Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WY43_LEIDO

TriTrypDb:

LdBPK_240540.1 , LdCL_240010200 , LDHU3_24.0650

Length:

227

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WY43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WY43

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.604
CLV_NRD_NRD_1	103	105	PF00675	0.447
CLV_NRD_NRD_1	111	113	PF00675	0.426
CLV_NRD_NRD_1	147	149	PF00675	0.588
CLV_NRD_NRD_1	171	173	PF00675	0.665
CLV_PCSK_KEX2_1	110	112	PF00082	0.447
CLV_PCSK_KEX2_1	147	149	PF00082	0.588
CLV_PCSK_KEX2_1	171	173	PF00082	0.665
CLV_PCSK_KEX2_1	213	215	PF00082	0.422
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.596
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.433
CLV_PCSK_SKI1_1	182	186	PF00082	0.533
CLV_PCSK_SKI1_1	192	196	PF00082	0.510
CLV_PCSK_SKI1_1	214	218	PF00082	0.453
CLV_PCSK_SKI1_1	55	59	PF00082	0.509
DEG_APCC_DBOX_1	213	221	PF00400	0.412
DEG_Nend_UBRbox_2	1	3	PF02207	0.637
DOC_CKS1_1	139	144	PF01111	0.525
DOC_CYCLIN_RxL_1	189	199	PF00134	0.462
DOC_MAPK_gen_1	213	220	PF00069	0.466
DOC_MAPK_MEF2A_6	213	220	PF00069	0.502
DOC_PP1_RVXF_1	53	59	PF00149	0.371
DOC_USP7_MATH_1	178	182	PF00917	0.552
DOC_USP7_MATH_1	190	194	PF00917	0.480
DOC_WW_Pin1_4	138	143	PF00397	0.586
DOC_WW_Pin1_4	3	8	PF00397	0.765
DOC_WW_Pin1_4	60	65	PF00397	0.574
LIG_14-3-3_CanoR_1	158	162	PF00244	0.588
LIG_FHA_1	114	120	PF00498	0.604
LIG_FHA_2	121	127	PF00498	0.564
LIG_Integrin_RGD_1	112	114	PF01839	0.583
LIG_LIR_Apic_2	2	7	PF02991	0.586
LIG_MYND_1	28	32	PF01753	0.615
LIG_PDZ_Class_1	222	227	PF00595	0.548
LIG_SH2_CRK	17	21	PF00017	0.626
LIG_SH2_CRK	4	8	PF00017	0.579
LIG_SH2_CRK	50	54	PF00017	0.343
LIG_SH2_NCK_1	4	8	PF00017	0.579
LIG_SH2_STAP1	196	200	PF00017	0.453
LIG_SH2_STAT5	127	130	PF00017	0.620
LIG_SH2_STAT5	140	143	PF00017	0.634
LIG_SH3_3	7	13	PF00018	0.575
LIG_SUMO_SIM_par_1	215	223	PF11976	0.496
LIG_TRAF2_1	199	202	PF00917	0.509
LIG_TRAF2_1	42	45	PF00917	0.382
LIG_TYR_ITIM	15	20	PF00017	0.639
LIG_UBA3_1	206	213	PF00899	0.520
MOD_CDK_SPK_2	140	145	PF00069	0.565
MOD_CDK_SPxxK_3	138	145	PF00069	0.521
MOD_CDK_SPxxK_3	60	67	PF00069	0.468
MOD_CK2_1	196	202	PF00069	0.658
MOD_GlcNHglycan	105	108	PF01048	0.453
MOD_GlcNHglycan	198	201	PF01048	0.552
MOD_GSK3_1	186	193	PF00069	0.502
MOD_NEK2_1	195	200	PF00069	0.506
MOD_PKA_2	103	109	PF00069	0.481
MOD_PKA_2	157	163	PF00069	0.716
MOD_Plk_1	120	126	PF00069	0.603
MOD_Plk_2-3	120	126	PF00069	0.558
MOD_Plk_4	157	163	PF00069	0.590
MOD_Plk_4	190	196	PF00069	0.588
MOD_ProDKin_1	138	144	PF00069	0.586
MOD_ProDKin_1	3	9	PF00069	0.764
MOD_ProDKin_1	60	66	PF00069	0.577
TRG_DiLeu_BaEn_1	202	207	PF01217	0.539
TRG_ENDOCYTIC_2	17	20	PF00928	0.635
TRG_ENDOCYTIC_2	50	53	PF00928	0.349
TRG_ER_diArg_1	109	112	PF00400	0.456
TRG_ER_diArg_1	147	149	PF00400	0.585
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDI0	Leptomonas seymouri	69%	98%
A0A1X0NIJ7	Trypanosomatidae	34%	88%
A0A422P3Y6	Trypanosoma rangeli	37%	94%
A4HDB0	Leishmania braziliensis	82%	100%
A4I0P3	Leishmania infantum	100%	100%
D0A721	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	97%
E9AWP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QAS8	Leishmania major	96%	100%