LeishMANIAdb
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Aspartate_aminotransferase_putative/GeneDB:LmjF.2 4.0370

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Aspartate_aminotransferase_putative/GeneDB:LmjF.2 4.0370
Gene product:
aspartate aminotransferase, putative
Species:
Leishmania donovani
UniProt:
A0A3S7WY33_LEIDO
TriTrypDb:
LdBPK_240370.1 , LdCL_240008600 , LDHU3_24.0460
Length:
431

Annotations

Annotations by Jardim et al.

Amino acid metabolism, aspartate aminotransferase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005739 mitochondrion 5 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S7WY33
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WY33

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 13
GO:0006520 amino acid metabolic process 3 13
GO:0006807 nitrogen compound metabolic process 2 13
GO:0008152 metabolic process 1 13
GO:0009058 biosynthetic process 2 13
GO:0009987 cellular process 1 13
GO:0019752 carboxylic acid metabolic process 5 13
GO:0043436 oxoacid metabolic process 4 13
GO:0044237 cellular metabolic process 2 13
GO:0044238 primary metabolic process 2 13
GO:0044281 small molecule metabolic process 2 13
GO:0071704 organic substance metabolic process 2 13
GO:1901564 organonitrogen compound metabolic process 3 13
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 13
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity 5 13
GO:0005488 binding 1 13
GO:0008483 transaminase activity 4 13
GO:0016740 transferase activity 2 13
GO:0016769 transferase activity, transferring nitrogenous groups 3 13
GO:0019842 vitamin binding 3 13
GO:0030170 pyridoxal phosphate binding 4 13
GO:0036094 small molecule binding 2 13
GO:0043167 ion binding 2 13
GO:0043168 anion binding 3 13
GO:0070279 vitamin B6 binding 3 13
GO:0097159 organic cyclic compound binding 2 13
GO:1901363 heterocyclic compound binding 2 13

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 23 25 PF00675 0.677
CLV_NRD_NRD_1 78 80 PF00675 0.444
CLV_PCSK_KEX2_1 23 25 PF00082 0.677
CLV_PCSK_SKI1_1 114 118 PF00082 0.534
CLV_PCSK_SKI1_1 408 412 PF00082 0.492
CLV_Separin_Metazoa 330 334 PF03568 0.492
DEG_Nend_Nbox_1 1 3 PF02207 0.646
DEG_SPOP_SBC_1 25 29 PF00917 0.476
DOC_CKS1_1 332 337 PF01111 0.492
DOC_MAPK_DCC_7 235 244 PF00069 0.370
DOC_MAPK_HePTP_8 232 244 PF00069 0.351
DOC_MAPK_MEF2A_6 235 244 PF00069 0.339
DOC_MAPK_MEF2A_6 57 64 PF00069 0.351
DOC_PP1_RVXF_1 107 113 PF00149 0.366
DOC_PP1_RVXF_1 406 412 PF00149 0.492
DOC_PP2B_LxvP_1 155 158 PF13499 0.382
DOC_PP4_FxxP_1 112 115 PF00568 0.408
DOC_USP7_MATH_1 158 162 PF00917 0.444
DOC_USP7_MATH_1 202 206 PF00917 0.379
DOC_USP7_MATH_1 365 369 PF00917 0.411
DOC_WW_Pin1_4 156 161 PF00397 0.448
DOC_WW_Pin1_4 219 224 PF00397 0.483
DOC_WW_Pin1_4 331 336 PF00397 0.386
LIG_14-3-3_CanoR_1 123 130 PF00244 0.338
LIG_14-3-3_CanoR_1 24 34 PF00244 0.487
LIG_14-3-3_CanoR_1 295 303 PF00244 0.397
LIG_14-3-3_CanoR_1 3 11 PF00244 0.659
LIG_14-3-3_CanoR_1 314 318 PF00244 0.327
LIG_APCC_ABBA_1 238 243 PF00400 0.386
LIG_APCC_ABBA_1 62 67 PF00400 0.351
LIG_FHA_1 131 137 PF00498 0.392
LIG_FHA_1 150 156 PF00498 0.366
LIG_FHA_1 184 190 PF00498 0.339
LIG_FHA_1 249 255 PF00498 0.423
LIG_FHA_1 269 275 PF00498 0.213
LIG_FHA_1 287 293 PF00498 0.375
LIG_FHA_1 332 338 PF00498 0.492
LIG_FHA_2 215 221 PF00498 0.338
LIG_FHA_2 296 302 PF00498 0.492
LIG_FHA_2 88 94 PF00498 0.387
LIG_Integrin_isoDGR_2 406 408 PF01839 0.351
LIG_LIR_Apic_2 316 320 PF02991 0.389
LIG_LIR_Gen_1 224 233 PF02991 0.363
LIG_LIR_Gen_1 28 39 PF02991 0.473
LIG_LIR_Gen_1 369 379 PF02991 0.349
LIG_LIR_Nem_3 175 181 PF02991 0.377
LIG_LIR_Nem_3 224 229 PF02991 0.351
LIG_LIR_Nem_3 243 249 PF02991 0.257
LIG_LIR_Nem_3 28 34 PF02991 0.458
LIG_LIR_Nem_3 281 285 PF02991 0.393
LIG_LIR_Nem_3 369 375 PF02991 0.349
LIG_LIR_Nem_3 93 97 PF02991 0.343
LIG_RPA_C_Fungi 283 295 PF08784 0.492
LIG_SH2_CRK 317 321 PF00017 0.359
LIG_SH2_CRK 94 98 PF00017 0.338
LIG_SH2_GRB2like 181 184 PF00017 0.471
LIG_SH2_GRB2like 317 320 PF00017 0.338
LIG_SH2_NCK_1 317 321 PF00017 0.338
LIG_SH2_NCK_1 94 98 PF00017 0.338
LIG_SH2_SRC 94 97 PF00017 0.351
LIG_SH2_STAP1 399 403 PF00017 0.459
LIG_SH2_STAT3 197 200 PF00017 0.485
LIG_SH2_STAT3 421 424 PF00017 0.444
LIG_SH2_STAT5 197 200 PF00017 0.471
LIG_SH2_STAT5 259 262 PF00017 0.516
LIG_SH2_STAT5 272 275 PF00017 0.516
LIG_SH2_STAT5 30 33 PF00017 0.613
LIG_SH2_STAT5 374 377 PF00017 0.440
LIG_SH2_STAT5 402 405 PF00017 0.464
LIG_SH2_STAT5 421 424 PF00017 0.224
LIG_SH3_3 157 163 PF00018 0.420
LIG_SH3_3 32 38 PF00018 0.570
LIG_SUMO_SIM_anti_2 205 210 PF11976 0.351
LIG_TRAF2_1 222 225 PF00917 0.414
LIG_WRC_WIRS_1 100 105 PF05994 0.411
MOD_CDK_SPxxK_3 331 338 PF00069 0.492
MOD_CK1_1 126 132 PF00069 0.359
MOD_CK1_1 147 153 PF00069 0.408
MOD_CK1_1 29 35 PF00069 0.566
MOD_CK1_1 412 418 PF00069 0.408
MOD_CK2_1 219 225 PF00069 0.411
MOD_CK2_1 295 301 PF00069 0.411
MOD_GlcNHglycan 125 128 PF01048 0.446
MOD_GlcNHglycan 13 16 PF01048 0.552
MOD_GlcNHglycan 130 133 PF01048 0.413
MOD_GlcNHglycan 146 149 PF01048 0.447
MOD_GlcNHglycan 31 34 PF01048 0.613
MOD_GlcNHglycan 411 414 PF01048 0.338
MOD_GlcNHglycan 7 10 PF01048 0.587
MOD_GSK3_1 126 133 PF00069 0.367
MOD_GSK3_1 143 150 PF00069 0.410
MOD_GSK3_1 25 32 PF00069 0.512
MOD_GSK3_1 274 281 PF00069 0.481
MOD_GSK3_1 304 311 PF00069 0.478
MOD_GSK3_1 397 404 PF00069 0.446
MOD_GSK3_1 409 416 PF00069 0.313
MOD_GSK3_1 99 106 PF00069 0.462
MOD_LATS_1 293 299 PF00433 0.492
MOD_N-GLC_1 182 187 PF02516 0.542
MOD_N-GLC_2 59 61 PF02516 0.492
MOD_NEK2_1 103 108 PF00069 0.496
MOD_NEK2_1 130 135 PF00069 0.396
MOD_NEK2_1 143 148 PF00069 0.415
MOD_NEK2_1 278 283 PF00069 0.448
MOD_NEK2_1 309 314 PF00069 0.401
MOD_NEK2_1 382 387 PF00069 0.327
MOD_NEK2_2 151 156 PF00069 0.382
MOD_PIKK_1 295 301 PF00454 0.379
MOD_PIKK_1 304 310 PF00454 0.299
MOD_PIKK_1 87 93 PF00454 0.483
MOD_PKA_2 144 150 PF00069 0.382
MOD_PKA_2 294 300 PF00069 0.492
MOD_PKA_2 313 319 PF00069 0.492
MOD_PKA_2 87 93 PF00069 0.382
MOD_Plk_1 174 180 PF00069 0.382
MOD_Plk_4 174 180 PF00069 0.397
MOD_Plk_4 202 208 PF00069 0.386
MOD_Plk_4 26 32 PF00069 0.482
MOD_Plk_4 268 274 PF00069 0.492
MOD_Plk_4 397 403 PF00069 0.430
MOD_Plk_4 99 105 PF00069 0.486
MOD_ProDKin_1 156 162 PF00069 0.448
MOD_ProDKin_1 219 225 PF00069 0.483
MOD_ProDKin_1 331 337 PF00069 0.386
TRG_DiLeu_BaEn_3 224 230 PF01217 0.408
TRG_ENDOCYTIC_2 181 184 PF00928 0.462
TRG_ENDOCYTIC_2 246 249 PF00928 0.338
TRG_ENDOCYTIC_2 94 97 PF00928 0.341
TRG_ER_diArg_1 23 25 PF00400 0.617
TRG_ER_diArg_1 355 358 PF00400 0.366
TRG_Pf-PMV_PEXEL_1 262 266 PF00026 0.411

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0F7CUE9 Hapsidospora irregularis 28% 100%
A0A0N0P7Z5 Leptomonas seymouri 73% 98%
A0A0N1PAS7 Leptomonas seymouri 31% 100%
A0A0S4IPP7 Bodo saltans 48% 100%
A0A0S4JFW4 Bodo saltans 36% 100%
A0A1X0NIT8 Trypanosomatidae 36% 100%
A0A1X0NJG0 Trypanosomatidae 52% 100%
A0A1X0NJN9 Trypanosomatidae 37% 100%
A0A1X0NKG0 Trypanosomatidae 51% 100%
A0A3Q8IG20 Leishmania donovani 34% 100%
A0A3R7MWM6 Trypanosoma rangeli 51% 100%
A0A422NI78 Trypanosoma rangeli 36% 100%
A4HD93 Leishmania braziliensis 92% 100%
A4HMB3 Leishmania braziliensis 35% 100%
A5A6K8 Pan troglodytes 38% 100%
D0A277 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
D0A706 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
E9AH48 Leishmania infantum 100% 100%
E9AWM7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
E9B5W2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
O42652 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 41% 100%
O85746 Klebsiella pneumoniae 35% 100%
O94320 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 42% 99%
P00503 Sus scrofa 38% 100%
P00504 Gallus gallus 39% 100%
P00505 Homo sapiens 41% 100%
P00506 Sus scrofa 41% 100%
P00507 Rattus norvegicus 41% 100%
P00508 Gallus gallus 41% 100%
P00509 Escherichia coli (strain K12) 38% 100%
P04693 Escherichia coli (strain K12) 36% 100%
P05201 Mus musculus 39% 100%
P05202 Mus musculus 41% 100%
P08906 Equus caballus 39% 100%
P08907 Equus caballus 40% 100%
P12344 Bos taurus 42% 100%
P12345 Oryctolagus cuniculus 42% 100%
P13221 Rattus norvegicus 38% 100%
P17174 Homo sapiens 38% 100%
P23542 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 39% 100%
P26563 Lupinus angustifolius 40% 95%
P28011 Medicago sativa 41% 100%
P28734 Daucus carota 42% 100%
P33097 Bos taurus 38% 100%
P37833 Oryza sativa subsp. japonica 40% 100%
P43336 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 37% 100%
P44425 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 35% 100%
P46248 Arabidopsis thaliana 40% 95%
P46643 Arabidopsis thaliana 41% 100%
P46644 Arabidopsis thaliana 40% 96%
P46645 Arabidopsis thaliana 38% 100%
P46646 Arabidopsis thaliana 37% 100%
P58661 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 38% 100%
P72173 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 37% 100%
P74861 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 36% 100%
P95468 Paracoccus denitrificans 30% 100%
Q01802 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 35% 96%
Q02636 Rhizobium meliloti (strain 1021) 34% 100%
Q22067 Caenorhabditis elegans 37% 100%
Q28F67 Xenopus tropicalis 40% 100%
Q2PD92 Leishmania infantum 34% 100%
Q2T9S8 Bos taurus 29% 100%
Q4FX34 Leishmania major 35% 100%
Q4QAU4 Leishmania major 97% 100%
Q4R559 Macaca fascicularis 41% 100%
Q4R5L1 Macaca fascicularis 39% 100%
Q54SF7 Dictyostelium discoideum 42% 98%
Q55F21 Dictyostelium discoideum 41% 100%
Q56114 Salmonella typhi 38% 100%
Q5R691 Pongo abelii 38% 100%
Q5REB0 Pongo abelii 41% 100%
Q7SYK7 Danio rerio 40% 100%
Q7TSV6 Mus musculus 29% 100%
Q8NHS2 Homo sapiens 28% 100%
V5BSS0 Trypanosoma cruzi 36% 100%
V5BVY2 Trypanosoma cruzi 49% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS