Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WY36_LEIDO

TriTrypDb:

LdBPK_231960.1 , LdCL_230026800 , LDHU3_23.2570

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WY36

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WY36

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	318	320	PF00675	0.403
CLV_NRD_NRD_1	74	76	PF00675	0.480
CLV_PCSK_KEX2_1	263	265	PF00082	0.497
CLV_PCSK_KEX2_1	76	78	PF00082	0.495
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.510
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.546
CLV_PCSK_SKI1_1	167	171	PF00082	0.470
CLV_PCSK_SKI1_1	252	256	PF00082	0.411
CLV_PCSK_SKI1_1	275	279	PF00082	0.480
CLV_PCSK_SKI1_1	77	81	PF00082	0.505
CLV_Separin_Metazoa	272	276	PF03568	0.438
DEG_Nend_Nbox_1	1	3	PF02207	0.649
DEG_SCF_FBW7_1	85	92	PF00400	0.632
DOC_CKS1_1	86	91	PF01111	0.561
DOC_MAPK_gen_1	263	273	PF00069	0.479
DOC_MAPK_MEF2A_6	269	278	PF00069	0.496
DOC_MAPK_RevD_3	61	77	PF00069	0.494
DOC_PP2B_LxvP_1	51	54	PF13499	0.502
DOC_PP4_FxxP_1	307	310	PF00568	0.505
DOC_PP4_MxPP_1	82	85	PF00568	0.386
DOC_USP7_MATH_1	26	30	PF00917	0.476
DOC_USP7_MATH_1	315	319	PF00917	0.569
DOC_USP7_MATH_1	334	338	PF00917	0.464
DOC_USP7_MATH_1	54	58	PF00917	0.504
DOC_USP7_MATH_1	67	71	PF00917	0.367
DOC_WW_Pin1_4	120	125	PF00397	0.623
DOC_WW_Pin1_4	284	289	PF00397	0.526
DOC_WW_Pin1_4	85	90	PF00397	0.565
LIG_14-3-3_CanoR_1	106	111	PF00244	0.541
LIG_14-3-3_CanoR_1	191	196	PF00244	0.433
LIG_14-3-3_CanoR_1	209	219	PF00244	0.498
LIG_14-3-3_CanoR_1	247	251	PF00244	0.581
LIG_14-3-3_CanoR_1	266	272	PF00244	0.396
LIG_APCC_ABBA_1	301	306	PF00400	0.462
LIG_BRCT_BRCA1_1	110	114	PF00533	0.505
LIG_BRCT_BRCA1_1	256	260	PF00533	0.416
LIG_EH_1	155	159	PF12763	0.410
LIG_FHA_1	222	228	PF00498	0.519
LIG_FHA_1	330	336	PF00498	0.528
LIG_FHA_1	53	59	PF00498	0.530
LIG_FHA_2	139	145	PF00498	0.619
LIG_FHA_2	191	197	PF00498	0.450
LIG_LIR_Apic_2	29	35	PF02991	0.496
LIG_LIR_Apic_2	306	310	PF02991	0.510
LIG_LIR_Gen_1	193	203	PF02991	0.431
LIG_LIR_Nem_3	193	198	PF02991	0.419
LIG_LIR_Nem_3	255	261	PF02991	0.476
LIG_MAD2	226	234	PF02301	0.376
LIG_MAD2	78	86	PF02301	0.390
LIG_NRBOX	272	278	PF00104	0.351
LIG_Pex14_2	114	118	PF04695	0.553
LIG_SH2_SRC	175	178	PF00017	0.445
LIG_SH2_STAT3	235	238	PF00017	0.433
LIG_SH2_STAT3	323	326	PF00017	0.482
LIG_SH2_STAT3	47	50	PF00017	0.459
LIG_SH2_STAT5	192	195	PF00017	0.338
LIG_SH2_STAT5	235	238	PF00017	0.578
LIG_SH2_STAT5	258	261	PF00017	0.466
LIG_SH3_3	42	48	PF00018	0.546
LIG_SH3_3	83	89	PF00018	0.545
LIG_WRC_WIRS_1	192	197	PF05994	0.427
MOD_CK1_1	123	129	PF00069	0.559
MOD_CK1_1	178	184	PF00069	0.393
MOD_CK2_1	106	112	PF00069	0.456
MOD_CK2_1	138	144	PF00069	0.627
MOD_CK2_1	209	215	PF00069	0.350
MOD_CK2_1	91	97	PF00069	0.451
MOD_GlcNHglycan	212	215	PF01048	0.508
MOD_GlcNHglycan	63	66	PF01048	0.566
MOD_GlcNHglycan	97	101	PF01048	0.561
MOD_GSK3_1	118	125	PF00069	0.504
MOD_GSK3_1	171	178	PF00069	0.442
MOD_GSK3_1	246	253	PF00069	0.481
MOD_GSK3_1	67	74	PF00069	0.498
MOD_GSK3_1	85	92	PF00069	0.486
MOD_NEK2_1	190	195	PF00069	0.382
MOD_NEK2_1	250	255	PF00069	0.393
MOD_NEK2_1	322	327	PF00069	0.388
MOD_NEK2_1	96	101	PF00069	0.490
MOD_NEK2_2	2	7	PF00069	0.493
MOD_NEK2_2	221	226	PF00069	0.331
MOD_OFUCOSY	87	93	PF10250	0.468
MOD_PIKK_1	228	234	PF00454	0.380
MOD_PIKK_1	322	328	PF00454	0.364
MOD_PKA_2	190	196	PF00069	0.431
MOD_PKA_2	210	216	PF00069	0.510
MOD_PKA_2	246	252	PF00069	0.581
MOD_PKA_2	315	321	PF00069	0.578
MOD_PKB_1	104	112	PF00069	0.539
MOD_Plk_1	144	150	PF00069	0.531
MOD_Plk_4	144	150	PF00069	0.525
MOD_Plk_4	246	252	PF00069	0.504
MOD_Plk_4	54	60	PF00069	0.581
MOD_Plk_4	91	97	PF00069	0.607
MOD_ProDKin_1	120	126	PF00069	0.626
MOD_ProDKin_1	284	290	PF00069	0.521
MOD_ProDKin_1	85	91	PF00069	0.568
TRG_DiLeu_BaEn_1	13	18	PF01217	0.471
TRG_DiLeu_BaEn_1	272	277	PF01217	0.273
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.456
TRG_DiLeu_LyEn_5	272	277	PF01217	0.273
TRG_ENDOCYTIC_2	192	195	PF00928	0.338
TRG_ER_diArg_1	208	211	PF00400	0.506
TRG_NES_CRM1_1	291	306	PF08389	0.407
TRG_NLS_MonoCore_2	74	79	PF00514	0.394
TRG_NLS_MonoExtN_4	72	79	PF00514	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC82	Leptomonas seymouri	52%	100%
A0A1X0NWL6	Trypanosomatidae	28%	100%
A0A422NJF2	Trypanosoma rangeli	31%	99%
A4HD40	Leishmania braziliensis	76%	100%
C9ZNR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AH18	Leishmania infantum	98%	100%
E9AWI8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QAY2	Leishmania major	92%	100%
V5BFT2	Trypanosoma cruzi	29%	95%