TIP41-like family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GAF domain/TIP41-like family, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WY26_LEIDO

TriTrypDb:

LdBPK_231860.1 , LdCL_230025800 , LDHU3_23.2450

Length:

523

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WY26

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WY26

Function

Biological processes
Term	Name	Level	Count
GO:0010921	regulation of phosphatase activity	5	11
GO:0019220	regulation of phosphate metabolic process	6	11
GO:0019222	regulation of metabolic process	3	11
GO:0031323	regulation of cellular metabolic process	4	11
GO:0031399	regulation of protein modification process	6	11
GO:0035303	regulation of dephosphorylation	7	11
GO:0035304	regulation of protein dephosphorylation	7	11
GO:0043666	regulation of phosphoprotein phosphatase activity	6	11
GO:0050789	regulation of biological process	2	11
GO:0050790	regulation of catalytic activity	3	11
GO:0050794	regulation of cellular process	3	11
GO:0051171	regulation of nitrogen compound metabolic process	4	11
GO:0051174	regulation of phosphorus metabolic process	5	11
GO:0051246	regulation of protein metabolic process	5	11
GO:0051336	regulation of hydrolase activity	4	11
GO:0060255	regulation of macromolecule metabolic process	4	11
GO:0065007	biological regulation	1	11
GO:0065009	regulation of molecular function	2	11
GO:0080090	regulation of primary metabolic process	4	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016491	oxidoreductase activity	2	1
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	1
GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	4	1
GO:0070191	methionine-R-sulfoxide reductase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	386	390	PF00656	0.508
CLV_PCSK_KEX2_1	34	36	PF00082	0.537
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.537
CLV_PCSK_SKI1_1	272	276	PF00082	0.459
CLV_PCSK_SKI1_1	34	38	PF00082	0.488
CLV_PCSK_SKI1_1	519	523	PF00082	0.575
DEG_APCC_DBOX_1	266	274	PF00400	0.472
DEG_SCF_FBW7_1	3	10	PF00400	0.500
DEG_SPOP_SBC_1	226	230	PF00917	0.714
DEG_SPOP_SBC_1	234	238	PF00917	0.730
DOC_CDC14_PxL_1	79	87	PF14671	0.424
DOC_CYCLIN_yCln2_LP_2	342	348	PF00134	0.374
DOC_MAPK_DCC_7	467	477	PF00069	0.490
DOC_MAPK_MEF2A_6	136	145	PF00069	0.443
DOC_MAPK_MEF2A_6	309	316	PF00069	0.417
DOC_MAPK_MEF2A_6	335	344	PF00069	0.486
DOC_MAPK_MEF2A_6	399	407	PF00069	0.469
DOC_PP1_RVXF_1	359	365	PF00149	0.486
DOC_PP1_RVXF_1	69	75	PF00149	0.467
DOC_PP2B_LxvP_1	197	200	PF13499	0.526
DOC_PP2B_LxvP_1	342	345	PF13499	0.303
DOC_PP4_FxxP_1	60	63	PF00568	0.459
DOC_PP4_FxxP_1	80	83	PF00568	0.145
DOC_USP7_MATH_1	130	134	PF00917	0.299
DOC_USP7_UBL2_3	247	251	PF12436	0.596
DOC_USP7_UBL2_3	357	361	PF12436	0.508
DOC_WW_Pin1_4	3	8	PF00397	0.602
DOC_WW_Pin1_4	301	306	PF00397	0.470
DOC_WW_Pin1_4	34	39	PF00397	0.433
DOC_WW_Pin1_4	344	349	PF00397	0.427
DOC_WW_Pin1_4	465	470	PF00397	0.593
DOC_WW_Pin1_4	496	501	PF00397	0.467
LIG_14-3-3_CanoR_1	431	441	PF00244	0.532
LIG_14-3-3_CanoR_1	94	102	PF00244	0.388
LIG_Actin_WH2_2	469	484	PF00022	0.455
LIG_APCC_ABBA_1	212	217	PF00400	0.757
LIG_APCC_ABBA_1	457	462	PF00400	0.469
LIG_BIR_III_4	389	393	PF00653	0.508
LIG_BRCT_BRCA1_1	32	36	PF00533	0.518
LIG_BRCT_BRCA1_1	351	355	PF00533	0.508
LIG_BRCT_BRCA1_1	433	437	PF00533	0.559
LIG_BRCT_BRCA1_2	351	357	PF00533	0.508
LIG_deltaCOP1_diTrp_1	310	316	PF00928	0.510
LIG_deltaCOP1_diTrp_1	363	370	PF00928	0.444
LIG_deltaCOP1_diTrp_1	451	460	PF00928	0.470
LIG_EH1_1	315	323	PF00400	0.470
LIG_FHA_1	235	241	PF00498	0.756
LIG_FHA_1	255	261	PF00498	0.475
LIG_FHA_1	298	304	PF00498	0.389
LIG_FHA_1	423	429	PF00498	0.532
LIG_FHA_1	506	512	PF00498	0.522
LIG_FHA_2	107	113	PF00498	0.374
LIG_FHA_2	157	163	PF00498	0.282
LIG_FHA_2	266	272	PF00498	0.416
LIG_FHA_2	273	279	PF00498	0.408
LIG_FXI_DFP_1	182	186	PF00024	0.407
LIG_FXI_DFP_1	408	412	PF00024	0.308
LIG_IRF3_LxIS_1	282	289	PF10401	0.482
LIG_LIR_Gen_1	16	25	PF02991	0.317
LIG_LIR_Gen_1	310	321	PF02991	0.473
LIG_LIR_Gen_1	347	358	PF02991	0.477
LIG_LIR_Gen_1	410	418	PF02991	0.535
LIG_LIR_Gen_1	435	445	PF02991	0.477
LIG_LIR_LC3C_4	115	119	PF02991	0.350
LIG_LIR_Nem_3	16	21	PF02991	0.314
LIG_LIR_Nem_3	310	316	PF02991	0.491
LIG_LIR_Nem_3	331	337	PF02991	0.513
LIG_LIR_Nem_3	347	353	PF02991	0.477
LIG_LIR_Nem_3	434	440	PF02991	0.461
LIG_MLH1_MIPbox_1	434	438	PF16413	0.470
LIG_Pex14_1	366	370	PF04695	0.444
LIG_Pex14_1	74	78	PF04695	0.283
LIG_Pex14_2	407	411	PF04695	0.488
LIG_Pex14_2	437	441	PF04695	0.469
LIG_REV1ctd_RIR_1	243	251	PF16727	0.610
LIG_SH2_CRK	202	206	PF00017	0.661
LIG_SH2_STAP1	18	22	PF00017	0.409
LIG_SH2_STAP1	202	206	PF00017	0.661
LIG_SH2_STAT3	78	81	PF00017	0.318
LIG_SH2_STAT5	78	81	PF00017	0.297
LIG_SH3_3	247	253	PF00018	0.493
LIG_SH3_3	342	348	PF00018	0.362
LIG_SH3_3	378	384	PF00018	0.467
LIG_SUMO_SIM_anti_2	149	155	PF11976	0.374
LIG_SUMO_SIM_par_1	115	121	PF11976	0.235
LIG_SUMO_SIM_par_1	141	146	PF11976	0.355
LIG_SUMO_SIM_par_1	149	155	PF11976	0.269
LIG_SUMO_SIM_par_1	299	304	PF11976	0.463
LIG_SUMO_SIM_par_1	507	512	PF11976	0.410
LIG_SxIP_EBH_1	236	247	PF03271	0.635
MOD_CK1_1	304	310	PF00069	0.583
MOD_CK2_1	10	16	PF00069	0.406
MOD_CK2_1	106	112	PF00069	0.424
MOD_CK2_1	118	124	PF00069	0.299
MOD_CK2_1	132	138	PF00069	0.214
MOD_CK2_1	213	219	PF00069	0.585
MOD_CK2_1	272	278	PF00069	0.455
MOD_CK2_1	304	310	PF00069	0.558
MOD_CK2_1	321	327	PF00069	0.349
MOD_GlcNHglycan	112	115	PF01048	0.348
MOD_GlcNHglycan	132	135	PF01048	0.205
MOD_GlcNHglycan	202	205	PF01048	0.592
MOD_GlcNHglycan	288	291	PF01048	0.460
MOD_GlcNHglycan	323	326	PF01048	0.364
MOD_GlcNHglycan	434	437	PF01048	0.449
MOD_GlcNHglycan	469	472	PF01048	0.530
MOD_GlcNHglycan	503	506	PF01048	0.514
MOD_GSK3_1	106	113	PF00069	0.445
MOD_GSK3_1	130	137	PF00069	0.315
MOD_GSK3_1	225	232	PF00069	0.731
MOD_GSK3_1	234	241	PF00069	0.557
MOD_GSK3_1	282	289	PF00069	0.495
MOD_GSK3_1	297	304	PF00069	0.410
MOD_GSK3_1	3	10	PF00069	0.606
MOD_GSK3_1	30	37	PF00069	0.483
MOD_GSK3_1	501	508	PF00069	0.528
MOD_N-GLC_1	146	151	PF02516	0.424
MOD_N-GLC_2	369	371	PF02516	0.320
MOD_NEK2_1	1	6	PF00069	0.612
MOD_NEK2_1	265	270	PF00069	0.450
MOD_NEK2_1	282	287	PF00069	0.380
MOD_NEK2_1	321	326	PF00069	0.456
MOD_NEK2_1	398	403	PF00069	0.374
MOD_NEK2_1	423	428	PF00069	0.374
MOD_NEK2_2	349	354	PF00069	0.320
MOD_PIKK_1	272	278	PF00454	0.434
MOD_PK_1	299	305	PF00069	0.396
MOD_Plk_1	399	405	PF00069	0.291
MOD_Plk_2-3	162	168	PF00069	0.225
MOD_Plk_4	146	152	PF00069	0.424
MOD_Plk_4	333	339	PF00069	0.497
MOD_Plk_4	505	511	PF00069	0.464
MOD_ProDKin_1	3	9	PF00069	0.588
MOD_ProDKin_1	301	307	PF00069	0.481
MOD_ProDKin_1	34	40	PF00069	0.427
MOD_ProDKin_1	344	350	PF00069	0.260
MOD_ProDKin_1	465	471	PF00069	0.489
MOD_ProDKin_1	496	502	PF00069	0.463
MOD_SUMO_for_1	246	249	PF00179	0.619
MOD_SUMO_rev_2	277	282	PF00179	0.531
MOD_SUMO_rev_2	327	337	PF00179	0.420
MOD_SUMO_rev_2	356	362	PF00179	0.432
MOD_SUMO_rev_2	488	498	PF00179	0.581
TRG_DiLeu_BaEn_1	333	338	PF01217	0.535
TRG_DiLeu_BaEn_1	376	381	PF01217	0.252
TRG_ENDOCYTIC_2	18	21	PF00928	0.332
TRG_ENDOCYTIC_2	202	205	PF00928	0.654
TRG_ENDOCYTIC_2	408	411	PF00928	0.424
TRG_ENDOCYTIC_2	430	433	PF00928	0.374
TRG_ER_diArg_1	377	380	PF00400	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5N3	Leptomonas seymouri	68%	100%
A0A0S4JL71	Bodo saltans	35%	100%
A0A1X0NWX3	Trypanosomatidae	45%	97%
A0A422NJH6	Trypanosoma rangeli	45%	94%
A4HD30	Leishmania braziliensis	83%	100%
A4I0L7	Leishmania infantum	99%	100%
C9ZNQ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	91%
E9AWH8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QAZ2	Leishmania major	95%	100%
V5BB88	Trypanosoma cruzi	47%	95%