Protein-serine/threonine kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pyruvate dehydrogenase (lipoamide) kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WY35_LEIDO

TriTrypDb:

LdBPK_240010.1 , LdCL_240005000 , LDHU3_24.0030

Length:

483

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	12
GO:0031974	membrane-enclosed lumen	2	12
GO:0043233	organelle lumen	3	12
GO:0070013	intracellular organelle lumen	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7WY35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WY35

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0044237	cellular metabolic process	2	12
GO:0006109	regulation of carbohydrate metabolic process	5	1
GO:0006468	protein phosphorylation	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0010675	obsolete regulation of cellular carbohydrate metabolic process	5	1
GO:0010906	regulation of glucose metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0019538	protein metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0062012	regulation of small molecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	54	58	PF00656	0.591
CLV_NRD_NRD_1	157	159	PF00675	0.260
CLV_NRD_NRD_1	209	211	PF00675	0.236
CLV_NRD_NRD_1	35	37	PF00675	0.539
CLV_NRD_NRD_1	69	71	PF00675	0.647
CLV_PCSK_KEX2_1	157	159	PF00082	0.315
CLV_PCSK_KEX2_1	209	211	PF00082	0.236
CLV_PCSK_KEX2_1	35	37	PF00082	0.554
CLV_PCSK_KEX2_1	394	396	PF00082	0.480
CLV_PCSK_PC1ET2_1	394	396	PF00082	0.480
CLV_PCSK_SKI1_1	124	128	PF00082	0.438
CLV_PCSK_SKI1_1	209	213	PF00082	0.222
CLV_PCSK_SKI1_1	395	399	PF00082	0.433
CLV_PCSK_SKI1_1	93	97	PF00082	0.621
CLV_Separin_Metazoa	241	245	PF03568	0.384
DEG_APCC_DBOX_1	148	156	PF00400	0.422
DEG_APCC_DBOX_1	2	10	PF00400	0.444
DEG_APCC_DBOX_1	259	267	PF00400	0.422
DEG_APCC_DBOX_1	27	35	PF00400	0.599
DEG_SCF_FBW7_1	189	196	PF00400	0.460
DEG_SPOP_SBC_1	73	77	PF00917	0.560
DOC_CKS1_1	105	110	PF01111	0.512
DOC_CKS1_1	134	139	PF01111	0.388
DOC_CYCLIN_yClb5_NLxxxL_5	99	106	PF00134	0.541
DOC_CYCLIN_yCln2_LP_2	102	108	PF00134	0.535
DOC_CYCLIN_yCln2_LP_2	293	299	PF00134	0.454
DOC_MAPK_gen_1	120	128	PF00069	0.466
DOC_MAPK_gen_1	203	213	PF00069	0.549
DOC_MAPK_gen_1	312	319	PF00069	0.421
DOC_MAPK_gen_1	375	385	PF00069	0.481
DOC_MAPK_gen_1	394	400	PF00069	0.306
DOC_MAPK_gen_1	93	102	PF00069	0.547
DOC_MAPK_HePTP_8	287	299	PF00069	0.331
DOC_MAPK_HePTP_8	335	347	PF00069	0.359
DOC_MAPK_JIP1_4	3	9	PF00069	0.402
DOC_MAPK_MEF2A_6	290	299	PF00069	0.366
DOC_MAPK_MEF2A_6	3	11	PF00069	0.446
DOC_MAPK_MEF2A_6	338	347	PF00069	0.361
DOC_MAPK_MEF2A_6	378	387	PF00069	0.461
DOC_PP1_RVXF_1	122	129	PF00149	0.387
DOC_PP1_RVXF_1	260	266	PF00149	0.413
DOC_PP2B_LxvP_1	293	296	PF13499	0.444
DOC_PP2B_LxvP_1	471	474	PF13499	0.328
DOC_SPAK_OSR1_1	264	268	PF12202	0.422
DOC_USP7_MATH_1	16	20	PF00917	0.389
DOC_USP7_MATH_1	327	331	PF00917	0.318
DOC_USP7_MATH_1	479	483	PF00917	0.474
DOC_USP7_MATH_1	72	76	PF00917	0.480
DOC_USP7_UBL2_3	120	124	PF12436	0.481
DOC_USP7_UBL2_3	321	325	PF12436	0.438
DOC_USP7_UBL2_3	378	382	PF12436	0.482
DOC_USP7_UBL2_3	67	71	PF12436	0.486
DOC_WW_Pin1_4	104	109	PF00397	0.518
DOC_WW_Pin1_4	133	138	PF00397	0.473
DOC_WW_Pin1_4	189	194	PF00397	0.527
DOC_WW_Pin1_4	436	441	PF00397	0.359
DOC_WW_Pin1_4	74	79	PF00397	0.438
LIG_14-3-3_CanoR_1	399	407	PF00244	0.322
LIG_Actin_WH2_2	19	37	PF00022	0.456
LIG_APCC_ABBA_1	295	300	PF00400	0.479
LIG_BIR_II_1	1	5	PF00653	0.443
LIG_Clathr_ClatBox_1	8	12	PF01394	0.410
LIG_deltaCOP1_diTrp_1	65	69	PF00928	0.487
LIG_EH1_1	215	223	PF00400	0.422
LIG_eIF4E_1	216	222	PF01652	0.436
LIG_FHA_1	273	279	PF00498	0.418
LIG_FHA_1	292	298	PF00498	0.360
LIG_FHA_1	352	358	PF00498	0.331
LIG_FHA_1	48	54	PF00498	0.605
LIG_FHA_1	95	101	PF00498	0.641
LIG_FHA_2	105	111	PF00498	0.406
LIG_FHA_2	134	140	PF00498	0.341
LIG_FHA_2	194	200	PF00498	0.460
LIG_FHA_2	234	240	PF00498	0.509
LIG_FHA_2	243	249	PF00498	0.368
LIG_FHA_2	379	385	PF00498	0.467
LIG_FHA_2	46	52	PF00498	0.591
LIG_IRF3_LxIS_1	396	401	PF10401	0.315
LIG_LIR_Gen_1	109	119	PF02991	0.382
LIG_LIR_Gen_1	12	23	PF02991	0.409
LIG_LIR_Gen_1	125	134	PF02991	0.327
LIG_LIR_Gen_1	185	194	PF02991	0.450
LIG_LIR_Gen_1	233	243	PF02991	0.460
LIG_LIR_Gen_1	245	253	PF02991	0.450
LIG_LIR_Gen_1	354	362	PF02991	0.430
LIG_LIR_Gen_1	48	56	PF02991	0.599
LIG_LIR_Nem_3	109	114	PF02991	0.391
LIG_LIR_Nem_3	12	18	PF02991	0.410
LIG_LIR_Nem_3	125	131	PF02991	0.311
LIG_LIR_Nem_3	145	151	PF02991	0.324
LIG_LIR_Nem_3	185	189	PF02991	0.427
LIG_LIR_Nem_3	233	238	PF02991	0.511
LIG_LIR_Nem_3	245	249	PF02991	0.449
LIG_LIR_Nem_3	354	358	PF02991	0.277
LIG_LIR_Nem_3	417	422	PF02991	0.434
LIG_LIR_Nem_3	48	52	PF02991	0.600
LIG_LIR_Nem_3	65	69	PF02991	0.614
LIG_MYND_1	43	47	PF01753	0.533
LIG_PDZ_Class_2	478	483	PF00595	0.325
LIG_Pex14_2	252	256	PF04695	0.422
LIG_Pex14_2	59	63	PF04695	0.581
LIG_PTB_Apo_2	127	134	PF02174	0.452
LIG_PTB_Apo_2	266	273	PF02174	0.454
LIG_PTB_Phospho_1	127	133	PF10480	0.456
LIG_PTB_Phospho_1	266	272	PF10480	0.454
LIG_SH2_CRK	270	274	PF00017	0.470
LIG_SH2_CRK	355	359	PF00017	0.301
LIG_SH2_CRK	422	426	PF00017	0.436
LIG_SH2_GRB2like	133	136	PF00017	0.471
LIG_SH2_SRC	355	358	PF00017	0.412
LIG_SH2_SRC	472	475	PF00017	0.399
LIG_SH2_STAP1	331	335	PF00017	0.420
LIG_SH2_STAP1	445	449	PF00017	0.313
LIG_SH2_STAT3	118	121	PF00017	0.333
LIG_SH2_STAT5	133	136	PF00017	0.429
LIG_SH2_STAT5	151	154	PF00017	0.351
LIG_SH2_STAT5	272	275	PF00017	0.425
LIG_SH2_STAT5	352	355	PF00017	0.264
LIG_SH2_STAT5	472	475	PF00017	0.320
LIG_SH3_3	102	108	PF00018	0.535
LIG_SH3_3	345	351	PF00018	0.345
LIG_SUMO_SIM_anti_2	315	320	PF11976	0.406
LIG_SUMO_SIM_par_1	315	320	PF11976	0.329
LIG_TRAF2_1	107	110	PF00917	0.477
LIG_TRAF2_1	281	284	PF00917	0.520
LIG_TYR_ITIM	353	358	PF00017	0.299
LIG_UBA3_1	316	321	PF00899	0.417
LIG_WRC_WIRS_1	56	61	PF05994	0.489
MOD_CDC14_SPxK_1	439	442	PF00782	0.323
MOD_CDK_SPK_2	74	79	PF00069	0.568
MOD_CDK_SPxK_1	436	442	PF00069	0.353
MOD_CK1_1	220	226	PF00069	0.515
MOD_CK1_1	417	423	PF00069	0.446
MOD_CK1_1	434	440	PF00069	0.512
MOD_CK2_1	104	110	PF00069	0.422
MOD_CK2_1	194	200	PF00069	0.464
MOD_CK2_1	242	248	PF00069	0.470
MOD_CK2_1	278	284	PF00069	0.520
MOD_CK2_1	378	384	PF00069	0.497
MOD_CK2_1	45	51	PF00069	0.596
MOD_CK2_1	88	94	PF00069	0.522
MOD_CMANNOS	181	184	PF00535	0.254
MOD_GlcNHglycan	18	21	PF01048	0.668
MOD_GlcNHglycan	366	369	PF01048	0.327
MOD_GSK3_1	189	196	PF00069	0.550
MOD_GSK3_1	216	223	PF00069	0.422
MOD_GSK3_1	410	417	PF00069	0.377
MOD_GSK3_1	431	438	PF00069	0.464
MOD_GSK3_1	74	81	PF00069	0.488
MOD_N-GLC_1	216	221	PF02516	0.230
MOD_N-GLC_1	455	460	PF02516	0.373
MOD_NEK2_1	271	276	PF00069	0.436
MOD_NEK2_1	317	322	PF00069	0.460
MOD_NEK2_1	38	43	PF00069	0.503
MOD_NEK2_2	182	187	PF00069	0.422
MOD_NEK2_2	405	410	PF00069	0.493
MOD_PIKK_1	167	173	PF00454	0.422
MOD_PKA_1	312	318	PF00069	0.374
MOD_PKA_2	398	404	PF00069	0.307
MOD_Plk_1	216	222	PF00069	0.436
MOD_Plk_1	383	389	PF00069	0.433
MOD_Plk_1	455	461	PF00069	0.339
MOD_Plk_4	143	149	PF00069	0.508
MOD_Plk_4	217	223	PF00069	0.506
MOD_Plk_4	312	318	PF00069	0.338
MOD_ProDKin_1	104	110	PF00069	0.516
MOD_ProDKin_1	133	139	PF00069	0.470
MOD_ProDKin_1	189	195	PF00069	0.527
MOD_ProDKin_1	436	442	PF00069	0.353
MOD_ProDKin_1	74	80	PF00069	0.440
MOD_SUMO_rev_2	330	340	PF00179	0.418
MOD_SUMO_rev_2	60	69	PF00179	0.484
MOD_SUMO_rev_2	90	98	PF00179	0.540
TRG_DiLeu_BaEn_4	109	115	PF01217	0.439
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.552
TRG_ENDOCYTIC_2	246	249	PF00928	0.481
TRG_ENDOCYTIC_2	270	273	PF00928	0.427
TRG_ENDOCYTIC_2	355	358	PF00928	0.301
TRG_ENDOCYTIC_2	422	425	PF00928	0.455
TRG_ER_diArg_1	157	160	PF00400	0.460
TRG_ER_diArg_1	208	210	PF00400	0.436
TRG_ER_diArg_1	260	263	PF00400	0.422
TRG_ER_diArg_1	34	36	PF00400	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAJ6	Leptomonas seymouri	68%	100%
A0A0S4JGW0	Bodo saltans	38%	100%
A0A1X0NJE4	Trypanosomatidae	55%	100%
A0A422MQ68	Trypanosoma rangeli	48%	100%
A4HD59	Leishmania braziliensis	91%	100%
A4I0M4	Leishmania infantum	100%	100%
D0A6X1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AWJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O02623	Ascaris suum	22%	100%
O54937	Rattus norvegicus	23%	100%
O88345	Ictidomys tridecemlineatus	21%	100%
Q02332	Caenorhabditis elegans	22%	100%
Q15118	Homo sapiens	23%	100%
Q15119	Homo sapiens	23%	100%
Q15120	Homo sapiens	23%	100%
Q16654	Homo sapiens	22%	100%
Q1KMR4	Rhinolophus ferrumequinum	22%	100%
Q4QAX9	Leishmania major	95%	100%
Q64536	Rattus norvegicus	23%	100%
Q922H2	Mus musculus	23%	100%
Q9JK42	Mus musculus	24%	100%
Q9SBJ1	Arabidopsis thaliana	23%	100%
V5C0T8	Trypanosoma cruzi	50%	100%