Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WY18_LEIDO

TriTrypDb:

LdBPK_240050.1 , LdCL_240005400 , LDHU3_24.0070

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WY18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WY18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.516
CLV_NRD_NRD_1	224	226	PF00675	0.361
CLV_PCSK_KEX2_1	216	218	PF00082	0.367
CLV_PCSK_KEX2_1	224	226	PF00082	0.323
CLV_PCSK_KEX2_1	32	34	PF00082	0.597
CLV_PCSK_KEX2_1	398	400	PF00082	0.349
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.436
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.597
CLV_PCSK_PC1ET2_1	398	400	PF00082	0.349
CLV_PCSK_PC7_1	220	226	PF00082	0.382
CLV_PCSK_SKI1_1	155	159	PF00082	0.596
CLV_PCSK_SKI1_1	170	174	PF00082	0.442
CLV_PCSK_SKI1_1	19	23	PF00082	0.674
CLV_PCSK_SKI1_1	216	220	PF00082	0.386
CLV_PCSK_SKI1_1	263	267	PF00082	0.431
CLV_PCSK_SKI1_1	283	287	PF00082	0.396
CLV_PCSK_SKI1_1	423	427	PF00082	0.418
CLV_PCSK_SKI1_1	457	461	PF00082	0.521
DEG_APCC_DBOX_1	23	31	PF00400	0.582
DEG_COP1_1	410	417	PF00400	0.362
DEG_MDM2_SWIB_1	189	196	PF02201	0.360
DEG_Nend_Nbox_1	1	3	PF02207	0.543
DEG_SCF_FBW7_1	71	76	PF00400	0.532
DOC_CKS1_1	37	42	PF01111	0.568
DOC_CYCLIN_RxL_1	134	144	PF00134	0.456
DOC_CYCLIN_yClb5_NLxxxL_5	291	300	PF00134	0.301
DOC_MAPK_DCC_7	225	235	PF00069	0.474
DOC_MAPK_gen_1	216	223	PF00069	0.475
DOC_MAPK_MEF2A_6	292	300	PF00069	0.469
DOC_MAPK_MEF2A_6	42	51	PF00069	0.539
DOC_PP1_RVXF_1	135	142	PF00149	0.370
DOC_PP1_RVXF_1	156	162	PF00149	0.452
DOC_USP7_MATH_1	115	119	PF00917	0.309
DOC_USP7_MATH_1	267	271	PF00917	0.379
DOC_USP7_UBL2_3	62	66	PF12436	0.626
DOC_WW_Pin1_4	205	210	PF00397	0.496
DOC_WW_Pin1_4	36	41	PF00397	0.550
DOC_WW_Pin1_4	69	74	PF00397	0.639
DOC_WW_Pin1_4	91	96	PF00397	0.590
LIG_14-3-3_CanoR_1	140	149	PF00244	0.514
LIG_14-3-3_CanoR_1	190	194	PF00244	0.457
LIG_14-3-3_CanoR_1	283	288	PF00244	0.484
LIG_14-3-3_CanoR_1	399	407	PF00244	0.378
LIG_14-3-3_CanoR_1	434	438	PF00244	0.486
LIG_14-3-3_CanoR_1	457	464	PF00244	0.417
LIG_BRCT_BRCA1_1	185	189	PF00533	0.557
LIG_Clathr_ClatBox_1	146	150	PF01394	0.324
LIG_FHA_1	124	130	PF00498	0.505
LIG_FHA_1	190	196	PF00498	0.467
LIG_FHA_1	276	282	PF00498	0.386
LIG_FHA_1	63	69	PF00498	0.687
LIG_FHA_2	266	272	PF00498	0.580
LIG_FHA_2	312	318	PF00498	0.521
LIG_FHA_2	346	352	PF00498	0.429
LIG_FHA_2	363	369	PF00498	0.394
LIG_FHA_2	74	80	PF00498	0.508
LIG_GBD_Chelix_1	424	432	PF00786	0.451
LIG_GBD_Chelix_1	82	90	PF00786	0.614
LIG_LIR_Apic_2	249	254	PF02991	0.374
LIG_LIR_Gen_1	252	261	PF02991	0.497
LIG_LIR_Gen_1	345	354	PF02991	0.361
LIG_LIR_Nem_3	192	196	PF02991	0.458
LIG_LIR_Nem_3	252	258	PF02991	0.478
LIG_LIR_Nem_3	270	276	PF02991	0.290
LIG_LIR_Nem_3	345	349	PF02991	0.370
LIG_LIR_Nem_3	351	357	PF02991	0.311
LIG_LIR_Nem_3	368	373	PF02991	0.313
LIG_NRBOX	194	200	PF00104	0.469
LIG_OCRL_FandH_1	288	300	PF00620	0.469
LIG_Pex14_2	189	193	PF04695	0.364
LIG_Pex14_2	354	358	PF04695	0.417
LIG_SH2_CRK	273	277	PF00017	0.478
LIG_SH2_CRK	435	439	PF00017	0.486
LIG_SH2_NCK_1	251	255	PF00017	0.365
LIG_SH2_PTP2	242	245	PF00017	0.338
LIG_SH2_STAT5	228	231	PF00017	0.547
LIG_SH2_STAT5	242	245	PF00017	0.409
LIG_SH2_STAT5	273	276	PF00017	0.406
LIG_SH2_STAT5	435	438	PF00017	0.480
LIG_SH3_1	228	234	PF00018	0.382
LIG_SH3_3	228	234	PF00018	0.423
LIG_Sin3_3	418	425	PF02671	0.383
LIG_SUMO_SIM_anti_2	126	132	PF11976	0.554
LIG_SUMO_SIM_anti_2	143	150	PF11976	0.259
LIG_SUMO_SIM_anti_2	450	456	PF11976	0.405
LIG_SUMO_SIM_par_1	147	154	PF11976	0.454
LIG_SUMO_SIM_par_1	206	213	PF11976	0.561
LIG_SUMO_SIM_par_1	450	456	PF11976	0.359
LIG_TRAF2_1	314	317	PF00917	0.426
LIG_TYR_ITIM	240	245	PF00017	0.442
LIG_UBA3_1	392	398	PF00899	0.343
LIG_UBA3_1	56	62	PF00899	0.645
MOD_CDK_SPxK_1	36	42	PF00069	0.595
MOD_CK1_1	208	214	PF00069	0.429
MOD_CK1_1	305	311	PF00069	0.461
MOD_CK1_1	333	339	PF00069	0.425
MOD_CK1_1	94	100	PF00069	0.681
MOD_CK2_1	266	272	PF00069	0.426
MOD_CK2_1	311	317	PF00069	0.462
MOD_CK2_1	73	79	PF00069	0.517
MOD_Cter_Amidation	214	217	PF01082	0.468
MOD_GlcNHglycan	117	120	PF01048	0.506
MOD_GlcNHglycan	143	146	PF01048	0.524
MOD_GlcNHglycan	212	215	PF01048	0.429
MOD_GlcNHglycan	304	307	PF01048	0.391
MOD_GlcNHglycan	332	335	PF01048	0.458
MOD_GlcNHglycan	381	384	PF01048	0.471
MOD_GlcNHglycan	52	55	PF01048	0.532
MOD_GSK3_1	115	122	PF00069	0.454
MOD_GSK3_1	267	274	PF00069	0.468
MOD_GSK3_1	433	440	PF00069	0.570
MOD_GSK3_1	69	76	PF00069	0.568
MOD_GSK3_1	90	97	PF00069	0.638
MOD_LATS_1	138	144	PF00433	0.359
MOD_N-GLC_1	379	384	PF02516	0.483
MOD_N-GLC_1	69	74	PF02516	0.511
MOD_NEK2_1	151	156	PF00069	0.390
MOD_NEK2_1	189	194	PF00069	0.492
MOD_NEK2_1	291	296	PF00069	0.284
MOD_NEK2_1	50	55	PF00069	0.499
MOD_NEK2_1	60	65	PF00069	0.638
MOD_NEK2_1	90	95	PF00069	0.512
MOD_PIKK_1	200	206	PF00454	0.538
MOD_PIKK_1	311	317	PF00454	0.541
MOD_PKA_2	189	195	PF00069	0.503
MOD_PKA_2	291	297	PF00069	0.533
MOD_PKA_2	308	314	PF00069	0.387
MOD_PKA_2	433	439	PF00069	0.489
MOD_Plk_1	183	189	PF00069	0.544
MOD_Plk_2-3	345	351	PF00069	0.304
MOD_Plk_4	189	195	PF00069	0.440
MOD_Plk_4	433	439	PF00069	0.534
MOD_ProDKin_1	205	211	PF00069	0.488
MOD_ProDKin_1	36	42	PF00069	0.550
MOD_ProDKin_1	69	75	PF00069	0.628
MOD_ProDKin_1	91	97	PF00069	0.593
TRG_DiLeu_BaEn_1	416	421	PF01217	0.530
TRG_DiLeu_BaEn_1	450	455	PF01217	0.402
TRG_ENDOCYTIC_2	242	245	PF00928	0.452
TRG_ENDOCYTIC_2	273	276	PF00928	0.477
TRG_ENDOCYTIC_2	435	438	PF00928	0.480
TRG_ER_diArg_1	223	225	PF00400	0.346
TRG_NLS_MonoExtN_4	395	401	PF00514	0.327
TRG_Pf-PMV_PEXEL_1	371	375	PF00026	0.378
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	88	92	PF00026	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBX3	Leptomonas seymouri	52%	100%
A0A1X0NIQ1	Trypanosomatidae	28%	100%
A0A3R7MWR0	Trypanosoma rangeli	28%	98%
A4HD63	Leishmania braziliensis	80%	100%
A4I0M8	Leishmania infantum	99%	100%
D0A6X6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	99%
E9AWJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QAX5	Leishmania major	93%	100%
V5BRC9	Trypanosoma cruzi	29%	99%