00069	0.706
MOD_CK1_1	313	319	PF00069	0.747
MOD_CK1_1	333	339	PF00069	0.543
MOD_CK1_1	359	365	PF00069	0.843
MOD_CK1_1	396	402	PF00069	0.722
MOD_CK2_1	105	111	PF00069	0.789
MOD_CK2_1	368	374	PF00069	0.638
MOD_GlcNHglycan	141	144	PF01048	0.579
MOD_GlcNHglycan	209	212	PF01048	0.672
MOD_GlcNHglycan	234	237	PF01048	0.708
MOD_GlcNHglycan	304	308	PF01048	0.783
MOD_GlcNHglycan	31	34	PF01048	0.669
MOD_GlcNHglycan	312	315	PF01048	0.725
MOD_GlcNHglycan	358	361	PF01048	0.634
MOD_GlcNHglycan	398	401	PF01048	0.716
MOD_GSK3_1	196	203	PF00069	0.658
MOD_GSK3_1	205	212	PF00069	0.582
MOD_GSK3_1	235	242	PF00069	0.811
MOD_GSK3_1	279	286	PF00069	0.690
MOD_GSK3_1	308	315	PF00069	0.788
MOD_GSK3_1	31	38	PF00069	0.706
MOD_GSK3_1	333	340	PF00069	0.719
MOD_GSK3_1	356	363	PF00069	0.850
MOD_GSK3_1	396	403	PF00069	0.734
MOD_GSK3_1	7	14	PF00069	0.759
MOD_NEK2_1	150	155	PF00069	0.510
MOD_NEK2_1	207	212	PF00069	0.777
MOD_NEK2_1	239	244	PF00069	0.788
MOD_NEK2_1	337	342	PF00069	0.783
MOD_NEK2_1	395	400	PF00069	0.758
MOD_NEK2_1	60	65	PF00069	0.542
MOD_NEK2_1	76	81	PF00069	0.394
MOD_PIKK_1	308	314	PF00454	0.621
MOD_PKA_2	137	143	PF00069	0.606
MOD_PKA_2	400	406	PF00069	0.686
MOD_Plk_1	163	169	PF00069	0.490
MOD_Plk_1	35	41	PF00069	0.734
MOD_Plk_4	150	156	PF00069	0.527
MOD_Plk_4	179	185	PF00069	0.648
MOD_Plk_4	271	277	PF00069	0.708
MOD_Plk_4	333	339	PF00069	0.830
MOD_Plk_4	35	41	PF00069	0.671
MOD_ProDKin_1	105	111	PF00069	0.675
MOD_ProDKin_1	269	275	PF00069	0.661
MOD_ProDKin_1	280	286	PF00069	0.708
MOD_ProDKin_1	294	300	PF00069	0.726
MOD_ProDKin_1	327	333	PF00069	0.774
MOD_ProDKin_1	360	366	PF00069	0.770
MOD_ProDKin_1	7	13	PF00069	0.715
TRG_ENDOCYTIC_2	175	178	PF00928	0.697
TRG_ER_diArg_1	299	302	PF00400	0.612
TRG_ER_diArg_1	327	329	PF00400	0.724
TRG_ER_diArg_1	6	9	PF00400	0.784

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEP2	Leptomonas seymouri	36%	100%
A4HDU6	Leishmania braziliensis	61%	100%
A4I0N7	Leishmania infantum	98%	100%
E9AWN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QAT4	Leishmania major	88%	100%